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  1. Article ; Online: Targeting B cells for treatment of systemic sclerosis.

    Terui, Hitoshi / Segawa, Yuichiro / Asano, Yoshihide

    Current opinion in rheumatology

    2023  Volume 35, Issue 6, Page(s) 317–323

    Abstract: Purpose of review: The pathogenesis of systemic sclerosis (SSc) has been linked to dysfunctional B cells as demonstrated in previous research. This review aims to show the evidence and ongoing clinical trials of B cell-targeted therapy and overview the ... ...

    Abstract Purpose of review: The pathogenesis of systemic sclerosis (SSc) has been linked to dysfunctional B cells as demonstrated in previous research. This review aims to show the evidence and ongoing clinical trials of B cell-targeted therapy and overview the various aspects of B cell involvement in SSc.
    Recent findings: We provide an overview of the current understanding and therapeutic strategies targeting B cells in SSc patients. Several molecular targets of B cells have been identified for treating SSc, including CD20, CD19, B-cell activating factor (BAFF), and proteasome.
    Summary: Many clinical trials have demonstrated that B cells play a critical role in the pathogenesis of SSc and may be a potential therapeutic target to improve disease symptoms. Although large-scale clinical studies are needed, various B cell-targeted therapies have the potential to address the unmet needs of SSc patients.
    MeSH term(s) Humans ; Scleroderma, Systemic/pathology ; B-Lymphocytes ; Longitudinal Studies
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000961
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3028: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Case series of modified dermis graft for skin defects of the nasal region.

    Segawa, Yuichiro / Tono, Hisayuki / Chiba, Hiromu / Sato, Yota / Asano, Yoshihide

    The Journal of dermatology

    2022  Volume 49, Issue 12, Page(s) 1330–1333

    Abstract: Local skin flap from the surrounding area is often chosen for reconstruction of skin defects in the nasal region, but it is problematic because it creates new facial scar and requires skill of design. On the other hand, full-thickness skin graft is ... ...

    Abstract Local skin flap from the surrounding area is often chosen for reconstruction of skin defects in the nasal region, but it is problematic because it creates new facial scar and requires skill of design. On the other hand, full-thickness skin graft is associated with problems such as color mismatch and scar contracture at the recipient site. We reconstructed nasal defects of seven patients using modified dermis graft technique. In this method, de-epithelialized full-thickness skin graft is transplanted and then epithelialized from the surrounding area. This is a simple and easy procedure without causing a new scar on the face and is aesthetically and functionally superior to a standard full-thickness skin graft; therefore, it is a useful method of reconstruction of the nasal area.
    MeSH term(s) Humans ; Cicatrix/etiology ; Cicatrix/surgery ; Nose/surgery ; Skin Transplantation/methods ; Surgical Flaps/surgery ; Dermis/surgery ; Reconstructive Surgical Procedures/methods
    Language English
    Publishing date 2022-08-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16544
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Serum levels of AGGF1: Potential association with cutaneous and cardiopulmonary involvements in systemic sclerosis.

    Takahashi, Takuya / Takahashi, Takehiro / Ikawa, Tetsuya / Terui, Hitoshi / Takahashi, Toshiya / Segawa, Yuichiro / Sumida, Hayakazu / Yoshizaki, Ayumi / Sato, Shinichi / Asano, Yoshihide

    The Journal of dermatology

    2024  

    Abstract: Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, aberrant immune activation, and extensive tissue fibrosis of the skin and internal organs. Because of the complicated nature of its pathogenesis, the underlying mechanisms ... ...

    Abstract Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, aberrant immune activation, and extensive tissue fibrosis of the skin and internal organs. Because of the complicated nature of its pathogenesis, the underlying mechanisms of SSc remain incompletely understood. Angiogenic factor with a G-patch domain and a Forkhead-associated domain 1 (AGGF1) is a critical factor in angiogenesis expressed on vascular endothelial cells, associated with inflammatory and fibrotic responses. To elucidate the possible implication of AGGF1 in SSc pathogenesis, we investigated the association between serum AGGF1 levels and clinical manifestations in SSc patients. We conducted a cross-sectional analysis of AGGF1 levels in sera from 60 SSc patients and 19 healthy controls with enzyme-linked immunosorbent assay. Serum AGGF1 levels in SSc patients were significantly higher than those in healthy individuals. In particular, diffuse cutaneous SSc patients with shorter disease duration had higher levels compared to those with longer disease duration and limited cutaneous SSc patients. Patients with higher serum AGGF1 levels had a higher incidence of digital ulcers, higher modified Rodnan Skin Scores (mRSS), elevated serum Krebs von den Lungen-6 (KL-6) levels, C-reactive protein levels, and right ventricular systolic pressures (RVSP) on the echocardiogram, whereas they had reduced percentage of vital capacity (%VC) and percentage of diffusing capacity of the lungs for carbon monoxide (%DLCO) in pulmonary functional tests. In line, serum AGGF1 levels were significantly correlated with mRSS, serum KL-6 and surfactant protein D levels, RVSP, and %DLCO. These results uncovered notable correlations between serum AGGF1 levels and key cutaneous and vascular involvements in SSc, suggesting potential roles of AGGF1 in SSc pathogenesis.
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.17233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Successful treatment of pustulotic arthro-osteitis with amoxicillin: A case report and review of the literature.

