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  1. Book ; Online: Algorithms for Sparse Linear Systems

    Scott, Jennifer / Tůma, Miroslav

    (Nečas Center Series)

    2023  

    Author's details by Jennifer Scott, Miroslav Tůma
    Series title Nečas Center Series
    Keywords Numerical analysis ; Algebras, Linear ; Mathematics—Data processing
    Language English
    Size 1 Online-Ressource (XIX, 242 p. 70 illus., 27 illus. in color)
    Edition 1st ed. 2023
    Publisher Springer International Publishing ; Imprint: Birkhäuser
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT030004947
    ISBN 978-3-031-25820-6 ; 9783031258190 ; 9783031258213 ; 3-031-25820-7 ; 3031258193 ; 3031258215
    DOI 10.1007/978-3-031-25820-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Algorithms for Sparse Linear Systems

    Scott, Jennifer / Tůma, Miroslav

    (Nečas Center Series)

    2023  

    Series title Nečas Center Series
    Keywords Numerical analysis ; Algebra ; Maths for scientists ; Sparse Matrices ; Algebraic Preconditioners ; Sparse Direct Methods ; Incomplete Factorizations ; Approximate Inverses
    Language English
    Size 1 electronic resource (242 pages)
    Publisher Springer Nature
    Publishing place Cham
    Document type Book ; Online
    Note English
    HBZ-ID HT030377856
    ISBN 9783031258190 ; 3031258193
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: The role of methionine synthases in fungal metabolism and virulence.

    Scott, Jennifer / Amich, Jorge

    Essays in biochemistry

    2023  Volume 67, Issue 5, Page(s) 853–863

    Abstract: Methionine synthases (MetH) catalyse the methylation of homocysteine (Hcy) with 5-methyl-tetrahydrofolate (5, methyl-THF) acting as methyl donor, to form methionine (Met) and tetrahydrofolate (THF). This function is performed by two unrelated classes of ... ...

    Abstract Methionine synthases (MetH) catalyse the methylation of homocysteine (Hcy) with 5-methyl-tetrahydrofolate (5, methyl-THF) acting as methyl donor, to form methionine (Met) and tetrahydrofolate (THF). This function is performed by two unrelated classes of enzymes that differ significantly in both their structures and mechanisms of action. The genomes of plants and many fungi exclusively encode cobalamin-independent enzymes (EC.2.1.1.14), while some fungi also possess proteins from the cobalamin-dependent (EC.2.1.1.13) family utilised by humans. Methionine synthase's function connects the methionine and folate cycles, making it a crucial node in primary metabolism, with impacts on important cellular processes such as anabolism, growth and synthesis of proteins, polyamines, nucleotides and lipids. As a result, MetHs are vital for the viability or virulence of numerous prominent human and plant pathogenic fungi and have been proposed as promising broad-spectrum antifungal drug targets. This review provides a summary of the relevance of methionine synthases to fungal metabolism, their potential as antifungal drug targets and insights into the structures of both classes of MetH.
    MeSH term(s) Humans ; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/chemistry ; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/metabolism ; Antifungal Agents ; Virulence ; Tetrahydrofolates/metabolism ; Vitamin B 12/metabolism ; Vitamin B 12/pharmacology ; Methionine/metabolism
    Chemical Substances 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (EC 2.1.1.13) ; Antifungal Agents ; Tetrahydrofolates ; Vitamin B 12 (P6YC3EG204) ; Methionine (AE28F7PNPL)
    Language English
    Publishing date 2023-06-30
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1744-1358 ; 0071-1365
    ISSN (online) 1744-1358
    ISSN 0071-1365
    DOI 10.1042/EBC20230007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pediatric Acne Vulgaris: A Guide for Recognition, Examination, Referral, and Treatment.

    Scott, Jennifer B / Allen, Natalie G / Zaenglein, Andrea L

    Pediatric annals

    2024  Volume 53, Issue 4, Page(s) e115–e120

    Abstract: Acne is a common skin condition in adolescent patients but much less common in childhood. Pediatric providers should be familiar with the varying presentations in the pediatric population and recognize when additional physical signs of hyperandrogenism ... ...

    Abstract Acne is a common skin condition in adolescent patients but much less common in childhood. Pediatric providers should be familiar with the varying presentations in the pediatric population and recognize when additional physical signs of hyperandrogenism are present. This article details the pathogenesis and presentation of acne in infancy, mid-childhood, and preadolescence. The differential diagnosis is discussed and recommendations for initial workup, referral, and treatment are provided.
    MeSH term(s) Adolescent ; Child ; Humans ; Acne Vulgaris/diagnosis ; Acne Vulgaris/etiology ; Acne Vulgaris/therapy ; Hyperandrogenism ; Diagnosis, Differential ; Referral and Consultation
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195430-1
    ISSN 1938-2359 ; 0090-4481
    ISSN (online) 1938-2359
    ISSN 0090-4481
    DOI 10.3928/19382359-20240205-05
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Addressing gender bias in global health imagery.

