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  1. Book ; Online: Advances in Diagnosis and Therapy of Neuroendocrine Neoplasms

    Segelov, Eva

    2021  

    Keywords Medicine ; small bowel neuroendocrine tumours ; pancreatic neuroendocrine tumours ; liver metastases ; midgut ; meta-analysis ; neuroendocrine tumors ; carcinoid heart disease ; carcinoid syndrome ; somatostatin analogues ; metastases ; multidisciplinary ; management ; outcome ; grading ; staging ; neuroendocrine neoplasms ; chemotherapy ; temozolomide ; metronomic treatment ; second-line ; NOTCH ; cancer-driven genes ; mutational mechanism ; germline mutations ; small cell lung carcinoma ; pancreatic NET ; small bowel NET ; medullary thyroid carcinoma ; malignant castration-resistant prostatic cells ; quality performance indicators ; QPIs ; cancer care ; neuroendocrine tumour ; NETs ; modified Delphi ; CommNETs ; pancreatic neuroendocrine neoplasms ; neuroendocrine tumor ; long-term functional outcomes ; pancreatectomy ; diabetes mellitus ; pancreatic exocrine insufficiency ; body mass index ; parenchyma-sparing surgery ; neuroendocrine tumours ; curative surgery ; resection ; follow-up ; guidelines ; relapse ; recurrence ; risk factor ; mixed non-neuroendocrine neuroendocrine neoplasms ; MiNENs ; mixed adeno-neuroendocrine carcinoma ; MANEC ; 2017 WHO classification ; 2019 WHO classification
    Size 1 electronic resource (144 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021044563
    ISBN 9783039437467 ; 3039437461
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Advances in the Molecular Understanding of Colorectal Cancer

    Segelov, Eva

    2019  

    Keywords Oncology ; epigenetics, biomarker, mass spectrometry, proteomics, dna methylation, personalized medicine
    Language English
    Size 1 electronic resource (172 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030645645
    ISBN 9781839620041 ; 1839620048
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Current Cancer Treatment

    Rajer, Mirjana / Segelov, Eva

    2020  

    Keywords Oncology
    Size 1 electronic resource (216 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046537
    ISBN 9781838809980 ; 1838809988
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Improving Equity Across Cancer Care Continuum in Asia Pacific.

    Martina, Diah / Segelov, Eva

    JCO global oncology

    2023  Volume 9, Page(s) e2300056

    MeSH term(s) Humans ; Asia/epidemiology ; Continuity of Patient Care ; Neoplasms/diagnosis ; Neoplasms/therapy
    Language English
    Publishing date 2023-05-27
    Publishing country United States
    Document type Journal Article
    ISSN 2687-8941
    ISSN (online) 2687-8941
    DOI 10.1200/GO.23.00056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Role of Chromogranin A in the Diagnosis and Follow-up of Neuroendocrine Tumors: Real-World Experience.

    Nguyen, Mike / Li, Michelle / Travers, Avraham / Segelov, Eva

    Pancreas

    2022  Volume 51, Issue 8, Page(s) 1007–1010

    Abstract: Objective: The aim of this study was to assess the utility of serum chromogranin A (CgA) along the clinical pathway of patients with neuroendocrine tumors (NETs).: Methods: A retrospective review of medical records was conducted of patients with NET ... ...

    Abstract Objective: The aim of this study was to assess the utility of serum chromogranin A (CgA) along the clinical pathway of patients with neuroendocrine tumors (NETs).
    Methods: A retrospective review of medical records was conducted of patients with NET who had at least 1 measurement of CgA between January 2015 and April 2021 at a large metropolitan Australian hospital. Chromogranin A was classified as increased or decreased if there was at least a 25% change in sequential levels and was compared with disease response by anatomical or functional imaging if within 6 weeks (considered concurrent).
    Results: Of 102 patients with NETs, 67 had at least 1 serum CgA level: 50 had been ordered during diagnostic workup, of which 33 were elevated (sensitivity: 66%; 95% confidence interval, 51%-79%). Of 129 CgA results concurrent with imaging, the sensitivity for detecting progressive disease was 28% (95% confidence interval, 15%-44%).
    Conclusions: Our findings support previous concerns that CgA adds little value in clinical decision-making.
    MeSH term(s) Humans ; Neuroendocrine Tumors/pathology ; Chromogranin A ; Follow-Up Studies ; Australia ; Retrospective Studies ; Biomarkers, Tumor
    Chemical Substances Chromogranin A ; Biomarkers, Tumor
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632831-3
    ISSN 1536-4828 ; 0885-3177
    ISSN (online) 1536-4828
    ISSN 0885-3177
    DOI 10.1097/MPA.0000000000002132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Cancer and Indigenous Populations: Time to End the Disparity.

