Article ; Online: Effectiveness of Pharmacist Interventions on Cardiovascular Risk in Patients With CKD: A Subgroup Analysis of the Randomized Controlled R
American journal of kidney diseases : the official journal of the National Kidney Foundation
2017 Volume 71, Issue 1, Page(s) 42–51
Abstract: Background: Affecting a substantial proportion of adults, chronic kidney disease (CKD) is considered a major risk factor for cardiovascular (CV) events. It has been reported that patients with CKD are underserved when it comes to CV risk reduction ... ...
| Abstract | Background: Affecting a substantial proportion of adults, chronic kidney disease (CKD) is considered a major risk factor for cardiovascular (CV) events. It has been reported that patients with CKD are underserved when it comes to CV risk reduction efforts. Study design: Prespecified subgroup analysis of a randomized controlled trial. Setting & participants: Adults with CKD and at least 1 uncontrolled CV risk factor were enrolled from 56 pharmacies across Alberta, Canada. Intervention: Patient, laboratory, and individualized CV risk assessments; treatment recommendations; prescription adaptation(s) and/or initiation as necessary; and regular monthly follow-up for 3 months. Outcomes: The primary outcome was change in estimated CV risk from baseline to 3 months after randomization. Secondary outcomes were change between baseline and 3 months after randomization in individual CV risk factors (ie, low-density lipoprotein cholesterol, blood pressure, and hemoglobin A Measurements: CV risk was estimated using the Framingham, UK Prospective Diabetes Study, and international risk assessment equations depending on the patients' comorbid conditions. Results: 290 of the 723 participants enrolled in R Limitations: The 3-month follow-up period can be considered relatively short. It is possible that larger reduction in CV risk could have been observed with a longer follow up period. Conclusions: This subgroup analysis demonstrated that a community pharmacy-based intervention program reduced CV risk and improved control of individual CV risk factors. This represents a promising approach to identifying and managing patients with CKD that could have important public health implications. |
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| MeSH term(s) | Adult ; Aged ; Alberta ; Cardiovascular Diseases/epidemiology ; Community Pharmacy Services/statistics & numerical data ; Disease Progression ; Female ; Humans ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/epidemiology ; Male ; Middle Aged ; Pharmacists ; Professional Role ; Renal Insufficiency, Chronic/epidemiology ; Risk Assessment/methods ; Risk Assessment/statistics & numerical data ; Risk Factors | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2017-09-12 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 604539-x | ||||||||||
| ISSN | 1523-6838 ; 0272-6386 | ||||||||||
| ISSN (online) | 1523-6838 | ||||||||||
| ISSN | 0272-6386 | ||||||||||
| DOI | 10.1053/j.ajkd.2017.07.012 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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