    Sharma, Vandana / Sawyer, Jennifer / Scott, Jennifer

    The Lancet. Global health

    2023  Volume 11, Issue 4, Page(s) e503

    MeSH term(s) Humans ; Male ; Female ; Sexism ; Global Health ; Imagery, Psychotherapy ; Emotions
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(23)00047-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The dermatologic and histologic spectrum of hypereosinophilic syndrome.

    Long, Calista / Scott, Jennifer L / Flamm, Alexandra

    JAAD case reports

    2023  Volume 39, Page(s) 21–25

    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2023.06.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Increasing Awareness on Substance Use Disorder.

    Scott, Jennifer / Schachman, Kathleen / Hupert, Cynthia

    Journal of addictions nursing

    2023  Volume 33, Issue 4, Page(s) 317–321

    Abstract: Background: There is a lack of substance use disorder (SUD) providers in the micropolitan Midwestern state. Individuals who live in rural areas with SUD may have a gap in treatment for their addiction.: Objective: The objective of this quality ... ...

    Abstract Background: There is a lack of substance use disorder (SUD) providers in the micropolitan Midwestern state. Individuals who live in rural areas with SUD may have a gap in treatment for their addiction.
    Objective: The objective of this quality improvement project was to increase the engagement, participation, and awareness of rural primary care providers in treatment of individuals with SUD.
    Methods: This is a quality improvement project that utilized a skip-logic standardized survey to evaluate participants who attended Project ECHO (Extension for Community Healthcare Outcomes) Addiction educational sessions.
    Results: Findings included 176 participants over 14 sessions, while reaching primary care providers in 62 clinics over a 7-month period. However, it was found that only half of those participants completed the survey. A variety of topics surrounding SUD were offered. In addition, each session included a case study with feedback provided by the team. Seventy participants (79%) rated "strongly agree" and "agree" to "I will make changes to my practice." Participants provided feedback as to how they would change their practice after an educational session; responses included adapting how naltrexone is prescribed based on the recommendations made during the presentation, update treatment guidelines, screen for adverse childhood experiences, utilize motivational interviewing, feeling more confident in providing medication-assisted treatment for patients, and finally, better able to manage pain in those with SUD.
    Conclusion: Project ECHO Addiction is an evidence-based translational quality improvement project that reaches rural primary care providers to help increase awareness, engagement, and networking in treatment of patients with SUD, which in turn improves patient outcomes as they receive treatment in a timely fashion.
    MeSH term(s) Humans ; Substance-Related Disorders/therapy ; Naltrexone ; Community Health Services ; Surveys and Questionnaires ; Motivational Interviewing
    Chemical Substances Naltrexone (5S6W795CQM)
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2124319-0
    ISSN 1548-7148 ; 1088-4602
    ISSN (online) 1548-7148
    ISSN 1088-4602
    DOI 10.1097/JAN.0000000000000498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Unincorporated Health: Understanding Residents' Perspectives on Factors Impacting Their Health and Emergent Place-Based Solutions.

    Todić, Jelena / Scott, Jennifer

    Social work in public health

    2021  Volume 36, Issue 3, Page(s) 317–329

    Abstract: Increased mortality rates and decreased life expectancy in the United States are associated with rurality, even after adjusting for poverty. In unincorporated rural communities, high population density may compound the negative health impact of the ... ...

    Abstract Increased mortality rates and decreased life expectancy in the United States are associated with rurality, even after adjusting for poverty. In unincorporated rural communities, high population density may compound the negative health impact of the upstream factors associated with rurality, yet little is known about how this context contributes to residents' health. We conducted nine focus groups with youth and adults from March-July 2017 in two Texas unincorporated rural communities. Using ecosocial theory and applied thematic analysis for focus groups, we investigated social, political, and historical factors that affect health. We identified two primary themes: upstream barriers to community health and K-12 schools as facilitators of community health. K-12 schools, and full-service community schools, in particular, may have an important role in closing the rural-urban health gap, even in the context of structural constraints associated with unincorporated rural status.
    MeSH term(s) Adolescent ; Adult ; Focus Groups ; Humans ; Poverty ; Rural Health ; Rural Population ; Texas ; United States
    Language English
    Publishing date 2021-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2414992-5
    ISSN 1937-190X ; 1937-1918
    ISSN (online) 1937-190X
    ISSN 1937-1918
    DOI 10.1080/19371918.2021.1900976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2832: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Novel treatments for pediatric atopic dermatitis.

