LIVIVO - Search results -

Search results

Result 1 - 10 of total 14

Search options

Article ; Online: Preclinical evaluation of tuberculosis vaccine candidates: Is it time to harmonize study design and readouts for prioritizing their development?

Flores-Valdez, Mario Alberto / Segura-Cerda, Cristian Alfredo

2020 Volume 39, Issue 2, Page(s) 173–175

MeSH term(s)	BCG Vaccine ; Humans ; Mycobacterium tuberculosis ; Tuberculosis/prevention & control ; Tuberculosis Vaccines
Chemical Substances	BCG Vaccine ; Tuberculosis Vaccines
Language	English
Publishing date	2020-12-14
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2020.11.073
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: BCG and BCGΔBCG1419c transiently protect hypersusceptible I/St mice and induce different influx of macrophages and neutrophils during pulmonary tuberculosis.

Korotetskaya, Maria / Baikuzina, Polina / Segura-Cerda, Cristian Alfredo / Aceves-Sánchez, Michel de Jesús / Apt, Alexander / Flores-Valdez, Mario Alberto

Journal of medical microbiology

2022 Volume 71, Issue 1

Abstract: Background. ...

Abstract	Background.
MeSH term(s)	Animals ; BCG Vaccine/therapeutic use ; Macrophages/immunology ; Mice ; Mycobacterium tuberculosis/immunology ; Neutrophils/immunology ; Tuberculosis, Pulmonary/prevention & control ; Weight Loss
Chemical Substances	BCG Vaccine
Language	English
Publishing date	2022-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	218356-0
ISSN	1473-5644 ; 0022-2615
ISSN (online)	1473-5644
ISSN	0022-2615
DOI	10.1099/jmm.0.001485
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 634: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Changes in Host Response to

Segura-Cerda, Cristian Alfredo / López-Romero, Wendy / Flores-Valdez, Mario Alberto

Frontiers in cellular and infection microbiology

2019 Volume 9, Page(s) 342

Abstract: Tuberculosis (TB) remains as the first cause of death among infectious diseases worldwide. Global incidence of tuberculosis is in part coincident with incidence of type 2 diabetes (T2D). Incidence of T2D is recognized as a high-risk factor that may ... ...

Abstract	Tuberculosis (TB) remains as the first cause of death among infectious diseases worldwide. Global incidence of tuberculosis is in part coincident with incidence of type 2 diabetes (T2D). Incidence of T2D is recognized as a high-risk factor that may contribute to tuberculosis dissemination. However, mechanisms which favor infection under T2D are just starting to emerge. Here, we first discuss the evidences that are available to support a metabolic connection between TB and T2D. Then, we analyze the evidences of metabolic changes which occur during T2D gathered thus far for its influence on susceptibility to
MeSH term(s)	Adaptive Immunity ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/metabolism ; Disease Susceptibility/immunology ; Dyslipidemias ; Energy Metabolism ; Host-Pathogen Interactions/immunology ; Humans ; Hyperglycemia ; Immunity, Innate ; Immunomodulation ; Mycobacterium tuberculosis/immunology ; Radiography, Thoracic ; Tuberculosis/complications ; Tuberculosis/diagnosis ; Tuberculosis/immunology ; Tuberculosis/metabolism
Language	English
Publishing date	2019-10-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2019.00342
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Modulation of autophagy as a strategy for development of new vaccine candidates against tuberculosis.

Flores-Valdez, Mario Alberto / Segura-Cerda, Cristian Alfredo / Gaona-Bernal, Jorge

Molecular immunology

2018 Volume 97, Page(s) 16–19

Abstract: Effective prevention of tuberculosis (Tb) would undoubtedly be of paramount relevance in the control of its global burden, which resulted in more than 6 million new cases in 2016. Research aimed to improve the current vaccine, Bacillus Calmette- Guérin ( ... ...

Abstract	Effective prevention of tuberculosis (Tb) would undoubtedly be of paramount relevance in the control of its global burden, which resulted in more than 6 million new cases in 2016. Research aimed to improve the current vaccine, Bacillus Calmette- Guérin (BCG), or directed to develop new candidates, has taken into account the interaction between the host and Mycobacterium tuberculosis (Mtb). Recently, autophagy, an intracellular process of the host, has been shown to act as a mechanism that contributes to bacilli clearance in vitro and in vivo. Stimulation of autophagy, if correctly balanced, is an approach that has the potential to enhance the immune response of the host, and offers new avenues for developing immunogens that may give an improved protection upon immunization, given that in fact, some recent rBCG vaccine candidates have been shown to modulate autophagy. In this Discussion, we analyze the role of autophagy in the context of mycobacterial infection, its modulation via mycobacterial elements, and the management of host response as an alternative to develop new, hopefully improved, Tb-vaccine candidates.
MeSH term(s)	Animals ; Antitubercular Agents/immunology ; Antitubercular Agents/therapeutic use ; Autophagy/immunology ; Drug Design ; Humans ; Mycobacterium bovis/immunology ; Mycobacterium tuberculosis/immunology ; Tuberculosis/immunology ; Tuberculosis/prevention & control ; Tuberculosis Vaccines/metabolism ; Tuberculosis Vaccines/therapeutic use
Chemical Substances	Antitubercular Agents ; Tuberculosis Vaccines
Language	English
Publishing date	2018-03-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2018.03.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 166: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Macrophage infection with combinations of BCG mutants reduces induction of TNF-α, IL-6, IL-1β and increases IL-4.

