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  1. Book ; Online ; Thesis: T-Zellantwort nach Salmonella typhimurium-Infektion im Mausmodell

    Seibert, Sabine

    2007  

    Author's details vorgelegt von Sabine Seibert
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Techn. Univ., Diss--Berlin, 2007
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book ; Online ; Thesis: T-Zellantwort nach Salmonella typhimurium-Infektion im Mausmodell

    Seibert, Sabine [Verfasser]

    2007  

    Author's details vorgelegt von Sabine Seibert
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article ; Online: Acceptance of the extracare program by Beta interferon-treated patients with multiple sclerosis: results of the explore study.

    Freidel, Matthias / Ortler, Sonja / Fuchs, Alexander / Seibert, Sabine / Schuh, Katrin

    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses

    2015  Volume 47, Issue 1, Page(s) E31–9

    Abstract: Background: To gain full benefit from disease-modifying therapies such as interferon β-1b, patients with multiple sclerosis (MS) need to adhere to treatment in the long term. Treatment adherence requires high patient satisfaction with treatment and care. ...

    Abstract Background: To gain full benefit from disease-modifying therapies such as interferon β-1b, patients with multiple sclerosis (MS) need to adhere to treatment in the long term. Treatment adherence requires high patient satisfaction with treatment and care.
    Objectives: Our aim was to evaluate the satisfaction of patients with MS receiving interferon β-1b Extavia with the patient care program Extracare. Efficacy and safety of treatment were evaluated as secondary objectives.
    Methods: In this prospective, noninterventional 1-year study, data on the satisfaction of 174 patients with MS with Extracare were obtained by questionnaires. Disability and symptom severity as well as patients' reported activity limitations, quality of life, and fatigue were recorded.
    Results: We observed high levels of patients' satisfaction with MS nurses, telephonic care, and information provided by Extracare (values ≤ 1.53 on a Likert scale ranging from 1 [very good] to 6 [insufficient]). Patient reported quality of life (Patient Reported Indices for MS QoL) improved from 11.82 ± 11.36 at baseline to 9.74 ± 10.94 at the end of the study (p = .02), whereas clinical parameters of disease progression remained unchanged. Rate of adverse events was as expected.
    Conclusions: This study provides the basis for further improvements of care programs to increase treatment adherence of patients with MS.
    MeSH term(s) Adult ; Disability Evaluation ; Female ; House Calls ; Humans ; Interferon beta-1b/administration & dosage ; Longitudinal Studies ; Male ; Middle Aged ; Multiple Sclerosis/nursing ; Nurse-Patient Relations ; Nursing Assessment ; Patient Acceptance of Health Care ; Patient Education as Topic ; Prospective Studies ; Quality of Life ; Self Administration/nursing
    Chemical Substances Interferon beta-1b (145155-23-3)
    Language English
    Publishing date 2015-01-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632790-4
    ISSN 1945-2810 ; 0888-0395
    ISSN (online) 1945-2810
    ISSN 0888-0395
    DOI 10.1097/JNN.0000000000000100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1501: Show issues Location:
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  4. Article ; Online: Additivity, antagonism, and synergy in arsenic trioxide-induced growth inhibition of C6 glioma cells: effects of genistein, quercetin and buthionine-sulfoximine.

    Klauser, Ellen / Gülden, Michael / Maser, Edmund / Seibert, Sabine / Seibert, Hasso

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2014  Volume 67, Page(s) 212–221

    Abstract: Arsenic trioxide (ATO) induces clinical remission in acute promyelocytic leukemia and growth inhibition in various cancer cell lines in vitro. Recently, genistein and quercetin were reported to potentiate ATO-provoked apoptosis in leukemia and ... ...

