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  1. Article ; Online: Fecal microbiota transplantation in autoimmune diseases - An extensive paper on a pathogenetic therapy.

    Seida, Isa / Al Shawaf, Maisam / Mahroum, Naim

    Autoimmunity reviews

    2024  , Page(s) 103541

    Abstract: The role of infections in the pathogenesis of autoimmune diseases has long been recognized and reported. In addition to infectious agents, the internal composition of the "friendly" living bacteria, (microbiome) and its correlation to immune balance and ... ...

    Abstract The role of infections in the pathogenesis of autoimmune diseases has long been recognized and reported. In addition to infectious agents, the internal composition of the "friendly" living bacteria, (microbiome) and its correlation to immune balance and dysregulation have drawn the attention of researchers for decades. Nevertheless, only recently, scientific papers regarding the potential role of transferring microbiome from healthy donor subjects to patients with autoimmune diseases has been proposed. Fecal microbiota transplantation or FMT, carries the logic of transferring microorganisms responsible for immune balance from healthy donors to individuals with immune dysregulation or more accurately for our paper, autoimmune diseases. Viewing the microbiome as a pathogenetic player allows us to consider FMT as a pathogenetic-based treatment. Promising results alongside improved outcomes have been demonstrated in patients with different autoimmune diseases following FMT. Therefore, in our current extensive review, we aimed to highlight the implication of FMT in various autoimmune diseases, such as inflammatory bowel disease, autoimmune thyroid and liver diseases, systemic lupus erythematosus, and type 1 diabetes mellitus, among others. Presenting all the aspects of FMT in more than 12 autoimmune diseases in one paper, to the best of our knowledge, is the first time presented in medical literature. Viewing FMT as such could contribute to better understanding and newer application of the model in the therapy of autoimmune diseases, indeed.
    Language English
    Publishing date 2024-04-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2024.103541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5913: Show issues Location:
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  2. Article ; Online: Post Trauma Acinetobacter Baumanii Meningitis Treatment Approach.

    Erdoğan, Cem / Balcioglu, Zeynep Betul / Seida, Isa / Kizilaslan, Denız

    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

    2024  Volume 30, Issue 3, Page(s) 221–225

    Abstract: A. baumannii, which is said to be associated with nosocomial infections is considered a significant mortality risk if not adequately addressed. A. baumannii infections typically occur in the aftermath of surgery or trauma. Our patient developed ... ...

    Title translation Post Travmatik Hastada Acinetobacter Baumanii Menenjit Tedavi Yönetimi.
    Abstract A. baumannii, which is said to be associated with nosocomial infections is considered a significant mortality risk if not adequately addressed. A. baumannii infections typically occur in the aftermath of surgery or trauma. Our patient developed complicated A. baumannii meningitis with lateral ventriculitis and a lumbar abscess post surgery after suffering from a fall. The patient was treated with a 21-day regimen of intrathecally administered colistin and polymyxin B. Following this therapeutic period, the patient's condition improved, ultimately leading to successful recovery and subsequent discharge. This case report serves to highlight the ability of intrathecal administration of antibiotics, that normally have limited potential of crossing the blood-brain-barrier, to lead to improved survival outcomes in multi-drug resistant nosocomial meningitis.
    MeSH term(s) Humans ; Meningitis, Bacterial/drug therapy ; Acinetobacter Infections/drug therapy ; Acinetobacter baumannii ; Anti-Bacterial Agents/therapeutic use ; Colistin/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Colistin (Z67X93HJG1)
    Language English
    Publishing date 2024-03-20
    Publishing country Turkey
    Document type Case Reports
    ZDB-ID 2253739-9
    ISSN 1307-7945 ; 1306-696X
    ISSN (online) 1307-7945
    ISSN 1306-696X
    DOI 10.14744/tjtes.2024.65051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vaccines and Autoimmunity-From Side Effects to ASIA Syndrome.

    Seida, Isa / Seida, Ravend / Elsalti, Abdulrahman / Mahroum, Naim

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 2

    Abstract: Since vaccines are in fact manufactured chemical compounds such as drugs, the appearance of side effects following their use is not surprising. Similarly, as the main goal of vaccines is to stimulate the immune system bringing out the production of ... ...

    Abstract Since vaccines are in fact manufactured chemical compounds such as drugs, the appearance of side effects following their use is not surprising. Similarly, as the main goal of vaccines is to stimulate the immune system bringing out the production of protective antibodies, autoimmune-related side effects as a consequence of increased immune activity do not seem irrational. Fortunately, the rate of such side effects is low; however, the importance of reporting adverse events following vaccinations, understanding the mechanisms behind their appearance, making early diagnosis, and appropriate treatment cannot be overemphasized. In fact, autoimmune-related side effects of vaccines, particularly those based on adjuvants, were reported long before the introduction of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Nevertheless, ASIA gathered and united the side effects of vaccines under one title, a step which helped organize the research and call for better immune stimulators than adjuvants. New technologies and methods of making vaccines were clearly noticed during the pandemic of COVID-19 after the introduction of mRNA-based vaccines. In our current paper, we introduce the notion of side effects to vaccines, particularly those of autoimmune nature, the mechanisms of ASIA, and the main vaccines linked with the syndrome including the recent COVID-19 vaccines. The transition from side effects to ASIA is the main idea behind our work.
    MeSH term(s) Humans ; Adjuvants, Immunologic/adverse effects ; Autoimmune Diseases ; Autoimmunity ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Drug-Related Side Effects and Adverse Reactions ; mRNA Vaccines ; Syndrome ; Vaccines/adverse effects
    Chemical Substances Adjuvants, Immunologic ; COVID-19 Vaccines ; mRNA Vaccines ; Vaccines
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59020364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The COVID-19 pandemic - How many times were we warned before?

