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  1. Article ; Online: Corrigendum to "Past and present seroprevalence and disease burden estimates of Toxoplasma gondii infections in Germany: An appreciation of the role of serodiagnostics" [Int. J. Med. Microbiol. 313 (2023) 151592].

    Seeber, Frank

    International journal of medical microbiology : IJMM

    2024  , Page(s) 151618

    Language English
    Publishing date 2024-04-06
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2006518-8
    ISSN 1618-0607 ; 1438-4221
    ISSN (online) 1618-0607
    ISSN 1438-4221
    DOI 10.1016/j.ijmm.2024.151618
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    Zs.A 5333: Show issues Location:
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  2. Article ; Online: Past and present seroprevalence and disease burden estimates of Toxoplasma gondii infections in Germany: An appreciation of the role of serodiagnostics.

    Seeber, Frank

    International journal of medical microbiology : IJMM

    2023  Volume 313, Issue 6, Page(s) 151592

    Abstract: Toxoplasmosis is one of the major foodborne parasitic diseases in Germany, with 49% of its population chronically infected with its causative agent, Toxoplasma gondii. Although the acute disease is usually benign in immunocompetent individuals, it is a ... ...

    Abstract Toxoplasmosis is one of the major foodborne parasitic diseases in Germany, with 49% of its population chronically infected with its causative agent, Toxoplasma gondii. Although the acute disease is usually benign in immunocompetent individuals, it is a threat for immunocompromised patients as well as for fetuses of seronegative mothers. As a result of infection, congenital and ocular toxoplasmosis can have serious lifelong consequences. Here I will highlight the epidemiologic situation, from its past in the two separate parts of Germany, to its unification 30 years ago and up to the present day. The main identified risk factor for infection in Germany is thought to be the consumption of undercooked or raw meat or sausages. However, the relative impact of this risky eating habit as well as that of other risk factors are changing and are discussed and compared to the situation in the Netherlands. Finally, the importance of robust and efficient high-throughput serological assays for obtaining reliable epidemiological data, on which public health decisions can be made, is highlighted. The potential of bead-based multiplex assays, which allow the incorporation of multiple antigens with different analytical properties and thus yield additional information, are described in this context. It illustrates the interdependence of new analytic assay developments and sound epidemiology, a foundation that decades-old data from Germany did not have.
    MeSH term(s) Humans ; Toxoplasma ; Seroepidemiologic Studies ; Antibodies, Protozoan ; Toxoplasmosis/diagnosis ; Toxoplasmosis/epidemiology ; Risk Factors ; Germany/epidemiology ; Cost of Illness ; Foodborne Diseases
    Chemical Substances Antibodies, Protozoan
    Language English
    Publishing date 2023-12-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2006518-8
    ISSN 1618-0607 ; 1438-4221
    ISSN (online) 1618-0607
    ISSN 1438-4221
    DOI 10.1016/j.ijmm.2023.151592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5333: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Book ; Thesis: Altersschätzung von Skelettfunden anhand von Zähnen unter besonderer Berücksichtigung der Abrasion

    Seeber, Frank

    ein Methodenvergleich

    2006  

    Author's details von Frank Seeber
    Language German
    Size 119, [19], A76 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Jena, Univ., Diss., 2006
    HBZ-ID HT015092126
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2007 E 913 order for loan Magazin

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  4. Article ; Online: Advances towards the complete

    Warschkau, David / Seeber, Frank

    Faculty reviews

    2023  Volume 12, Page(s) 1

    Abstract: The full life cycle ... ...

    Abstract The full life cycle of
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2732-432X
    ISSN (online) 2732-432X
    DOI 10.12703/r/12-1
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  5. Book ; Online ; Thesis: Comparative analysis of immune responses of intestinal organoids from wild rodents upon infection: Challenging the Toxoplasma gondii

    Seeber, Frank [Gutachter] / Heitlinger, Emanuel [Gutachter] / Steinfeldt, Tobias [Gutachter]

    2024  

    Author's details house mouse model / Gutachter: Frank Seeber, Emanuel Heitlinger, Tobias Steinfeldt
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Humboldt-Universität zu Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
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  6. Article ; Online: Generation of Mature

    Maus, Deborah / Curtis, Blake / Warschkau, David / Betancourt, Estefanía Delgado / Seeber, Frank / Blume, Martin

    Bio-protocol

    2024  Volume 14, Issue 1, Page(s) e4916

    Abstract: Toxoplasma ... ...

    Abstract Toxoplasma gondii
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Toxoplasma gondii Infections and Associated Factors in Female Children and Adolescents, Germany.

    Giese, Laura / Seeber, Frank / Aebischer, Anton / Kuhnert, Ronny / Schlaud, Martin / Stark, Klaus / Wilking, Hendrik

    Emerging infectious diseases

    2024  Volume 30, Issue 5, Page(s) 995–999

    Abstract: In a representative sample of female children and adolescents in Germany, Toxoplasma gondii seroprevalence was 6.3% (95% CI 4.7%-8.0%). With each year of life, the chance of being seropositive increased by 1.2, indicating a strong force of infection. ... ...