    Abstract Arsenic trioxide (ATO) induces clinical remission in acute promyelocytic leukemia and growth inhibition in various cancer cell lines in vitro. Recently, genistein and quercetin were reported to potentiate ATO-provoked apoptosis in leukemia and hepatocellular carcinoma cells. Genistein acted via enhanced ROS generation and quercetin via glutathione depletion. Searching for potential strategies for the treatment of malignant gliomas in this study the capacity of these flavonoids to sensitize rat C6 astroglioma cells for the cytotoxic action of ATO was investigated. ATO inhibited cell growth in a concentration- and time-dependent manner. This effect was accompanied neither by enhanced radical generation nor lipid peroxidation and was not attributed to apoptosis. ATO treatment concentration-dependently increased glutathione levels. Genistein enhanced radical generation. Combined with ATO it inhibited cell growth additively. Additivity was also obtained after cotreatment with ATO and H2O2. Quercetin acted antagonistically on ATO-induced growth inhibition. Quercetin increased glutathione levels. In contrast, buthionine-sulfoximine (BSO) depleted cellular glutathione and acted synergistically with ATO. In conclusion, in C6 cells neither genistein nor quercetin are suited as sensitizing agent, in contrast to BSO. Depletion of cellular glutathione content rather than an increase of ROS generation plays a central role in the enhancement of ATO-toxicity in C6 cells.
    MeSH term(s) Animals ; Arsenicals ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Buthionine Sulfoximine/pharmacology ; Cell Division/drug effects ; Cell Line, Tumor ; Genistein/pharmacology ; Glioma/metabolism ; Glioma/pathology ; Oxides/toxicity ; Quercetin/pharmacology ; Rats
    Chemical Substances Arsenicals ; Oxides ; Buthionine Sulfoximine (5072-26-4) ; Quercetin (9IKM0I5T1E) ; Genistein (DH2M523P0H) ; arsenic trioxide (S7V92P67HO)
    Language English
    Publishing date 2014-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2014.02.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 529: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Cytoprotective activity against peroxide-induced oxidative damage and cytotoxicity of flavonoids in C6 rat glioma cells.

    Seibert, Hasso / Maser, Edmund / Schweda, Kathrin / Seibert, Sabine / Gülden, Michael

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2011  Volume 49, Issue 9, Page(s) 2398–2407

    Abstract: The aim of this study was to investigate the relationship between cytoprotective and cytotoxic activities of selected plant flavonoids in C6 glioma cells. Apigenin, kaempferol, luteolin, and quercetin were cytotoxic at low μM concentrations (LOECs: 5-20 ... ...

    Abstract The aim of this study was to investigate the relationship between cytoprotective and cytotoxic activities of selected plant flavonoids in C6 glioma cells. Apigenin, kaempferol, luteolin, and quercetin were cytotoxic at low μM concentrations (LOECs: 5-20 μM), whereas myricetin was less toxic (LOEC>20 μM). Cytotoxicity was not due to H(2)O(2) generation from flavonoids in culture medium. Quercetin, luteolin, and kaempferol protected the cells from peroxide-induced cytotoxicity. Concentration-effect curves for cytoprotection had a biphasic shape. In contrast, apigenin and myricetin did not exhibit any cytoprotective activity. The first three compounds also inhibited cellular lipid peroxidation induced by CHP, while the latter were ineffective. Importantly, concentrations of luteolin and kaempferol protecting cells under oxidative stress were identical to those causing cell damage under normal conditions. Only in case of quercetin there was a narrow range of concentrations protecting cells without being cytotoxic to non-stressed cells. Thus, even for flavonoids with a high antioxidant capacity in cell-free systems the cytoprotective selectivity (LOEC(cytotox)/LOEC(cytoprot)) was very low or even absent. These results should be taken into account when the prophylactic or therapeutic application of flavonoids as antioxidants is discussed.
    MeSH term(s) Animals ; Antineoplastic Agents, Phytogenic/toxicity ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Flavonoids/toxicity ; Glioma/metabolism ; Glioma/pathology ; Hydrogen Peroxide/toxicity ; Lipid Peroxidation ; Oxidative Stress ; Rats
    Chemical Substances Antineoplastic Agents, Phytogenic ; Flavonoids ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2011-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2011.06.055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 529: Show issues Location:
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  6. Article: Cytoprotective activity against peroxide-induced oxidative damage and cytotoxicity of flavonoids in C6 rat glioma cells

    Seibert, Hasso / Maser, Edmund / Schweda, Kathrin / Seibert, Sabine / Gülden, Michael

    Food and chemical toxicology. 2011 Sept., v. 49, no. 9

    2011  

    Abstract: The aim of this study was to investigate the relationship between cytoprotective and cytotoxic activities of selected plant flavonoids in C6 glioma cells. Apigenin, kaempferol, luteolin, and quercetin were cytotoxic at low μM concentrations (LOECs: 5– ... ...