    Segelov, Eva / Garvey, Gail

    JCO global oncology

    2020  Volume 6, Page(s) 80–82

    MeSH term(s) Humans ; Indians, North American ; Native Hawaiian or Other Pacific Islander ; Neoplasms
    Language English
    Publishing date 2020-02-06
    Publishing country United States
    Document type Editorial
    ISSN 2687-8941
    ISSN (online) 2687-8941
    DOI 10.1200/JGO.19.00379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Gender profile of principal investigators in a large academic clinical trials group.

    Luong, Vi Thi Thao / Ho, Cindy / Aedo-Lopez, Veronica / Segelov, Eva

    Frontiers in surgery

    2022  Volume 9, Page(s) 962120

    Abstract: Introduction: Gender equity in medicine has become a significant topic of discussion due to consistently low female representation in academia and leadership roles. Gender imbalance directly affects patient care. This study examined the gender and craft ...

    Abstract Introduction: Gender equity in medicine has become a significant topic of discussion due to consistently low female representation in academia and leadership roles. Gender imbalance directly affects patient care. This study examined the gender and craft group of the Principal Investigators (PI) of clinical trials run by the Australasian Gastro-Intestinal Trials Group (AGITG).
    Methods: Publicly available data was obtained from the AGITG website. Trials were divided into upper, lower gastrointestinal cancer, miscellaneous (neuroendocrine and gastrointestinal stromal tumours). Where multiple PIs were listed, all were counted. Craft group was assigned as surgical, medical, radiation oncology or other.
    Results: There were 69 trials with 89 PI, where 52 trials were represented exclusively by male PIs. Of all PIs, 18 were women (20.2%); all were medical oncologists. Prior to 2005, all PIs were male. The craft group distribution of PIs was: 79% medical oncologists, 12% surgical oncologists, 8% radiation oncologist, 1% nuclear medicine physicians. Regarding trials with multiple PI's, there were 19 in total. Of these, 11 had only male PIs, which included 5 surgeons. Females were more likely to be a co-PI (42%) as opposed to sole PI (18%). There was no gender policy publicly available on the AGITG website.
    Conclusions: There is a low percentage of female PIs in academic oncology trials in the portfolio of this large international trials group. No trial was led by a female surgical or radiation oncologist. There is a need to understand the reasons driving the disparity so that specific strategies can be put in place.
    Language English
    Publishing date 2022-07-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.962120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Atherosclerotic Cardiovascular Risk With Combination Avelumab and Axitinib.

    Tan, Sean / Day, Daphne / Nicholls, Stephen J / Segelov, Eva

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 40, Issue 29, Page(s) 3467–3469

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Axitinib/adverse effects ; Carcinoma, Renal Cell ; Cardiovascular Diseases/chemically induced ; Heart Disease Risk Factors ; Humans ; Kidney Neoplasms ; Risk Factors
    Chemical Substances Antibodies, Monoclonal, Humanized ; Axitinib (C9LVQ0YUXG) ; avelumab (KXG2PJ551I)
    Language English
    Publishing date 2022-06-16
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.00712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

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  9. Article ; Online: Cardiovascular risk factor reporting in immune checkpoint inhibitor trials: A systematic review.

    Tan, Sean / Sivakumar, Seiyon / Segelov, Eva / Nicholls, Stephen J / Nelson, Adam J

    Cancer epidemiology

    2023  Volume 83, Page(s) 102334

    Abstract: Background: Immune checkpoint inhibitors (ICI) have revolutionized the treatment of numerous cancers but are associated with increased risk of myocardial infarction. The prevalence of traditional cardiovascular risk factors (CVRF) in patients treated ... ...

