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Article: Early-Staged Carotid Artery Stenting Prior to Coronary Artery Bypass Grafting: Analysis of the Early and Mid-Term Results in Comparison with a Consecutive Cohort of Isolated Coronary Artery Surgery Patients.

Nardi, Paolo / Altieri, Claudia / Pisano, Calogera / Oddi, Fabio Massimo / Ranucci, Alessandro / Fresilli, Mauro / Salvati, Alessandro Cristian / Buioni, Dario / Scognamiglio, Mattia / Ajello, Valentina / Bassano, Carlo / Ascoli Marchetti, Andrea / Ippoliti, Arnaldo / Ruvolo, Giovanni

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Aim: The aim of the present study was to analyze retrospectively the results of patients who underwent early-staged, i.e., within 24-48 h, carotid artery stenting (e-s CAS) before coronary artery bypass grafting (CABG).: Methods: Between December ... ...

Abstract	Aim: The aim of the present study was to analyze retrospectively the results of patients who underwent early-staged, i.e., within 24-48 h, carotid artery stenting (e-s CAS) before coronary artery bypass grafting (CABG). Methods: Between December 2014 and December 2022, 1046 consecutive patients underwent CABG; 31 of these patients (3%) were subjected to e-s CAS prior to CABG (e-s CAS + CABG group). Preoperative and intraoperative variables and early and mid-term results of the e-s CAS + CABG group were compared with those of patients who underwent isolated CABG (CABG group). Results: As compared with the CABG group, the e-s CAS + CABG group showed a worse clinical risk profile due to higher Euroscore-2 values and incidence of obstructive pulmonary disease and bilateral carotid artery and peripheral artery diseases ( Conclusions: CABG preceded by e-s CAS appears to be associated with satisfactory early outcomes while limiting the risk of myocardial infarction to a very short time interval between the two procedures. Freedom from late all-causes death, cardiac death, and MACCEs were comparable and equally satisfactory, underscoring the positive protective effects of CAS and CABG on the carotid and coronary territories over time.
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020480
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Article: The role of the female gender on mid-term outcome after coronary artery bypass grafting: a retrospective study.

Nardi, Paolo / Pisano, Calogera / Bassano, Carlo / Bertoldo, Fabio / Buioni, Dario / Labriola, Vincenzo / Salvati, Alessandro Cristian / Scognamiglio, Mattia / Altieri, Claudia / Ruvolo, Giovanni

Journal of thoracic disease

2024 Volume 16, Issue 2, Page(s) 862–874

Abstract: Background: Data on female gender differences on clinical prognosis after coronary artery bypass grafting (CABG) are still controversial. We evaluated retrospectively the impact of women patients in comparison with men undergoing CABG on mid-term ... ...

Abstract	Background: Data on female gender differences on clinical prognosis after coronary artery bypass grafting (CABG) are still controversial. We evaluated retrospectively the impact of women patients in comparison with men undergoing CABG on mid-term outcome. Methods: Between December 2014 and March 2022, 1,044 consecutive patients (162 females, 15.5%, 882 males, 84.5%) underwent isolated CABG. The mean follow-up was 40±27 (median 38) months. Logistic and Cox model analysis regressions were used to assess the risk of female gender and other variables, Kaplan-Meier estimates to assess survival rates. Results: Women did not have a significant higher operative mortality than men (3.09% Conclusions: Women undergoing CABG with the same surgical techniques currently adopted for men, do not appear to be associated with worse early prognosis. Freedom from late all-causes mortality, cardiac death and adverse cardiac events are comparable and equally satisfactory, highlighting the positive protective effect of CABG over time also in women.
Language	English
Publishing date	2024-02-04
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-932
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Article ; Online: Initial Surgical Strategy for the Treatment of Type A Acute Aortic Dissection: Does Proximal or Distal Extension of the Aortic Resection Influence the Outcomes?

Bassano, Carlo / Pugliese, Marta / Mve Mvondo, Charles / Pisano, Calogera / Nardi, Paolo / Buioni, Dario / Bertoldo, Fabio / Scognamiglio, Mattia / Salvati, Alessandro C / Altieri, Claudia / Ruvolo, Giovanni

International journal of environmental research and public health

2022 Volume 19, Issue 14

Abstract: 1) Background: We sought to analyze and compare the outcomes in terms of early and late mortality and freedom from a redo operation in patients undergoing surgical treatment for a type A acute aortic dissection in relation to the initial surgical ... ...

