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  1. Article: Unsuspected large left ventricular pseudoaneurysm: rapid bedside diagnosis by contrast-enhanced echocardiography.

    Sehmi, Jobanpreet S / Dungu, Jason / Davies, Simon W / Khattar, Rajdeep / Senior, Roxy / Chahal, Navtej

    Oxford medical case reports

    2015  Volume 2015, Issue 11, Page(s) 358–359

    Language English
    Publishing date 2015-11-03
    Publishing country England
    Document type Case Reports
    ZDB-ID 2766251-2
    ISSN 2053-8855
    ISSN 2053-8855
    DOI 10.1093/omcr/omv062
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  2. Article ; Online: Automated Left Ventricular Dimension Assessment Using Artificial Intelligence Developed and Validated by a UK-Wide Collaborative.

    Howard, James P / Stowell, Catherine C / Cole, Graham D / Ananthan, Kajaluxy / Demetrescu, Camelia D / Pearce, Keith / Rajani, Ronak / Sehmi, Jobanpreet / Vimalesvaran, Kavitha / Kanaganayagam, G Sunthar / McPhail, Eleanor / Ghosh, Arjun K / Chambers, John B / Singh, Amar P / Zolgharni, Massoud / Rana, Bushra / Francis, Darrel P / Shun-Shin, Matthew J

    Circulation. Cardiovascular imaging

    2021  Volume 14, Issue 5, Page(s) e011951

    Abstract: Background: requires training and validation to standards expected of humans. We developed an online platform and established the Unity Collaborative to build a dataset of expertise from 17 hospitals for training, validation, and standardization of such ...

    Abstract Background: requires training and validation to standards expected of humans. We developed an online platform and established the Unity Collaborative to build a dataset of expertise from 17 hospitals for training, validation, and standardization of such techniques.
    Methods: The training dataset consisted of 2056 individual frames drawn at random from 1265 parasternal long-axis video-loops of patients undergoing clinical echocardiography in 2015 to 2016. Nine experts labeled these images using our online platform. From this, we trained a convolutional neural network to identify keypoints. Subsequently, 13 experts labeled a validation dataset of the end-systolic and end-diastolic frame from 100 new video-loops, twice each. The 26-opinion consensus was used as the reference standard. The primary outcome was precision SD, the SD of the differences between AI measurement and expert consensus.
    Results: In the validation dataset, the AI's precision SD for left ventricular internal dimension was 3.5 mm. For context, precision SD of individual expert measurements against the expert consensus was 4.4 mm. Intraclass correlation coefficient between AI and expert consensus was 0.926 (95% CI, 0.904-0.944), compared with 0.817 (0.778-0.954) between individual experts and expert consensus. For interventricular septum thickness, precision SD was 1.8 mm for AI (intraclass correlation coefficient, 0.809; 0.729-0.967), versus 2.0 mm for individuals (intraclass correlation coefficient, 0.641; 0.568-0.716). For posterior wall thickness, precision SD was 1.4 mm for AI (intraclass correlation coefficient, 0.535 [95% CI, 0.379-0.661]), versus 2.2 mm for individuals (0.366 [0.288-0.462]). We present all images and annotations. This highlights challenging cases, including poor image quality and tapered ventricles.
    Conclusions: Experts at multiple institutions successfully cooperated to build a collaborative AI. This performed as well as individual experts. Future echocardiographic AI research should use a consensus of experts as a reference. Our collaborative welcomes new partners who share our commitment to publish all methods, code, annotations, and results openly.
    Language English
    Publishing date 2021-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.120.011951
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  3. Article ; Online: The CXCL16 A181V mutation selectively inhibits monocyte adhesion to CXCR6 but is not associated with human coronary heart disease.