    Abstract Background: Immune checkpoint inhibitors (ICI) have revolutionized the treatment of numerous cancers but are associated with increased risk of myocardial infarction. The prevalence of traditional cardiovascular risk factors (CVRF) in patients treated with ICIs is unknown. This study sought to describe the frequency of reporting of CVRFs among landmark ICI trials.
    Methods: A systematic review of all phase 2 or 3 cancer trials employing ICIs that led to United States Food and Drug Administration approval was conducted.
    Results: Of the 69 identified trials, only one study reported baseline rates of hypertension, diabetes mellitus, and dyslipidemia. Smoking history was reported in 27 studies (39 %) and three (4 %) reported body mass index. No study reported history of previous cardiovascular disease, although 17 (25 %), six (9 %), and 21 (30 %) studies excluded patients with recent myocardial infarction, revascularization and heart failure respectively. Similarly low rates of cardiovascular risk factor reporting were observed in studies employing concurrent vascular endothelial growth factor inhibitors and recruiting (neo)adjuvant cohorts.
    Conclusion: The prevalence of CVRFs is poorly described in ICI trials despite increasingly reported risks of myocardial infarction. A systematic approach to collecting and reporting CVRFs should be considered in future trials and real world populations.
    MeSH term(s) United States ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Cardiovascular Diseases/epidemiology ; Risk Factors ; Vascular Endothelial Growth Factor A ; Neoplasms/drug therapy ; Myocardial Infarction/drug therapy ; Heart Disease Risk Factors
    Chemical Substances Immune Checkpoint Inhibitors ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2023-01-18
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2508729-0
    ISSN 1877-783X ; 1877-7821
    ISSN (online) 1877-783X
    ISSN 1877-7821
    DOI 10.1016/j.canep.2023.102334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1427: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Differences in cancer clinical trial activity and trial characteristics at metropolitan and rural trial sites in Victoria, Australia.

    McPhee, Narelle J / Leach, Michael / Nightingale, Claire E / Harris, Samuel J / Segelov, Eva / Ristevski, Eli

    The Australian journal of rural health

    2024  

    Abstract: Objective: Cancer clinical trials (CCTs) provide access to emerging therapies and extra clinical care. We aimed to describe the volume and characteristics of CCTs available across Victoria, Australia, and identify factors associated with rural trial ... ...

    Abstract Objective: Cancer clinical trials (CCTs) provide access to emerging therapies and extra clinical care. We aimed to describe the volume and characteristics of CCTs available across Victoria, Australia, and identify factors associated with rural trial location.
    Methods: Quantitative analysis of secondary data from Cancer Council Victoria's Clinical Trials Management Scheme dataset.
    Design: A cross-sectional study design was used.
    Setting: CCTs were available Victoria-wide in 2018.
    Participants: There were 1669 CCTs and 5909 CCT participants.
    Main outcome measures: Rural CCT location was assessed as a binary variable with categories of 'yes' (modified Monash [MM] categories 2-7) and 'no' (MM category 1). MM categories were determined from postcodes. The highest ('least rural') MM category was used for postcodes with multiple MM categories.
    Results: Of 1669 CCTs, 168 (10.1%) were conducted in rural areas. Of 5909 CCT participants, 315 (5.3%) participated in rural CCTs. There were 526 CCTs (31.5%) with 1907 (32.3%) newly enrolled participants. Of 1892 newly enrolled participants with postcode data, 488 (25.8%) were rural residents. Of them, 368 (75.4%) participated in metropolitan CCTs. In a multivariable logistic regression analysis for all 1669 CCTs, odds of a rural rather than metropolitan CCT location were significantly (p-value <0.05) lower for early-phase than late-phase trials and non-solid than solid tumour trials but significantly (p-value <0.05) higher for non-industry than industry-sponsored trials.
    Conclusions: In Victoria, 10% of CCTs are at rural sites. Most rural-residing CCT participants travel to metropolitan sites, where there are more late-phase, non-solid-tumour and industry-sponsored trials. Approaches to increase the volume and variety of rural CCTs should be considered.
    Language English
    Publishing date 2024-04-17
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2069573-1
    ISSN 1440-1584 ; 1038-5282
    ISSN (online) 1440-1584
    ISSN 1038-5282
    DOI 10.1111/ajr.13102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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