    Mahroum, Naim / Seida, Isa / Esirgün, Sevval Nil / Bragazzi, Nicola Luigi

    European journal of internal medicine

    2022  Volume 105, Page(s) 8–14

    Abstract: Infectious diseases are known to act in both predictable and unpredictable ways, which leads to the notions of emerging and reemerging infectious diseases. Emerging diseases with their disastrous consequences might be surprising and unpredictable, but ... ...

    Abstract Infectious diseases are known to act in both predictable and unpredictable ways, which leads to the notions of emerging and reemerging infectious diseases. Emerging diseases with their disastrous consequences might be surprising and unpredictable, but they could be foreseen. For instance, some emerging diseases and recently the coronavirus disease 2019 (COVID-19) were the reason for papers published by the World Health Organization (WHO) and other researchers addressing the likely pathogens causing future outbreaks, according to the reports of the WHO in 2016 and 2018. Although it might seem like a wisdom in retrospect, several studies had already indicated possible future outbreaks caused by coronaviruses. Announcements, which may be viewed as "warnings," appeared since the emergence of the first coronavirus-related outbreak caused by severe acute respiratory syndrome coronavirus (SARS-CoV) in the winter of 2002-2003 and a later outbreak caused by the Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012-2013. Therefore, we were curious to review the medical literature prior to the COVID-19 pandemic with an aim to enumerate and evaluate studies addressing and warning against future outbreaks, and surprisingly pandemics, of members of coronaviruses. Interestingly, we found numerous studies that correctly predicted the current pandemic of COVID-19. While this part is highly interesting, how authorities reacted and prepared for warnings, if any, and how will they get prepared for the next warnings are our main messages. Taking these points into serious consideration will certainly aid in analyzing reports regarding possible future outbreaks as well as in developing various strategies for prevention and coping with such epidemics.
    MeSH term(s) Humans ; Pandemics/prevention & control ; COVID-19 ; SARS-CoV-2 ; Middle East Respiratory Syndrome Coronavirus ; SARS Virus
    Language English
    Publishing date 2022-07-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2022.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications.

    Seida, Isa / Alrais, Mahmoud / Seida, Ravend / Alwani, Abdulkarim / Kiyak, Zeynep / Elsalti, Abdulrahman / Nil Esirgun, Sevval / Abali, Tunahan / Mahroum, Naim

    Clinical and experimental immunology

    2023  Volume 213, Issue 1, Page(s) 87–101

    Abstract: Adjuvants, as the name indicates, are adjoined material aimed to assist in functioning as when added to vaccines they are meant to boost the effect and strongly stimulate the immune system. The response of the immune system can be unpredictable, and the ... ...

    Abstract Adjuvants, as the name indicates, are adjoined material aimed to assist in functioning as when added to vaccines they are meant to boost the effect and strongly stimulate the immune system. The response of the immune system can be unpredictable, and the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was developed to address possible adverse reactions of an autoimmune and inflammatory type that may be caused by adjuvants. While ASIA, as a syndrome, was coined and defined in 2011; reports describing patients with vague and nonspecific clinical symptoms following vaccinations appeared much earlier. In other words, ASIA came to define, arrange, and unite the variety of symptoms, related to autoimmunity, caused not by the vaccine itself, rather by the adjuvant part of the vaccine such as aluminum, among others. Accordingly, the introduction of ASIA enabled better understanding, proper diagnosis, and early treatment of the disorder. Furthermore, ASIA was shown to be associated with almost all body systems and various rheumatic and autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, and systemic sclerosis. In addition, the correlation between COVID-19 and ASIA was noticed during the pandemic. In this review, we summarized the reported effects of adjuvants and medical literature before and after ASIA was defined, the several ways ASIA can manifest and impact different systems of the body, and the incidences of ASIA during the COVID-19 pandemic. It is important to clarify, that vaccines are among, if not the, most effective means of fighting infectious diseases however, we believe that vaccines manufacturing is not above criticism, particularly when it comes to added substances possessing a risk of side effects.
    MeSH term(s) Humans ; Pandemics ; COVID-19/epidemiology ; Autoimmune Diseases/epidemiology ; Autoimmune Diseases/etiology ; Adjuvants, Immunologic/adverse effects ; Vaccines/adverse effects
    Chemical Substances Adjuvants, Immunologic ; Vaccines
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1093/cei/uxad033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 337: Show issues Location:
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  6. Article ; Online: The mosaic of autoimmunity - Finally discussing in person. The 13

    Mahroum, Naim / Elsalti, Abdulrahman / Alwani, Abdulkarim / Seida, Isa / Alrais, Mahmoud / Seida, Ravend / Esirgun, Sevval Nil / Abali, Tunahan / Kiyak, Zeynep / Zoubi, Magdi / Shoenfeld, Yehuda

    Autoimmunity reviews

    2022  Volume 21, Issue 10, Page(s) 103166

    Abstract: While autoimmunity is a branch of medicine linked to every single organ system via direct and indirect pathways, meeting in person to discuss autoimmunity during the ... ...

    Abstract While autoimmunity is a branch of medicine linked to every single organ system via direct and indirect pathways, meeting in person to discuss autoimmunity during the 13
    MeSH term(s) Autoantibodies ; Autoimmune Diseases/therapy ; Autoimmunity ; COVID-19 ; COVID-19 Vaccines/therapeutic use ; Humans ; Immunosuppressive Agents ; SARS-CoV-2
    Chemical Substances Autoantibodies ; COVID-19 Vaccines ; Immunosuppressive Agents
    Language English
    Publishing date 2022-08-04
    Publishing country Netherlands
    Document type Congress ; Editorial
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2022.103166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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