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Article: The trend of economic development of the agricultural enterprises from Ukraine and Donetsk region

Sedov, A.

Agrarian Science

2015 , Issue no.1, Page(s) p. 151–158

Abstract: The article presents the study on the condition of the agricultural enterprises of Ukraine and the Donetsk region, identifies the main trends of their development in the period from 1990 to 2012, and namely: the dynamics of land-resource potential in the ...

Abstract	The article presents the study on the condition of the agricultural enterprises of Ukraine and the Donetsk region, identifies the main trends of their development in the period from 1990 to 2012, and namely: the dynamics of land-resource potential in the context of ownership; analysis of the changes in the number of agricultural enterprises of different organizational forms during the period of land reform; calculation and analysis of the economic indicators of agricultural enterprises gross output, the economic efficiency of land use; the comprehensive assessment of the effectiveness of agricultural enterprise production activity. The research results may further become a basis for the adoption of measures aimed at improving the situation in the agricultural sector.
Keywords	FARM RESULTS ; RENTABILIDAD ; UKRAINE ; EFFICACITE ; EFFICIENCY ; EXPLOTACIONES AGRARIAS ; EXPLOITATION AGRICOLE ; RESULTAT DE L'EXPLOITATION AGRICOLE ; PROFITABILITY ; EFICACIA ; RESULTADOS DE LA EXPLOTACION ; UCRANIA ; FARMS ; RENTABILITE
Language	Russian
Document type	Article
ISSN	1857-0003
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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Article ; Online: Pallidal multifractal complexity is a new potential physiomarker of dystonia.

Semenova, Ulia / Dzhalagoniya, Indiko / Gamaleya, Anna / Tomskiy, Alexey / Shaikh, Aasef G / Sedov, Alexey

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

2024 Volume 162, Page(s) 31–40

Abstract: Objective: Low-frequency 4-12 Hz pallidal oscillations are being considered as potential physiomarkers for dystonia. We suggest investigating the multifractal properties of pallidal activity as an additional marker.: Methods: We employed local field ... ...

Abstract	Objective: Low-frequency 4-12 Hz pallidal oscillations are being considered as potential physiomarkers for dystonia. We suggest investigating the multifractal properties of pallidal activity as an additional marker. Methods: We employed local field potentials (LFP) recordings from 23 patients with dystonia who were undergoing deep brain stimulation (DBS) surgery to explore the connection between disease severity and the multifractal characteristics of pallidal activity. Furthermore, we performed an analysis of LFP recordings from four patients, following the externalization of DBS lead electrodes, to investigate the impact of DBS and neck muscle vibration on multifractal parameters. Results: Greater dystonia severity exhibited a correlation with a narrower multifractal spectrum width but higher multifractal spectral asymmetry. Both GPi DBS and muscle vibration in dystonia patients expanded the multifractal spectrum width while restoring multifractal spectral symmetry. Notably, the threshold peak intensities for an increase in multifractal spectrum width substantially overlapped with the optimal volume of tissue activated. A broader multifractal spectrum during DBS corresponded to more favorable clinical outcomes. Conclusions: Multifractal properties of pallidal neuronal activity serve as indicators of neural dysfunction in dystonia. Significance: These findings suggest the potential of utilizing multifractal characteristics as predictive factors for the DBS outcome in dystonia.
Language	English
Publishing date	2024-03-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1463630-x
ISSN	1872-8952 ; 0921-884X ; 1388-2457
ISSN (online)	1872-8952
ISSN	0921-884X ; 1388-2457
DOI	10.1016/j.clinph.2024.03.012
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Article ; Online: Excessive α-β Oscillations Mark Enlarged Motor Sign Severity and Parkinson's Disease Duration.

Belova, Elena / Semenova, Ulia / Gamaleya, Anna / Tomskiy, Alexey / Sedov, Alexey

Movement disorders : official journal of the Movement Disorder Society

2023 Volume 38, Issue 6, Page(s) 1027–1035

Abstract: Background: β Oscillations in the subthalamic nucleus (STN) have been proven to contribute to Parkinson's disease (PD), but the exact borders of β subbands vary substantially across the studies, and information regarding heterogeneity of β rhythmic ... ...

