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  1. Article ; Online: Frequency and Focus of in Vitro Studies of Microglia-Expressed Cytokines in Response to Viral Infection: A Systematic Review.

    Barrios-González, Diego A / Philibert-Rosas, Santiago / Martínez-Juárez, Iris E / Sotelo-Díaz, Fernando / Rivas-Alonso, Verónica / Sotelo, Julio / Sebastián-Díaz, Mario A

    Cellular and molecular neurobiology

    2024  Volume 44, Issue 1, Page(s) 21

    Abstract: It is well known that as part of their response to infectious agents such as viruses, microglia transition from a quiescent state to an activated state that includes proinflammatory and anti-inflammatory phases; this behavior has been described through ... ...

    Abstract It is well known that as part of their response to infectious agents such as viruses, microglia transition from a quiescent state to an activated state that includes proinflammatory and anti-inflammatory phases; this behavior has been described through in vitro studies. However, recent in vivo studies on the function of microglia have questioned the two-phase paradigm; therefore, a change in the frequency of in vitro studies is expected. A systematic review was carried out to identify the microglial cytokine profile against viral infection that has been further evaluated through in vitro studies (pro-inflammatory or anti-inflammatory), along with analysis of its publication frequency over the years. For this review, 531 articles published in the English language were collected from PubMed, Web of Science, EBSCO and ResearchGate. Only 27 papers met the inclusion criteria for this systematic review. In total, 19 cytokines were evaluated in these studies, most of which are proinflammatory; the most common are IL-6, followed by TNF-α and IL-1β. It should be pointed out that half of the studies were published between 2015 and 2022 (raw data available in https://github.com/dadriba05/SystematicReview.git ). In this review, we identified that evaluation of pro-inflammatory cytokines released by microglia against viral infections has been performed more frequently than that of anti-inflammatory cytokines; additionally, a higher frequency of evaluation of the response of microglia cells to viral infection through in vitro studies from 2015 and beyond was noted.
    MeSH term(s) Humans ; Cytokines ; Microglia ; Virus Diseases ; Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents
    Chemical Substances Cytokines ; Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 283404-2
    ISSN 1573-6830 ; 0272-4340
    ISSN (online) 1573-6830
    ISSN 0272-4340
    DOI 10.1007/s10571-024-01454-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1727: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Electroencephalographic findings in asymptomatic relatives of patients with juvenile myoclonic epilepsy: relationship with the degree of kinship.

    Martínez-Juárez, Iris E / Jara-Prado, Aurelio / Ochoa-Morales, Adriana / Castro-Veloz, Nancy / Santos-Peyret, Andrea / Armenta-Báez, Jimena / Sebastián-Díaz, Mario A

    Gaceta medica de Mexico

    2022  Volume 157, Issue 4, Page(s) 411–415

    Abstract: Introduction: A prevalence of 1 to 71% of electroencephalogram (EEG) abnormalities has been reported in asymptomatic relatives of patients with juvenile myoclonic epilepsy (JME).: Objective: To determine the frequency of EEG abnormalities in ... ...

    Title translation Hallazgos electroencefalográficos en familiares asintomáticos de pacientes con epilepsia mioclónica juvenil: su relación con el grado de parentesco.
    Abstract Introduction: A prevalence of 1 to 71% of electroencephalogram (EEG) abnormalities has been reported in asymptomatic relatives of patients with juvenile myoclonic epilepsy (JME).
    Objective: To determine the frequency of EEG abnormalities in asymptomatic relatives of patients with JME according to the degree of kinship.
    Methods: Prospective, analytical study. First-, second, and third-degree relatives of patients with JME who agreed to participate and signed informed consent were included. The analysis was descriptive, bivariate.
    Results: 209 asymptomatic relatives were included, out of which 115 (55%) were females and 94 (45%) were males, with a mean age of 35.9 ± 16.9 (range between 6 and 73 years). Forty-four (21.1%) relatives had abnormal EEGs. First-degree relatives (12%) had abnormalities more frequently in comparison with second- and third-degree relatives (p = 0.007).
    Conclusions: EEG abnormalities were observed in one third of asymptomatic relatives. It is important to highlight that there were more alterations among first-degree relatives. In the future, these findings might enable for the risk of clinically developing the disease to be estimated and for genetic counseling to be provided.
    MeSH term(s) Adolescent ; Adult ; Aged ; Child ; Electroencephalography ; Female ; Humans ; Male ; Middle Aged ; Myoclonic Epilepsy, Juvenile/diagnosis ; Myoclonic Epilepsy, Juvenile/epidemiology ; Myoclonic Epilepsy, Juvenile/genetics ; Prevalence ; Prospective Studies ; Young Adult
    Language English
    Publishing date 2022-02-08
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 425456-9
    ISSN 0016-3813
    ISSN 0016-3813
    DOI 10.24875/GMM.M21000583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.38: Show issues Location:
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  3. Article: Documento de consenso sobre el uso de iSGLT2 en pacientes con enfermedad renal crónica y diabetes.

