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  1. Book: Characterization of a Pseudorabies virus mutant lacking the pUS3 kinase and the tegument protein pUL21 in vitro and in vivo and the evaluation of an improved animal model for human Herpes Simplex Encephalitis

    Sehl, Julia

    (Edition Scientifique)

    2020  

    Abstract: Alphaherpesviruses are neuroinvasive viruses with the ability to cause severe diseases in humans and animals. HSV-1 is a human pathogen known to sporadically induce fronto-temporal meningoencephalitis, which is associated with high mortality rates and ... ...

    Series title Edition Scientifique
    Abstract Alphaherpesviruses are neuroinvasive viruses with the ability to cause severe diseases in humans and animals. HSV-1 is a human pathogen known to sporadically induce fronto-temporal meningoencephalitis, which is associated with high mortality rates and long lasting sequelae such as chronic or relapsing inflammation, cognitive alterations or epilepsy. PrV is an animal pathogen causing CNS disorders primarily in piglets. In non-porcine species PrV infection leads to severe itching followed by au...
    Keywords Wissenschaft ; Doktorarbeit ; Uni
    Language English
    Size 134 p.
    Publisher VVB Laufersweiler Verlag
    Document type Book
    Note Hochschulschriften Medizin
    Format 146 x 210
    ISBN 9783835968813 ; 3835968815
    Database PDA

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  2. Thesis ; Online: Characterization of a Pseudorabies virus mutant lacking the pUS3 kinase and the tegument protein pUL21 in vitro and in vivo and the evaluation of an improved animal model for human Herpes Simplex Encephalitis

    Sehl, Julia

    2020  

    Abstract: Alphaherpesviruses are neuroinvasive viruses with the ability to cause severe diseases in humans and animals. HSV-1 is a human pathogen known to sporadically induce fronto-temporal meningoencephalitis, which is associated with high mortality rates and ... ...

    Abstract Alphaherpesviruses are neuroinvasive viruses with the ability to cause severe diseases in humans and animals. HSV-1 is a human pathogen known to sporadically induce fronto-temporal meningoencephalitis, which is associated with high mortality rates and long lasting sequelae such as chronic or relapsing inflammation, cognitive alterations or epilepsy. PrV is an animal pathogen causing CNS disorders primarily in piglets. In non-porcine species PrV infection leads to severe itching followed by automutilation and death of the infected and diseased animal. After primary replication in epithelial cells, HSV-1 and PrV infect sensory neurons in which they are transported to peripheral ganglia and towards the CNS. In the past, the function of different PrV proteins for neuroinvasion has been studied in mice using corresponding viral gene deletion mutants. These studies revealed that infection with a PrV mutant lacking the tegument protein pUL21 and the pUS3 kinase led not only to a significantly prolonged survival time but unlike to infection with PrV wildtype or other mutants, which was always fatal, most mice survived the infection. In this thesis, this phenotype was studied in detail. To test whether the effect resulted from the absence of the pUS3 kinase function of or from the absence as virion structural component, virus mutants PrV-US3deltakin and PrV-deltaUL21/US3deltakin were constructed and compared to PrV- deltaUS3 and PrV-deltaUL21/US3. In addition to the influence of the kinase-active pUS3, the function of the two described isoforms, pUS3- S and pUS3-L, was analyzed. In vitro data showed that while pUS3-L plays no major role in the viral replication cycle, the abundant, catalytically active short isoform of pUS3 is required for efficient nuclear egress and production of infectious progeny. However, the accumulations of primary virions in huge herniations of the INM described for mutants lacking US3 are not the cause for the observed drop in virus titers. PrV-deltaUS3, lacking the open reading frame ...
    Keywords Text ; ddc:630
    Subject code 801
    Language English
    Publishing date 2020-11-04
    Publisher VVB Laufersweiler Verlag
    Publishing country de
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Audio / Video ; Online: PrV-ΔUL21/US3Δkin in mice – an appropriate animal model for herpes simplex virus induced encephalitis?

    Sehl, Julia

    2019  

    Keywords Text ; ddc:570
    Language English
    Publishing date 2019-09-20
    Publishing country de
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Die Lungenseuche der Rinder – Einblicke in die Immunpathologie

    Sehl, Julia

    2018  

    Keywords Text ; ddc:630 ; Lungenseuche der Rinder -- Contagious Bovine Pleuropneumonia -- CBPP
    Language German
    Publishing date 2018-08-28
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Comparative Pathology of Pseudorabies in Different Naturally and Experimentally Infected Species-A Review.

    Sehl, Julia / Teifke, Jens Peter

    Pathogens (Basel, Switzerland)

    2020  Volume 9, Issue 8

    Abstract: The pseudorabies virus (PRV) is an alphaherpesvirus and the causative agent of Aujeszky's disease (AD). PRV infects a wide range of animal species including swine as the natural host as well as ruminants, carnivores, rodents and lagomorphs. In these ... ...