Abstract	(1) Background: We sought to analyze and compare the outcomes in terms of early and late mortality and freedom from a redo operation in patients undergoing surgical treatment for a type A acute aortic dissection in relation to the initial surgical treatment strategy, i.e., proximal or distal extension of the aortic segment resection, compared with isolated resection of the supracoronary ascending aorta. (2) Methods: This is a retrospective study in which we included 269 patients who underwent operations for a type A acute aortic dissection in the Department of Cardiac Surgery of Tor Vergata University from May 2006 to May 2016. The patients were grouped according to the extent of the performed surgical treatment: isolated replacement of the supracoronary ascending aorta (NE, no extension), replacement of the aortic root (PE, proximal extension), replacement of the aortic arch (DE, distal extension), and both (BE, bilateral extension). The analyzed variables were in-hospital mortality, postoperative complications (incidence of neurological damage, renal failure and need for prolonged intubation), late mortality and need for a redo operation. (3) Results: Unilateral cerebral perfusion was performed in 49.3% of the patients, and bilateral perfusion-in 50.6%. The overall in-hospital mortality was 31.97%. In the multivariate analysis, advanced age, cardiopulmonary bypass time and preoperative orotracheal intubation were independent predictors of in-hospital mortality. In the population of patients who survived the surgery, the probability of survival at 92 months was 70 ± 5%, the probability of freedom from a redo operation was 71.5 ± 5%, the probability of freedom from the combined end-point death and a redo operation was 50 ± 5%. The re-intervention rate in the general population was 16.9%. The overall probability of freedom from re-intervention was higher in patients undergoing aortic root replacement, although not reaching a level of statistical significance. Patients who underwent aortic arch treatment showed reduced survival. (4) Conclusions: In the treatment of type A acute aortic dissection, all the surgical strategies adopted were associated with satisfactory long-term survival. In the group of patients in which the aortic root had not been replaced, we observed reduced event-free survival.
MeSH term(s)	Aneurysm, Dissecting/surgery ; Aorta/surgery ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis Implantation ; Hospital Mortality ; Humans ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2022-07-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19148878
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Article ; Online: Bentall Operation: Early Surgical Results, Seven-Year Outcomes, and Risk Factors Analysis.

Nardi, Paolo / Pisano, Calogera / Bassano, Carlo / Bertoldo, Fabio / Salvati, Alessandro Cristian / Buioni, Dario / Trombetti, Daniele / Asta, Laura / Scognamiglio, Mattia / Altieri, Claudia / Ruvolo, Giovanni

International journal of environmental research and public health

2022 Volume 20, Issue 1

Abstract: Aim: To analyze early and mid-term outcomes of the Bentall operation. Methods: Two hundred and seventeen patients (mean age 65.6 ± 15.9 years, males/females 172/45) underwent Bentall operation in a 7-year period (January 2015−December 2021), on average, ... ...