Abstract	Background: β Oscillations in the subthalamic nucleus (STN) have been proven to contribute to Parkinson's disease (PD), but the exact borders of β subbands vary substantially across the studies, and information regarding heterogeneity of β rhythmic activity is still limited. Recently, α oscillations in the basal ganglia have also become the focus of PD research. Objectives: The aim was to study rhythmic oscillations in the STN in PD patients to identify different subbands with stable oscillatory peaks within a broad α-β range and to establish their associations with motor symptoms. Methods: Local field potentials inside the STN were recorded during deep brain stimulation (DBS) surgeries. After calculating power spectra and extracting an aperiodic component, oscillatory peaks in the 8- to 35-Hz range with amplitude exceeding 90th percentile were clustered into three bands. Peak parameters were estimated for two lower subbands. Clinical features were compared in patients with and without oscillation peaks in the lowest α-β subband. Results: We isolated α-β (8-15 Hz), β (15-25 Hz), and β-γ (25-35 Hz) subbands within the 8- to 35-Hz spectral range using oscillatory parameters and Ward's hierarchical clustering. Additional α-β oscillatory peaks were found in about half of patients with β peaks; they were located more ventrally compared to β. We have found a significant increase in disease duration, bradykinesia, and rigidity scores in the group with additional α-β peaks. Conclusions: Increased α-β oscillations may emerge as additional phenomena complementing β oscillations; they may mark disease progression in PD and affect DBS stimulation setup. © 2023 International Parkinson and Movement Disorder Society.
MeSH term(s)	Humans ; Parkinson Disease/therapy ; Deep Brain Stimulation ; Basal Ganglia ; Subthalamic Nucleus/surgery ; Beta Rhythm/physiology
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.29393
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Zs.A 2555: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Attenuation of neural responses in subthalamic nucleus during internally guided voluntary movements in Parkinson's disease.

Filyushkina, Veronika / Belova, Elena / Usova, Svetlana / Tomskiy, Alexey / Sedov, Alexey

Frontiers in human neuroscience

2022 Volume 16, Page(s) 977784

Abstract: The proposed models of segregated functional loops describe the organization of motor control over externally triggered (ET) and internally guided (IG) movements. The dopamine deficiency in Parkinson's disease (PD) is considered to cause a disturbance in ...

Abstract	The proposed models of segregated functional loops describe the organization of motor control over externally triggered (ET) and internally guided (IG) movements. The dopamine deficiency in Parkinson's disease (PD) is considered to cause a disturbance in the functional loop regulating IG movements. At the same time, the neural mechanisms of movement performance and the role of basal ganglia in motor control remain unclear.The aim of this study was to compare neuronal responses in the subthalamic nucleus (STN) during ET and IG movements in PD. We found and analyzed 26 sensitive neurons in 12 PD patients who underwent surgery for implantation of electrodes for deep brain stimulation. We also analyzed the local field potentials (LFP) of the STN of six patients during the postoperative period. Patients were asked to perform voluntary movements (clenching and unclenching the fist) evoked by verbal command (ET) or self-initiated (IG). We showed heterogeneity of neuronal responses and did not find sensitive neurons associated with only one type of movement. Most cells were characterized by leading responses, indicating that the STN has an important role in movement initiation. At the same time, we found attenuation of motor responses during IG movement vs. stable responses during ET movements. LFP analysis also showed attenuation of beta desynchronization during multiple IG movements.We propose that stable neuronal response to ET movements is associated with the reboot of the motor program for each movement, while attenuation of responses to IG movement is associated with single motor program launching for multiple movements.
Language	English
Publishing date	2022-10-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2022.977784
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Article ; Online: Experimental demonstration of the third cyclotron harmonic excitation in technological gyrotron with delayed selective feedback.

Fokin, A P / Sedov, A S / Zuev, A S

The Review of scientific instruments

2020 Volume 91, Issue 2, Page(s) 24706

Abstract: The excitation and effective selection of modes at high harmonics of the cyclotron frequency are experimentally demonstrated using a delayed feedback into the gyrotron. The operation at the third cyclotron harmonic at the frequency of 40.5 GHz with the ... ...

Abstract	The excitation and effective selection of modes at high harmonics of the cyclotron frequency are experimentally demonstrated using a delayed feedback into the gyrotron. The operation at the third cyclotron harmonic at the frequency of 40.5 GHz with the output power of 3 kW and efficiency 8% is observed in a continuous wave gyrotron with an oil-cooled magnet with a field of 0.5 T in the interaction space.
Language	English
Publishing date	2020-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/1.5140720
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Article ; Online: Proprioceptive Modulation of Pallidal Physiology in Cervical Dystonia.

Sedov, Alexey / Joshi, Prajakta / Semenova, Ulia / Usova, Svetlana / Asriyants, Svetlana / Gamaleya, Anna / Tomskiy, Alexey / Jinnah, Hyder A / Shaikh, Aasef G

Movement disorders : official journal of the Movement Disorder Society

2023 Volume 38, Issue 11, Page(s) 2094–2102

Abstract: Background: There is a growing body of evidence suggesting that botulinum toxin can alter proprioceptive feedback and modulate the muscle-spindle output for the treatment of dystonia. However, the mechanism for this modulation remains unclear.: ... ...