    Scott, Jennifer B / Paller, Amy S

    Current opinion in pediatrics

    2021  Volume 33, Issue 4, Page(s) 392–401

    Abstract: Purpose of review: To describe new and emerging therapies for pediatric atopic dermatitis (AD).: Recent findings: Recent investigations have highlighted the importance of type 2 immunity and interrelationships among the skin immune system, epidermal ... ...

    Abstract Purpose of review: To describe new and emerging therapies for pediatric atopic dermatitis (AD).
    Recent findings: Recent investigations have highlighted the importance of type 2 immunity and interrelationships among the skin immune system, epidermal barrier, and microbiome in the pathogenesis of AD, including in infants and children. These discoveries have translated into more targeted therapy. Crisaborole ointment, a topical phosphodiesterase 4 (PDE4) inhibitor, and dupilumab, a subcutaneously injected interleukin (IL)-4 receptor inhibitor, are now Food and Drug Administration-approved. Topical agents under investigation for use in the pediatric population include Janus kinase (JAK) inhibitors, PDE4 inhibitors, an aryl hydrocarbon receptor agonist, an antimicrobial peptide, and commensal skin bacteria. Emerging systemic agents for pediatric AD include biologics targeting IL-13, the IL-31 receptor, and the IL-5 receptor, as well as oral JAK inhibitors.
    Summary: Increased understanding of AD pathogenesis has resulted in the development of new, more targeted therapies that show promising safety and efficacy results in Phase 2 and 3 clinical trials, although long-term safety remains to be evaluated. AD is a heterogeneous disease and having choices of therapies with different mechanisms of action will allow a broader group of children and adolescents with moderate-to-severe disease to achieve disease control.
    MeSH term(s) Adolescent ; Child ; Dermatitis, Atopic/drug therapy ; Eczema ; Humans ; Microbiota ; Phosphodiesterase 4 Inhibitors/therapeutic use ; Skin
    Chemical Substances Phosphodiesterase 4 Inhibitors
    Language English
    Publishing date 2021-05-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1049374-8
    ISSN 1531-698X ; 1040-8703
    ISSN (online) 1531-698X
    ISSN 1040-8703
    DOI 10.1097/MOP.0000000000001027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3049: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: The Clinical Resource Hub Telehealth Program and Use of Primary Care, Emergency, and Inpatient Care During the COVID-19 Pandemic.

    Gujral, Kritee / Scott, Jennifer Y / Dismuke-Greer, Clara E / Jiang, Hao / Wong, Emily / Yoon, Jean

    Journal of general internal medicine

    2024  Volume 39, Issue Suppl 1, Page(s) 118–126

    Abstract: Background: The COVID-19 pandemic disrupted delivery of health care services worldwide. We examined the impact of the pandemic on clinics participating in the Veterans Affairs (VA) Clinical Resource Hub (CRH) program, rolled out nationally in October ... ...

    Abstract Background: The COVID-19 pandemic disrupted delivery of health care services worldwide. We examined the impact of the pandemic on clinics participating in the Veterans Affairs (VA) Clinical Resource Hub (CRH) program, rolled out nationally in October 2019, to improve access to care at under-resourced VA clinics or "spoke" sites through telehealth services delivered by regional "hub" sites.
    Objective: To assess whether the CRH program was associated with increased access to primary care, we compared use of primary, emergency, and inpatient care at sites that adopted CRH for primary care (CRH-PC) with sites that did not adopt CRH-PC, pre-post pandemic onset.
    Design: Difference-in-difference and event study analyses, adjusting for site characteristics.
    Study cohort: A total of 1050 sites (254 CRH-PC sites; 796 comparison sites), fiscal years (FY) 2019-2021.
    Intervention: CRH Program for Primary Care.
    Main measures: Quarterly number of VA visits per site for primary care (across all and by modality, in-person, video, and phone), emergency care, and inpatient care.
    Results: In adjusted analyses, CRH-PC sites, compared with non-CRH-PC sites, had on average 221 additional primary care visits (a volume increase of 3.4% compared to pre-pandemic). By modality, CRH-PC sites had 643 fewer in-person visits post-pandemic (- 14.4%) but 723 and 128 more phone and video visits (+ 39.9% and + 159.5%), respectively. CRH-PC sites, compared with non-CRH-PC sites, had fewer VA ED visits (- 4.2%) and hospital stays (- 5.1%) in VA medical centers. Examining visits per patient, we found that CRH-PC sites had 48 additional telephone primary care visits per 1000 primary care patients (an increase of 9.8%), compared to non-program sites.
    Conclusions: VA's pre-pandemic rollout of a new primary care telehealth program intended to improve access facilitated primary care visits during the pandemic, a period fraught with care disruptions, and limited in-person health care delivery, indicating the potential for the program to offer health system resilience.
    MeSH term(s) Humans ; Pandemics ; Inpatients ; COVID-19 ; Telemedicine ; Primary Health Care
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-023-08476-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2205: Show issues Location:
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