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  1. Article ; Online: Can lessons be learned from reviewing peri-operative cardiac arrests?

    Scott, D A / Phan, T D

    Anaesthesia

    2023  Volume 79, Issue 1, Page(s) 3–6

    MeSH term(s) Humans ; Anesthesia ; Heart Arrest/therapy ; Cardiopulmonary Resuscitation
    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Editorial
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.16180
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    Zs.A 388: Show issues Location:
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  2. Article ; Online: Suicide and second victims.

    Scott, D A

    Anaesthesia

    2019  Volume 74, Issue 11, Page(s) 1351–1353

    MeSH term(s) Anesthetists/psychology ; Anger ; Attitude of Health Personnel ; Attitude to Death ; Guilt ; Humans ; Suicide/psychology ; Survivors/psychology ; United Kingdom
    Language English
    Publishing date 2019-07-02
    Publishing country England
    Document type Editorial
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.14763
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  3. Article ; Online: Caring for the ageing mind.

    Scott, D A / Evered, L A

    Anaesthesia

    2019  Volume 74, Issue 3, Page(s) 271–273

    MeSH term(s) Aged ; Aged, 80 and over ; Cognitive Dysfunction/therapy ; Health Services for the Aged ; Humans ; Perioperative Care ; Practice Guidelines as Topic
    Language English
    Publishing date 2019-01-11
    Publishing country England
    Document type Editorial
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.14473
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    Zs.A 388: Show issues Location:
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  4. Article ; Online: Acute peri-operative neurocognitive disorders: a narrative review.

    Evered, L / Atkins, K / Silbert, B / Scott, D A

    Anaesthesia

    2022  Volume 77 Suppl 1, Page(s) 34–42

    Abstract: Peri-operative neurocognitive disorders are the most common complication experienced by older individuals undergoing anaesthesia and surgery. Peri-operative neurocognitive disorders, particularly postoperative delirium, result in long-term poor outcomes ... ...

    Abstract Peri-operative neurocognitive disorders are the most common complication experienced by older individuals undergoing anaesthesia and surgery. Peri-operative neurocognitive disorders, particularly postoperative delirium, result in long-term poor outcomes including: death; dementia; loss of independence; and poor cognitive and functional outcomes. Recent changes to the nomenclature of these disorders aims to align peri-operative neurocognitive disorders with cognitive disorders in the community, with consistent definitions and clinical diagnosis. Possible mechanisms include: undiagnosed neurodegenerative disease; inflammation and resulting neuroinflammation; neuronal damage; and comorbid systemic disease. Pre-operative frailty represents a significant risk for poor postoperative outcomes; it is associated with an increase in the incidence of cognitive decline at 3 and 12 months postoperatively. In addition to cognitive decline, frailty is associated with poor functional outcomes following elective non-cardiac surgery. It was recently shown that 29% of frail patients died or experienced institutionalisation or new disability within 90 days of major elective surgery. Identification of vulnerable patients before undergoing surgery and anaesthesia is the key to preventing peri-operative neurocognitive disorders. Current approaches include: pre-operative delirium and cognitive screening; blood biomarker analysis; intra-operative management that may reduce the incidence of postoperative delirium such as lighter anaesthesia using processed electroencephalography devices; and introduction of guidelines which may reduce or prevent delirium and postoperative neurocognitive disorders. This review will address these issues and advocate for an approach to care for older peri-operative patients which starts in the community and continues throughout the pre-operative, intra-operative, postoperative and post-discharge phases of care management, involving multidisciplinary medical teams, as well as family and caregivers wherever possible.
    MeSH term(s) Acute Disease ; Aged ; Aged, 80 and over ; Brain/metabolism ; Frail Elderly/psychology ; Humans ; Inflammation Mediators/metabolism ; Neurocognitive Disorders/metabolism ; Neurocognitive Disorders/prevention & control ; Neurocognitive Disorders/psychology ; Perioperative Care/methods ; Postoperative Complications/metabolism ; Postoperative Complications/prevention & control ; Postoperative Complications/psychology
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2022-01-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.15613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 388: Show issues Location:
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  5. Article ; Online: Potential Mechanisms Underlying Marijuana-Associated Periodontal Tissue Destruction.