    Abstract The pseudorabies virus (PRV) is an alphaherpesvirus and the causative agent of Aujeszky's disease (AD). PRV infects a wide range of animal species including swine as the natural host as well as ruminants, carnivores, rodents and lagomorphs. In these species, except for the pig, PRV infection causes acute, severe disease, characterized by insatiable itching, and is always lethal. Horses, chickens and non-human primates have been shown to be largely resistant to PRV infection, while disease in humans is still controversial. PRV is a pantropic virus, which preferably invades neural tissue, but also infects epithelia of various organs, whereupon multisystemic lesions may result. Although AD is mainly associated with severe pruritus, also known as "mad itch", there are notable differences regarding infection route, clinical signs, viral distribution and lesion patterns in different animal species. In this comprehensive review, we will present clinico-pathologic findings from different species, which have been either shown to be susceptible to PRV infection or have been tested experimentally.
    Language English
    Publishing date 2020-08-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens9080633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Comparative Pathology of Pseudorabies in Different Naturally and Experimentally Infected Species—A Review

    Sehl, Julia / Teifke, Jens Peter

    Pathogens. 2020 Aug. 04, v. 9, no. 8

    2020  

    Abstract: The pseudorabies virus (PRV) is an alphaherpesvirus and the causative agent of Aujeszky’s disease (AD). PRV infects a wide range of animal species including swine as the natural host as well as ruminants, carnivores, rodents and lagomorphs. In these ... ...

    Abstract The pseudorabies virus (PRV) is an alphaherpesvirus and the causative agent of Aujeszky’s disease (AD). PRV infects a wide range of animal species including swine as the natural host as well as ruminants, carnivores, rodents and lagomorphs. In these species, except for the pig, PRV infection causes acute, severe disease, characterized by insatiable itching, and is always lethal. Horses, chickens and non-human primates have been shown to be largely resistant to PRV infection, while disease in humans is still controversial. PRV is a pantropic virus, which preferably invades neural tissue, but also infects epithelia of various organs, whereupon multisystemic lesions may result. Although AD is mainly associated with severe pruritus, also known as “mad itch”, there are notable differences regarding infection route, clinical signs, viral distribution and lesion patterns in different animal species. In this comprehensive review, we will present clinico-pathologic findings from different species, which have been either shown to be susceptible to PRV infection or have been tested experimentally.
    Keywords Aujeszky disease ; Lagomorpha ; Primates ; Suid alphaherpesvirus 1 ; carnivores ; chickens ; disease severity ; epithelium ; horses ; humans ; infection ; pathogens ; pruritus ; rodents ; ruminants ; swine ; viruses
    Language English
    Dates of publication 2020-0804
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens9080633
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Comparative Pathology of Pseudorabies in Different Naturally and Experimentally Infected Species

    Sehl, Julia / Teifke, Jens Peter

    A Review

    2020  

    Abstract: The pseudorabies virus (PRV) is an alphaherpesvirus and the causative agent of Aujeszky’s disease (AD). PRV infects a wide range of animal species including swine as the natural host as well as ruminants, carnivores, rodents and lagomorphs. In these ... ...

    Abstract The pseudorabies virus (PRV) is an alphaherpesvirus and the causative agent of Aujeszky’s disease (AD). PRV infects a wide range of animal species including swine as the natural host as well as ruminants, carnivores, rodents and lagomorphs. In these species, except for the pig, PRV infection causes acute, severe disease, characterized by insatiable itching, and is always lethal. Horses, chickens and non-human primates have been shown to be largely resistant to PRV infection, while disease in humans is still controversial. PRV is a pantropic virus, which preferably invades neural tissue, but also infects epithelia of various organs, whereupon multisystemic lesions may result. Although AD is mainly associated with severe pruritus, also known as “mad itch”, there are notable differences regarding infection route, clinical signs, viral distribution and lesion patterns in different animal species. In this comprehensive review, we will present clinico-pathologic findings from different species, which have been either shown to be susceptible to PRV infection or have been tested experimentally.
    Keywords Text ; ddc:570 ; pseudorabies virus -- Aujeszky’s disease -- clinical signs -- necropsy -- histopathology -- porcine -- non-porcine species -- natural infection -- experimental infection
    Subject code 630
    Language English
    Publishing date 2020-08-04
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Book ; Audio / Video ; Online: Porphyrie beim Wildschwein – ein Jäger sieht rot!

    Sehl, Julia* / Pfannenstiel, H. D. / Teifke, Jens Peter

    2020  

    Keywords Text ; ddc:630
    Language German
    Publishing date 2020-03-07
    Publishing country de
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: An improved animal model for herpesvirus encephalitis in humans.