Abstract	Aim: To analyze early and mid-term outcomes of the Bentall operation. Methods: Two hundred and seventeen patients (mean age 65.6 ± 15.9 years, males/females 172/45) underwent Bentall operation in a 7-year period (January 2015−December 2021), on average, 30 Bentall operations occurred per year, using biological (n = 104) or mechanical (n = 113) valved conduits for the treatment of ascending aorta−aortic root aneurysms. Associate procedures were performed in 58 patients (26.7%); coronary artery bypass grafting (CABG) in 35 (16%). Mean follow-up was 55.2 ± 24 (median 60.2) months. Cox model analysis was used to assess risk factors, Kaplan−Meier and log-rank tests were used to assess different survival rates. Results: Operative mortality was 1.38%. At 7 years, survival, freedom from cardiac death, and event-free survival were 93% ± 2%, 99% ± 1%, and 81% ± 5%. NYHA class (p < 0.0001), trans-aortic valve mean (p < 0.0001) and maximum (p < 0.000) gradients, left ventricular hypertrophy (p < 0.05), and pulmonary arterial pressure (p = 0.002) significantly improved vs. preoperative values. Concomitant CABG during Bentall operation independently affected late outcomes (HR 1.9−2.3; p-values < 0.05). Late survival was affected by concomitant CABG (84% ± 8% vs. 95% ± 2%, p = 0.04), preoperative myocardial infarction (91% ± 9% vs. 97% ± 2%, p = 0.02), and biological vs. mechanical prostheses valved conduits (91% ± 9% vs. 95% ± 3%, p = 0.02). Event-free survival also was affected by concomitant CABG (62% ± 14% vs. 85% ± 5%, p = 0.005) and biological prostheses (78% ± 8% vs. 84% ± 6%, p = 0.06). Freedom from endocarditis−redo operation was 83% ± 9% for biological prostheses vs. 89% ± 6% for mechanical prostheses (p = 0.49). Conclusions: Low rates of operative mortality and late complications make Bentall operation the gold standard for the treatment of ascending aorta−aortic root aneurysms. Coronary ischemic disease affects late outcomes. Biological prostheses should be preferred for the elderly.
MeSH term(s)	Humans ; Male ; Female ; Aged ; Middle Aged ; Aged, 80 and over ; Treatment Outcome ; Aorta ; Aortic Valve/surgery ; Aortic Aneurysm/complications ; Aortic Aneurysm/surgery ; Time Factors ; Risk Factors ; Retrospective Studies
Language	English
Publishing date	2022-12-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20010212
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Article ; Online: Brain and lower body protection during aortic arch surgery.

Calafiore, Antonio M / de Paulis, Ruggero / Iesu, Severino / Paparella, Domenico / Angelini, Gianni / Scognamiglio, Mattia / Centofanti, Paolo / Nicolardi, Salvatore / Chivasso, Pierpaolo / Canosa, Carlo / Zaccaria, Salvatore / de Martino, Luigi / Magnano, Diego / Mastrototaro, Giuseppe / Di Mauro, Michele

Journal of cardiac surgery

2022 Volume 37, Issue 12, Page(s) 4982–4990

Abstract: Background: Deep hypothermic circulatory arrest (DHCA) at ≤20°C for aortic arch surgery has been widely used for decades, with or without cerebral perfusion (CP), antegrade (antegrade cerebral perfusion [ACP]), or retrograde. In recent years nadir ... ...

Abstract	Background: Deep hypothermic circulatory arrest (DHCA) at ≤20°C for aortic arch surgery has been widely used for decades, with or without cerebral perfusion (CP), antegrade (antegrade cerebral perfusion [ACP]), or retrograde. In recent years nadir temperature progressively increased to 26°C-28°C (moderately hypothermic circulatory arrest [MHCA]), adding ACP. Aim of this multicentric study is to evaluate early results of aortic arch surgery and if DHCA with 10 min of cold reperfusion at the same nadir temperature of the CA before rewarming (delayed rewarming [DR]) can provide a neuroprotection and a lower body protection similar to that provided by MHCA + ACP. Methods: A total of 210 patients were included in the study. DHCA + DR was used in 59 patients and MHCA + ACP in 151. Primary endpoints were death, neurologic event (NE), temporary (TNE), or permanent (permanent neurologic deficit [PND]), and need of renal replacement therapy (RRT). Results: Operative mortality occurred in 14 patients (6.7%), NEs in 17 (8.1%), and PNDs in 10 (4.8%). A total of 23 patients (10.9%) needed RRT. Death + PND occurred in 21 patients (10%) and composite endpoint in 35 (19.2%). Intergroup weighed logistic regression analysis showed similar prevalence of deaths, NDs, and death + PND, but need of RRT (odds ratio [OR]: 7.39, confidence interval [CI]: 1.37-79.1) and composite endpoint (OR: 8.97, CI: 1.95-35.3) were significantly lower in DHCA + DR group compared with MHCA + ACP group. Conclusions: The results of our study demonstrate that DHCA + DR has the same prevalence of operative mortality, NE and association of death+PND than MHCA + ACP. However, the data suggests that DHCA + DR when compared with MHCA + ACP provides better renal protection and reduced prevalence of composite endpoint.
MeSH term(s)	Humans ; Aorta, Thoracic/surgery ; Treatment Outcome ; Circulatory Arrest, Deep Hypothermia Induced/methods ; Brain ; Cardiopulmonary Bypass/methods ; Perfusion/methods ; Cerebrovascular Circulation ; Retrospective Studies
Language	English
Publishing date	2022-11-20
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.17207
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Zs.A 2221: Show issues

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Article: Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism.

