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  1. Article: First COVID-19 sub-intensive respiratory unit in Europe: the Italian experience.

    Henchi, Sonia / Conti, Clara Benedetta / Vanoni, Nicolò / Repossi, Alice Claudia / Cipolla, Giuseppe / Marra, Mirko / Esposti, Elena / Fiini, Michela / Raimondi Cominesi, Irene / Crepaldi, Monica / Scozzafava, Mariano

    Multidisciplinary respiratory medicine

    2020  Volume 15, Issue 1, Page(s) 682

    Abstract: European SARS-CoV-2 pandemic epicenter was detected in Northern Italy, in a little Italian town of Lodi province, the Lodi Hospital was therefore rapidly saturated, and in particularly the departments of respiratory diseases and Intensive Care Unit had ... ...

    Abstract European SARS-CoV-2 pandemic epicenter was detected in Northern Italy, in a little Italian town of Lodi province, the Lodi Hospital was therefore rapidly saturated, and in particularly the departments of respiratory diseases and Intensive Care Unit had been largely involved. In this paper, we describe how the first Sub-intensive Respiratory Unit in Europe completely dedicated to COVID-19 patients was organized and managed in our hospital. From February 25
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2677839-7
    ISSN 2049-6958 ; 1828-695X
    ISSN (online) 2049-6958
    ISSN 1828-695X
    DOI 10.4081/mrm.2020.682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ventilatory associated barotrauma in COVID-19 patients: A multicenter observational case control study (COVI-MIX-study).

    Vetrugno, Luigi / Castaldo, Nadia / Fantin, Alberto / Deana, Cristian / Cortegiani, Andrea / Longhini, Federico / Forfori, Francesco / Cammarota, Gianmaria / Grieco, Domenico Luca / Isola, Miriam / Navalesi, Paolo / Maggiore, Salvatore Maurizio / Bassetti, Matteo / Chetta, Alfredo / Confalonieri, Marco / De Martino, Maria / Ferrari, Giovanni / Francisi, Daniela / Luzzati, Roberto /
    Meini, Simone / Scozzafava, Mariano / Sozio, Emanuela / Tascini, Carlo / Bassi, Flavio / Patruno, Vincenzo / De Robertis, Edoardo / Aldieri, Chiara / Ball, Lorenzo / Baratella, Elisa / Bartoletti, Michele / Boscolo, Annalisa / Burgazzi, Barbara / Catalanotti, Vito / Confalonieri, Paola / Corcione, Silvia / De Rosa, Francesco Giuseppe / De Simoni, Alessandro / Bono, Valerio Del / Tria, Roberta Di / Forlani, Sara / Giacobbe, Daniele Roberto / Granozzi, Bianca / Labate, Laura / Lococo, Sara / Lupia, Tommaso / Matellon, Carola / Mehrabi, Sara / Morosi, Sabrina / Mongodi, Silvia / Mura, Maddalena / Nava, Stefano / Pol, Riccardo / Pettenuzzo, Tommaso / Quyen, Nguyen Hoang / Rescigno, Carolina / Righi, Elda / Ruaro, Barbara / Salton, Francesco / Scabini, Silvia / Scarda, Angelo / Sibani, Marcella / Tacconelli, Evelina / Tartaglione, Gennaro / Tazza, Beatrice / Vania, Eleonora / Viale, Pierluigi / Vianello, Andrea / Visentin, Alessandro / Zuccon, Umberto / Meroi, Francesco / Buonsenso, Danilo

    Pulmonology

    2022  Volume 29, Issue 6, Page(s) 457–468

    Abstract: Background: The risk of barotrauma associated with different types of ventilatory support is unclear in COVID-19 patients. The primary aim of this study was to evaluate the effect of the different respiratory support strategies on barotrauma occurrence; ...

    Abstract Background: The risk of barotrauma associated with different types of ventilatory support is unclear in COVID-19 patients. The primary aim of this study was to evaluate the effect of the different respiratory support strategies on barotrauma occurrence; we also sought to determine the frequency of barotrauma and the clinical characteristics of the patients who experienced this complication.
    Methods: This multicentre retrospective case-control study from 1 March 2020 to 28 February 2021 included COVID-19 patients who experienced barotrauma during hospital stay. They were matched with controls in a 1:1 ratio for the same admission period in the same ward of treatment. Univariable and multivariable logistic regression (OR) were performed to explore which factors were associated with barotrauma and in-hospital death.
    Results: We included 200 cases and 200 controls. Invasive mechanical ventilation was used in 39.3% of patients in the barotrauma group, and in 20.1% of controls (p<0.001). Receiving non-invasive ventilation (C-PAP/PSV) instead of conventional oxygen therapy (COT) increased the risk of barotrauma (OR 5.04, 95% CI 2.30 - 11.08, p<0.001), similarly for invasive mechanical ventilation (OR 6.24, 95% CI 2.86-13.60, p<0.001). High Flow Nasal Oxygen (HFNO), compared with COT, did not significantly increase the risk of barotrauma. Barotrauma frequency occurred in 1.00% [95% CI 0.88-1.16] of patients; these were older (p=0.022) and more frequently immunosuppressed (p=0.013). Barotrauma was shown to be an independent risk for death (OR 5.32, 95% CI 2.82-10.03, p<0.001).
    Conclusions: C-PAP/PSV compared with COT or HFNO increased the risk of barotrauma; otherwise HFNO did not. Barotrauma was recorded in 1.00% of patients, affecting mainly patients with more severe COVID-19 disease. Barotrauma was independently associated with mortality.
    Trial registration: this case-control study was prospectively registered in clinicaltrial.gov as NCT04897152 (on 21 May 2021).
    MeSH term(s) Humans ; COVID-19/complications ; COVID-19/epidemiology ; Case-Control Studies ; Retrospective Studies ; Hospital Mortality ; Oxygen/therapeutic use ; Barotrauma/epidemiology ; Barotrauma/etiology
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-11-24
    Publishing country Spain
    Document type Multicenter Study ; Journal Article
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2022.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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