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  1. Article ; Online: MEK and PD-L1 inhibition in colorectal cancer: a burning blaze turning into a flash in the pan.

    Sclafani, Francesco

    The Lancet. Oncology

    2019  Volume 20, Issue 6, Page(s) 752–753

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Azetidines ; B7-H1 Antigen ; Colorectal Neoplasms ; Humans ; Phenylurea Compounds ; Piperidines ; Pyridines
    Chemical Substances Antibodies, Monoclonal, Humanized ; Azetidines ; B7-H1 Antigen ; Phenylurea Compounds ; Piperidines ; Pyridines ; regorafenib (24T2A1DOYB) ; atezolizumab (52CMI0WC3Y) ; cobimetinib (ER29L26N1X)
    Language English
    Publishing date 2019-04-16
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(19)30076-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5696: Show issues Location:
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    Zs.MO 460: Show issues

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  2. Article ; Online: Building evidence-based treatment recommendations for advanced anal cancer: the time is now.

    Sclafani, Francesco

    The Lancet. Oncology

    2018  Volume 19, Issue 8, Page(s) 1009–1011

    MeSH term(s) Anus Neoplasms ; Carcinoma, Squamous Cell ; Cisplatin ; Docetaxel ; Epitopes ; Fluorouracil ; Humans ; Neoplasm Recurrence, Local
    Chemical Substances Epitopes ; Docetaxel (15H5577CQD) ; Cisplatin (Q20Q21Q62J) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2018-07-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(18)30360-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5696: Show issues Location:
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  3. Article ; Online: Editorial: 'All you need is immunotherapy': a new treatment paradigm in sight for early-stage, mismatch repair-deficient/microsatellite instability high gastrointestinal cancers?

    Sclafani, Francesco / Hendlisz, Alain

    Current opinion in oncology

    2022  Volume 34, Issue 4, Page(s) 379–381

    MeSH term(s) DNA Mismatch Repair ; Gastrointestinal Neoplasms/genetics ; Gastrointestinal Neoplasms/therapy ; Humans ; Immunotherapy ; Microsatellite Instability
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Neoadjuvant chemotherapy for resectable colon cancer in the era of precision oncology: a step forward or a step back?

    Audisio, Alessandro / Fazio, Roberta / Hendlisz, Alain / Sclafani, Francesco

    Current opinion in oncology

    2023  Volume 35, Issue 4, Page(s) 315–317

    MeSH term(s) Humans ; Neoadjuvant Therapy ; Precision Medicine ; Chemotherapy, Adjuvant ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/surgery ; Pancreatic Neoplasms/drug therapy
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: PD-1 inhibition in metastatic dMMR/MSI-H colorectal cancer.

    Sclafani, Francesco

    The Lancet. Oncology

    2017  Volume 18, Issue 9, Page(s) 1141–1142

    MeSH term(s) Colorectal Neoplasms ; DNA Mismatch Repair ; Humans ; Microsatellite Instability ; Programmed Cell Death 1 Receptor
    Chemical Substances Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2017-07-19
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(17)30512-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Editorial: Radioembolization for metastatic colorectal cancer: towards maturity, at last?

    Hendlisz, Alain / Sclafani, Francesco

    Current opinion in oncology

    2021  Volume 33, Issue 4, Page(s) 351–352

    MeSH term(s) Carcinoma, Hepatocellular/radiotherapy ; Carcinoma, Hepatocellular/secondary ; Carcinoma, Hepatocellular/therapy ; Clinical Trials, Phase III as Topic ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/radiotherapy ; Colorectal Neoplasms/therapy ; Embolization, Therapeutic/methods ; Humans ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; Randomized Controlled Trials as Topic ; Yttrium Radioisotopes/administration & dosage
    Chemical Substances Yttrium Radioisotopes
    Language English
    Publishing date 2021-03-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Editorial: Adjuvant chemotherapy for gastrointestinal cancers: we can do much better.

    Sclafani, Francesco / Hendlisz, Alain

    Current opinion in oncology

    2020  Volume 32, Issue 4, Page(s) 344–346

    MeSH term(s) Chemotherapy, Adjuvant ; Gastrointestinal Neoplasms/drug therapy ; Gastrointestinal Neoplasms/surgery ; Humans
    Language English
    Publishing date 2020-08-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Debating Pros and Cons of Total Neoadjuvant Therapy in Rectal Cancer.

    Sclafani, Francesco / Corrò, Claudia / Koessler, Thibaud

    Cancers

    2021  Volume 13, Issue 24

    Abstract: Recently, two large, randomised phase III clinical trials of total neoadjuvant therapy (TNT) in locally advanced rectal cancer were published (RAPIDO and PRODIGE 23). These two trials compared short-course radiotherapy (SCRT) followed by chemotherapy ... ...