Abstract	Background: There is a growing body of evidence suggesting that botulinum toxin can alter proprioceptive feedback and modulate the muscle-spindle output for the treatment of dystonia. However, the mechanism for this modulation remains unclear. Methods: We conducted a study involving 17 patients with cervical dystonia (CD), seven of whom had prominent CD and 10 with generalized dystonia (GD) along with CD. We investigated the effects of neck vibration, a form of proprioceptive modulation, on spontaneous single-neuron responses and local field potentials (LFPs) recorded from the globus pallidum externus (GPe) and internus (GPi). Results: Our findings demonstrated that neck vibration notably increased the regularity of neck-sensitive GPi neurons in focal CD patients. Additionally, in patients with GD and CD, the vibration enhanced the firing regularity of non-neck-sensitive neurons. These effects on single-unit activity were also mirrored in ensemble responses measured through LFPs. Notably, the LFP modulation was particularly pronounced in areas populated with burst neurons compared to pause or tonic cells. Conclusion: The results from our study emphasize the significance of burst neurons in the pathogenesis of dystonia and in the efficacy of proprioceptive modulation for its treatment. Moreover, we observed that the effects of vibration on focal CD were prominent in the α band LFP, indicating modulation of pallido-cerebellar connectivity. Moreover, the pallidal effects of vibration in GD with CD involved modulation of cerebro-pallidal θ band connectivity. Our analysis provides insight into how vibration-induced changes in pallidal activity are integrated into the downstream motor circuit. © 2023 International Parkinson and Movement Disorder Society.
MeSH term(s)	Humans ; Torticollis/drug therapy ; Torticollis/pathology ; Globus Pallidus/pathology ; Deep Brain Stimulation/methods ; Dystonic Disorders/therapy ; Neck
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.29603
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Zs.A 2555: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 238: Show issues

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Article: Does Pallidal Physiology Determine the Success of Unilateral Deep Brain Stimulation in Cervical Dystonia?

Sedov, Alexey / Gamaleya, Anna / Semenova, Ulia / Medvednik, Rita / Tomskiy, Alexey / Jinnah, Hyder A / Shaikh, Aasef

Advances in neurobiology

2023 Volume 31, Page(s) 211–221

Abstract: Pallidal deep brain stimulation is a well-known surgical treatment for cervical dystonia. The resolution of dystonia typically requires bilateral pallidal stimulation, but in some instances, unilateral stimulation has been successful. In such instances, ... ...

Abstract	Pallidal deep brain stimulation is a well-known surgical treatment for cervical dystonia. The resolution of dystonia typically requires bilateral pallidal stimulation, but in some instances, unilateral stimulation has been successful. In such instances, generally, the stimulated hemisphere was contralateral to the dystonic sternocleidomastoid, but rarely it was ipsilateral. We sought for the physiological features that determine the basis for success and laterality of deep brain stimulation for cervical dystonia with prominent torticollis. We found that pallidal physiology such as high burst to tonic ratio and significant interhemispheric differences in the neuronal firing rate and regularity are critical determinants of successful treatment with unilateral deep brain stimulation. We also found that higher lateralized differences in pallidal physiological parameters predict more robust improvement. In three out of four patients, the stimulation of the hemisphere ipsilateral to the dystonic sternocleidomastoid muscle was effective. These patients did not have any structural brain abnormalities on clinically available imaging studies. One patient responded to the unilateral deep brain stimulation in the hemisphere contralateral to the dystonic sternocleidomastoid. This patient had a structural putamen lesion on brain MRI. These results provide objective parameters determining the success of pallidal deep brain stimulation for treatment of cervical dystonia. The results also depict differences in the pallidal physiology in patients where ipsilateral versus contralateral deep brain stimulation was effective.
MeSH term(s)	Humans ; Torticollis/diagnostic imaging ; Torticollis/therapy ; Deep Brain Stimulation/methods ; Globus Pallidus/diagnostic imaging ; Magnetic Resonance Imaging ; Neuroimaging
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article
ISSN	2190-5215
ISSN	2190-5215
DOI	10.1007/978-3-031-26220-3_12
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: SARS-CoV-2-indutsirovannyi nebakterial'nyi endomiokardit s razvitiem priobretennykh porokov serdtsa.

