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  1. Article: Risques des préparations magistrales en pédiatrie.

    Rosen, Charlotte / Jacqmart, Caroline / Charlier, Corinne / Beghetti, Maurice / Seghaye, Marie-Christine

    Revue medicale de Liege

    2024  Volume 79, Issue 2, Page(s) 104–109

    Abstract: Vasoreactive pulmonary arterial hypertension (PAH) in children is a form of idiopathic PAH that responds to vasoreactive testing with nitric oxide (NO) by a significant decrease of pulmonary vascular resistances and pressure. Oral calcium channel ... ...

    Title translation Risks of magistral preparations in pediatrics.
    Abstract Vasoreactive pulmonary arterial hypertension (PAH) in children is a form of idiopathic PAH that responds to vasoreactive testing with nitric oxide (NO) by a significant decrease of pulmonary vascular resistances and pressure. Oral calcium channel antagonists (CCA) that allow pulmonary arterial vasodilation are the treatment of choice. The therapeutic effect is strongly depending on adequate drug intake. In growing children, drug dose must be adapted to weight. In case of unavailability of low-dose pharmaceutical preparations, officinal formulations become mandatory. Officinal formulations may be related to a multitude of errors at different steps including prescription, transcription, preparation and administration. This may have life-threatening consequences for the child.To illustrate this, we report a case of a compounding error with underdosage of CCA, leading to acute cardiovascular failure in an adolescent with vasoreactive PAH.
    MeSH term(s) Adolescent ; Humans ; Calcium Channel Blockers/adverse effects ; Calcium Channel Blockers/therapeutic use ; Hypertension, Pulmonary/drug therapy ; Nitric Oxide/therapeutic use
    Chemical Substances Calcium Channel Blockers ; Nitric Oxide (31C4KY9ESH)
    Language French
    Publishing date 2024-02-15
    Publishing country Belgium
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 414001-1
    ISSN 0370-629X ; 0035-3663
    ISSN 0370-629X ; 0035-3663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 597: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Management of children with congenital heart defect: state of the art and future prospects.

    Seghaye, Marie-Christine

    Future cardiology

    2017  Volume 13, Issue 1, Page(s) 65–79

    Abstract: The treatment of children with congenital heart defects has evolved in the last 60 years from conservative care to a highly specialized management where advances in imaging, surgical, interventional and support techniques meet together to ensure ... ...

    Abstract The treatment of children with congenital heart defects has evolved in the last 60 years from conservative care to a highly specialized management where advances in imaging, surgical, interventional and support techniques meet together to ensure satisfactory development and good quality of life to the child and to the upcoming grown up. Management of congenital heart defects best begins before birth with the aim, whenever possible, to maintain or establish biventricular physiology or, if this is excluded, to optimize the conditions for univentricular physiology. Current research in the field of genetics, device bioengineering and miniaturization, stem cell therapy, and fusion imaging technology is expected to help to improve further patient outcome. In this review, current management strategies and future prospects are discussed.
    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274267-0
    ISSN 1744-8298 ; 1479-6678
    ISSN (online) 1744-8298
    ISSN 1479-6678
    DOI 10.2217/fca-2016-0039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Évolution naturelle d’une coarctation de l’aorte de l’enfant.

    Dutilleux, Tanguy / Farhat, Nesrine / Bruyère, Pierre-Julien / Seghaye, Marie-Christine

    Revue medicale de Liege

    2023  Volume 78, Issue 7-8, Page(s) 403–406

    Abstract: Aortic coarctation is a frequent congenital heart disease that presents in form of two entities, the infant type and the child or adult type. The infant type is the most frequent and manifests acutely by heart failure or shock. The second one shows a ... ...

    Title translation Natural course of an aortic coarctation in a child.
    Abstract Aortic coarctation is a frequent congenital heart disease that presents in form of two entities, the infant type and the child or adult type. The infant type is the most frequent and manifests acutely by heart failure or shock. The second one shows a slow and progressive course with no or few initial symptoms. For that reason, the diagnosis is usually missed until symptomatic arterial hypertension or hypertrophic cardiomyopathy develop. We report the case of an initially asymptomatic boy in whom the development of an aortic coarctation could be precisely documented over a period of 10 years by repeated bidimensional and Doppler echocardiography. The patient underwent successful balloon angioplasty of the aortic isthmus and stent implantation. This case points out the importance of strict follow-up in any young child in whom an even mild anomaly of the aortic arch is detected. This is critical in order not to miss an aortic coarctation that influences significantly morbidity in adulthood.
    MeSH term(s) Infant ; Male ; Adult ; Child ; Humans ; Aortic Coarctation/diagnostic imaging ; Treatment Outcome ; Angioplasty, Balloon ; Angioplasty, Balloon, Coronary ; Heart Failure ; Stents
    Language French
    Publishing date 2023-08-07
    Publishing country Belgium
    Document type Case Reports ; English Abstract
    ZDB-ID 414001-1
    ISSN 0370-629X ; 0035-3663
    ISSN 0370-629X ; 0035-3663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 597: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Cas clinique. Cardiopathie congénitale complexe : à propos d’un cas de syndrome de Noonan.

