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Article ; Online: Feasibility of robotic cholecystectomy at an academic center with a young robotic surgery program: a retrospective cohort study with umbrella review.

Corzo, Maria Paula / Tomey, Daniel / Martinino, Alessandro / Secchi, Roberto / Elzein, Steven / Lee, Yoon Kyung / Abou-Mrad, Adel / Oviedo, Rodolfo J

Journal of robotic surgery

2024 Volume 18, Issue 1, Page(s) 93

Abstract: Laparoscopic cholecystectomy (LC) has been standard of care for surgical treatment of benign gallbladder pathology for decades. With the advent of robotic surgical technology, robotic cholecystectomy (RC) has gained attention as an alternative to ... ...

Abstract	Laparoscopic cholecystectomy (LC) has been standard of care for surgical treatment of benign gallbladder pathology for decades. With the advent of robotic surgical technology, robotic cholecystectomy (RC) has gained attention as an alternative to conventional laparoscopy. This study introduces a single-surgeon experience with laparoscopic versus robotic cholecystectomy and an umbrella systematic review of the outcomes of both approaches. A retrospective chart review was performed at a single institution on a prospectively maintained database of patients undergoing laparoscopic or robotic cholecystectomy for benign gallbladder pathology. An umbrella systematic review was conducted using PRISMA methodology. A total of 103 patients were identified; 61 patients underwent LC and 42 underwent RC. In the RC cohort, 17 cases were completed using a four-port technique while 25 were completed using a three-port technique. Patients undergoing RC were older compared to the LC group (44.78 vs 57.02 years old; p < 0.001) and exhibited lower body mass index (29.37 vs 32.37 kg/m
MeSH term(s)	Humans ; Middle Aged ; Robotic Surgical Procedures/methods ; Retrospective Studies ; Feasibility Studies ; Robotics ; Cholecystectomy
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	2268283-1
ISSN	1863-2491 ; 1863-2483
ISSN (online)	1863-2491
ISSN	1863-2483
DOI	10.1007/s11701-024-01824-x
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Article: CT Images in Follicular Lymphoma: Changes after Treatment Are Predictive of Cardiac Toxicity in Patients Treated with Anthracycline-Based or R-B Regimens.

Esposito, Fabiana / Mezzanotte, Valeria / Tesei, Cristiano / Luciano, Alessandra / Gigliotti, Paola Elda / Nunzi, Andrea / Secchi, Roberto / Angeloni, Cecilia / Pitaro, Maria / Meconi, Federico / Cerocchi, Martina / Garaci, Francesco / Venditti, Adriano / Postorino, Massimiliano / Chiocchi, Marcello

Cancers

2024 Volume 16, Issue 3

Abstract: The aim of this study is to evaluate changes in epicardial adipose tissue (EAT) and cardiac extracellular volume (ECV) in patients with follicular lymphoma (FL) treated with R-CHOP-like regimens or R-bendamustine. We included 80 patients with FL between ... ...

Abstract	The aim of this study is to evaluate changes in epicardial adipose tissue (EAT) and cardiac extracellular volume (ECV) in patients with follicular lymphoma (FL) treated with R-CHOP-like regimens or R-bendamustine. We included 80 patients with FL between the ages of 60 and 80 and, using computed tomography (CT) performed at onset and at the end of treatment, we assessed changes in EAT by measuring tissue density at the level of the cardiac apex, anterior interventricular sulcus and posterior interventricular sulcus of the heart. EAT is known to be associated with metabolic syndrome, increased calcium in the coronary arteries and therefore increased risk of coronary artery disease. We also evaluated changes in ECV, which can be used as an early imaging marker of cardiac fibrosis and thus myocardial damage. The R-CHOP-like regimen was associated with lower EAT values (
Language	English
Publishing date	2024-01-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16030563
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Article ; Online: The ISTH DIC-score predicts early mortality in patients with non-promyelocitic acute myeloid leukemia.

