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  1. Article ; Online: Time for action: The Patient Protection and Affordable Care Act Medicaid expansion significantly improves breast cancer care for women in Louisiana.

    Seewaldt, Victoria L

    Cancer

    2020  Volume 127, Issue 5, Page(s) 672–675

    MeSH term(s) Breast Neoplasms/epidemiology ; Breast Neoplasms/therapy ; Female ; Humans ; Insurance Coverage ; Louisiana ; Medicaid ; Patient Protection and Affordable Care Act ; United States
    Language English
    Publishing date 2020-11-03
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.33264
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  2. Article ; Online: Residential Racial and Economic Segregation and Cancer Mortality in the US-Speaking Out on Inequality and Injustice.

    Seewaldt, Victoria L / Winn, Robert A

    JAMA oncology

    2022  Volume 9, Issue 1, Page(s) 126–127

    MeSH term(s) Humans ; United States/epidemiology ; Neoplasms/epidemiology ; Racial Groups ; Socioeconomic Factors ; Residence Characteristics
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2022.5272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Aspirin and Chemoprevention-Have We Arrived?

    Seewaldt, Victoria L

    JAMA oncology

    2018  Volume 4, Issue 12, Page(s) 1668–1669

    MeSH term(s) Aspirin ; Carcinoma, Hepatocellular ; Chemoprevention ; Colorectal Neoplasms ; Humans ; Liver Neoplasms
    Chemical Substances Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2018-10-04
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2018.4138
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  4. Article ; Online: Reply to Corrections: Breast cancer screening guidelines for young women of color.

    Seewaldt, Victoria L / Bernstein, Leslie

    Cancer

    2021  Volume 128, Issue 4, Page(s) 851

    MeSH term(s) Breast Neoplasms/diagnosis ; Breast Neoplasms/prevention & control ; Early Detection of Cancer/standards ; Female ; Humans ; Mammography/standards ; Mass Screening/standards ; Skin Pigmentation
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.33989
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  5. Article ; Online: The perils of generalization: Rethinking breast cancer screening guidelines for young women of color.

    Seewaldt, Victoria L / Bernstein, Leslie

    Cancer

    2021  Volume 127, Issue 23, Page(s) 4359–4361

    MeSH term(s) Breast Neoplasms/diagnosis ; Breast Neoplasms/prevention & control ; Early Detection of Cancer/standards ; Female ; Humans ; Mammography/standards ; Mass Screening/standards ; Skin Pigmentation
    Language English
    Publishing date 2021-08-24
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.33840
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  6. Article ; Online: Molecular features of androgen-receptor low, estrogen receptor-negative breast cancers in the Carolina breast cancer study.

    Jinna, Nikita D / Van Alsten, Sarah / Rida, Padmashree / Seewaldt, Victoria L / Troester, Melissa A

    Breast cancer research and treatment

    2023  Volume 201, Issue 2, Page(s) 171–181

    Abstract: Purpose: Androgen receptor (AR) expression is absent in 40-90% of estrogen receptor (ER)-negative breast cancers. The prognostic value of AR in ER-negative patients and therapeutic targets for patients absent in AR remains poorly explored.: Methods: ... ...

    Abstract Purpose: Androgen receptor (AR) expression is absent in 40-90% of estrogen receptor (ER)-negative breast cancers. The prognostic value of AR in ER-negative patients and therapeutic targets for patients absent in AR remains poorly explored.
    Methods: We used an RNA-based multigene classifier to identify AR-low and AR-high ER-negative participants in the Carolina Breast Cancer Study (CBCS; N = 669) and The Cancer Genome Atlas (TCGA; N = 237). We compared AR-defined subgroups by demographics, tumor characteristics, and established molecular signatures [PAM50 risk of recurrence (ROR), homologous recombination deficiency (HRD), and immune response].
    Results: AR-low tumors were more prevalent among younger (RFD =  + 10%, 95% CI = 4% to 16%) participants in CBCS and were associated with HER2 negativity (RFD = - 35%, 95% CI = - 44% to - 26%), higher grade (RFD =  + 17%, 95% CI = 8% to 26%), and higher risk of recurrence scores (RFD =  + 22%, 95% CI = 16.1% to 28%), with similar results in TCGA. The AR-low subgroup was strongly associated with HRD in CBCS (RFD =  + 33.3%, 95% CI = 23.8% to 43.2%) and TCGA (RFD =  + 41.5%, 95% CI = 34.0% to 48.6%). In CBCS, AR-low tumors had high adaptive immune marker expression.
    Conclusion: Multigene, RNA-based low AR expression is associated with aggressive disease characteristics as well as DNA repair defects and immune phenotypes, suggesting plausible precision therapies for AR-low, ER-negative patients.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/epidemiology ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Androgens ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism ; Triple Negative Breast Neoplasms/pathology ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Prognosis ; RNA ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism
    Chemical Substances Androgens ; Receptors, Estrogen ; Receptors, Androgen ; RNA (63231-63-0) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2023-07-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-023-07014-x
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    Zs.A 1655: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Mammographic Density Laws and Inclusion-Time for Change.

    Tossas, Katherine Y / Winn, Robert A / Seewaldt, Victoria L

    JAMA oncology

    2021  Volume 8, Issue 1, Page(s) 39–40

    MeSH term(s) Breast/diagnostic imaging ; Breast Density ; Breast Neoplasms/diagnostic imaging ; Female ; Humans ; Mammography ; Postmenopause ; Risk Factors
    Language English
    Publishing date 2021-11-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2021.6196
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  8. Article ; Online: Disparities in the use of screening breast magnetic resonance imaging persist in Louisiana after the Affordable Care Act: A question of access, policy, institutional support, or something else?