    Terui, Hitoshi / Segawa, Yuichiro / Otake, Eika / Omori, Ryoko / Tsuchiyama, Kenichiro / Kikuchi, Katsuko / Yamasaki, Kenshi / Aiba, Setsuya / Asano, Yoshihide

    The Journal of dermatology

    2023  Volume 50, Issue 11, Page(s) 1478–1483

    Abstract: Palmoplantar pustulosis (PPP) is a chronic skin inflammatory disease characterized by sterile pustules on the palms and soles. Pustulotic arthro-osteitis (PAO) is a major comorbidity of PPP, frequently affecting the anterior chest wall. PPP and PAO are ... ...

    Abstract Palmoplantar pustulosis (PPP) is a chronic skin inflammatory disease characterized by sterile pustules on the palms and soles. Pustulotic arthro-osteitis (PAO) is a major comorbidity of PPP, frequently affecting the anterior chest wall. PPP and PAO are thought to be closely associated with focal infection. We report a female in her 40s who developed pustules on her palms and soles with tenderness of both sternoclavicular and left sacroiliac joints, which were not improved with non-steroidal anti-inflammatory drugs. Of note, she showed a great response to amoxicillin, resulting in the almost complete resolution of her skin lesions and arthralgia. We also reviewed previous reports to learn more about the potential therapeutic options of antibiotics for PAO.
    MeSH term(s) Humans ; Female ; Amoxicillin/therapeutic use ; Osteitis/diagnosis ; Osteitis/drug therapy ; Osteitis/etiology ; Psoriasis/pathology ; Skin/pathology ; Comorbidity ; Skin Diseases, Vesiculobullous/complications
    Chemical Substances Amoxicillin (804826J2HU)
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Author reply to antibiotics in SAPHO syndrome.

    Terui, Hitoshi / Segawa, Yuichiro / Otake, Eika / Omori, Ryoko / Tsuchiyama, Kenichiro / Kikuchi, Katsuko / Yamasaki, Kenshi / Aiba, Setsuya / Asano, Yoshihide

    The Journal of dermatology

    2023  Volume 51, Issue 1, Page(s) e26

    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Fixed erythrodysaesthesia plaque on the neck near indwelling subcutaneous port and catheter due to vinorelbine and cisplatin treatment.

    Yamazaki, Emi / Kikuchi, Katsuko / Segawa, Yuichiro / Aiba, Setsuya

    The Journal of dermatology

    2019  Volume 47, Issue 3, Page(s) e73–e74

    MeSH term(s) Adenocarcinoma/drug therapy ; Adenocarcinoma/secondary ; Adult ; Antineoplastic Agents/adverse effects ; Catheters, Indwelling/adverse effects ; Cisplatin/adverse effects ; Female ; Humans ; Skin/pathology ; Skin Diseases/chemically induced ; Skin Diseases/pathology ; Vinorelbine/adverse effects
    Chemical Substances Antineoplastic Agents ; Cisplatin (Q20Q21Q62J) ; Vinorelbine (Q6C979R91Y)
    Language English
    Publishing date 2019-12-29
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.15203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Short anagen syndrome: A unique short hair syndrome without any characteristic hair morphological abnormality.

    Segawa, Yuichiro / Yamasaki, Kenshi / Otake, Eika / Kikuchi, Katsuko / Aiba, Setsuya

    The Journal of dermatology

    2020  Volume 47, Issue 10, Page(s) e349–e351

    MeSH term(s) Alopecia/diagnosis ; Alopecia/genetics ; Hair ; Hair Diseases/diagnosis ; Hair Diseases/genetics ; Hair Follicle ; Humans ; Syndrome
    Language English
    Publishing date 2020-07-12
    Publishing country England
    Document type Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.15494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article: IL-23 Expression in Stewart-Treves Syndrome: Two Case Reports and Immunohistochemical Investigation.

    Yoshida, Saaya / Fujimura, Taku / Ohuchi, Kentaro / Kambayashi, Yumi / Segawa, Yuichiro / Yamazaki, Emi / Tono, Hisayuki / Takahashi, Toshiya / Tsuchiyama, Kenichiro / Aiba, Setsuya

    Case reports in oncology

    2020  Volume 13, Issue 1, Page(s) 462–467

    Abstract: Stewart-Treves syndrome (STS) is a rare cutaneous lymphangiosarcoma developing from chronic lymph edema as a consequence of radical mastectomy or surgical invasion of the groin for the treatment of cervical or penile cancer. Previous reports suggested ... ...

    Abstract Stewart-Treves syndrome (STS) is a rare cutaneous lymphangiosarcoma developing from chronic lymph edema as a consequence of radical mastectomy or surgical invasion of the groin for the treatment of cervical or penile cancer. Previous reports suggested possible mechanisms in the development of lymphangiosarcoma that correlate with the immunological background of STS patients. In this report, we described two cases of STS developing in patients who underwent radical dissection for cervical cancer, we employed immunohistochemical staining of IL-23 and IL-17.
    Language English
    Publishing date 2020-04-30
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000506975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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