Paterno, Giovangiacinto / Palmieri, Raffaele / Tesei, Cristiano / Nunzi, Andrea / Ranucci, Giorgia / Mallegni, Flavia / Moretti, Federico / Meddi, Elisa / Tiravanti, Ilaria / Marinoni, Massimiliano / Page, Camilla / Fagiolo, Solaria / Buzzatti, Elisa / Secchi, Roberto / Gurnari, Carmelo / Maurillo, Luca / Buccisano, Francesco / Venditti, Adriano / Del Principe, Maria Ilaria

Thrombosis research

2024 Volume 236, Page(s) 30–36

Abstract: Coagulation disorders frequently complicate the clinical course of acute myeloid leukemia (AML) patients. This study examined the frequency and prognostic significance, with regards of early mortality, of the presence of overt disseminated intravascular ... ...

Abstract	Coagulation disorders frequently complicate the clinical course of acute myeloid leukemia (AML) patients. This study examined the frequency and prognostic significance, with regards of early mortality, of the presence of overt disseminated intravascular coagulation (DIC) at AML diagnosis and its correlation with clinical and biological characteristics. A retrospective analysis of 351 newly diagnosed non-promyelocytic AML patients was conducted, utilizing the 2018 ISTH DIC-Score criteria to evaluate the presence of overt DIC at AML onset. The study cohort had a median age of 65 years with a predominance of male gender (59 %). Overt DIC was present in 21 % of cases and was associated with advanced age, comorbidities, poor performance status, hyperleukocytosis, LDH levels, NPM1 mutations, expression of CD33 and CD4, and lack of expression of CD34. With a median follow-up of 72 months (3-147 months), the 6-year overall survival (OS) was 17.4 %, with patients having overt DIC showing significantly poorer outcomes (7.2 % compared to 20.3 % of those without DIC, p < 0.001). Patients with overt DIC showed markedly high early mortality rates at 30 (42.5 % vs 8 %), 60 (49.3 % vs 16.9 %), and 120 days (64.4 % vs 25.6 %) from disease onset. In multivariate analysis overt DIC retained its independent prognostic value for early mortality. In conclusion, the prevalence and clinical relevance of DIC in non-promyelocytic AML is not negligible, underlining its potential as an unfavorable prognostic marker. In newly diagnosed patients with AML, early recognition and measure to counteract coagulation disturbances might help mitigate the elevated mortality risk associated with DIC.
MeSH term(s)	Humans ; Male ; Aged ; Female ; Disseminated Intravascular Coagulation/etiology ; Retrospective Studies ; Leukemia, Myeloid, Acute/complications ; Prognosis ; Blood Coagulation
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2024.02.017
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Book ; Conference proceedings: Il pensiero delle forme tra architettura e scienze della vita

Secchi, Roberto

[rielaborazione degli interventi del seminario di studi tenutosi a Frascati nei giorni 7, 8 e 9 ottobre 2004]

(Tracce ; 4)

2005

Event/congress	Seminario di studi (2004.10.07-09, Frascati)
Author's details	a cura di Roberto Secchi
Series title	Tracce ; 4
Language	Italian
Size	303 S, Ill, 24 cm
Publisher	Officina Ed
Publishing place	Roma
Document type	Book ; Conference proceedings
ISBN	8887570876 ; 8887670876 ; 9788887570878 ; 9788887670875
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Body Composition in Patients with Follicular Lymphoma: Asso-Ciations between Changes in Radiomic Parameters in Patients Treated with R-CHOP-like and R-B Regimens: LyRa 01F.

Esposito, Fabiana / Pascale, Maria Rosaria / Tesei, Cristiano / Gigliotti, Paola Elda / Luciano, Alessandra / Angeloni, Cecilia / Marinoni, Massimiliano / Meconi, Federico / Secchi, Roberto / Patanè, Alberto / Postorino, Massimiliano / Cantonetti, Maria / Manenti, Guglielmo

Cancers

2023 Volume 15, Issue 4

Abstract: In patients with follicular lymphoma (FL), therapeutic advances have led to improved survival, and within this framework, it is important to identify treatment strategies offering a better quality of life. Using (18)F-fluorodeoxyglucose positron emission ...

Abstract	In patients with follicular lymphoma (FL), therapeutic advances have led to improved survival, and within this framework, it is important to identify treatment strategies offering a better quality of life. Using (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT), in patients treated with R-CHOP-like or R-Bendamustine regimens, we assessed changes in the bone mineral density (BMD), musculoskeletal index (SMI), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) at disease onset and at the end of therapy. We evaluated whether the high-steroid regimen could lead to more significant radiological changes than those induced by the steroid-free regimen and whether a low BMD at disease onset is an unfavorable prognostic index. Seventy-nine patients between 60 and 80 years old with a new diagnosis of FL were included in the study. Evaluation of Delta values (pre- and post-therapy mean values) in the two immunochemotherapy regimens showed differences in radiomic parameters within the two patient cohorts. The R-CHOP-like regimen was associated with a significant reduction in BMD, an increase in SAT and VAT, and a reduction in skeletal muscle density (SMD) and SMI. Moreover, patients with high FLIPI showed a BMD below the cut-off value. This study represents the first study demonstrating a prognostic correlation between FLIPI and low BMD.
Language	English
Publishing date	2023-02-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15040999
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Article: The Role of Erythrocyte Sedimentation Rate (ESR) in Myeloproliferative and Lymphoproliferative Diseases: Comparison between DIESSE CUBE 30 TOUCH and Alifax Test 1.

Pelagalli, Martina / Tomassetti, Flaminia / Nicolai, Eleonora / Giovannelli, Alfredo / Codella, Silvia / Iozzo, Mariannina / Massoud, Renato / Secchi, Roberto / Venditti, Adriano / Pieri, Massimo / Bernardini, Sergio

Diseases (Basel, Switzerland)

2023 Volume 11, Issue 4

Abstract: 1) Background: The erythrocyte sedimentation rate (ESR) is widely diffused in hematology laboratories to monitor inflammatory statuses, response to therapies (such as antibiotics), and oncologic diseases. However, ESR is not a specific diagnostic marker ...

Abstract	(1) Background: The erythrocyte sedimentation rate (ESR) is widely diffused in hematology laboratories to monitor inflammatory statuses, response to therapies (such as antibiotics), and oncologic diseases. However, ESR is not a specific diagnostic marker but needs to be contextualized and compared with clinical and other laboratory findings. This study aimed to investigate the performance of two automated instruments, namely the DIESSE CUBE 30 TOUCH (DIESSE, Siena, Italy) and the Alifax Test 1 (Alifax Srl, Polverara, Italy), in comparison with the gold standard, the Westergren method, in lymphoproliferative and myeloproliferative patients. (2) Methods: 97 EDTA samples were selected from the hematology department of Roma Tor Vergata Hospital and analyzed. Statistical analysis was applied. (3) A good correlation between CUBE 30 TOUCH and the gold standard was observed in the overall sample (R
Language	English
Publishing date	2023-11-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720869-2
ISSN	2079-9721
ISSN	2079-9721
DOI	10.3390/diseases11040169
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Article: Role of Neutrophil-to-Lymphocyte Ratio (NLR) in Patients with Mycosis Fungoides.

Di Raimondo, Cosimo / Lombardo, Paolo / Tesei, Cristiano / Esposito, Fabiana / Meconi, Federico / Secchi, Roberto / Lozzi, Flavia / Monopoli, Alessandro / Narducci, Maria Grazia / Scala, Enrico / Angeloni, Cecilia / De Stefano, Alberto / Rahimi, Siavash / Bianchi, Luca / Cantonetti, Maria

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 11

Abstract: Background: The neutrophil/lymphocyte ratio (NLR) at baseline has been demonstrated to correlate with higher stages of disease and to be a prognostic factor in numerous cancers. However, its function as a prognostic factor for mycosis fungoides (MF) has ...

Abstract	Background: The neutrophil/lymphocyte ratio (NLR) at baseline has been demonstrated to correlate with higher stages of disease and to be a prognostic factor in numerous cancers. However, its function as a prognostic factor for mycosis fungoides (MF) has not been yet clarified. Objective: Our work aimed to assess the association of the NLR with different stages of MF and to outline whether higher values of this marker are related to a more aggressive MF. Methods: We retrospectively calculated the NLRs in 302 MF patients at the moment of diagnosis. The NLR was obtained using the complete blood count values. Results: The median NLR among patients with early stage disease (low-grade IA-IB-IIA) was 1.88, while the median NLR for patients with high-grade MF (IIB-IIIA-IIIB) was 2.64. Statistical analysis showed positive associations of advanced MF stages with NLRs higher than 2.3. Conclusions: Our analysis demonstrates that the NLR represents a cheap and easily available parameter functioning as a marker for advanced MF. This might guide physicians in recognizing patients with advanced stages of disease requiring a strict follow-up or an early treatment.
Language	English
Publishing date	2023-06-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13111979
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Article: Efficacy and Safety of Cyclophosphamide Low-Dose Pre-Phase Chemotherapy in Diffuse Large B Cell Lymphoma with Gastrointestinal Involvement.