    Petit, Sarah J / Wise, Emma L / Chambers, John C / Sehmi, Jobanpreet / Chayen, Naomi E / Kooner, Jaspal S / Pease, James E

    Arteriosclerosis, thrombosis, and vascular biology

    2011  Volume 31, Issue 4, Page(s) 914–920

    Abstract: Objective: The chemokine CXCL16 serves as a scavenger receptor for oxidized low-density lipoprotein and as an adhesion molecule and chemoattractant for cells expressing the receptor CXCR6. A commonly occurring CXCL16 allele has been described containing ...

    Abstract Objective: The chemokine CXCL16 serves as a scavenger receptor for oxidized low-density lipoprotein and as an adhesion molecule and chemoattractant for cells expressing the receptor CXCR6. A commonly occurring CXCL16 allele has been described containing 2 nonsynonymous single-nucleotide polymorphisms in complete linkage disequilibrium, although the effects on CXCL16 function are unknown. Here, we examined the effect of the single-nucleotide polymorphisms on CXCL16 function and assessed the association of the mutant allele with coronary heart disease (CHD).
    Methods and results: Both wild-type and mutant T123V181-CXCL16 were readily expressed in vitro and were similarly functional in assays of oxidized low-density lipoprotein scavenging and chemotaxis. However, unlike wild-type CXCL16, T123V181-CXCL16 was unable to promote adhesion of CXCR6(+) cells. Findings were confirmed ex vivo, with monocytes from donors homozygous for the T123V181 allele unable to facilitate adhesion of CXCR6 transfectants. In the London Life Sciences Prospective Population cohort (n = 2797), we found that the T123V181 allele was not associated with protection or susceptibility to CHD (adjusted odds ratio, 1.01; 95% CI, 0.95 to 1.10; P = 0.74).
    Conclusions: CXCL16-mediated cell adhesion plays at best a modest role in CHD, and the scavenging and chemotactic properties of the chemokine are more likely to be more important in disease pathogenesis.
    MeSH term(s) Adult ; Aged ; Animals ; Case-Control Studies ; Cell Adhesion ; Chemokine CXCL16 ; Chemokines, CXC/genetics ; Chemokines, CXC/metabolism ; Chemotaxis ; Coculture Techniques ; Coronary Disease/genetics ; Coronary Disease/immunology ; Female ; Genetic Predisposition to Disease ; HEK293 Cells ; Homozygote ; Humans ; Lipoproteins, LDL/metabolism ; Logistic Models ; London ; Male ; Mice ; Middle Aged ; Monocytes/immunology ; Mutagenesis, Site-Directed ; Mutation ; Odds Ratio ; Phenotype ; Polymorphism, Single Nucleotide ; Prospective Studies ; Receptors, CXCR6 ; Receptors, Chemokine/genetics ; Receptors, Chemokine/metabolism ; Receptors, Scavenger/genetics ; Receptors, Scavenger/metabolism ; Receptors, Virus/genetics ; Receptors, Virus/metabolism ; Risk Assessment ; Risk Factors ; Time Factors ; Transfection
    Chemical Substances CXCL16 protein, human ; CXCR6 protein, human ; Chemokine CXCL16 ; Chemokines, CXC ; Lipoproteins, LDL ; Receptors, CXCR6 ; Receptors, Chemokine ; Receptors, Scavenger ; Receptors, Virus ; oxidized low density lipoprotein
    Language English
    Publishing date 2011-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.110.220558
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  4. Article: Variability in the concentrations of intravenous drug infusions prepared in a critical care unit.

    Wheeler, Daniel Wren / Degnan, Beverley Ann / Sehmi, Jobanpreet Singh / Burnstein, Rowan Margaret / Menon, David Krishna / Gupta, Arun Kumar

    Intensive care medicine

    2008  Volume 34, Issue 8, Page(s) 1441–1447

    Abstract: Objective: To quantify the variability in the concentration of drug infusions prepared on an intensive care unit and establish whether there was a relationship between the quality of syringe labeling and drug preparation.: Design: Audit carried out ... ...