    Abstract In a representative sample of female children and adolescents in Germany, Toxoplasma gondii seroprevalence was 6.3% (95% CI 4.7%-8.0%). With each year of life, the chance of being seropositive increased by 1.2, indicating a strong force of infection. Social status and municipality size were found to be associated with seropositivity.
    MeSH term(s) Humans ; Female ; Germany/epidemiology ; Toxoplasmosis/epidemiology ; Toxoplasmosis/parasitology ; Adolescent ; Child ; Toxoplasma/immunology ; Seroepidemiologic Studies ; Child, Preschool ; Risk Factors ; Infant ; Antibodies, Protozoan/blood
    Chemical Substances Antibodies, Protozoan
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid3005.231045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4778: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: The ferredoxin redox system - an essential electron distributing hub in the apicoplast of Apicomplexa.

    Akuh, Ojo-Ajogu / Elahi, Rubayet / Prigge, Sean T / Seeber, Frank

    Trends in parasitology

    2022  Volume 38, Issue 10, Page(s) 868–881

    Abstract: The apicoplast, a relict plastid found in most species of the phylum Apicomplexa, harbors the ferredoxin redox system which supplies electrons to enzymes of various metabolic pathways in this organelle. Recent reports in Toxoplasma gondii and Plasmodium ... ...

    Abstract The apicoplast, a relict plastid found in most species of the phylum Apicomplexa, harbors the ferredoxin redox system which supplies electrons to enzymes of various metabolic pathways in this organelle. Recent reports in Toxoplasma gondii and Plasmodium falciparum have shown that the iron-sulfur cluster (FeS)-containing ferredoxin is essential in tachyzoite and blood-stage parasites, respectively. Here we review ferredoxin's crucial contribution to isoprenoid and lipoate biosynthesis as well as tRNA modification in the apicoplast, highlighting similarities and differences between the two species. We also discuss ferredoxin's potential role in the initial reductive steps required for FeS synthesis as well as recent evidence that offers an explanation for how NADPH required by the redox system might be generated in Plasmodium spp.
    MeSH term(s) Apicomplexa/genetics ; Apicomplexa/metabolism ; Apicoplasts/genetics ; Electrons ; Ferredoxins/genetics ; Ferredoxins/metabolism ; Iron/metabolism ; NADP/metabolism ; Oxidation-Reduction ; Plasmodium falciparum/genetics ; Plasmodium falciparum/metabolism ; RNA, Transfer/metabolism ; Sulfur/metabolism ; Terpenes/metabolism ; Toxoplasma/genetics
    Chemical Substances Ferredoxins ; Terpenes ; NADP (53-59-8) ; Sulfur (70FD1KFU70) ; RNA, Transfer (9014-25-9) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2022-08-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2022.08.002
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    Zs.B 2898: Show issues Location:
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    Zs.MG 16: Show issues
    Zs.MO 251: Show issues

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  9. Article ; Online: Late Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses.

    Arranz-Solís, David / Warschkau, David / Fabian, Benedikt T / Seeber, Frank / Saeij, Jeroen P J

    mBio

    2023  Volume 14, Issue 2, Page(s) e0286822

    Abstract: Toxoplasma gondii oocysts, which are shed in large quantities in the feces from infected felines, are very stable in the environment, resistant to most inactivation procedures, and highly infectious. The oocyst wall provides an important physical barrier ...

    Abstract Toxoplasma gondii oocysts, which are shed in large quantities in the feces from infected felines, are very stable in the environment, resistant to most inactivation procedures, and highly infectious. The oocyst wall provides an important physical barrier for sporozoites contained inside oocysts, protecting them from many chemical and physical stressors, including most inactivation procedures. Furthermore, sporozoites can withstand large temperature changes, even freeze-thawing, as well as desiccation, high salinity, and other environmental insults; however, the genetic basis for this environmental resistance is unknown. Here, we show that a cluster of four genes encoding Late Embryogenesis Abundant (LEA)-related proteins are required to provide
    MeSH term(s) Animals ; Cats ; Toxoplasma/metabolism ; Oocysts/metabolism ; Intrinsically Disordered Proteins/metabolism ; Cryoprotective Agents/metabolism ; Escherichia coli/genetics ; Sporozoites/metabolism ; Lactate Dehydrogenases/metabolism
    Chemical Substances Intrinsically Disordered Proteins ; Cryoprotective Agents ; Lactate Dehydrogenases (EC 1.1.-)
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02868-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online ; Thesis: A novel in vitro model for mature Toxoplasma gondii tissue cysts allows functional characterization of bradyzoite biology

    Christiansen, Céline [Verfasser] / Mattuschewski, Kai [Gutachter] / Seeber, Frank [Gutachter] / Lüder, Carsten [Gutachter]

    2023  

    Author's details Céline Christiansen ; Gutachter: Kai Mattuschewski, Frank Seeber, Carsten Lüder
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Humboldt-Universität zu Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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