    Magotteaux, Samia / Farhat, Nesrine / Jacquinet, Adeline / Seghaye, Marie-Christine

    Revue medicale de Liege

    2023  Volume 78, Issue 3, Page(s) 130–136

    Abstract: We present the case of a young girl in whom pre-natal echocardiography showed double outlet right ventricle associated with severe infundibular- and pulmonary valve stenosis. The genetic testing has shown a mutation on the LZTR1 gene, which confirms the ... ...

    Title translation Complex congenital heart disease : about a case of Noonan syndrome.
    Abstract We present the case of a young girl in whom pre-natal echocardiography showed double outlet right ventricle associated with severe infundibular- and pulmonary valve stenosis. The genetic testing has shown a mutation on the LZTR1 gene, which confirms the diagnosis of a Noonan Syndrome, also present in the mother and an elder sister. The infant was born premature at 34 weeks and 5 days of gestational age. During the neonatal period, feeding difficulties are noted linked to oral aversion and exacerbated by difficulties in the mother-child bond. At 1 month of age, the child presented hypoxic spells caused by the infundibular stenosis which required emergency aorto-pulmonary anastomosis placement ensuring sufficient pulmonary blood flow. This anastomosis needed to be replaced by a larger one at 9th month of age. The child is now 4 years old and has undergone a complete surgical correction. The multidisciplinary management englobes not only follow up in cardiology, genetics, neurology, ophthalmology and hematology but also feeding support and psychomotor development support. The socio-economic precariousness of the family leads to a constant assistance to allow the best possible development of the child.
    MeSH term(s) Infant, Newborn ; Infant ; Female ; Humans ; Aged ; Child, Preschool ; Noonan Syndrome/complications ; Noonan Syndrome/diagnosis ; Noonan Syndrome/genetics ; Echocardiography ; Pulmonary Valve Stenosis/diagnosis ; Pulmonary Valve Stenosis/surgery ; Pulmonary Valve Stenosis/complications ; Transcription Factors
    Chemical Substances LZTR1 protein, human ; Transcription Factors
    Language French
    Publishing date 2023-03-06
    Publishing country Belgium
    Document type Case Reports ; English Abstract
    ZDB-ID 414001-1
    ISSN 0370-629X ; 0035-3663
    ISSN 0370-629X ; 0035-3663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 597: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Vena cava inferior thrombosis diagnosed 12 years after interventional atrial septum defect closure in an infant.

    Farhat, Khaldoun / Farhat, Nesrine / Bruyère, Pierre-Julien / Seghaye, Marie-Christine

    Acta cardiologica

    2023  Volume 79, Issue 1, Page(s) 70–71

    MeSH term(s) Infant ; Humans ; Atrial Septum ; Heart Septal Defects, Atrial/diagnosis ; Heart Septal Defects, Atrial/surgery ; Thrombosis ; Venous Thrombosis ; Vena Cava, Inferior/diagnostic imaging ; Vena Cava, Inferior/surgery
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 390197-x
    ISSN 1784-973X ; 0001-5385
    ISSN (online) 1784-973X
    ISSN 0001-5385
    DOI 10.1080/00015385.2023.2177372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Thesis: Pathophysiologie der durch den extrakorporalen Kreislauf bedingten entzündlichen Reaktion im Kindesalter

    Seghaye, Marie-Christine

    1996  

    Author's details vorgelegt von Marie-Christine Seghaye
    Language German
    Size VI, 146 Bl. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Aachen, Techn. Hochsch., Habil.-Schr., 1996
    HBZ-ID HT007476680
    Database Catalogue ZB MED Medicine, Health

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    97 E 1454 order to use in reading room Magazin

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  7. Article: Uni-ventricular palliation vs. bi-ventricular repair: differential inflammatory response.

    Sigler, Matthias / Rouatbi, Hatem / Vazquez-Jimenez, Jaime / Seghaye, Marie-Christine

    Molecular and cellular pediatrics

    2022  Volume 9, Issue 1, Page(s) 5

    Abstract: Background: To examine whether uni-ventricular palliation (UVP) and bi-ventricular repair (BVR) result in a different pattern of systemic inflammatory response to pediatric cardiac surgery with extra-corporeal circulation (ECC).: Methods: In 20 ... ...