    Abstract Objective: To quantify the variability in the concentration of drug infusions prepared on an intensive care unit and establish whether there was a relationship between the quality of syringe labeling and drug preparation.
    Design: Audit carried out over 3 weeks in May 2006 and completed in May 2007.
    Setting: The adult neurosciences critical care unit of a UK university teaching hospital.
    Interventions: Daily collections of discarded syringes containing midazolam, insulin, norepinephrine, dopamine, potassium or magnesium.
    Measurements and results: Residual solutions in the syringes were sampled and the concentrations measured. Syringe labels were inspected and awarded a score for labeling quality based on an 11-point scale. A total of 149 syringes were analyzed. Six of the magnesium syringes contained 4-5 times too much Mg(2+), presumably because of confusion about converting millimoles to grams. The majority of the other infusions differed from the expected concentration by more than 10%. Magnesium infusions were least likely to be properly labeled (p= 0.012), and there was a positive correlation between quality of syringe labeling and drug preparation (p=0.002). After the introduction of a new electrolyte prescription chart, magnesium and potassium preparation significantly improved but there was still substantial variability.
    Conclusions: These findings present a strong argument for the use of pre-prepared syringes or standardized drug preparation and labeling systems. They also highlight once again the difficulties healthcare professionals encounter when dealing with different ways of expressing drug concentrations.
    MeSH term(s) Anticonvulsants/administration & dosage ; Drug Labeling ; Electrolytes/administration & dosage ; Humans ; Infusions, Intravenous ; Intensive Care Units/statistics & numerical data ; Magnesium Sulfate/administration & dosage ; Medical Audit/methods ; Medical Audit/statistics & numerical data ; Medication Errors/prevention & control ; Medication Errors/statistics & numerical data ; Syringes ; United Kingdom
    Chemical Substances Anticonvulsants ; Electrolytes ; Magnesium Sulfate (7487-88-9)
    Language English
    Publishing date 2008-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0342-4642 ; 0340-0964 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0342-4642 ; 0340-0964 ; 0935-1701
    DOI 10.1007/s00134-008-1113-9
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  5. Article ; Online: 52 Genetic Loci Influencing Myocardial Mass.