Blagova, O V / Kogan, E A / Pavlenko, E V / Sedov, A V / Lerner, Yu V / Chernyavskij, S V

Arkhiv patologii

2023 Volume 85, Issue 6, Page(s) 52–61

Abstract: Patients with damage of the mitral, aortic and tricuspid valves and systolic myocardial dysfunction associated with previous SARS-CoV-2 infection are described. The diagnosis of acquired defect was established in 4 patients based on medical history, ... ...

Title translation	SARS-CoV-2-induced non-bacterial endomyocarditis with the development of acquired heart defects.
Abstract	Patients with damage of the mitral, aortic and tricuspid valves and systolic myocardial dysfunction associated with previous SARS-CoV-2 infection are described. The diagnosis of acquired defect was established in 4 patients based on medical history, electrocardiography, echocardiography, magnetic resonance imaging of the heart, endomyocardial or intraoperative myocardial biopsy, and in one case, autopsy. The study of the myocardium included H&E, Van Gieson staining, immunohistochemical (IHC) study with antibodies to CD3, CD20, CD45, CD68, to the nucleocapsid and Spike proteins of SARS-CoV-2. Previous valve diseases (prolapse, bicuspid aortic valve) served as a background for the development of the defect in 2 patients. In all cases, IHC studies revealed coronavirus proteins, lymphocytic endocarditis and myocarditis, moderate fibrosis, and signs of connective tissue disorganization. High titers of anticardiac antibodies indicated an autoimmune mechanism for carditis. No signs of infective endocarditis or thromboembolic complications were identified in any case. In patients with an unclear nature of valvular heart defects, a previous new coronavirus infection should be identified and taken into account as a possible etiological factor. The simultaneous development of lymphocytic myocarditis significantly increases the risk of surgical intervention on the valves and requires an integrated approach to treatment.
MeSH term(s)	Humans ; Myocarditis/complications ; SARS-CoV-2 ; COVID-19/complications ; Endocarditis/diagnosis ; Endocarditis/diagnostic imaging ; Heart Defects, Congenital
Language	Russian
Publishing date	2023-11-27
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	127285-8
ISSN	0004-1955
ISSN	0004-1955
DOI	10.17116/patol20238506152
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Article: Istoriya izucheniya patogeneza i khirurgicheskogo lecheniya tservikal'noi distonii.

Popov, V A / Tomskiy, A A / Gamaleya, A A / Sedov, A S

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2020 Volume 120, Issue 7, Page(s) 128–133

Abstract: In the past few decades, approaches to surgical treatment of dystonia passed through paradigmatic shift. Intradural upper cervical anterior rhizotomy was replaced by selective peripheral denervation with lesser spectrum of side-effects. Such techniques ... ...

Title translation	Historical view on the pathogenesis and surgical treatment of cervical dystonia.
Abstract	In the past few decades, approaches to surgical treatment of dystonia passed through paradigmatic shift. Intradural upper cervical anterior rhizotomy was replaced by selective peripheral denervation with lesser spectrum of side-effects. Such techniques as microvascular decompression of accessory nerve or spinal cord stimulation for cervical dystonia were abandoned due to lack of proven efficacy. Introducing globus pallidus interna (GPi) DBS in 1990's to treat all types of dystonia, including cervical dystonia, was a fundamental factor. With the growing body of knowledge on the pathophysiology of dystonia, GPi DBS appears to be the most expedient, effective and safe method with limited indications to peripheral destructive procedures.
MeSH term(s)	Deep Brain Stimulation ; Dystonic Disorders/therapy ; Globus Pallidus ; Humans ; Torticollis ; Treatment Outcome
Language	Russian
Publishing date	2020-08-13
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro2020120071128
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Zs.MO 587: Show issues

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Article: [The automatized lexical control of medical documents as an obligatory component of informatization of medical organizations].

Berseneva, E A / Sedov, A A

Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny

2016 Volume 24, Issue 5, Page(s) 297–300

Abstract: The article considers issues of development and implementation of systems of lexical control of medical documents as a tool of increasing of quality of medical documents in conditions of electronic formation. The main characteristics of elaboration of ... ...

Abstract	The article considers issues of development and implementation of systems of lexical control of medical documents as a tool of increasing of quality of medical documents in conditions of electronic formation. The main characteristics of elaboration of the system of lexical control "Elex" and perspectives of its development are considered.
MeSH term(s)	Electronic Health Records/standards ; Humans ; Medical Informatics/standards ; Russia ; Terminology as Topic
Language	English
Publishing date	2016-09
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	1483853-9
ISSN	0869-866X
ISSN	0869-866X
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