Gloria-Bottini, Fulvia / Saccucci, Patrizia / Banci, Maria / Nardi, Paolo / Scognamiglio, Mattia / Pellegrino, Antonio / Bottini, Egidio / Chiariello, Luigi

World journal of cardiology

2014 Volume 6, Issue 6, Page(s) 376–380

Abstract: PTPN22 has been previously found associated with coronary artery disease (CAD). In the present note we have studied the effect of p53 codon 72, acid phosphatse locus 1 (ACP1) and adenosine deaminase (ADA) genetic polymorphism on the strength of ... ...

Abstract	PTPN22 has been previously found associated with coronary artery disease (CAD). In the present note we have studied the effect of p53 codon 72, acid phosphatse locus 1 (ACP1) and adenosine deaminase (ADA) genetic polymorphism on the strength of association between PTPN22 and CAD. We have studied 133 non diabetic subjects with CAD, 122 non diabetic cardiovascular patients without CAD and 269 healthy blood donors. Informed written consent was obtained from all subjects and the study was approved by the Ethical Committee. A high significant association between PTPN22 and CAD is observed in carriers of A allele of ACP1 with a higher proportion of T allele carriers in non diabetic subjects with CAD as compared to controls and to non diabetic subjects with cardiovascular disease without CAD. A similar pattern is observed in carriers of Pro allele of p53 codon 72 with a higher proportion of T allele carriers in non diabetic subjects with CAD as compared to other groups. A highly significant association between PTPN22 and CAD is observed in carriers of ADA2 2 allele with higher proportion of T allele carriers in non diabetic subjects with CAD as compared to other group. There is a high significant correlation between the number of factors that contributes to increase the strength of association between PTPN22 T and CAD and the proportion of T carriers in CAD. ACP1, p53 codon 72 and ADA are involved in immune reaction and give an important additive contribution to the strength of association between PTPN22 and CAD. This study stresses the importance of the simultaneous analysis of multiple genes functionally related to a specific disease: the approach may give important hints to understand multifactorial disorders.
Language	English
Publishing date	2014-05-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2573665-6
ISSN	1949-8462
ISSN	1949-8462
DOI	10.4330/wjc.v6.i6.376
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Article ; Online: Protective effect of dimethyl sulfoxide on acute myocardial infarction in rats.

Parisi, Antonio / Alfieri, Alessio / Mazzella, Marialuisa / Mazzella, Antonio / Scognamiglio, Mattia / Scognamiglio, Gianluigi / Mascolo, Nicola / Cicala, Carla

Journal of cardiovascular pharmacology

2010 Volume 55, Issue 1, Page(s) 106–109

Abstract: Dimethyl sulfoxide (DMSO) is an organic compound widely used as solvent in biological studies and as vehicle for drug administration. DMSO has been shown to possess several biological effects, including antioxidant, anti-inflammatory, antinociceptive ... ...

Abstract	Dimethyl sulfoxide (DMSO) is an organic compound widely used as solvent in biological studies and as vehicle for drug administration. DMSO has been shown to possess several biological effects, including antioxidant, anti-inflammatory, antinociceptive effects, and it has been proposed to be therapeutic in several disorders, such as gastrointestinal diseases, rheumatologic diseases, and for the treatment of several manifestations of amyloidosis. To better define the biological profile of DMSO, we investigated its effect on an in vivo model of acute myocardial infarction in rats, caused by left anterior descending coronary artery ligation. Our results show that pretreatment of rats with intraperitoneal (ip) DMSO (500 microL/Kg) for 3 consecutive days before left anterior descending coronary artery ligation significantly (P < 0.05) reduced cardiac damage from 18.75 +/- 4.88% (n = 12) to 4.46 +/- 2.01% (n = 8); serum levels of troponin I from 29.35 +/- 12.32 ng/mL (n = 8) to 2.95 +/- 1.32 ng/mL (n = 4); and serum levels of myoglobin from 46.86 +/- 10.35 ng/mL (n = 7) to 13.75 +/- 0.85 ng/mL (n = 4). Our data demonstrate that DMSO has a protective effect in a model of acute myocardial infarction in rats.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Dimethyl Sulfoxide/pharmacology ; Disease Models, Animal ; Injections, Intraperitoneal ; Male ; Myocardial Infarction/drug therapy ; Myocardial Infarction/physiopathology ; Myoglobin/blood ; Myoglobin/drug effects ; Rats ; Rats, Wistar ; Troponin I/blood ; Troponin I/drug effects
Chemical Substances	Antioxidants ; Myoglobin ; Troponin I ; Dimethyl Sulfoxide (YOW8V9698H)
Language	English
Publishing date	2010-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0b013e3181c87a65
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Zs.A 1471: Show issues