    van der Harst, Pim / van Setten, Jessica / Verweij, Niek / Vogler, Georg / Franke, Lude / Maurano, Matthew T / Wang, Xinchen / Mateo Leach, Irene / Eijgelsheim, Mark / Sotoodehnia, Nona / Hayward, Caroline / Sorice, Rossella / Meirelles, Osorio / Lyytikäinen, Leo-Pekka / Polašek, Ozren / Tanaka, Toshiko / Arking, Dan E / Ulivi, Sheila / Trompet, Stella /
    Müller-Nurasyid, Martina / Smith, Albert V / Dörr, Marcus / Kerr, Kathleen F / Magnani, Jared W / Del Greco M, Fabiola / Zhang, Weihua / Nolte, Ilja M / Silva, Claudia T / Padmanabhan, Sandosh / Tragante, Vinicius / Esko, Tõnu / Abecasis, Gonçalo R / Adriaens, Michiel E / Andersen, Karl / Barnett, Phil / Bis, Joshua C / Bodmer, Rolf / Buckley, Brendan M / Campbell, Harry / Cannon, Megan V / Chakravarti, Aravinda / Chen, Lin Y / Delitala, Alessandro / Devereux, Richard B / Doevendans, Pieter A / Dominiczak, Anna F / Ferrucci, Luigi / Ford, Ian / Gieger, Christian / Harris, Tamara B / Haugen, Eric / Heinig, Matthias / Hernandez, Dena G / Hillege, Hans L / Hirschhorn, Joel N / Hofman, Albert / Hubner, Norbert / Hwang, Shih-Jen / Iorio, Annamaria / Kähönen, Mika / Kellis, Manolis / Kolcic, Ivana / Kooner, Ishminder K / Kooner, Jaspal S / Kors, Jan A / Lakatta, Edward G / Lage, Kasper / Launer, Lenore J / Levy, Daniel / Lundby, Alicia / Macfarlane, Peter W / May, Dalit / Meitinger, Thomas / Metspalu, Andres / Nappo, Stefania / Naitza, Silvia / Neph, Shane / Nord, Alex S / Nutile, Teresa / Okin, Peter M / Olsen, Jesper V / Oostra, Ben A / Penninger, Josef M / Pennacchio, Len A / Pers, Tune H / Perz, Siegfried / Peters, Annette / Pinto, Yigal M / Pfeufer, Arne / Pilia, Maria Grazia / Pramstaller, Peter P / Prins, Bram P / Raitakari, Olli T / Raychaudhuri, Soumya / Rice, Ken M / Rossin, Elizabeth J / Rotter, Jerome I / Schafer, Sebastian / Schlessinger, David / Schmidt, Carsten O / Sehmi, Jobanpreet / Silljé, Herman H W / Sinagra, Gianfranco / Sinner, Moritz F / Slowikowski, Kamil / Soliman, Elsayed Z / Spector, Timothy D / Spiering, Wilko / Stamatoyannopoulos, John A / Stolk, Ronald P / Strauch, Konstantin / Tan, Sian-Tsung / Tarasov, Kirill V / Trinh, Bosco / Uitterlinden, Andre G / van den Boogaard, Malou / van Duijn, Cornelia M / van Gilst, Wiek H / Viikari, Jorma S / Visscher, Peter M / Vitart, Veronique / Völker, Uwe / Waldenberger, Melanie / Weichenberger, Christian X / Westra, Harm-Jan / Wijmenga, Cisca / Wolffenbuttel, Bruce H / Yang, Jian / Bezzina, Connie R / Munroe, Patricia B / Snieder, Harold / Wright, Alan F / Rudan, Igor / Boyer, Laurie A / Asselbergs, Folkert W / van Veldhuisen, Dirk J / Stricker, Bruno H / Psaty, Bruce M / Ciullo, Marina / Sanna, Serena / Lehtimäki, Terho / Wilson, James F / Bandinelli, Stefania / Alonso, Alvaro / Gasparini, Paolo / Jukema, J Wouter / Kääb, Stefan / Gudnason, Vilmundur / Felix, Stephan B / Heckbert, Susan R / de Boer, Rudolf A / Newton-Cheh, Christopher / Hicks, Andrew A / Chambers, John C / Jamshidi, Yalda / Visel, Axel / Christoffels, Vincent M / Isaacs, Aaron / Samani, Nilesh J / de Bakker, Paul I W

    Journal of the American College of Cardiology

    2016  Volume 68, Issue 13, Page(s) 1435–1448

    Abstract: Background: Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). ... ...

    Abstract Background: Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death.
    Objectives: This meta-analysis sought to gain insights into the genetic determinants of myocardial mass.
    Methods: We carried out a genome-wide association meta-analysis of 4 QRS traits in up to 73,518 individuals of European ancestry, followed by extensive biological and functional assessment.
    Results: We identified 52 genomic loci, of which 32 are novel, that are reliably associated with 1 or more QRS phenotypes at p < 1 × 10(-8). These loci are enriched in regions of open chromatin, histone modifications, and transcription factor binding, suggesting that they represent regions of the genome that are actively transcribed in the human heart. Pathway analyses provided evidence that these loci play a role in cardiac hypertrophy. We further highlighted 67 candidate genes at the identified loci that are preferentially expressed in cardiac tissue and associated with cardiac abnormalities in Drosophila melanogaster and Mus musculus. We validated the regulatory function of a novel variant in the SCN5A/SCN10A locus in vitro and in vivo.
    Conclusions: Taken together, our findings provide new insights into genes and biological pathways controlling myocardial mass and may help identify novel therapeutic targets.
    MeSH term(s) Animals ; Cardiomegaly/genetics ; Genetic Loci ; Genome-Wide Association Study ; Humans
    Language English
    Publishing date 2016-09-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2016.07.729
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  6. Article ; Online: A Low-Frequency Inactivating