    Scott, D A / Dukka, H / Saxena, D

    Journal of dental research

    2021  Volume 101, Issue 2, Page(s) 133–142

    Abstract: While definitive evidence awaits, cannabis is emerging as a likely risk factor for periodontal tissue destruction. The mechanisms that underlie potential cannabis-induced or cannabis-enhanced periodontal diseases, however, remain to be elucidated. Herein, ...

    Abstract While definitive evidence awaits, cannabis is emerging as a likely risk factor for periodontal tissue destruction. The mechanisms that underlie potential cannabis-induced or cannabis-enhanced periodontal diseases, however, remain to be elucidated. Herein, we 1) examine insights obtained from the endocannabinoid system, 2) summarize animal models of exposure to cannabinoid receptor agonists and antagonists, 3) review the evidence suggesting that cannabis and cannabis-derived molecules exert a profound influence on components of the oral microbiome, and 4) assess studies indicating that marijuana and phytocannabinoids compromise the immune response to plaque. Furthermore, we address how knowledge of cannabinoid influences in the oral cavity may be exploited to provide potential novel periodontal therapeutics, while recognizing that such medicinal approaches may be most appropriate for nonhabitual marijuana users. The suspected increase in susceptibility to periodontitis in marijuana users is multifaceted, and it is clear that we are only beginning to understand the complex toxicological, cellular, and microbial interactions involved. With marijuana consumption increasing across all societal demographics, periodontal complications of use may represent a significant, growing oral health concern. In preparation, an enhanced research response would seem appropriate.
    MeSH term(s) Animals ; Cannabinoid Receptor Agonists ; Cannabinoids/adverse effects ; Cannabis/adverse effects ; Oral Health ; Periodontitis
    Chemical Substances Cannabinoid Receptor Agonists ; Cannabinoids
    Language English
    Publishing date 2021-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/00220345211036072
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    Zs.MO 262: Show issues

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  6. Article ; Online: On the differences between studies of aerosolisation during tracheal intubation and extubation.

    Dhillon, R S / Humphries, R S / Scott, D A

    Anaesthesia

    2021  Volume 76 Suppl 3, Page(s) 20–22

    MeSH term(s) Aerosols/adverse effects ; Airway Extubation/methods ; COVID-19/prevention & control ; Humans ; Intubation, Intratracheal/methods ; SARS-CoV-2
    Chemical Substances Aerosols
    Language English
    Publishing date 2021-01-06
    Publishing country England
    Document type Letter
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.15371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 388: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: The long-term incidence of chronic post-surgical pain after coronary artery bypass surgery - A prospective observational study.

    Charlton, E / Atkins, K J / Evered, L / Silbert, B / Scott, D A

    European journal of pain (London, England)

    2023  Volume 28, Issue 4, Page(s) 599–607

    Abstract: Background: Chronic post-surgical pain (CPSP) represents a significant issue for many patients following surgery; however, the long-term incidence and impact have not been well described following cardiac surgery. Our aim was to characterize CPSP at ... ...

