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  1. Book ; Online ; E-Book: Gastrointestinal stromal tumors

    Scoggins, Charles R. / Raut, Chandrajit P. / Mullen, John T.

    bench to bedside

    2017  

    Author's details Charles R. Scoggins, Chandrajit P. Raut, John T. Mullen editors
    Keywords Gastrointestinal Stromal Tumors ; Krebs ; Gastrointestinaltrakt
    Subject Magen-Darm-Kanal ; Magen-Darm-Trakt ; Magen-Darmtrakt ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Language English
    Size 1 Online-Ressource (xi, 243 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019496684
    ISBN 978-3-319-42632-7 ; 9783319426303 ; 3-319-42632-X ; 3319426303
    DOI 10.1007/978-3-319-42632-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: TACE or TARE for Unresectable Neuroendocrine Liver Metastases: Can we Finally Start to Focus on Value?

    Scoggins, Charles R

    Annals of surgical oncology

    2021  Volume 28, Issue 4, Page(s) 1876–1877

    MeSH term(s) Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic ; Humans ; Liver Neoplasms/drug therapy ; Treatment Outcome
    Language English
    Publishing date 2021-01-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-09598-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4042: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Splenic Preservation Just Might Be Reasonable for Patients with Left-Sided Pancreatic Cancer.

    Scoggins, Charles R

    Annals of surgical oncology

    2019  Volume 26, Issue 4, Page(s) 924–925

    MeSH term(s) Humans ; Organ Sparing Treatments ; Pancreatectomy ; Pancreatic Neoplasms/surgery ; Prognosis ; Spleen/surgery
    Language English
    Publishing date 2019-01-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-018-07124-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4042: Show issues Location:
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  4. Article: Radiographic features and behaviors of neuroendocrine tumors: can we judge a book by its cover?

    Mouw, Tyler J / Scoggins, Charles R

    Hepatobiliary surgery and nutrition

    2021  Volume 10, Issue 4, Page(s) 573–574

    Language English
    Publishing date 2021-08-24
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-21-174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Improved Access to Healthcare is Good for Everyone.

    Scoggins, Charles R / Egger, Michael E

    Annals of surgical oncology

    2021  Volume 29, Issue 1, Page(s) 17–19

    MeSH term(s) Health Services Accessibility ; Humans
    Language English
    Publishing date 2021-09-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10793-6
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  6. Article ; Online: Cancer Immunotherapy for the General Surgeon.

    Fromer, Marc W / Scoggins, Charles R

    The American surgeon

    2020  Volume 86, Issue 4, Page(s) 284–292

    Abstract: Progress in the arena of cancer immunotherapy has been immense in recent years. The fact remains that most of the cancer resections in the United States are performed by general surgeons and not oncologic specialists. A busy practice in general surgery ... ...

    Abstract Progress in the arena of cancer immunotherapy has been immense in recent years. The fact remains that most of the cancer resections in the United States are performed by general surgeons and not oncologic specialists. A busy practice in general surgery will invariably make it difficult to keep pace with such rapid advancement. This review offers a concise summary of the major concepts and trials that have driven the immunotherapy revolution and their implications for surgeons who deliver cancer care.
    MeSH term(s) CTLA-4 Antigen/antagonists & inhibitors ; CTLA-4 Antigen/immunology ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Chemotherapy, Adjuvant ; Gastrointestinal Neoplasms/drug therapy ; Humans ; Immunotherapy/adverse effects ; Liver Neoplasms/drug therapy ; Melanoma/drug therapy ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology ; Skin Neoplasms/drug therapy
    Chemical Substances CTLA-4 Antigen ; CTLA4 protein, human ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2020-05-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Developing sarcopenia during neoadjuvant therapy is associated with worse survival in esophageal adenocarcinoma patients.

    Pierce, Katherine / Philips, Prejesh / Egger, Michael E / Scoggins, Charles R / Martin, Robert Cg

    Surgery

    2023  Volume 175, Issue 3, Page(s) 718–725

    Abstract: Background: Sarcopenia in cancer patients has been associated with mixed postoperative outcomes. The aim of this study was to evaluate whether the development of sarcopenia during the neoadjuvant period is predictive of postoperative mortality in ... ...