    Manning, Alisa / Highland, Heather M / Gasser, Jessica / Sim, Xueling / Tukiainen, Taru / Fontanillas, Pierre / Grarup, Niels / Rivas, Manuel A / Mahajan, Anubha / Locke, Adam E / Cingolani, Pablo / Pers, Tune H / Viñuela, Ana / Brown, Andrew A / Wu, Ying / Flannick, Jason / Fuchsberger, Christian / Gamazon, Eric R / Gaulton, Kyle J /
    Im, Hae Kyung / Teslovich, Tanya M / Blackwell, Thomas W / Bork-Jensen, Jette / Burtt, Noël P / Chen, Yuhui / Green, Todd / Hartl, Christopher / Kang, Hyun Min / Kumar, Ashish / Ladenvall, Claes / Ma, Clement / Moutsianas, Loukas / Pearson, Richard D / Perry, John R B / Rayner, N William / Robertson, Neil R / Scott, Laura J / van de Bunt, Martijn / Eriksson, Johan G / Jula, Antti / Koskinen, Seppo / Lehtimäki, Terho / Palotie, Aarno / Raitakari, Olli T / Jacobs, Suzanne B R / Wessel, Jennifer / Chu, Audrey Y / Scott, Robert A / Goodarzi, Mark O / Blancher, Christine / Buck, Gemma / Buck, David / Chines, Peter S / Gabriel, Stacey / Gjesing, Anette P / Groves, Christopher J / Hollensted, Mette / Huyghe, Jeroen R / Jackson, Anne U / Jun, Goo / Justesen, Johanne Marie / Mangino, Massimo / Murphy, Jacquelyn / Neville, Matt / Onofrio, Robert / Small, Kerrin S / Stringham, Heather M / Trakalo, Joseph / Banks, Eric / Carey, Jason / Carneiro, Mauricio O / DePristo, Mark / Farjoun, Yossi / Fennell, Timothy / Goldstein, Jacqueline I / Grant, George / Hrabé de Angelis, Martin / Maguire, Jared / Neale, Benjamin M / Poplin, Ryan / Purcell, Shaun / Schwarzmayr, Thomas / Shakir, Khalid / Smith, Joshua D / Strom, Tim M / Wieland, Thomas / Lindstrom, Jaana / Brandslund, Ivan / Christensen, Cramer / Surdulescu, Gabriela L / Lakka, Timo A / Doney, Alex S F / Nilsson, Peter / Wareham, Nicholas J / Langenberg, Claudia / Varga, Tibor V / Franks, Paul W / Rolandsson, Olov / Rosengren, Anders H / Farook, Vidya S / Thameem, Farook / Puppala, Sobha / Kumar, Satish / Lehman, Donna M / Jenkinson, Christopher P / Curran, Joanne E / Hale, Daniel Esten / Fowler, Sharon P / Arya, Rector / DeFronzo, Ralph A / Abboud, Hanna E / Syvänen, Ann-Christine / Hicks, Pamela J / Palmer, Nicholette D / Ng, Maggie C Y / Bowden, Donald W / Freedman, Barry I / Esko, Tõnu / Mägi, Reedik / Milani, Lili / Mihailov, Evelin / Metspalu, Andres / Narisu, Narisu / Kinnunen, Leena / Bonnycastle, Lori L / Swift, Amy / Pasko, Dorota / Wood, Andrew R / Fadista, João / Pollin, Toni I / Barzilai, Nir / Atzmon, Gil / Glaser, Benjamin / Thorand, Barbara / Strauch, Konstantin / Peters, Annette / Roden, Michael / Müller-Nurasyid, Martina / Liang, Liming / Kriebel, Jennifer / Illig, Thomas / Grallert, Harald / Gieger, Christian / Meisinger, Christa / Lannfelt, Lars / Musani, Solomon K / Griswold, Michael / Taylor, Herman A / Wilson, Gregory / Correa, Adolfo / Oksa, Heikki / Scott, William R / Afzal, Uzma / Tan, Sian-Tsung / Loh, Marie / Chambers, John C / Sehmi, Jobanpreet / Kooner, Jaspal Singh / Lehne, Benjamin / Cho, Yoon Shin / Lee, Jong-Young / Han, Bok-Ghee / Käräjämäki, Annemari / Qi, Qibin / Qi, Lu / Huang, Jinyan / Hu, Frank B / Melander, Olle / Orho-Melander, Marju / Below, Jennifer E / Aguilar, David / Wong, Tien Yin / Liu, Jianjun / Khor, Chiea-Chuen / Chia, Kee Seng / Lim, Wei Yen / Cheng, Ching-Yu / Chan, Edmund / Tai, E Shyong / Aung, Tin / Linneberg, Allan / Isomaa, Bo / Meitinger, Thomas / Tuomi, Tiinamaija / Hakaste, Liisa / Kravic, Jasmina / Jørgensen, Marit E / Lauritzen, Torsten / Deloukas, Panos / Stirrups, Kathleen E / Owen, Katharine R / Farmer, Andrew J / Frayling, Timothy M / O'Rahilly, Stephen P / Walker, Mark / Levy, Jonathan C / Hodgkiss, Dylan / Hattersley, Andrew T / Kuulasmaa, Teemu / Stančáková, Alena / Barroso, Inês / Bharadwaj, Dwaipayan / Chan, Juliana / Chandak, Giriraj R / Daly, Mark J / Donnelly, Peter J / Ebrahim, Shah B / Elliott, Paul / Fingerlin, Tasha / Froguel, Philippe / Hu, Cheng / Jia, Weiping / Ma, Ronald C W / McVean, Gilean / Park, Taesung / Prabhakaran, Dorairaj / Sandhu, Manjinder / Scott, James / Sladek, Rob / Tandon, Nikhil / Teo, Yik Ying / Zeggini, Eleftheria / Watanabe, Richard M / Koistinen, Heikki A / Kesaniemi, Y Antero / Uusitupa, Matti / Spector, Timothy D / Salomaa, Veikko / Rauramaa, Rainer / Palmer, Colin N A / Prokopenko, Inga / Morris, Andrew D / Bergman, Richard N / Collins, Francis S / Lind, Lars / Ingelsson, Erik / Tuomilehto, Jaakko / Karpe, Fredrik / Groop, Leif / Jørgensen, Torben / Hansen, Torben / Pedersen, Oluf / Kuusisto, Johanna / Abecasis, Gonçalo / Bell, Graeme I / Blangero, John / Cox, Nancy J / Duggirala, Ravindranath / Seielstad, Mark / Wilson, James G / Dupuis, Josee / Ripatti, Samuli / Hanis, Craig L / Florez, Jose C / Mohlke, Karen L / Meigs, James B / Laakso, Markku / Morris, Andrew P / Boehnke, Michael / Altshuler, David / McCarthy, Mark I / Gloyn, Anna L / Lindgren, Cecilia M

    Diabetes

    2017  Volume 66, Issue 7, Page(s) 2019–2032

    Abstract: To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together with an additional 390,225 variants ...

    Abstract To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together with an additional 390,225 variants from exome sequence in up to 39,339 normoglycemic individuals from five ancestry groups. We identified a novel association between the coding variant (p.Pro50Thr) in
    MeSH term(s) African Americans/genetics ; Alleles ; Asians/genetics ; Case-Control Studies ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Fasting/metabolism ; Finland ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Hispanic or Latino/genetics ; Humans ; Insulin/metabolism ; Insulin Resistance/genetics ; Odds Ratio ; Proto-Oncogene Proteins c-akt/genetics ; Whites/genetics
    Chemical Substances Insulin ; AKT2 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2017-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db16-1329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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