Segura-Cerda, Cristian Alfredo / Aceves-Sánchez, Michel de Jesús / Pérez-Koldenkova, Vadim / Flores-Valdez, Mario Alberto

Tuberculosis (Edinburgh, Scotland)

2019 Volume 115, Page(s) 42–48

Abstract: Tuberculosis (TB) is the most prevalent infectious disease worldwide, with no fully effective vaccine yet available. Considering that BCG strains devoid of the BCG1416c or BCG1419c genes afforded protection in mice versus highly virulent M. tuberculosis ... ...

Abstract	Tuberculosis (TB) is the most prevalent infectious disease worldwide, with no fully effective vaccine yet available. Considering that BCG strains devoid of the BCG1416c or BCG1419c genes afforded protection in mice versus highly virulent M. tuberculosis challenge, or in chronic infection models compared to BCG, respectively, we hypothesized that a synergistic effect of these strains might occur and provide enhanced protection against TB. Herein, we evaluated this hypothesis throughout an experimental design approach, where different combinations of these strains were tested for their capacity to induce cytokines in vitro, compared to individual strains. Our results show that mixed-infection of murine macrophages using these strains significantly decreases induction of TNF-α, IL-1β, IL-6 but increases IL-4 induction compared with individual strains. These results suggest the existence of interaction effects during infection, which reduce induction of pro-inflammatory cytokines, even though individual intracellular replication is not altered when strains are combined. This is the first report of the evaluation of a potential whole-live combined vaccine against tuberculosis, which paradoxically seems to reduce production of pro-inflammatory cytokines while induces IL-4, leading us to further hypothesize that this combination might contribute as a therapeutic vaccine to reduce inflammation in severe TB cases.
MeSH term(s)	Animals ; BCG Vaccine ; Host-Pathogen Interactions ; Interleukin-1beta/metabolism ; Interleukin-4/metabolism ; Interleukin-6/metabolism ; Interleukins/metabolism ; Macrophages/microbiology ; Mice ; Mutation/physiology ; Mycobacterium bovis/genetics ; Mycobacterium bovis/physiology ; Mycobacterium tuberculosis/genetics ; Tuberculosis/metabolism ; Tuberculosis/prevention & control ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	BCG Vaccine ; Interleukin-1beta ; Interleukin-6 ; Interleukins ; Tumor Necrosis Factor-alpha ; Interleukin-4 (207137-56-2)
Language	English
Publishing date	2019-01-25
Publishing country	Scotland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2046804-0
ISSN	1873-281X ; 1472-9792
ISSN (online)	1873-281X
ISSN	1472-9792
DOI	10.1016/j.tube.2019.01.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh II Zs.221: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Erratum to "BCGΔBCG1419c and BCG differ in induction of autophagy, c-di-GMP content, proteome, and progression of lung pathology in Mycobacterium tuberculosis HN878-infected male BALB/c mice" [Vaccine 41(26) (2023) 3824-3835].

Aceves-Sánchez, Michel de Jesús / Barrios-Payán, Jorge Alberto / Segura-Cerda, Cristian Alfredo / Flores-Valdez, Mario Alberto / Mata-Espinosa, Dulce / Pedroza-Roldán, César / Yadav, Rahul / Saini, Deepak Kumar / de la Cruz, Miguel Angel / Ares, Miguel A / Bielefeldt-Ohmann, Helle / Baay-Guzmán, Guillermina / Vergne, Isabelle / Velázquez-Fernández, Jesús Bernardino / Barba León, Jeannette / Hernández-Pando, Rogelio

Vaccine

2024 Volume 42, Issue 7, Page(s) 1852–1853

Language	English
Publishing date	2024-02-15
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2024.02.030
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

Order via subito

Details ▾

Article ; Online: BCGΔBCG1419c increased memory CD8<sup>+</sup> T cell-associated immunogenicity and mitigated pulmonary inflammation compared with BCG in a model of chronic tuberculosis.