Guarnera, Luca / Meconi, Federico / Secchi, Roberto / Pascale, Maria Rosaria / Esposito, Fabiana / Zizzari, Annagiulia / Rapisarda, Vito Mario / Rizzo, Manuela / Pupo, Livio / Cantonetti, Maria

Mediterranean journal of hematology and infectious diseases

2022 Volume 14, Issue 1, Page(s) e2022017

Abstract: Background: Gastric Diffuse large B-cell lymphoma (DLBCL) is the most common extranodal site of lymphoma's involvement (30%-40% of all extranodal lymphomas and 55%-65% of all gastrointestinal lymphomas). However, gastric localizations are also sometimes ...

Abstract	Background: Gastric Diffuse large B-cell lymphoma (DLBCL) is the most common extranodal site of lymphoma's involvement (30%-40% of all extranodal lymphomas and 55%-65% of all gastrointestinal lymphomas). However, gastric localizations are also sometimes found in systemic DLBCL. Gastric complications such as bleeding, perforation, and stenosis under chemotherapy are well documented. Methods: We retrospectively analyzed 15 patients with newly diagnosed DLBCL with gastrointestinal involvement. Endoscopies were performed in these patients before and after treatment. Treatment consisted of cyclophosphamide low-dose pre-phase chemotherapy before conventional-dose chemotherapy. Results: Endoscopy at staging detected ulcers in 12 patients (80%). After low-dose pre-phase chemotherapy, GI ulcers healed in 91.6% of cases (1 ulcer detected). After the whole treatment (Low-dose pre-phase + chemotherapy) 9 patients (60%) achieved complete response, 4 patients (26.6%) partial response, 2 (13,3%) patients presented disease progression. The most frequent adverse event was neutropenia (73.3%); the most frequent non-hematological adverse event was transaminases elevation (20%). Conclusion: Cyclophosphamide low-dose pre-phase chemotherapy resulted in a safe and effective way to prevent adverse events in systemic DLBCL with gastrointestinal involvement.
Language	English
Publishing date	2022-03-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2674750-9
ISSN	2035-3006
ISSN	2035-3006
DOI	10.4084/mjhid.2022.017
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Article: A case of metachronous peripheral T-Cell non-Hodgkin lymphoma following chemotherapy for Hodgkin disease successfully treated with brentuximab vedotin.

Meconi, Federico / Provenzano, Ida / Nasso, Daniela / Mariotti, Benedetta / Pupo, Livio / Secchi, Roberto / Cerretti, Raffaella / Lucia, Anemona / Arcese, William / Cantonetti, Maria

Clinical case reports

2020 Volume 8, Issue 8, Page(s) 1353–1356

Abstract: Occasionally, non-Hodgkin lymphomas (NHL) occur simultaneously or subsequently to Hodgkin disease. We report on a case of a woman with Hodgkin lymphoma treated with ABVD, who developed 4 years later T-cell NHL with both nodal and extranodal involvement. ... ...

Abstract	Occasionally, non-Hodgkin lymphomas (NHL) occur simultaneously or subsequently to Hodgkin disease. We report on a case of a woman with Hodgkin lymphoma treated with ABVD, who developed 4 years later T-cell NHL with both nodal and extranodal involvement. Brentuximab vedotin could be an effective choice in treating metachronous T-cell NHL.
Language	English
Publishing date	2020-05-05
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.2898
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Book: Mode, modernità, architettura

Abruzzese, Alberto / Secchi, Roberto

(Tracce ; 2)

2003

Author's details	a cura di Roberto Secchi. Scritti di [Alberto] Abruzzese
Series title	Tracce ; 2
Language	Italian
Size	207 S, Ill, 24 cm
Publisher	Officina
Publishing place	Roma
Document type	Book
Note	Collected essays ; Contains bibliography
ISBN	8887570604 ; 9788887570601
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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