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  1. Article ; Online: Dual antiplatelet therapy in patients with acute coronary syndrome during the coronavirus disease of 2019 pandemia: the right choice at the right time.

    Scudiero, Fernando / Parodi, Guido

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2020  Volume 21, Issue 8, Page(s) 535–537

    MeSH term(s) Acute Coronary Syndrome/drug therapy ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Humans ; Pandemics ; Platelet Aggregation Inhibitors/therapeutic use ; Pneumonia, Viral ; Prasugrel Hydrochloride/therapeutic use ; SARS-CoV-2
    Chemical Substances Platelet Aggregation Inhibitors ; Prasugrel Hydrochloride (G89JQ59I13)
    Keywords covid19
    Language English
    Publishing date 2020-07-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001028
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    Zs.A 5210: Show issues Location:
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  2. Article: Dual antiplatelet therapy in patients with acute coronary syndrome during the coronavirus disease of 2019 pandemia: the right choice at the right time

    Scudiero, Fernando / Parodi, Guido

    J Cardiovasc Med (Hagerstown)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #620788
    Database COVID19

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  3. Article ; Online: Acute pulmonary embolism in COVID-19 patient: a case report of free-floating right heart thrombus successfully treated with fibrinolysis.

    Scudiero, Fernando / Pitì, Antonino / Keim, Roberto / Parodi, Guido

    European heart journal. Case reports

    2020  Volume 5, Issue 1, Page(s) ytaa388

    Abstract: Background: Despite the fast-growing understanding of the coronavirus disease 2019 (COVID-19), patient management remains largely empirical or based on retrospective studies. In this complex scenario, an important clinical issue appears to be ... ...

    Abstract Background: Despite the fast-growing understanding of the coronavirus disease 2019 (COVID-19), patient management remains largely empirical or based on retrospective studies. In this complex scenario, an important clinical issue appears to be represented by the high prevalence of thromboembolic events, but the data regarding high-risk pulmonary embolism (PE) is still not available.
    Case summary: A patient with COVID-19 developed sudden shortness of breath and hypoxia. Early echocardiographic diagnosis of high-risk PE related to right heart thrombus was performed. Systemic thrombolysis was administered with excellent clinical and haemodynamic response.
    Discussion: Pulmonary thromboembolism is a common occurrence in severe COVID-19 infection. In our experience, systemic thrombolysis proved to be effective and for this reason may be considered for life-threatening PE in COVID-19 patients.
    Language English
    Publishing date 2020-12-28
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytaa388
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  4. Article: Drug-drug interactions between antithrombotics and direct-acting antivirals in hepatitis C virus (HCV) patients: A brief, updated report.

    Canonico, Mario Enrico / Sanna, Giuseppe Damiano / Siciliano, Roberta / Scudiero, Fernando / Esposito, Giovanni / Parodi, Guido

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 916361

    Abstract: Hepatitis C virus (HCV) is one of the leading causes of chronic liver disease affecting over 71 million people worldwide. An increased incidence of atherothrombotic events [e.g. coronary artery disease (CAD), atrial fibrillation (AF)] has been observed ... ...

    Abstract Hepatitis C virus (HCV) is one of the leading causes of chronic liver disease affecting over 71 million people worldwide. An increased incidence of atherothrombotic events [e.g. coronary artery disease (CAD), atrial fibrillation (AF)] has been observed in HCV seropositive patients. On the other hand, an increased bleeding risk is another clinical issue, particularly in subjects with liver cirrhosis, gastroesophageal varices, portal hypertension, thrombocytopenia and alcohol consumption. The introduction and progressively greater use of direct-acting antivirals (DAAs) (instead of protease and polymerase inhibitors) during the last decade has enabled a sustained virological response to be achieved in a significant percentage of patients. However, due to the high cardiovascular risk profile in HCV-infected patients, the concomitant use of antithrombotic therapies is often required, bearing in mind the possible contraindications. For example, despite better pharmacokinetic and pharmacodynamic properties compared with vitamin K-antagonists, plasma level fluctuations of direct oral anticoagulants (DOACs) due to pathological conditions (e.g. chronic kidney diseases or hepatic cirrhosis) or drug-drug interactions (DDIs) may be of great importance as regards their safety profile and overall clinical benefit. We aimed to examine and briefly summarize the significant DDIs observed between antithrombotic and HCV antiviral drugs.
    Language English
    Publishing date 2022-08-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.916361
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  5. Article: Triple troubles selecting optimal therapy for atrial fibrillation patients undergoing percutaneous coronary interventions.