    Abstract Background: Sarcopenia in cancer patients has been associated with mixed postoperative outcomes. The aim of this study was to evaluate whether the development of sarcopenia during the neoadjuvant period is predictive of postoperative mortality in esophageal adenocarcinoma patients.
    Methods: We queried a prospective database to retrieve the sarcopenic status of patients with esophageal adenocarcinoma who underwent cross-sectional imaging of the third lumbar vertebra at diagnosis and within 2 months of undergoing an esophagogastrectomy between 2014 and 2022.
    Results: Of the 71 patients included in the study, 36 (50.7%) presented with sarcopenia at diagnosis. Of the 35 non-sarcopenic patients, 14 (40%) developed sarcopenia during the neo-adjuvant period. Patients who were not sarcopenic at diagnosis but developed sarcopenia preoperatively had significantly worse overall survival than patients sarcopenic at diagnosis and not sarcopenic preoperatively and patients experiencing no change in sarcopenic status (median 18 vs 47 vs 31 months; P = .02). Diagnostic and preoperative sarcopenic status alone were not significantly associated with overall survival (P = .48 and P = .56, respectively). Although 37 (52.1%) patients died, the cause of death was often not cancer-related (54.1%) and included acute respiratory failure, pneumonia, and cardiac arrest. No significant survival difference was observed when stratified by >10% weight loss (P = .9) or large loss in body mass index (P = .8).
    Conclusion: Developing sarcopenia during the neo-adjuvant period may be associated with worse overall survival in patients requiring esophagogastrectomy.
    MeSH term(s) Humans ; Sarcopenia/diagnosis ; Sarcopenia/diagnostic imaging ; Neoadjuvant Therapy/adverse effects ; Esophageal Neoplasms/complications ; Esophageal Neoplasms/surgery ; Adenocarcinoma/complications ; Adenocarcinoma/surgery ; Retrospective Studies ; Prognosis
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2023.09.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.129: Show issues Location:
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  8. Article: Patient Selection and Outcomes of Laparoscopic Microwave Ablation of Hepatocellular Carcinoma.

    Martin, Robert C G / Woeste, Matthew / Egger, Michael E / Scoggins, Charles R / McMasters, Kelly M / Philips, Prejesh

    Cancers

    2023  Volume 15, Issue 7

    Abstract: Background: Laparoscopic microwave ablation (MWA) of hepatocellular carcinoma is underutilized and predictors of survival in this setting are not well characterized.: Methods: The prognostic value of clinicopathologic variables was evaluated on ... ...

    Abstract Background: Laparoscopic microwave ablation (MWA) of hepatocellular carcinoma is underutilized and predictors of survival in this setting are not well characterized.
    Methods: The prognostic value of clinicopathologic variables was evaluated on progression-free survival (PFS) and overall survival (OS) by univariate and multivariate analyses. The aim of this study was to evaluate a preferred laparoscopic MWA approach in HCC patients that are not candidates for percutaneous ablation and further classify clinicopathologic factors that may predict survival outcomes following operative MWA in the setting of primary HCC.
    Results: 184 patients with HCC (median age 66, (33-86), 70% male) underwent laparoscopic MWA (N = 162, 88% laparoscopic) compared to 12% undergoing open MWA (N = 22). Median PFS was 29.3 months (0.2-170) and OS was 44.2 months (2.8-170). Ablation success was confirmed in 100% of patients. Ablation recurrence occurred in 3% (6/184), and local/hepatic recurrence occurred in 34%, at a median time of 19 months (9-18). Distant progression was noted in 8%. Median follow up was 34.1 months (6.4-170). Procedure-related complications were recorded in six (9%) patients with one 90-day mortality. Further, >1 lesion, AFP levels ≥ 80 ng/mL, and an "invader" on pre-operative radiology were associated with increased risk of progression (>1 lesion HR 2.92, 95% CI 1.06 -7.99,
    Conclusions: Preoperative lesion number, AFP ≥ 80 ng/mL, and an aggressive imaging characteristic (Invader) independently predict PFS and OS following laparoscopic operative MWA.
    Language English
    Publishing date 2023-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15071965
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  9. Article ; Online: Multi-institutional review of adverse events associated with irreversible electroporation in the treatment of locally advanced pancreatic cancer.

    Stephens, Kyle / Philips, Prejesh P / Egger, Michael E / Scoggins, Charles R / McMasters, Kelly M / Martin, Robert C G

    Surgery

    2023  Volume 175, Issue 3, Page(s) 704–711

    Abstract: Background: Irreversible electroporation is a novel approach for treating locally advanced pancreatic adenocarcinoma. However, this ablative technique is not without risk and has the potential to precipitate adverse events. The aim of this study was to ... ...