Kwon, Kee Woong / Aceves-Sánchez, Michel de Jesús / Segura-Cerda, Cristian Alfredo / Choi, Eunsol / Bielefeldt-Ohmann, Helle / Shin, Sung Jae / Flores-Valdez, Mario Alberto

Scientific reports

2022 Volume 12, Issue 1, Page(s) 15824

Abstract: Previously, we reported that a hygromycin resistant version of the BCGΔBCG1419c vaccine candidate reduced tuberculosis (TB) disease in BALB/c, C57BL/6, and B6D2F1 mice infected with Mycobacterium tuberculosis (Mtb) H37Rv. Here, the second-generation ... ...

Abstract	Previously, we reported that a hygromycin resistant version of the BCGΔBCG1419c vaccine candidate reduced tuberculosis (TB) disease in BALB/c, C57BL/6, and B6D2F1 mice infected with Mycobacterium tuberculosis (Mtb) H37Rv. Here, the second-generation version of BCGΔBCG1419c (based on BCG Pasteur ATCC 35734, without antibiotic resistance markers, and a complete deletion of BCG1419c) was compared to its parental BCG for immunogenicity and protective efficacy against the Mtb clinical isolate M2 in C57BL/6 mice. Both BCG and BCGΔBCG1419c induced production of IFN-γ, TNF-α, and/or IL-2 by effector memory (CD44<sup>+</sup>CD62L<sup>-</sup>), PPD-specific, CD4<sup>+</sup> T cells, and only BCGΔBCG1419c increased effector memory, PPD-specific CD8<sup>+</sup> T cell responses in the lungs and spleens compared with unvaccinated mice before challenge. BCGΔBCG1419c increased levels of central memory (CD62L<sup>+</sup>CD44<sup>+</sup>) T CD4<sup>+</sup> and CD8<sup>+</sup> cells compared to those of BCG-vaccinated mice. Both BCG strains elicited Th1-biased antigen-specific polyfunctional effector memory CD4<sup>+</sup>/CD8<sup>+</sup> T cell responses at 10 weeks post-infection, and both vaccines controlled Mtb M2 growth in the lung and spleen. Only BCGΔBCG1419c significantly ameliorated pulmonary inflammation and decreased neutrophil infiltration into the lung compared to BCG-vaccinated and unvaccinated mice. Both BCG strains reduced pulmonary TNF-α, IFN-γ, and IL-10 levels. Taken together, BCGΔBCG1419c increased memory CD8+T cell-associated immunogenicity and mitigated pulmonary inflammation compared with BCG.
MeSH term(s)	Animals ; BCG Vaccine ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Interleukin-10 ; Interleukin-2 ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mycobacterium tuberculosis ; Pneumonia ; Tuberculin ; Tuberculosis/microbiology ; Tumor Necrosis Factor-alpha
Chemical Substances	BCG Vaccine ; Interleukin-2 ; Tuberculin ; Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2022-09-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-20017-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: BCG∆BCG1419c and BCG differ in induction of autophagy, c-di-GMP content, proteome, and progression of lung pathology in Mycobacterium tuberculosis HN878-infected male BALB/c mice

Aceves-Sánchez, Michel de Jesús / Barrios-Payán, Jorge Alberto / Segura-Cerda, Cristian Alfredo / Flores-Valdez, Mario Alberto / Mata-Espinosa, Dulce / Pedroza-Roldán, César / Yadav, Rahul / Saini, Deepak Kumar / de la Cruz, Miguel Angel / Ares, Miguel A. / Bielefeldt-Ohmann, Helle / Baay-Guzmán, Guillermina / Vergne, Isabelle / Bernardino Velázquez-Fernández, Jesús / Barba León, Jeannette / Hernández-Pando, Rogelio

Vaccine. 2023 May 08,

2023

Abstract: The efficacy of BCG vaccines against Mycobacterium tuberculosis (Mtb) strains of lineage 2 (Beijing) in preclinical models and humans has been questioned. We have developed BCG∆BCG1419c, by deletion of BCG1419c in BCG Pasteur, which improved control of ... ...

