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Article ; Online: Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron.

Liu, Jinyan / Chandrashekar, Abishek / Sellers, Daniel / Barrett, Julia / Jacob-Dolan, Catherine / Lifton, Michelle / McMahan, Katherine / Sciacca, Michaela / VanWyk, Haley / Wu, Cindy / Yu, Jingyou / Collier, Ai-Ris Y / Barouch, Dan H

Nature

2022 Volume 603, Issue 7901, Page(s) 493–496

Abstract: The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 spike ... ...

Abstract	The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 spike protein
MeSH term(s)	Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Vaccines/immunology ; Cross Reactions/immunology ; Humans ; Immunity, Cellular ; Immunity, Humoral ; SARS-CoV-2/chemistry ; SARS-CoV-2/classification ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/immunology ; T-Lymphocytes/immunology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-01-31
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-04465-y
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Vaccines Elicit Highly Cross-Reactive Cellular Immunity to the SARS-CoV-2 Omicron Variant.

Liu, Jinyan / Chandrashekar, Abishek / Sellers, Daniel / Barrett, Julia / Lifton, Michelle / McMahan, Katherine / Sciacca, Michaela / VanWyk, Haley / Wu, Cindy / Yu, Jingyou / Collier, Ai-Ris Y / Barouch, Dan H

medRxiv : the preprint server for health sciences

2022

Abstract	The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 Spike immunogen
Language	English
Publishing date	2022-01-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2022.01.02.22268634
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Waning Immunity Against XBB.1.5 Following Bivalent mRNA Boosters.

Lasrado, Ninaad / Collier, Ai-Ris Y / Miller, Jessica / Hachmann, Nicole P / Liu, Jinyan / Sciacca, Michaela / Wu, Cindy / Anand, Trisha / Bondzie, Esther A / Fisher, Jana L / Mazurek, Camille R / Patio, Robert C / Powers, Olivia / Rodrigues, Stefanie L / Rowe, Marjorie / Surve, Nehalee / Ty, Darren M / Korber, Bette / Barouch, Dan H

bioRxiv : the preprint server for biology

2023

Abstract: The SARS-CoV-2 Omicron variant has continued to evolve. XBB is a recombinant between two BA.2 sublineages, XBB.1 includes the G252V mutation, and XBB.1.5 includes the G252V and F486P mutations. XBB.1.5 has rapidly increased in frequency and has become ... ...

Abstract	The SARS-CoV-2 Omicron variant has continued to evolve. XBB is a recombinant between two BA.2 sublineages, XBB.1 includes the G252V mutation, and XBB.1.5 includes the G252V and F486P mutations. XBB.1.5 has rapidly increased in frequency and has become the dominant virus in New England. The bivalent mRNA vaccine boosters have been shown to increase neutralizing antibody (NAb) titers to multiple variants, but the durability of these responses remains to be determined. We assessed humoral and cellular immune responses in 30 participants who received the bivalent mRNA boosters and performed assays at baseline prior to boosting, at week 3 after boosting, and at month 3 after boosting. Our data demonstrate that XBB.1.5 substantially escapes NAb responses but not T cell responses after bivalent mRNA boosting. NAb titers to XBB.1 and XBB.1.5 were similar, suggesting that the F486P mutation confers greater transmissibility but not increased immune escape. By month 3, NAb titers to XBB.1 and XBB.1.5 declined essentially to baseline levels prior to boosting, while NAb titers to other variants declined less strikingly.
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.22.525079
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunogenicity of BA.5 Bivalent mRNA Vaccine Boosters.

The New England journal of medicine

2023 Volume 388, Issue 6, Page(s) 565–567

MeSH term(s)	Humans ; Antibodies, Neutralizing ; Antibodies, Viral ; Vaccines, Combined/immunology ; Vaccines, Combined/therapeutic use ; Vaccines, Synthetic/immunology ; Vaccines, Synthetic/therapeutic use ; Immunogenicity, Vaccine/immunology ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; mRNA Vaccines
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Vaccines, Combined ; Vaccines, Synthetic
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2213948
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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Mpox infection protects against re-challenge in rhesus macaques.

Aid, Malika / Sciacca, Michaela / McMahan, Katherine / Hope, David / Liu, Jinyan / Jacob-Dolan, Catherine / Powers, Olivia / Barrett, Julia / Wu, Cindy / Mutoni, Audrey / Murdza, Tetyana / Richter, Hannah / Velasco, Jason / Teow, Elyse / Boursiquot, Mona / Cook, Anthony / Orekov, Tatyana / Hamilton, Melissa / Pessaint, Laurent /

Ryan, Alaina / Hayes, Tammy / Martinot, Amanda J / Seaman, Michael S / Lewis, Mark G / Andersen, Hanne / Barouch, Dan H

Cell

2023 Volume 186, Issue 21, Page(s) 4652–4661.e13

Abstract: The mpox outbreak of 2022-2023 involved rapid global spread in men who have sex with men. We infected 18 rhesus macaques with mpox by the intravenous, intradermal, and intrarectal routes and observed robust antibody and T cell responses following all ... ...