    Abstract Background: Irreversible electroporation is a novel approach for treating locally advanced pancreatic adenocarcinoma. However, this ablative technique is not without risk and has the potential to precipitate adverse events. The aim of this study was to delineate risk factors that increase this risk, as well as to elucidate the risk profile associated with irreversible electroporation in the setting of locally advanced pancreatic adenocarcinoma.
    Methods: A review of our prospective multi-institutional database from December 2015 to March 2022 of patients with locally advanced pancreatic adenocarcinoma who underwent irreversible electroporation was analyzed for adverse events. These were then compared with a control population of patients undergoing pancreatectomy for adenocarcinoma.
    Results: Adverse events occurred in 51 patients of the 201 patients treated with irreversible electroporation compared with 78 of the 200 patients treated with pancreatectomy. The irreversible electroporation group had a significantly greater incidence of postoperative ascites in stage 3C patients. The most common complications in the irreversible electroporation group were infectious (n = 13), gastrointestinal bleed (n = 11), and ascites (n = 7). Multivariate analysis demonstrated increased risk of severe (grade ≥3) adverse events in the irreversible electroporation cohort who received high dose, neoadjuvant radiation (hazard ratio, 2.4; 95% confidence interval, 1.4-5.4), irreversible electroporation electrodes bracketing the superior mesenteric artery, superior mesenteric vein, and portal venous vein (hazard ratio, 1.9; 95% confidence interval, 1.3-3.4), and who had a bile duct stent in place for >6 months (hazard ratio, 1.7; 95% confidence interval, 1.2-5.6). There were similar rates of 90-day mortality in both groups, irreversible electroporation 2.4% vs pancreatectomy 2.8%.
    Conclusion: This study revealed a 25% rate of adverse events associated with irreversible electroporation in locally advanced pancreatic adenocarcinoma, which was significantly less (P = .004) than the 39% rate of adverse events associated with pancreatectomy in early-stage disease. Certain unique adverse events in the irreversible electroporation group have been established and should be understood in the care of these patients.
    MeSH term(s) Humans ; Pancreatic Neoplasms/surgery ; Prospective Studies ; Adenocarcinoma/surgery ; Ascites ; Electroporation/methods ; Treatment Outcome ; Multicenter Studies as Topic
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2023.08.042
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  10. Article ; Online: Combined pre-operative risk score predicts pancreatic leak after pancreatic resection.

    Clements, Noah A / Philips, Prejesh / Egger, Michael E / McMasters, Kelly M / Scoggins, Charles R / Martin, Robert C G

    Surgical endoscopy

    2023  Volume 38, Issue 2, Page(s) 742–756

    Abstract: Background: Post-operative pancreatic fistula (POPF) is a major complication following pancreatectomy and is currently difficult to predict pre-operatively. This study aims to validate pre-operative risk factors and develop a novel combined score for ... ...

    Abstract Background: Post-operative pancreatic fistula (POPF) is a major complication following pancreatectomy and is currently difficult to predict pre-operatively. This study aims to validate pre-operative risk factors and develop a novel combined score for the prediction of POPF in the pre-operative setting.
    Methods: Data were collected from 2016 to 2021 for radiologic main pancreatic duct diameter (MPD), body mass index (BMI), physical status classified by American Society of Anesthesiologists (ASA), polypharmacy, mean platelet ratio (MPR), comorbidity-polypharmacy score (CPS), and a novel Combined Pancreatic Leak Prediction Score (CPLPS) (derived from MPD diameter, BMI, and CPS) were obtained from pre-operative data and analyzed for their independent association with POPF occurrence.
    Results: In total, 166 patients who underwent pancreatectomy with pancreatic leak (Grade A, B, and C) occurring in 51(30.7%) of patients. Pre-operative radiologic MPD diameter < 4 mm (p < 0.001), < 5 mm (p < 0.001), < 6 mm (p = 0.001), BMI ≥ 25 (p = 0.009), and ≥ 30 (p = 0.017) were independently associated with the occurrence of pancreatic leak. CPLPS was also predictive of pancreatic leak following pancreatectomy on univariate (p = 0.005) and multivariate analysis (p = 0.036).
    Conclusion: MPD and BMI were independent risk factors predictive for the development of pancreatic leak. CPLPS, was an independent predictor of pancreatic leak following pancreatectomy and could be used to help guide surgical decision making and patient counseling.
    MeSH term(s) Humans ; Pancreatectomy/adverse effects ; Pancreaticoduodenectomy/adverse effects ; Pancreas/surgery ; Risk Factors ; Pancreatic Fistula/diagnosis ; Pancreatic Fistula/etiology ; Pancreatic Fistula/epidemiology ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies
    Language English
    Publishing date 2023-12-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-023-10602-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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