    Sehl, Julia / Hölper, Julia E / Klupp, Barbara G / Baumbach, Christina / Teifke, Jens P / Mettenleiter, Thomas C

    PLoS pathogens

    2020  Volume 16, Issue 3, Page(s) e1008445

    Abstract: Herpesviral encephalitis caused by Herpes Simplex Virus 1 (HSV-1) is one of the most devastating diseases in humans. Patients present with fever, mental status changes or seizures and when untreated, sequelae can be fatal. Herpes Simplex Encephalitis ( ... ...

    Abstract Herpesviral encephalitis caused by Herpes Simplex Virus 1 (HSV-1) is one of the most devastating diseases in humans. Patients present with fever, mental status changes or seizures and when untreated, sequelae can be fatal. Herpes Simplex Encephalitis (HSE) is characterized by mainly unilateral necrotizing inflammation effacing the frontal and mesiotemporal lobes with rare involvement of the brainstem. HSV-1 is hypothesized to invade the CNS via the trigeminal or olfactory nerve, but viral tropism and the exact route of infection remain unclear. Several mouse models for HSE have been developed, but they mimic natural infection only inadequately. The porcine alphaherpesvirus Pseudorabies virus (PrV) is closely related to HSV-1 and Varicella Zoster Virus (VZV). While pigs can control productive infection, it is lethal in other susceptible animals associated with severe pruritus leading to automutilation. Here, we describe the first mutant PrV establishing productive infection in mice that the animals are able to control. After intranasal inoculation with a PrV mutant lacking tegument protein pUL21 and pUS3 kinase activity (PrV-ΔUL21/US3Δkin), nearly all mice survived despite extensive infection of the central nervous system. Neuroinvasion mainly occurred along the trigeminal pathway. Whereas trigeminal first and second order neurons and autonomic ganglia were positive early after intranasal infection, PrV-specific antigen was mainly detectable in the frontal, mesiotemporal and parietal lobes at later times, accompanied by a long lasting lymphohistiocytic meningoencephalitis. Despite this extensive infection, mice showed only mild to moderate clinical signs, developed alopecic skin lesions, or remained asymptomatic. Interestingly, most mice exhibited abnormalities in behavior and activity levels including slow movements, akinesia and stargazing. In summary, clinical signs, distribution of viral antigen and inflammatory pattern show striking analogies to human encephalitis caused by HSV-1 or VZV not observed in other animal models of disease.
    MeSH term(s) Animals ; Disease Models, Animal ; Encephalitis, Varicella Zoster/genetics ; Encephalitis, Varicella Zoster/metabolism ; Female ; Ganglia, Autonomic/metabolism ; Ganglia, Autonomic/pathology ; Ganglia, Autonomic/virology ; Herpes Simplex/genetics ; Herpes Simplex/metabolism ; Herpesvirus 1, Human/genetics ; Herpesvirus 1, Human/metabolism ; Herpesvirus 1, Suid/genetics ; Herpesvirus 1, Suid/metabolism ; Herpesvirus 3, Human/genetics ; Herpesvirus 3, Human/metabolism ; Humans ; Mice ; Neurons/metabolism ; Neurons/pathology ; Neurons/virology ; Pseudorabies/genetics ; Pseudorabies/metabolism ; Pseudorabies/pathology ; Swine
    Language English
    Publishing date 2020-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1008445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: T-cell responses in domestic pigs and wild boar upon infection with the moderately virulent African swine fever virus strain 'Estonia2014'.

    Schäfer, Alexander / Zani, Laura / Pikalo, Jutta / Hühr, Jane / Sehl, Julia / Mettenleiter, Thomas C / Breithaupt, Angele / Blome, Sandra / Blohm, Ulrike

    Transboundary and emerging diseases

    2021  Volume 68, Issue 5, Page(s) 2733–2749

    Abstract: Infection with African swine fever virus (ASFV) causes a highly lethal haemorrhagic disease in domestic and Eurasian wild pigs. Thus, it is a major threat to pig populations worldwide and a cause of substantial economic losses. Recently, less virulent ... ...

    Abstract Infection with African swine fever virus (ASFV) causes a highly lethal haemorrhagic disease in domestic and Eurasian wild pigs. Thus, it is a major threat to pig populations worldwide and a cause of substantial economic losses. Recently, less virulent ASFV strains emerged naturally, which showed higher experimental virulence in wild boar than in domestic pigs. The reason for this difference in disease progression and outcome is unclear but likely involves different immunological responses. Unfortunately, besides the importance of CD8α
    MeSH term(s) African Swine Fever ; African Swine Fever Virus ; Animals ; Sus scrofa ; Swine ; Swine Diseases ; T-Lymphocytes ; Virulence
    Language English
    Publishing date 2021-03-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2414822-2
    ISSN 1865-1682 ; 1865-1674
    ISSN (online) 1865-1682
    ISSN 1865-1674
    DOI 10.1111/tbed.14048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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