    Abstract Background: To examine whether uni-ventricular palliation (UVP) and bi-ventricular repair (BVR) result in a different pattern of systemic inflammatory response to pediatric cardiac surgery with extra-corporeal circulation (ECC).
    Methods: In 20 children (median age 39.5 months) undergoing either UVP (n = 12) or BVR (n = 8), plasma levels of the inflammatory cytokines TNF-α, IL-6, IL-10, and IL-12 and of procalcitonin (PCT), were measured before, during and after open cardiac surgery up to postoperative day (POD) 10.
    Results: Epidemiologic, operative- and outcome variables were similar in both groups but post-operative central venous pressure that was higher in UVP. In the whole cohort, the inflammatory response was characterized by an early important, significant and parallel increase of IL-6 and IL-10 that reached their peak values either at the end of ECC (IL-10) or 4 h postoperatively (IL-6), respectively and by a significant and parallel decrease of TNF-α and IL-12 levels after connection to ECC, followed by a bi-phasic significant increase with a first peak 4 h after ECC and a second at POD 10, respectively. Patients after UVP showed a shift of the cytokine balance with lower IL-6- (p = 0.01) after connection to ECC, lower early post-operative TNF-α - (p = 0.02) and IL-12- (p = 0.04) concentrations and lower TNF-α/IL-10-ratio (p = 0.03) as compared with patients with BVR. Levels of PCT were similar in both groups.
    Conclusions: UVP is associated with an anti-inflammatory shift of the inflammatory response to cardiac surgery that might be related to the particular hemodynamic situation of patients with UVP.
    Language English
    Publishing date 2022-03-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2785551-X
    ISSN 2194-7791
    ISSN 2194-7791
    DOI 10.1186/s40348-022-00138-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Growing up with Idiopathic Pulmonary Arterial Hypertension: An Arduous Journey.

    Dutilleux, Tanguy / Farhat, Nesrine / Heying, Ruth / Seghaye, Marie-Christine / Beghetti, Maurice

    Pediatric reports

    2023  Volume 15, Issue 2, Page(s) 301–310

    Abstract: Idiopathic pulmonary arterial hypertension (IPAH) is an uncommon and severe disease. We report the case of a 7-year-old boy investigated for cardiac murmur and exercise intolerance. Pulmonary hypertension (PH) was suspected at clinical examination and ... ...

    Abstract Idiopathic pulmonary arterial hypertension (IPAH) is an uncommon and severe disease. We report the case of a 7-year-old boy investigated for cardiac murmur and exercise intolerance. Pulmonary hypertension (PH) was suspected at clinical examination and confirmed by echocardiography and cardiac catheterization. This case of pulmonary hypertension was classified as idiopathic given the negative etiological investigation. Vasoreactive testing with oxygen and nitric oxide was negative. Therefore, treatment with sildenafil (1.4 mg/kg/d) and bosentan (3 mg/kg/d) was initiated. This allowed the stabilization of, but not a decrease in, pulmonary artery pressure for the next 5 years, during which the patient's quality of life was significantly reduced. At a later follow-up, the estimated pulmonary pressure was found to have increased and become supra-systemic, with a consequent deterioration in the child's condition. This led to the decision to enter him into a clinical trial that is still ongoing. Idiopathic pulmonary arterial hypertension is a severe disease that can present with non-specific symptoms, such as asthenia and exercise limitation, which are important not to trivialize. The disease is associated with significantly decreased quality of life in affected children and carries a high burden in terms of mortality and morbidity. The current knowledge about IPAH in children is reviewed, with a particular focus on the future prospects for its treatment and the related quality of life of patients.
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Case Reports
    ISSN 2036-749X
    ISSN 2036-749X
    DOI 10.3390/pediatric15020026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Unusual Cardiac Manifestations of a Pheochromocytoma in a Girl.

    D'Angelo, Lisa / Parent, Anne-Simone / Derwael, Céline / Hustinx, Roland / Seghaye, Marie-Christine

    Pediatric reports

    2023  Volume 15, Issue 1, Page(s) 237–244

    Abstract: We report the case of an 11-year-old girl who complained about severe asthenia, orthostatic dizziness and abdominal pain for 4 weeks. The primary investigation concluded on febrile urinary tract infection treated by antibiotics. Symptom persistence ... ...

    Abstract We report the case of an 11-year-old girl who complained about severe asthenia, orthostatic dizziness and abdominal pain for 4 weeks. The primary investigation concluded on febrile urinary tract infection treated by antibiotics. Symptom persistence prompted cardiological and endocrinological investigations. A fluctuation in blood pressure, long QT interval, dilation of the aortic root and left ventricular hypertrophy were documented. Elevated levels of urinary catecholamines together with the presence of a right-sided adrenal mass shown via abdominal ultrasound and magnetic resonance imaging were highly suggestive of a pheochromocytoma. This was confirmed by through iodine-123-metaiodobenzylguathdine ([
    Language English
    Publishing date 2023-03-17
    Publishing country Switzerland
    Document type Case Reports
    ISSN 2036-749X
    ISSN 2036-749X
    DOI 10.3390/pediatric15010019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Thesis: Komplementaktivierung und Aktivierung des Plasmakontaktsystems während Herz-Lungen-Maschinen-Operationen beim Kind

    Seghaye, Marie-Christine

    Beziehung zum postoperativen Polyorganversagen

    1994  

    Author's details vorgelegt von Marie-Christine Seghaye
    Language German
    Size 44 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Aachen, Techn. Hochsch., Diss., 1994
    HBZ-ID HT006525474
    Database Catalogue ZB MED Medicine, Health

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