    Parodi, Guido / Scudiero, Fernando

    Postepy w kardiologii interwencyjnej = Advances in interventional cardiology

    2016  Volume 12, Issue 4, Page(s) 287–289

    Language English
    Publishing date 2016-11-16
    Publishing country Poland
    Document type Editorial
    ISSN 1734-9338
    ISSN 1734-9338
    DOI 10.5114/aic.2016.63625
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  6. Article ; Online: Pre-admission atrial fibrillation in COVID-19 patients: Prevalence and clinical impact.

    Russo, Vincenzo / Silverio, Angelo / Scudiero, Fernando / Micco, Pierpaolo Di / Maio, Marco Di

    European journal of internal medicine

    2021  Volume 88, Page(s) 133–135

    Language English
    Publishing date 2021-03-19
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2021.03.017
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    Zs.A 2608: Show issues Location:
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  7. Article ; Online: Outcomes of Left Main Revascularization after Percutaneous Intervention or Bypass Surgery.

    Scudiero, Fernando / Muraca, Iacopo / Migliorini, Angela / Marcucci, Rossella / Pennesi, Matteo / Mazzolai, Lapo / Carrabba, Nazario / Marchionni, Niccolò / Stefano, Pierluigi / Valenti, Renato

    Journal of interventional cardiology

    2022  Volume 2022, Page(s) 6496777

    Abstract: Background: This study is aimed at comparing the clinical outcomes of unprotected left main coronary artery disease (ULMCAD) treatment with contemporary percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in a "real-world" ...

    Abstract Background: This study is aimed at comparing the clinical outcomes of unprotected left main coronary artery disease (ULMCAD) treatment with contemporary percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in a "real-world" population.
    Methods and results: Overall, 558 consecutive patients with ULMCAD (mean age 71 ± 9 years, male gender 81%) undergoing PCI or CABG were compared. The primary endpoint was the composite of death, nonfatal myocardial infarction, or stroke. Diabetes was present in 29% and acute coronary syndrome in 56%; mean EuroSCORE was 11 ± 8. High coronary complexity (SYNTAX score >32) was present in 50% of patients. The primary composite endpoint was similar after PCI and CABG up to 4 years (15.5 ± 3.1% vs. 17.1 ± 2.6%;
    Conclusions: In a "real-world" population with ULMCAD, a contemporary revascularization strategy by PCI or CABG showed similar long-term clinical outcome regardless of the coronary complexity.
    MeSH term(s) Aged ; Aged, 80 and over ; Coronary Artery Bypass/adverse effects ; Coronary Artery Bypass/methods ; Coronary Artery Disease/surgery ; Humans ; Male ; Middle Aged ; Myocardial Infarction/epidemiology ; Percutaneous Coronary Intervention ; Treatment Outcome
    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1036325-7
    ISSN 1540-8183 ; 0896-4327
    ISSN (online) 1540-8183
    ISSN 0896-4327
    DOI 10.1155/2022/6496777
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    Zs.A 2719: Show issues Location:
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  8. Article ; Online: Dual Antiplatelet Therapy with 3

    Scudiero, Fernando / Canonico, Mario E / Sanna, Giuseppe D / Dossi, Filippo / Silverio, Angelo / Galasso, Gennaro / Esposito, Giovanni / Porto, Italo / Parodi, Guido

    Cardiovascular drugs and therapy

    2022  Volume 37, Issue 4, Page(s) 695–703

    Abstract: Purpose: This study aims to assess the association between body mass index (BMI) and platelet reactivity in STEMI patients treated with oral 3: Methods: Overall, 429 STEMI patients were enrolled in this study. Patients were divided into two groups ... ...