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Article: ACP1 Genetic Polymorphism and Coronary Artery Disease: Evidence of Effects on Clinical Parameters of Cardiac Function.

Gloria-Bottini, Fulvia / Banci, Maria / Saccucci, Patrizia / Nardi, Paolo / Scognamiglio, Mattia / Papetti, Federica / Adanti, Sara / Magrini, Andrea / Pellegrino, Antonio / Bottini, Egidio / Chiariello, Luigi

Cardiology research

2013 Volume 4, Issue 3, Page(s) 101–108

Abstract: Background: Kinases and phosphatases have an important role in the susceptibility and clinical variability of cardiac diseases. We have recently reported an association between a phosphoprotein phosphatase controlled by Acid Phosphatase locus 1 (ACP1), ... ...

Abstract	Background: Kinases and phosphatases have an important role in the susceptibility and clinical variability of cardiac diseases. We have recently reported an association between a phosphoprotein phosphatase controlled by Acid Phosphatase locus 1 (ACP1), and Coronary artery disease (CAD) suggesting an effect on the susceptibility to this disease. In the present note we have investigated a possible role of ACP1 in the variability of clinical parameters of cardiac function. Methods: We have studied 345 subjects admitted to Valmontone Hospital for cardiovascular diseases: 202 subjects with CAD and 143 without CAD, 53 subjects admitted to Cardiac Surgery Division of Tor Vergata University were also considered. Results: In diabetic patients with CAD there is a significant negative association between Left ventricular ejection fraction (LVEF) and ACP1 S isoform concentration. Genotypes with high S isoform concentration show a lower value of LVEF as compared to genotypes with low S isoform concentration. We have also found a significant positive association between cNYHA class and ACP1 S isoform. After surgical intervention, in subjects with high S isoform concentration the decrease of LVEF is more marked as compared to subjects with low S isoform concentration. Overall these observations indicate that high S isoform activity has negative effects on cardiac function. The observation in patients undergoing cardiac surgery confirms the negative association between high S isoform activity and LVEF. Conclusions: The present study suggests that ACP1 influences both susceptibility to CAD and clinical manifestations of the disease.
Language	English
Publishing date	2013-07-11
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2598593-0
ISSN	1923-2837 ; 1923-2829
ISSN (online)	1923-2837
ISSN	1923-2829
DOI	10.4021/cr277w
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Article ; Online: Early and long-term results of pectoralis muscle flap reconstruction versus sternal rewiring following failed sternal closure.

Zeitani, Jacob / Pompeo, Eugenio / Nardi, Paolo / Sergiacomi, Gianluigi / Scognamiglio, Mattia / Chiariello, Giovanni / Del Giudice, Costantino / Arganini, Chiara / Simonetti, Giovanni / Chiariello, Luigi

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2013 Volume 43, Issue 6, Page(s) e144–50

Abstract: Objectives: The aim of the study was to compare early and long-term results of pectoralis muscle flap reconstruction with those of sternal rewiring following failed sternal closure. Primary outcomes of the study were survival and failure rate. ... ...