    Correa-Rotter, Ricardo / Rosas-Guzmán, Juan / Méndez-Durán, Antonio / Sebastián-Díaz, Mario A / Díaz-Avendaño, Odette Del C / Mehta-Pravin, Roopa / Alcocer-Gamba, Marco A

    Gaceta medica de Mexico

    2021  Volume 158, Issue M2, Page(s) M1–M12

    Abstract: La enfermedad renal crónica (ERC) del paciente diabético es frecuentemente una consecuencia directa de la diabetes mellitus (DM) de larga evolución y se la conoce como nefropatía diabética. En México cerca del 50% de los pacientes en terapia sustitutiva ... ...

    Title translation Consesus document in the use of SGLT inhibitors in patients with diabetes and chronic kidney disease.
    Abstract La enfermedad renal crónica (ERC) del paciente diabético es frecuentemente una consecuencia directa de la diabetes mellitus (DM) de larga evolución y se la conoce como nefropatía diabética. En México cerca del 50% de los pacientes en terapia sustitutiva de la función renal tienen ERC por DM, y este porcentaje podría aumentar en los próximos años. Nuevas opciones terapéuticas, combinadas con cambios en el estilo de vida, han mejorado el control de la glucemia y pueden contribuir sustancialmente a retrasar la aparición o la progresión a estadios avanzados de la ERC. Las sociedades científicas internacionales han elaborado guías clínicas para el diagnóstico y manejo de la nefropatía diabética, sin embargo, en algunos puntos estas recomendaciones no se adaptan a la realidad mexicana. Se presentan las conclusiones de un consenso realizado por especialistas mexicanos sobre diabetes y ERC, con especial énfasis en el uso de los inhibidores del cotransportador de sodio-glucosa.
    Chronic kidney disease (CKD) in the diabetic patient is mainly a consequence of long-term diabetes mellitus itself. In Mexico approximately 50% of patients on dialysis are diabetics and this will could increase in the coming years. New therapeutic options available, combined with lifestyle changes, have improved glycemic control and may contribute to delay the onset as well as the progression of CKD. International scientific societies have developed clinical guidelines for the diagnosis and management of CKD in diabetics, although in some points, these recommendations are not adapted to the Mexican reality. We hereby present the conclusions of the consensus reached by Mexican specialists on diabetic nephropathy.
    MeSH term(s) Diabetes Mellitus/epidemiology ; Humans ; Mexico/epidemiology ; Renal Dialysis ; Renal Insufficiency, Chronic/epidemiology ; Retrospective Studies
    Language English
    Publishing date 2021-12-30
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 425456-9
    ISSN 0016-3813
    ISSN 0016-3813
    DOI 10.24875/GMM.M21000595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.38: Show issues Location:
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  4. Article ; Online: Increased non-attendance at epilepsy clinic in patients with neuropsychiatric comorbidities: A prospective study.

    Zertuche-Ortuño, Lizeth / Oropeza-Bustos, Nayeli / Crail-Meléndez, Daniel / Bribiesca-Contreras, Elisa / Sebastián-Díaz, Mario A / Martínez-Bustos, Verónica / Santos-Peyret, Andrea / Martínez-Medina, Salvador / Ochoa, Adriana / Jara-Prado, Aurelio / Martínez-Juárez, Iris E

    Epilepsy & behavior : E&B

    2021  Volume 122, Page(s) 108202

    Abstract: Background: In patients with epilepsy, regular follow-up is vital for adequate seizure control, antiseizure drugs' (ASDs) side effects, psychiatric comorbidities, and planning for epilepsy surgery. Non-attendance creates barriers to adequate patient ... ...

    Abstract Background: In patients with epilepsy, regular follow-up is vital for adequate seizure control, antiseizure drugs' (ASDs) side effects, psychiatric comorbidities, and planning for epilepsy surgery. Non-attendance creates barriers to adequate patient care, inefficient allocation of resources, loss of income, and unnecessary emergency department visits due to lack of seizure control. This study aimed to determine the causes and sociodemographic characteristics of the non-attendant population at the Epilepsy Clinic.
    Methods: A prospective and observational study was carried out on patients treated at the Epilepsy Clinic of the National Institute of Neurology and Neurosurgery (NINN) in Mexico from August 2015 to June 2016. A phone interview was made with all those patients who did not attend the epilepsy consultation. This call incorporated ad hoc questions to meet the objectives of this study.
    Results: During the study period, 1299 patients had an appointment at the epilepsy clinic, where 233 (17.9%) patients missed their consultation, 123 (52.8%) were male, mean age was 35.9 ± 14.42 years. The most frequent cause of non-attendance was forgetfulness of the appointment in 62 patients (26.6%). Two patients died; no patient was reported to have experienced SUDEP. Non-attendant patients showed statistically significant overall prevalence of psychiatric comorbidities (41.6%), particularly depression, anxiety, and interictal psychosis.
    Conclusion: Information on non-attendance at various specialist consultations is scarce, and to our knowledge, this is the first study to address non-attendance in patients with epilepsy in Latin America. Improving hospital protocols to reduce non-attendance can increase patient adherence to follow-up, ultimately improving the quality of care in the epilepsy clinic.
    MeSH term(s) Adult ; Ambulatory Care Facilities ; Appointments and Schedules ; Epilepsy/complications ; Epilepsy/epidemiology ; Epilepsy/therapy ; Humans ; Male ; Middle Aged ; Prospective Studies ; Seizures ; Young Adult
    Language English
    Publishing date 2021-07-26
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2021.108202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5289: Show issues Location:
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