    Abstract Purpose: This study aims to assess the association between body mass index (BMI) and platelet reactivity in STEMI patients treated with oral 3
    Methods: Overall, 429 STEMI patients were enrolled in this study. Patients were divided into two groups according to BMI (BMI < 25 vs ≥ 25 kg/m
    Results: After propensity score matching, patients with BMI ≥ 25 had similar values of baseline platelet reactivity, while they had higher level of platelet reactivity at 1 and 2 h after the LD and higher rate of HRPT. Furthermore, multivariate analysis demonstrated that BMI ≥ 25 was an independent predictor of HTPR at 2 h (OR 2.01, p = .009). Conversely, starting from 4 h after the LD, platelet reactivity values and HRPT rates were comparable among the two study groups.
    Conclusions: A BMI ≥ 25 kg/m
    MeSH term(s) Humans ; Platelet Aggregation Inhibitors ; Ticagrelor ; Prasugrel Hydrochloride/adverse effects ; Body Mass Index ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/drug therapy ; Blood Platelets ; Purinergic P2Y Receptor Antagonists/therapeutic use ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome
    Chemical Substances Platelet Aggregation Inhibitors ; Ticagrelor (GLH0314RVC) ; Prasugrel Hydrochloride (G89JQ59I13) ; Purinergic P2Y Receptor Antagonists
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639068-7
    ISSN 1573-7241 ; 0920-3206
    ISSN (online) 1573-7241
    ISSN 0920-3206
    DOI 10.1007/s10557-022-07322-2
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    Zs.B 3057: Show issues Location:
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  9. Article ; Online: Intravenous antiplatelet therapy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention : A report from the INVEST-STEMI group.

    Silverio, Angelo / Bellino, Michele / Scudiero, Fernando / Attisano, Tiziana / Baldi, Cesare / Catalano, Angelo / Centore, Mario / Cesaro, Arturo / Di Maio, Marco / Esposito, Luca / Granata, Giovanni / Maiellaro, Francesco / Muraca, Iacopo / Musumeci, Giuseppe / Parodi, Guido / Personeni, Davide / Valenti, Renato / Vecchione, Carmine / Calabrò, Paolo /
    Galasso, Gennaro

    Journal of thrombosis and thrombolysis

    2024  

    Abstract: The use of intravenous antiplatelet therapy during primary percutaneous coronary intervention (PPCI) is not fully standardized. The aim is to evaluate the effectiveness and safety of periprocedural intravenous administration of cangrelor or tirofiban in ... ...

    Abstract The use of intravenous antiplatelet therapy during primary percutaneous coronary intervention (PPCI) is not fully standardized. The aim is to evaluate the effectiveness and safety of periprocedural intravenous administration of cangrelor or tirofiban in a contemporary ST-segment elevation myocardial infarction (STEMI) population undergoing PPCI. This was a multicenter prospective cohort study including consecutive STEMI patients who received cangrelor or tirofiban during PPCI at seven Italian centers. The primary effectiveness measure was the angiographic evidence of thrombolysis in myocardial infarction (TIMI) flow < 3 after PPCI. The primary safety outcome was the in-hospital occurrence of BARC (Bleeding Academic Research Consortium) 2-5 bleedings. The study included 627 patients (median age 63 years, 79% males): 312 received cangrelor, 315 tirofiban. The percentage of history of bleeding, pulmonary edema and cardiogenic shock at admission was comparable between groups. Patients receiving cangrelor had lower ischemia time compared to tirofiban. TIMI flow before PPCI and TIMI thrombus grade were comparable between groups. At propensity score-weighted regression analysis, the risk of TIMI flow < 3 was significantly lower in patients treated with cangrelor compared to tirofiban (adjusted OR: 0.40; 95% CI: 0.30-0.53). The risk of BARC 2-5 bleeding was comparable between groups (adjusted OR:1.35; 95% CI: 0.92-1.98). These results were consistent across multiple prespecified subgroups, including subjects stratified for different total ischemia time, with no statistical interaction. In this real-world multicenter STEMI population, the use of cangrelor was associated with improved myocardial perfusion assessed by coronary angiography after PPCI without increasing clinically-relevant bleedings compared to tirofiban.
    Language English
    Publishing date 2024-04-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-024-02970-7
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  10. Article ; Online: The tug-of-war between coagulopathy and anticoagulant agents in patients with COVID-19.

    Canonico, Mario Enrico / Siciliano, Roberta / Scudiero, Fernando / Sanna, Giuseppe Damiano / Parodi, Guido

    European heart journal. Cardiovascular pharmacotherapy

    2020  Volume 6, Issue 4, Page(s) 262–264

    MeSH term(s) Anticoagulants ; Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Anticoagulants
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2808613-2
    ISSN 2055-6845 ; 2055-6837
    ISSN (online) 2055-6845
    ISSN 2055-6837
    DOI 10.1093/ehjcvp/pvaa048
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