Article ; Online: Clinical characteristics of early-onset versus late-onset Alzheimer's disease: a systematic review and meta-analysis.
International psychogeriatrics
2023 , Page(s) 1–17
Abstract: Objectives: A number of studies have compared Alzheimer's disease (AD), the commonest form of dementia, based on their age of onset, i.e. before the age of 65 years (early-onset AD, EO-AD) to those developing after 65 years of age (late-onset AD, LO-AD), ...
| Abstract | Objectives: A number of studies have compared Alzheimer's disease (AD), the commonest form of dementia, based on their age of onset, i.e. before the age of 65 years (early-onset AD, EO-AD) to those developing after 65 years of age (late-onset AD, LO-AD), but the differences are not clear. We performed a systematic review and meta-analysis to compare clinical characteristics between EO-AD and LO-AD. Design, measurements, and participants: Medline, Embase, PsycINFO, and CINAHL databases were systematically searched for studies comparing time to diagnosis, cognitive scores, annual cognitive decline, activities of daily living (ADLs), neuropsychiatric symptoms (NPS), quality of life (QoL), and survival time for EO-AD and LO-AD patients. Results: Forty-two studies were included (EO-AD participants Conclusions: Our findings suggest that EO-AD differs from LO-AD in baseline cognition, cognitive decline, and survival time but otherwise has similar clinical characteristics to LO-AD. Larger studies using standardized questionnaires focusing on the clinical presentations are needed to better understand the impact of age of onset in AD. |
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| Language | English | ||||||||||
| Publishing date | 2023-07-11 | ||||||||||
| Publishing country | England | ||||||||||
| Document type | Journal Article ; Review | ||||||||||
| ZDB-ID | 1038825-4 | ||||||||||
| ISSN | 1741-203X ; 1041-6102 | ||||||||||
| ISSN (online) | 1741-203X | ||||||||||
| ISSN | 1041-6102 | ||||||||||
| DOI | 10.1017/S1041610223000509 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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