Abstract	The mpox outbreak of 2022-2023 involved rapid global spread in men who have sex with men. We infected 18 rhesus macaques with mpox by the intravenous, intradermal, and intrarectal routes and observed robust antibody and T cell responses following all three routes of infection. Numerous skin lesions and high plasma viral loads were observed following intravenous and intradermal infection. Skin lesions peaked on day 10 and resolved by day 28 following infection. On day 28, we re-challenged all convalescent and 3 naive animals with mpox. All convalescent animals were protected against re-challenge. Transcriptomic studies showed upregulation of innate and inflammatory responses and downregulation of collagen formation and extracellular matrix organization following challenge, as well as rapid activation of T cell and plasma cell responses following re-challenge. These data suggest key mechanistic insights into mpox pathogenesis and immunity. This macaque model should prove useful for evaluating mpox vaccines and therapeutics.
MeSH term(s)	Animals ; Humans ; Male ; Homosexuality, Male ; Macaca mulatta ; Mpox (monkeypox)/immunology ; Sexual and Gender Minorities ; Monkeypox virus/physiology
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2023.08.023
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Zs.MG 58: Show issues

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Article ; Online: Waning Immunity Against XBB.1.5 Following Bivalent mRNA Boosters

Lasrado, Ninaad / Collier, Ai-ris / Miller, Jessica / Hachmann, Nicole / Liu, Jinyan / Sciacca, Michaela / Wu, Cindy / Anand, Trisha / Bondzie, Esther / Fisher, Jana / Mazurek, Camille / Patio, Robert / Powers, Olivia / Rodrigues, Stefanie / Rowe, Marjorie / Surve, Nehalee / Ty, Darren / Korber, Bette / Barouch, Dan H.

bioRxiv

Abstract	The SARS-CoV-2 Omicron variant has continued to evolve. XBB is a recombinant between two BA.2 sublineages, XBB.1 includes the G252V mutation, and XBB.1.5 includes the G252V and F486P mutations. XBB.1.5 has rapidly increased in frequency and has become the dominant virus in New England. The bivalent mRNA vaccine boosters have been shown to increase neutralizing antibody (NAb) titers to multiple variants, but the durability of these responses remains to be determined. We assessed humoral and cellular immune responses in 30 participants who received the bivalent mRNA boosters and performed assays at baseline prior to boosting, at week 3 after boosting, and at month 3 after boosting. Our data demonstrate that XBB.1.5 substantially escapes NAb responses but not T cell responses after bivalent mRNA boosting. NAb titers to XBB.1 and XBB.1.5 were similar, suggesting that the F486P mutation confers greater transmissibility but not increased immune escape. By month 3, NAb titers to XBB.1 and XBB.1.5 declined essentially to baseline levels prior to boosting, while NAb titers to other variants declined less strikingly.
Keywords	covid19
Language	English
Publishing date	2023-01-23
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2023.01.22.525079
Database	COVID19

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Article ; Online: Vaccines Elicit Highly Cross-Reactive Cellular Immunity to the SARS-CoV-2 Omicron Variant

medRxiv

Abstract	The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 Spike immunogen, resulting in increased breakthrough infections and reduced vaccine efficacy. Cellular immune responses, particularly CD8+ T cell responses, are likely critical for protection against severe SARS-CoV-2 disease. Here we show that cellular immunity induced by current SARS-CoV-2 vaccines is highly cross-reactive against the SARS-CoV-2 Omicron variant. Individuals who received Ad26.COV2.S or BNT162b2 vaccines demonstrated durable CD8+ and CD4+ T cell responses that showed extensive cross-reactivity against both the Delta and Omicron variants, including in central and effector memory cellular subpopulations. Median Omicron-specific CD8+ T cell responses were 82-84% of WA1/2020-specific CD8+ T cell responses. These data suggest that current vaccines may provide considerable protection against severe disease with the SARS-CoV-2 Omicron variant despite the substantial reduction of neutralizing antibody responses.
Keywords	covid19
Language	English
Publishing date	2022-01-03
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2022.01.02.22268634
Database	COVID19

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Article ; Online: CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques.

Liu, Jinyan / Yu, Jingyou / McMahan, Katherine / Jacob-Dolan, Catherine / He, Xuan / Giffin, Victoria / Wu, Cindy / Sciacca, Michaela / Powers, Olivia / Nampanya, Felix / Miller, Jessica / Lifton, Michelle / Hope, David / Hall, Kevin / Hachmann, Nicole P / Chung, Benjamin / Anioke, Tochi / Li, Wenjun / Muench, Jeanne /

Gamblin, Adrienne / Boursiquot, Mona / Cook, Anthony / Lewis, Mark G / Andersen, Hanne / Barouch, Dan H

Science immunology

2022 Volume 7, Issue 77, Page(s) eabq7647

Abstract: Spike-specific neutralizing antibodies (NAbs) are generally considered key correlates of vaccine protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recently, robust vaccine prevention of severe disease with SARS- ... ...