    Abstract Background: Chronic post-surgical pain (CPSP) represents a significant issue for many patients following surgery; however, the long-term incidence and impact have not been well described following cardiac surgery. Our aim was to characterize CPSP at least 5 years following coronary artery bypass grafting (CABG) surgery.
    Methods: This prospective observational study investigated a cohort of patients from a larger trial investigating cognitive outcomes following CABG surgery, with 89 of 148 eligible patients (60.1%) assessed for CPSP at a mean (standard deviation [SD]) of 6.8 [1.2] years. Questionnaires interrogated pain presence, intensity, location, neuropathic characteristics, Geriatric Depression Scale scores (GDS) and instrumental activities of daily living (IADL).
    Results: CPSP was described in 21/89 (23.6%), with 10 rating it as moderate to severe. Six of the CPSP patients (29%) met criteria for neuropathic pain (6.7% overall). The highest rate of CPSP was associated with the leg surgical site (chest 12/89 [13.5%], arm 8/68 [11.8%] and leg (saphenous vein graft-SVG) 11/37 [29.7%]; χ
    Conclusions: This study identified a CPSP incidence of 23.6% at a mean of 6.8 years after CABG surgery, with the highest pain proportion at SVG harvest sites. CPSP was associated with neuropathic pain symptoms and had a significant impact on IADLs. This emphasizes the need for long-term follow-up of CABG patients.
    Significance: This study highlights the impact of CPSP 7 years following cardiac surgery and highlights the effect of surgical site, neuropathic pain and the importance of including pain assessment and management in the long-term follow-up of cardiac surgical patients. Strategies to address and prevent chronic pain following cardiac surgery should be further explored.
    MeSH term(s) Humans ; Aged ; Incidence ; Activities of Daily Living ; Coronary Artery Bypass/adverse effects ; Chronic Pain/psychology ; Pain, Postoperative/etiology ; Neuralgia/epidemiology ; Neuralgia/etiology
    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 1390424-3
    ISSN 1532-2149 ; 1090-3801
    ISSN (online) 1532-2149
    ISSN 1090-3801
    DOI 10.1002/ejp.2203
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    Zs.A 5194: Show issues Location:
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  8. Article ; Online: Tobacco-induced suppression of the vascular response to dental plaque.

    Buduneli, N / Scott, D A

    Molecular oral microbiology

    2018  Volume 33, Issue 4, Page(s) 271–282

    Abstract: Cigarette smoking presents oral health professionals with a clinical and research conundrum: reduced periodontal vascular responsiveness to the oral biofilm accompanied by increased susceptibility to destructive periodontal diseases. This presents a ... ...

    Abstract Cigarette smoking presents oral health professionals with a clinical and research conundrum: reduced periodontal vascular responsiveness to the oral biofilm accompanied by increased susceptibility to destructive periodontal diseases. This presents a significant problem, hampering diagnosis and complicating treatment planning. The aim of this review is to summarize contemporary hypotheses that help to explain mechanistically the phenomenon of a suppressed bleeding response to dysbiotic plaque in the periodontia of smokers. The influence of smoke exposure on angiogenesis, innate cell function, the production of inflammatory mediators including cytokines and proteases, tobacco-bacteria interactions, and potential genetic predisposition are discussed.
    MeSH term(s) Animals ; Bacteria/metabolism ; Cigarette Smoking/adverse effects ; Cytokines/metabolism ; Dental Plaque/microbiology ; Gingiva/microbiology ; Humans ; Immunity, Innate ; Models, Animal ; Periodontal Diseases/genetics ; Periodontal Diseases/immunology ; Periodontal Diseases/microbiology ; Nicotiana/adverse effects
    Chemical Substances Cytokines
    Language English
    Publishing date 2018-07-01
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2537726-7
    ISSN 2041-1014 ; 2041-1006
    ISSN (online) 2041-1014
    ISSN 2041-1006
    DOI 10.1111/omi.12228
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    Zs.A 2199: Show issues Location:
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  9. Article ; Online: Confirming estimates of aerosol clearance time.

    Scott, D A / Humphries, R S / Dhillon, R S

    Anaesthesia

    2020  Volume 76 Suppl 3, Page(s) 22–23

    MeSH term(s) Aerosols/adverse effects ; COVID-19/prevention & control ; Humans ; SARS-CoV-2 ; Time
    Chemical Substances Aerosols
    Language English
    Publishing date 2020-12-23
    Publishing country England
    Document type Letter
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.15347
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  10. Article: Potential for inadvertent airway delivery of carbon dioxide with humidified high flow oxygen circuit.

    Ironfield, C M / Scott, D A

    Anaesthesia and intensive care

    2017  Volume 45, Issue 5, Page(s) 631

    MeSH term(s) Carbon Dioxide/administration & dosage ; Carbon Dioxide/adverse effects ; Equipment Design ; Equipment Failure ; Humans ; Oxygen Inhalation Therapy/methods
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2017-09-14
    Publishing country United States
    Document type Letter
    ZDB-ID 187524-3
    ISSN 1448-0271 ; 0310-057X
    ISSN (online) 1448-0271
    ISSN 0310-057X
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    Zs.A 1017: Show issues Location:
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