    Morrell, Brooke L / Morrell, Mignonne B / Ball, Jane A / Ochoa, Augusto C / Seewaldt, Victoria L

    Cancer

    2023  Volume 129, Issue 6, Page(s) 829–833

    Abstract: Background: Louisiana continues to have one of the highest breast cancer mortality rates in the nation, and Black women are disproportionally affected. Louisiana has made advances in improving access to breast cancer screening through the expansion of ... ...

    Abstract Background: Louisiana continues to have one of the highest breast cancer mortality rates in the nation, and Black women are disproportionally affected. Louisiana has made advances in improving access to breast cancer screening through the expansion of Medicaid. There remains, however, broad underuse of advanced imaging technology such as screening breast magnetic resonance imaging (MRI), particularly for Black women.
    Methods: Breast MRI has been proven to be very sensitive for the early detection of breast cancer in women at high risk. MRI is more sensitive than mammography for aggressive, invasive breast cancer types, which disproportionally affect Black women. Here the authors identify potential barriers to breast MRI screening in Black women, propose strategies to address disparities in access, and advocate for specific recommendations for change.
    Results: Cost was identified as one of the greatest barriers to screening breast MRI. The authors propose implementation of cost-saving, abbreviated protocols to address cost along with lobbying for further expansion of the Affordable Care Act (ACA) to include coverage for screening breast MRI. In addition, addressing gaps in communication and knowledge and facilitating providers' ability to readily identify women who might benefit from MRI could be particularly impactful for high-risk Black women in Louisiana communities.
    Conclusions: Since the adoption of the ACA in Louisiana, Black women have continued to have disproportionally high breast cancer mortality rates. This persistent disparity provides evidence that additional change is needed. This change should include exploring innovative ways to make advanced imaging technology such as breast MRI more accessible and expanding research to specifically address community and culturally specific barriers.
    MeSH term(s) United States ; Female ; Humans ; Patient Protection and Affordable Care Act ; Organizational Policy ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/prevention & control ; Mammography ; Louisiana/epidemiology ; Early Detection of Cancer/methods ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-01-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.34605
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  9. Article ; Online: Vascularity and Dynamic Contrast-Enhanced Breast Magnetic Resonance Imaging.

    Frankhouser, David E / Dietze, Eric / Mahabal, Ashish / Seewaldt, Victoria L

    Frontiers in radiology

    2021  Volume 1, Page(s) 735567

    Abstract: Angiogenesis is a key step in the initiation and progression of an invasive breast cancer. High microvessel density by morphological characterization predicts metastasis and poor survival in women with invasive breast cancers. However, morphologic ... ...

    Abstract Angiogenesis is a key step in the initiation and progression of an invasive breast cancer. High microvessel density by morphological characterization predicts metastasis and poor survival in women with invasive breast cancers. However, morphologic characterization is subject to variability and only can evaluate a limited portion of an invasive breast cancer. Consequently, breast Magnetic Resonance Imaging (MRI) is currently being evaluated to assess vascularity. Recently, through the new field of radiomics, dynamic contrast enhanced (DCE)-MRI is being used to evaluate vascular density, vascular morphology, and detection of aggressive breast cancer biology. While DCE-MRI is a highly sensitive tool, there are specific features that limit computational evaluation of blood vessels. These include (1) DCE-MRI evaluates gadolinium contrast and does not directly evaluate biology, (2) the resolution of DCE-MRI is insufficient for imaging small blood vessels, and (3) DCE-MRI images are very difficult to co-register. Here we review computational approaches for detection and analysis of blood vessels in DCE-MRI images and present some of the strategies we have developed for co-registry of DCE-MRI images and early detection of vascularization.
    Language English
    Publishing date 2021-12-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-8740
    ISSN (online) 2673-8740
    DOI 10.3389/fradi.2021.735567
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  10. Article ; Online: From COVID-19 to cancer, watching social determinants decide life: When will we stop spectating?

    Erhunmwunsee, Loretta / Seewaldt, Victoria L / Rebbeck, Timothy R / Winn, Robert A

    Journal of the National Medical Association

    2021  Volume 113, Issue 4, Page(s) 436–439

    Abstract: The COVID-19 pandemic reminds us that African American, Latinx, Indigenous, and poor communities face significant healthcare disparities. Members of these communities have increased exposure to the virus due to higher rates of crowded living conditions ... ...

    Abstract The COVID-19 pandemic reminds us that African American, Latinx, Indigenous, and poor communities face significant healthcare disparities. Members of these communities have increased exposure to the virus due to higher rates of crowded living conditions and employment in essential occupations. Furthermore, news reports and public health data show that residents of these communities have more comorbidities, utilize hospitals with fewer resources, and experience greater treatment delays, all resulting in higher mortality related to COVID-19. The same social determinants contributing to the inequities seen in COVID-19 drive similar disparities in oncology. Oncologic inequities have long predated the inequities associated with COVID-19 and have led to considerably more deaths. These stark realities demand that we stop merely reporting the impact of adverse social determinants on the health of communities. We must instead target these causes of healthcare disparities. Here, we discuss proposed action items from the 2019 National Cancer Policy Forum workshop entitled "Applying Big Data to Address the Social Determinants of Health in Oncology." These actions are critical first steps to address adverse social determinants and thereby decrease unnecessary deaths in underserved communities.
    MeSH term(s) African Americans ; Big Data ; COVID-19 ; Health Policy ; Health Status Disparities ; Healthcare Disparities ; Humans ; Neoplasms ; Pandemics ; Public Health ; Social Determinants of Health
    Language English
    Publishing date 2021-03-13
    Publishing country United States
    Document type Letter
    ZDB-ID 419737-9
    ISSN 1943-4693 ; 0027-9684
    ISSN (online) 1943-4693
    ISSN 0027-9684
    DOI 10.1016/j.jnma.2021.02.003
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