Abstract	The efficacy of BCG vaccines against Mycobacterium tuberculosis (Mtb) strains of lineage 2 (Beijing) in preclinical models and humans has been questioned. We have developed BCG∆BCG1419c, by deletion of BCG1419c in BCG Pasteur, which improved control of tuberculosis (TB) in preclinical models. Here, we compared the capacity of BCG and BCG∆BCG1419c to induce autophagy in murine macrophages, modify c-di-GMP content and transcript levels of BCG1416c, encoding the enzyme responsible for c-di-GMP synthesis/degradation, and of BCG1419c, encoding the phosphodiesterase involved in c-di-GMP degradation. Furthermore, we evaluated proteomic differences in vitro and compared protection against TB produced by a low dose of the HN878-Beijing strain at 3- and 6-months post-infection. We found that BCG∆BCG1419c induced more autophagy and produced different levels of c-di-GMP as well as different transcription of BCG1416c with no expression of BCG1419c. BCG∆BCG1419c differentially produced several proteins, including some involved in interaction with host cells. Vaccination with either BCG strain led to control of bacillary burden in lungs and spleen at 3- but not 6-months post-infection, whereas it reduced pneumonic areas compared with unvaccinated controls at 6 months post-infection. Vaccination with BCG∆BCG1419c delayed progression of lung necrosis as this was observed only at 6 months post-infection. Taken together, compared with BCG, BCG∆BCG1419c increased autophagy, presented different levels of c-di-GMP and transcription of BCG1416c in vitro in a growth-phase dependent manner, modified its proteome and delayed progression of lung pathology produced by a highly virulent Beijing strain.
Keywords	Mycobacterium tuberculosis ; autophagy ; cyclic GMP ; enzymes ; lungs ; macrophages ; males ; mice ; necrosis ; proteome ; proteomics ; spleen ; tuberculosis ; vaccination ; vaccines ; virulence ; China ; Beijing ; HN878 ; BCG ; BCG∆BCG1419c
Language	English
Dates of publication	2023-0508
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.04.065
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

Order via subito

Details ▾

Article ; Online: BCG∆BCG1419c and BCG differ in induction of autophagy, c-di-GMP content, proteome, and progression of lung pathology in Mycobacterium tuberculosis HN878-infected male BALB/c mice.

Vaccine

2023 Volume 41, Issue 26, Page(s) 3824–3835

Abstract	The efficacy of BCG vaccines against Mycobacterium tuberculosis (Mtb) strains of lineage 2 (Beijing) in preclinical models and humans has been questioned. We have developed BCG∆BCG1419c, by deletion of BCG1419c in BCG Pasteur, which improved control of tuberculosis (TB) in preclinical models. Here, we compared the capacity of BCG and BCG∆BCG1419c to induce autophagy in murine macrophages, modify c-di-GMP content and transcript levels of BCG1416c, encoding the enzyme responsible for c-di-GMP synthesis/degradation, and of BCG1419c, encoding the phosphodiesterase involved in c-di-GMP degradation. Furthermore, we evaluated proteomic differences in vitro and compared protection against TB produced by a low dose of the HN878-Beijing strain at 3- and 6-months post-infection. We found that BCG∆BCG1419c induced more autophagy and produced different levels of c-di-GMP as well as different transcription of BCG1416c with no expression of BCG1419c. BCG∆BCG1419c differentially produced several proteins, including some involved in interaction with host cells. Vaccination with either BCG strain led to control of bacillary burden in lungs and spleen at 3- but not 6-months post-infection, whereas it reduced pneumonic areas compared with unvaccinated controls at 6 months post-infection. Vaccination with BCG∆BCG1419c delayed progression of lung necrosis as this was observed only at 6 months post-infection. Taken together, compared with BCG, BCG∆BCG1419c increased autophagy, presented different levels of c-di-GMP and transcription of BCG1416c in vitro in a growth-phase dependent manner, modified its proteome and delayed progression of lung pathology produced by a highly virulent Beijing strain.
MeSH term(s)	Humans ; Male ; Animals ; Mice ; Mycobacterium tuberculosis ; BCG Vaccine ; Proteome ; Mice, Inbred BALB C ; Proteomics ; Tuberculosis/prevention & control ; Lung ; Mycobacterium bovis
Chemical Substances	BCG Vaccine ; Proteome ; bis(3',5')-cyclic diguanylic acid (61093-23-0)
Language	English
Publishing date	2023-05-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.04.065
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

Order via subito

Details ▾

Article ; Online: BCG and BCGΔBCG1419c protect type 2 diabetic mice against tuberculosis via different participation of T and B lymphocytes, dendritic cells and pro-inflammatory cytokines.

Segura-Cerda, Cristian Alfredo / Marquina-Castillo, Brenda / Lozano-Ordaz, Vasti / Mata-Espinosa, Dulce / Barrios-Payán, Jorge Alberto / López-Torres, Manuel O / Aceves-Sánchez, Michel de Jesús / Bielefeldt-Ohmann, Helle / Hernández-Pando, Rogelio / Flores-Valdez, Mario Alberto

NPJ vaccines

2020 Volume 5, Issue 1, Page(s) 21

Abstract: Comorbidity between Tuberculosis (TB) and type 2 diabetes (T2D) is one of the greatest contributors to the spread ... ...

Abstract	Comorbidity between Tuberculosis (TB) and type 2 diabetes (T2D) is one of the greatest contributors to the spread of
Language	English
Publishing date	2020-03-12
Publishing country	England
Document type	Journal Article
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-020-0169-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED