Article ; Online: Oral administration of bacterial probiotics improves Helicobacter pylori-induced memory impairment in rats: Insights from behavioral and biochemical investigations.
2024 Volume 463, Page(s) 114903
Abstract: There are numerous evidence supporting the association between Helicobacter pylori (H. pylori) infection and the occurrence of cognitive deficits in humans. In this regard, treatment of H. pylori infection has been suggested as an effective strategy to ... ...
| Abstract | There are numerous evidence supporting the association between Helicobacter pylori (H. pylori) infection and the occurrence of cognitive deficits in humans. In this regard, treatment of H. pylori infection has been suggested as an effective strategy to decelerate the neurodegenerative processes of memory deficits in AD patients. Numerous studies support the beneficial effects of probiotics on various pathological conditions, particularly cognitive deficits, however, this concern has not been addressed in relation to the memory impairment induced by H. pylori infection. In the present study, we aimed to reveal whether oral administration of two bacterial probiotics (including Lactobacillus rhamnosus and Lactobacillus plantarum), could ameliorate H. pylori-induced memory deficits at behavioral level in rats. Besides, cellular mechanisms were investigated by biochemical methods to find out how probiotic effects are mediated in hippocampal circuitry. Male Wistar rats were infected by H. pylori for 3 consecutive days, then probiotic treatment was done for the next 3 days and after a drug-free period (12 days), animals were assessed by Morris Water Maze and Novel Object Recognition tests. Finally, rats were euthanized by CO |
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| MeSH term(s) | Humans ; Rats ; Male ; Animals ; Helicobacter pylori ; Rats, Wistar ; Helicobacter Infections/microbiology ; Helicobacter Infections/pathology ; Helicobacter Infections/therapy ; Probiotics/pharmacology ; Memory Disorders/etiology ; Memory Disorders/therapy ; Administration, Oral |
| Language | English |
| Publishing date | 2024-02-09 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 449927-x |
| ISSN | 1872-7549 ; 0166-4328 |
| ISSN (online) | 1872-7549 |
| ISSN | 0166-4328 |
| DOI | 10.1016/j.bbr.2024.114903 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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