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  1. Book: Renal genetics and clinical practice

    Sedor, John R.

    (Nephron journals ; 118,1)

    2011  

    Author's details guest ed. John Sedor
    Series title Nephron journals ; 118,1
    Nephron
    Collection Nephron
    Language English
    Size c66 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT016778495
    ISBN 978-3-8055-9647-3 ; 9783805596480 ; 3-8055-9647-2 ; 3805596480
    Database Catalogue ZB MED Medicine, Health

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    Zs A 169 -118- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Kidney Genetics: Continuing Discoveries and a Roadmap to the Clinic.

    Sedor, John R

    Journal of the American Society of Nephrology : JASN

    2023  Volume 34, Issue 4, Page(s) 519–520

    MeSH term(s) Kidney ; Ambulatory Care Facilities
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3344: Show issues Location:
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  3. Article ; Online: APOL1 Kidney Disease: Discovery to Targeted Therapy in 10 Years.

    Sedor, John R

    Clinical journal of the American Society of Nephrology : CJASN

    2023  

    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000256
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  4. Article ; Online: APOL1

    Gadegbeku, Crystal A / Sedor, John R

    Clinical journal of the American Society of Nephrology : CJASN

    2023  Volume 16, Issue 12, Page(s) 1779–1780

    MeSH term(s) Humans ; Apolipoprotein L1/genetics ; COVID-19 ; Kidney ; Acute Kidney Injury ; Apolipoproteins/genetics ; Genetic Predisposition to Disease ; Genotype
    Chemical Substances Apolipoprotein L1 ; Apolipoproteins ; APOL1 protein, human
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.13571021
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  5. Article ; Online: Biobanks Linked to Electronic Health Records Accelerate Genomic Discovery.

    Crawford, Dana C / Sedor, John R

    Journal of the American Society of Nephrology : JASN

    2021  Volume 32, Issue 8, Page(s) 1828–1829

    MeSH term(s) Biological Specimen Banks ; Electronic Health Records ; Genome-Wide Association Study ; Genomics
    Language English
    Publishing date 2021-07-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2021060836
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  6. Article ; Online: Biologic Underpinnings of Type 1 Diabetic Kidney Disease.

    Sedor, John R / Freedman, Barry I

    Journal of the American Society of Nephrology : JASN

    2019  Volume 30, Issue 10, Page(s) 1782–1783

    MeSH term(s) Biological Products ; Collagen ; Diabetes Mellitus, Type 2 ; Diabetic Nephropathies ; Genome-Wide Association Study ; Glomerular Basement Membrane ; Humans ; Kidney Failure, Chronic
    Chemical Substances Biological Products ; Collagen (9007-34-5)
    Language English
    Publishing date 2019-09-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2019080803
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  7. Article ; Online: Microangiopathic hemolytic anemia in a female patient with systemic lupus erythematosus.

    Sohail, Mohammad A / Luong, Peter / Sedor, John / Kaw, Roop

    Cleveland Clinic journal of medicine

    2022  Volume 89, Issue 3, Page(s) 130–138

    MeSH term(s) Anemia, Hemolytic/diagnosis ; Anemia, Hemolytic/etiology ; Female ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/complications ; Purpura, Thrombotic Thrombocytopenic/diagnosis
    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.89a.21066
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  8. Book: Nephrology secrets

    Hricik, Donald E. / Sedor, John R. / Ganz, Michael B.

    [questions you will be asked on rounds, in the clinic, on oral exams]

    (The secrets series)

    1999  

    Author's details Donald E. Hricik ; John R. Sedor ; Michael B. Ganz
    Series title The secrets series
    Keywords Kidney Diseases Examination Questions
    Language English
    Size XI, 259 S. : Ill., graph. Darst.
    Publisher Hanley & Belfus
    Publishing place Philadelphia
    Publishing country United States
    Document type Book
    HBZ-ID HT011179455
    ISBN 1-560-53309-9 ; 978-1-560-53309-2
    Database Catalogue ZB MED Medicine, Health

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    2000 A 287 order for loan Magazin

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  9. Article ; Online: APOL1 and Preeclampsia: Intriguing Links, Uncertain Causality, Troubling Implications.

    Sedor, John R / Bruggeman, Leslie A / O'Toole, John F

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2021  Volume 77, Issue 6, Page(s) 863–865

    MeSH term(s) Apolipoprotein L1/genetics ; Female ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Pre-Eclampsia/epidemiology ; Pre-Eclampsia/genetics ; Pregnancy
    Chemical Substances APOL1 protein, human ; Apolipoprotein L1
    Language English
    Publishing date 2021-04-17
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2021.01.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 468: Show issues

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  10. Article ; Online: Apolipoprotein L1 and mechanisms of kidney disease susceptibility.

    Bruggeman, Leslie A / Sedor, John R / O'Toole, John F

    Current opinion in nephrology and hypertension

    2021  Volume 30, Issue 3, Page(s) 317–323

    Abstract: Purpose of review: Allelic variants in the gene for apolipoprotein L1 (APOL1), found only in individuals of African ancestry, explain a majority of the excess risk of kidney disease in African Americans. However, a clear understanding how the disease- ... ...

    Abstract Purpose of review: Allelic variants in the gene for apolipoprotein L1 (APOL1), found only in individuals of African ancestry, explain a majority of the excess risk of kidney disease in African Americans. However, a clear understanding how the disease-associated APOL1 variants cause kidney injury and the identity of environmental stressors that trigger the injury process have not been determined.
    Recent findings: Basic mechanistic studies of APOL1 biochemistry and cell biology, bolstered by new antibody reagents and inducible pluripotent stem cell-derived cell systems, have focused on the cytotoxic effect of the risk variants when APOL1 gene expression is induced. Since the APOL1 variants evolved to alter a key protein-protein interaction with the trypanosome serum resistance-associated protein, additional studies have begun to address differences in APOL1 interactions with other proteins expressed in podocytes, including new observations that APOL1 variants may alter podocyte cytoskeleton dynamics.
    Summary: A unified mechanism of pathogenesis for the various APOL1 nephropathies still remains unclear and controversial. As ongoing studies have consistently implicated the pathogenic gain-of-function effects of the variant proteins, novel therapeutic development inhibiting the synthesis or function of APOL1 proteins is moving toward clinical trials.
    MeSH term(s) Apolipoprotein L1/genetics ; Disease Susceptibility ; Genetic Predisposition to Disease ; Humans ; Kidney Diseases/genetics ; Kidney Diseases/therapy ; Podocytes
    Chemical Substances APOL1 protein, human ; Apolipoprotein L1
    Language English
    Publishing date 2021-03-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3686: Show issues Location:
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