    Abstract The aim of this study was to investigate the relationship between cytoprotective and cytotoxic activities of selected plant flavonoids in C6 glioma cells. Apigenin, kaempferol, luteolin, and quercetin were cytotoxic at low μM concentrations (LOECs: 5–20μM), whereas myricetin was less toxic (LOEC>20μM). Cytotoxicity was not due to H₂O₂ generation from flavonoids in culture medium. Quercetin, luteolin, and kaempferol protected the cells from peroxide-induced cytotoxicity. Concentration-effect curves for cytoprotection had a biphasic shape. In contrast, apigenin and myricetin did not exhibit any cytoprotective activity. The first three compounds also inhibited cellular lipid peroxidation induced by CHP, while the latter were ineffective. Importantly, concentrations of luteolin and kaempferol protecting cells under oxidative stress were identical to those causing cell damage under normal conditions. Only in case of quercetin there was a narrow range of concentrations protecting cells without being cytotoxic to non-stressed cells. Thus, even for flavonoids with a high antioxidant capacity in cell-free systems the cytoprotective selectivity (LOECcyₜₒₜₒₓ/LOECcyₜₒₚᵣₒₜ) was very low or even absent. These results should be taken into account when the prophylactic or therapeutic application of flavonoids as antioxidants is discussed.
    Keywords antioxidant activity ; antioxidants ; apigenin ; culture media ; cytotoxicity ; hydrogen peroxide ; kaempferol ; lipid peroxidation ; luteolin ; myricetin ; oxidative stress ; quercetin ; rats ; toxicology
    Language English
    Dates of publication 2011-09
    Size p. 2398-2407.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2011.06.055
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4035: Show issues

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  7. Article: Die Bewegungsbaustelle - ein Angebot für Kinder mit Behinderungen? Bericht über einen Projekttag in einem Förderkindergarten der Lebenshilfe in Mainz

    Hecklau-Seibert, Sabine

    Zeitschrift für Heilpädagogik

    2000  Volume 51, Issue 4, Page(s) 160–165

    Abstract: Es wird über die Durchführung der Bewegungsbaustelle in einem Förderkindergarten berichtet. Die Grundidee der Bewegungsbaustelle entspricht den Vorstellungen, die sich nach dem Paradigmawechsel in der Frühförderung durchgesetzt haben. Das Kind wird als ... ...

    Title translation The movement construction site: Movement education for disabled preschool-age children
    Abstract Es wird über die Durchführung der Bewegungsbaustelle in einem Förderkindergarten berichtet. Die Grundidee der Bewegungsbaustelle entspricht den Vorstellungen, die sich nach dem Paradigmawechsel in der Frühförderung durchgesetzt haben. Das Kind wird als Subjekt und als Akteur seiner eigenen Entwicklung betrachtet. Diese Grundannahme nimmt auch in dem Konzept Bewegen und Bauen eine zentrale Stellung ein. Es bietet in besonderem Maße die Möglichkeit, die im Kind innewohnenden Potenziale zu entfalten, sein Handlungsrepertoire zu erweitern und sein Selbstbewusstsein zu stärken. Durch offene Lernsituationen, wie sie die Bewegungsbaustelle bietet, werden Autonomie und Selbsttätigkeit gefordert und gefördert. Die Erfahrungen bei der Durchführung zeigen, dass die Bewegungsbaustelle auch für Kinder mit Behinderungen ein geeignetes Lernfeld darstellt.
    Keywords Children's Games ; Early Intervention ; Freizeit- und Erholungsspiele bei Kindern ; Frühförderung ; Förderunterricht ; Individualisierter Unterricht ; Individualized Instruction ; Kindergartenerziehung ; Perceptual Motor Processes ; Preschool Education ; Remedial Education ; Sensumotorische Prozesse
    Language German
    Document type Article
    ZDB-ID 202900-5
    ISSN 0513-9066
    ISSN 0513-9066
    Database PSYNDEX

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5762: Show issues Location:
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  8. Article ; Online: TLR2-, TLR4- and Myd88-independent acquired humoral and cellular immunity against Salmonella enterica serovar Typhimurium.