    Abstract Recently, two large, randomised phase III clinical trials of total neoadjuvant therapy (TNT) in locally advanced rectal cancer were published (RAPIDO and PRODIGE 23). These two trials compared short-course radiotherapy (SCRT) followed by chemotherapy with standard chemoradiotherapy (CRT) and chemotherapy followed by CRT with standard CRT, respectively. They showed improvement in some of the outcomes such as distant recurrence and pathological complete response (pCR). No improvement, however, was observed in local disease control or the de-escalation of surgical procedures. Although it seems lawful to integrate TNT within the treatment algorithm of localised stage II and III rectal cancer, many questions remain unanswered, including which are the optimal criteria to identify patients who are most likely to benefit from this intensive treatment. Instead of providing a sterile summary of trial results, we put these in perspective in a pros and cons manner. Moreover, we discuss some biological aspects of rectal cancer, which may provide some insights into the current decision-making process, and represent the basis for the future development of alternative, more effective treatment strategies.
    Language English
    Publishing date 2021-12-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13246361
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  9. Article ; Online: Editorial: Adjuvant chemotherapy for rectal cancer: playing the devil's advocate.

    Sclafani, Francesco / Hendlisz, Alain

    Current opinion in oncology

    2019  Volume 31, Issue 4, Page(s) 336–338

    MeSH term(s) Chemoradiotherapy, Adjuvant ; Chemotherapy, Adjuvant ; Clinical Trials, Phase III as Topic ; Humans ; Neoadjuvant Therapy ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/radiotherapy ; Rectal Neoplasms/surgery
    Language English
    Publishing date 2019-04-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Retrospective Evaluation of the Prognostic Value of Histological Growth Pattern in Patients with Colorectal Peritoneal Metastases Undergoing Curative-Intent Cytoreductive Surgery.

    Kamdem, Leonel / Asmar, Antoine El / Demetter, Pieter / Zana, Ismael Coulibaly / Khaled, Charif / Sclafani, Francesco / Donckier, Vincent / Vermeulen, Peter / Liberale, Gabriel

    Annals of surgical oncology

    2024  Volume 31, Issue 6, Page(s) 3778–3784

    Abstract: Background: Two distinct histological growth patterns (HGPs) were described in patients with peritoneal metastasis of colorectal cancer origin (PMCRC) with limited Peritoneal Cancer Index (PCI) ≤ 6 who did not receive neoadjuvant chemotherapy (NAC) and ... ...

    Abstract Background: Two distinct histological growth patterns (HGPs) were described in patients with peritoneal metastasis of colorectal cancer origin (PMCRC) with limited Peritoneal Cancer Index (PCI) ≤ 6 who did not receive neoadjuvant chemotherapy (NAC) and were treated with cytoreductive surgery (CRS) ± hyperthermic intraperitoneal chemotherapy (HIPEC): pushing HGP (P-HGP) and infiltrating HGP (I-HGP). Patients with dominant P-HGP (> 50%) had significantly better disease-free survival (DFS) and overall survival (OS).
    Objective: We aimed to determine whether these previous observations regarding the prognostic value of HGP in patients with PMCRC with low PCI (≤ 6) are also valid in all operable patients, regardless of whether they received NAC or not and regardless of PCI score.
    Methods: This was a retrospective study including 76 patients who underwent complete CRS ± HIPEC for PMCRC between July 2012 and March 2019. In each patient, up to five of the largest excised peritoneal nodules were analyzed for their tumor-to-peritoneum interface. Correlations between NAC, HGP, and prognosis were further explored.
    Results: Thirty-seven patients (49%) had dominant P-HGP and 39 (51%) had dominant I-HGP. On univariate analysis, patients with P-HGP ≤ 50% had significantly lower OS than those with dominant P-HGP > 50% (39 versus 60 months; p = 0.014) confirmed on multivariate analysis (hazard ratio 2.4, 95% confidence interval 1.3-4.5; p = 0.006). There were no significant associations between NAC and type of HGP.
    Conclusions: This study confirms the prognostic value and reproducibility of the two previously reported HGPs in PMCRC. Dominant P-HGP is associated with better DFS and OS in patients undergoing curative-intent CRS ± HIPEC compared with I-HGP, independently of the extent of peritoneal disease burden.
    MeSH term(s) Humans ; Peritoneal Neoplasms/secondary ; Peritoneal Neoplasms/therapy ; Peritoneal Neoplasms/mortality ; Cytoreduction Surgical Procedures/mortality ; Female ; Male ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Retrospective Studies ; Middle Aged ; Survival Rate ; Prognosis ; Hyperthermic Intraperitoneal Chemotherapy ; Aged ; Follow-Up Studies ; Neoadjuvant Therapy/mortality ; Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-024-15125-y
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