Article ; Online: Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells.
2023 Volume 39, Issue 6, Page(s) 3031–3059
Abstract: Analysis of the transcriptomic alterations upon chemical challenge, provides in depth mechanistic information on the compound's toxic mode of action, by revealing specific pathway activation and other transcriptional modulations. Mapping changes in ... ...
| Abstract | Analysis of the transcriptomic alterations upon chemical challenge, provides in depth mechanistic information on the compound's toxic mode of action, by revealing specific pathway activation and other transcriptional modulations. Mapping changes in cellular behaviour to chemical insult, facilitates the characterisation of chemical hazard. In this study, we assessed the transcriptional landscape of mitochondrial impairment through the inhibition of the electron transport chain (ETC) in a human renal proximal tubular cell line (RPTEC/TERT1). We identified the unfolded protein response pathway (UPR), particularly the PERK/ATF4 branch as a common cellular response across ETC I, II and III inhibitions. This finding and the specific genes elaborated may aid the identification of mitochondrial liabilities of chemicals in both legacy data and prospective transcriptomic studies. |
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| MeSH term(s) | Humans ; Electron Transport/genetics ; Prospective Studies ; Kidney/metabolism ; Cell Line ; Epithelial Cells/metabolism | |||||
| Language | English | |||||
| Publishing date | 2023-06-23 | |||||
| Publishing country | Switzerland | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 48824-0 | |||||
| ISSN | 1573-6822 ; 0742-2091 | |||||
| ISSN (online) | 1573-6822 | |||||
| ISSN | 0742-2091 | |||||
| DOI | 10.1007/s10565-023-09816-7 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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