Abstract	Spike-specific neutralizing antibodies (NAbs) are generally considered key correlates of vaccine protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recently, robust vaccine prevention of severe disease with SARS-CoV-2 variants that largely escape NAb responses has been reported, suggesting a role for other immune parameters for virologic control. However, direct data demonstrating a role of CD8
MeSH term(s)	Animals ; Humans ; SARS-CoV-2 ; CD8-Positive T-Lymphocytes ; Macaca mulatta ; Viral Vaccines ; Ad26COVS1 ; COVID-19/prevention & control
Chemical Substances	Viral Vaccines ; Ad26COVS1 (JT2NS6183B)
Language	English
Publishing date	2022-11-11
Publishing country	United States
Document type	Journal Article
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.abq7647
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters.

bioRxiv : the preprint server for biology

2022

Abstract: Waning immunity following mRNA vaccination and the emergence of SARS-CoV-2 variants has led to reduced mRNA vaccine efficacy against both symptomatic infection and severe disease. Bivalent mRNA boosters expressing the Omicron BA.5 and ancestral WA1/2020 ... ...

Abstract	Waning immunity following mRNA vaccination and the emergence of SARS-CoV-2 variants has led to reduced mRNA vaccine efficacy against both symptomatic infection and severe disease. Bivalent mRNA boosters expressing the Omicron BA.5 and ancestral WA1/2020 Spike proteins have been developed and approved, because BA.5 is currently the dominant SARS-CoV-2 variant and substantially evades neutralizing antibodies (NAbs). Our data show that BA.5 NAb titers were comparable following monovalent and bivalent mRNA boosters.
Language	English
Publishing date	2022-10-25
Publishing country	United States
Document type	Preprint
DOI	10.1101/2022.10.24.513619
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Article ; Online: Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques.

Solforosi, Laura / Costes, Lea M M / Tolboom, Jeroen T B M / McMahan, Katherine / Anioke, Tochi / Hope, David / Murdza, Tetyana / Sciacca, Michaela / Bouffard, Emily / Barrett, Julia / Wu, Cindy / Hachmann, Nicole / Miller, Jessica / Yu, Jingyou / He, Xuan / Jacob-Dolan, Catherine / Huber, Sietske K Rosendahl / Dekking, Liesbeth / Chamanza, Ronnie /

Choi, Ying / Boer, Karin Feddes-de / Barouch, Dan H / Schuitemaker, Hanneke / Zahn, Roland C / Wegmann, Frank

Nature communications

2023 Volume 14, Issue 1, Page(s) 1944

Abstract: Omicron spike (S) encoding vaccines as boosters, are a potential strategy to improve COVID-19 vaccine efficacy against Omicron. Here, macaques (mostly females) previously immunized with Ad26.COV2.S, are boosted with Ad26.COV2.S, Ad26.COV2.S.529 (encoding ...

Abstract	Omicron spike (S) encoding vaccines as boosters, are a potential strategy to improve COVID-19 vaccine efficacy against Omicron. Here, macaques (mostly females) previously immunized with Ad26.COV2.S, are boosted with Ad26.COV2.S, Ad26.COV2.S.529 (encoding Omicron BA.1 S) or a 1:1 combination of both vaccines. All booster vaccinations elicit a rapid antibody titers increase against WA1/2020 and Omicron S. Omicron BA.1 and BA.2 antibody responses are most effectively boosted by vaccines including Ad26.COV2.S.529. Independent of vaccine used, mostly WA1/2020-reactive or WA1/2020-Omicron BA.1 cross-reactive B cells are detected. Ad26.COV2.S.529 containing boosters provide only slightly higher protection of the lower respiratory tract against Omicron BA.1 challenge compared with Ad26.COV2.S-only booster. Antibodies and cellular immune responses are identified as complementary correlates of protection. Overall, a booster with an Omicron-spike based vaccine provide only moderately improved immune responses and protection compared with the original Wuhan-Hu-1-spike based vaccine, which still provide robust immune responses and protection against Omicron.
MeSH term(s)	Female ; Animals ; Humans ; Male ; Ad26COVS1 ; COVID-19 Vaccines ; Macaca ; SARS-CoV-2 ; COVID-19/prevention & control ; Vaccines ; Antibodies, Neutralizing ; Antibodies, Viral
Chemical Substances	Ad26COVS1 (JT2NS6183B) ; COVID-19 Vaccines ; Vaccines ; Antibodies, Neutralizing ; Antibodies, Viral
Language	English
Publishing date	2023-04-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-37715-2
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