    Seibert, Sabine A / Mex, Peggy / Köhler, Anne / Kaufmann, Stefan H E / Mittrücker, Hans-Willi

    Immunology letters

    2010  Volume 127, Issue 2, Page(s) 126–134

    Abstract: Toll-like receptors (TLR) are central to pathogen recognition by the innate immune system. However, their role in the generation of acquired immunity is less clear. Using experimental Salmonella enterica serovar Typhimurium (ST) infection of mice, we ... ...

    Abstract Toll-like receptors (TLR) are central to pathogen recognition by the innate immune system. However, their role in the generation of acquired immunity is less clear. Using experimental Salmonella enterica serovar Typhimurium (ST) infection of mice, we determined the role of TLR2, TLR4 and of the TLR adaptor protein Myeloid differentiation factor 88 (MyD88) in the generation of specific T- and B-cell responses against this pathogen. When infected with an attenuated ST strain, mice deficient in TLR4, TLR2 plus TLR4 or MyD88 suffered from exacerbated bacterial burden and delayed clearance. However, all mutant mice not only survived infection but also generated normal antibody responses. Compared to wild-type mice, TLR2+4 deficient mice displayed even enhanced CD4(+) T(H)1 and CD8(+) T cell responses. In contrast, T-cell responses in TLR2 deficient and MyD88 deficient mice were similar to those observed in wild-type controls. Overall, T- and B-cell responses were functional and provided protection against a challenge infection with virulent ST. Our results demonstrate that in the ST infection model, MyD88 as well as TLR2 and TLR4 were largely dispensable for the induction of protective acquired immunity.
    MeSH term(s) Animals ; Antibodies, Bacterial/blood ; Cell Separation ; Cells, Cultured ; Cytokines/biosynthesis ; Flow Cytometry ; Immunity, Cellular ; Immunity, Humoral ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/immunology ; Myeloid Differentiation Factor 88/metabolism ; Salmonella Infections, Animal/blood ; Salmonella Infections, Animal/immunology ; Salmonella enterica/immunology ; Salmonella enterica/pathogenicity ; Spleen/immunology ; Spleen/metabolism ; Spleen/microbiology ; Spleen/pathology ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 2/immunology ; Toll-Like Receptor 2/metabolism ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/immunology ; Toll-Like Receptor 4/metabolism ; Virulence
    Chemical Substances Antibodies, Bacterial ; Cytokines ; Myeloid Differentiation Factor 88 ; Tlr2 protein, mouse ; Tlr4 protein, mouse ; Toll-Like Receptor 2 ; Toll-Like Receptor 4
    Language English
    Publishing date 2010-01-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2009.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1512: Show issues Location:
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  9. Book ; Thesis: Effizienzüberprüfung psychomotorischer Fördermaßnahmen bei Kindern mit "minimaler cerebraler Dysfunktion"

    Hecklau-Seibert, Sabine

    (Europäische Hochschulschriften : Reihe 6, Psychologie ; 316)

    1990  

    Author's details Sabine Hecklau-Seibert
    Series title Europäische Hochschulschriften : Reihe 6, Psychologie ; 316
    Keywords Teilleistungsschwäche ; Psychomotorische Übungsbehandlung ; Therapieerfolg
    Language Undetermined
    Size IV, 220 S, graph. Darst
    Publisher Lang
    Publishing place Frankfurt am Main
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zugl.: Frankfurt (Main), Univ., Diss. : 1990
    Note Originally presented as the author's thesis (doctoral--Universität Frankfurt a.M., 1990)
    ISBN 3631433204 ; 9783631433201
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Thesis ; Book: Effizienzüberprüfung psychomotorischer Fördermassnahmen bei Kindern mit "minimaler cerebraler Dysfunktion"

    Hecklau-Seibert, Sabine

    (Europäische Hochschulschriften: Reihe 6; 316)

    1990  

    Author's details Sabine Hecklau-Seibert
    Series title Europäische Hochschulschriften: Reihe 6; 316
    Keywords Psychomotorische Übungsbehandlung ; Teilleistungsschwäche ; Therapieerfolg
    Size IV, 220 Seiten: graphische Darstellungen
    Publisher Lang; Frankfurt am Main [u.a.]
    Document type Thesis ; Book
    Thesis / German Habilitation thesis zugleich: Frankfurt (Main), Universität, Dissertation, 1990
    HBZ-ID HT003745643
    ISBN 3-631-43320-4 ; 978-3-631-43320-1
    Database Central Library of Sport Science of the German Sport University Cologne

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