Abstract	Objectives: The aim of the study was to compare early and long-term results of pectoralis muscle flap reconstruction with those of sternal rewiring following failed sternal closure. Primary outcomes of the study were survival and failure rate. Respiratory function, chronic pain and quality of life were also evaluated. Methods: In a propensity-score matching analysis, of 94 patients who underwent sternal reconstruction, 40 were selected; 20 underwent sternal reconstruction with bilateral pectoralis muscle flaps (Group 1) and 20 underwent sternal rewiring (Group 2). Survival and failure rates were evaluated by in-hospital records and at follow-up. Respiratory function measures, including vital capacity (VC), were evaluated both by spirometry and computed tomography (CT) volumetry. Chronic pain was evaluated by the visual analogue pain scale. Results: At 85 ± 24 months of follow-up, survival and procedure failure were 95 and 90% in Group 1 and 60 and 55% in Group 2, respectively (P < 0.01, for both comparisons). Based on CT-scan volumetry, in Group 1, severe non-union and hemisternal paradoxical movement occurred less frequently (2 vs 7, P = 0.01). At spirometry assessment, postoperative VC was greater in Group 1 (3220 ± 290 vs 3070 ± 290 ml, P = 0.04). The same trend was detected by CT-scan in-expiratory measures (4034 ± 1800 vs 3182 ± 862 mm(3), P < 0.05). Correspondingly, in Group 1, less patients presented in NYHA Class III (P < 0.05), and both chronic persistent pain score and physical health quality-of-life score were significantly better in the same group. Conclusions: In our study, muscle flap reconstruction guaranteed better early and late-term results as shown by lower rates of mortality, procedure failure and hemisternum stability. Moreover, Group 1 patients had greater postoperative VC, lower NYHA class and better quality of life. These results suggest that, in patients with multiple bone fracture, the rewiring approach does not promote physiological bone consolidation, whereas the muscle flap reconstruction can assure more physiological ventilatory dynamics.
MeSH term(s)	Aged ; Chi-Square Distribution ; Female ; Humans ; Length of Stay ; Male ; Middle Aged ; Pectoralis Muscles/surgery ; Postoperative Complications/surgery ; Propensity Score ; Reconstructive Surgical Procedures/methods ; Respiratory Function Tests ; Retrospective Studies ; Statistics, Nonparametric ; Sternum/surgery ; Surgical Flaps ; Survival Analysis ; Treatment Outcome
Language	English
Publishing date	2013-06
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezt080
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Zs.A 2303: Show issues

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Article ; Online: p53 codon 72 polymorphism and coronary artery disease: evidence of association with left ventricular ejection fraction.

Gloria-Bottini, Fulvia / Saccucci, Patrizia / Magrini, Andrea / Bottini, Egidio / Banci, Maria / Papetti, Federica / Nardi, Paolo / Scognamiglio, Mattia / Pellegrino, Antonio / Chiariello, Luigi

The American journal of the medical sciences

2012 Volume 343, Issue 2, Page(s) 127–130

Abstract: Introduction: Recently, there has been a surge of interest on the possible relationship between p53 polymorphism and coronary atherosclerosis. The authors have investigated the possible association of p53 codon 72 polymorphism with left ventricular ... ...

Abstract	Introduction: Recently, there has been a surge of interest on the possible relationship between p53 polymorphism and coronary atherosclerosis. The authors have investigated the possible association of p53 codon 72 polymorphism with left ventricular ejection fraction (LVEF) in subjects with and without coronary artery disease (CAD). Methods: The authors have studied 198 subjects admitted consecutively to Valmontone Hospital for CAD and 129 subjects admitted for cardiovascular diseases without CAD. Fifty-nine subjects admitted for CAD to Division of Cardiac Surgery of Tor Vergata University were also studied. All subjects were from the white population. The p53 polymorphism was evaluated using the restriction fragment length polymorphism polymerase chain reaction. Results: p53 codon 72 polymorphism is a significant independent predictor of LVEF in subjects with CAD but not in subjects with cardiovascular disease without CAD. In subjects with CAD, LVEF is significantly lower in subjects carrying the Pro variant than in Arg/Arg subjects. This effect is more evident in subjects with a positive history of infarction. Conclusions:* Our study points to a significant relationship of p53 codon 72 polymorphism with cardiac function in subjects with CAD.
MeSH term(s)	Adult ; Aged ; Codon/genetics ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/genetics ; Coronary Artery Disease/physiopathology ; Echocardiography ; Female ; Genes, p53 ; Humans ; Male ; Middle Aged ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Rome/epidemiology ; Stroke Volume
Chemical Substances	Codon
Language	English
Publishing date	2012-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1097/MAJ.0b013e318223ac71
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