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Book ; Thesis: Der Einfluss einer ayurvedischen Panchakarma-Kur auf die vegetative Regulation des menschlichen Organismus

Seidel, Larisa

eine Pilotstudie an Patienten eines Ayurveda-Kurhotels in Deutschland

2019

Author's details	vorgelegt 2019 von Larisa Seidel, geb. Dodonova
Language	German
Size	X, 145 Blätter, Illustrationen, Diagramme, 30 cm
Publishing place	Freiburg im Breisgau
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Albert-Ludwigs-Universität Freiburg im Breisgau, 2019
HBZ-ID	HT020469332
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Article ; Online: The complexity of providing behavioral healthcare in assisted living.

Cortes, Tara A / Seidel, Liz

Geriatric nursing (New York, N.Y.)

2023 Volume 54, Page(s) 369–370

Language	English
Publishing date	2023-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	632559-2
ISSN	1528-3984 ; 0197-4572
ISSN (online)	1528-3984
ISSN	0197-4572
DOI	10.1016/j.gerinurse.2023.10.010
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Article ; Online: Hybrid Anomaly Detection in Time Series by Combining Kalman Filters and Machine Learning Models.

Puder, Andreas / Zink, Moritz / Seidel, Luca / Sax, Eric

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 9

Abstract: Due to connectivity and automation trends, the medical device industry is experiencing increased demand for safety and security mechanisms. Anomaly detection has proven to be a valuable approach for ensuring safety and security in other industries, such ... ...

Abstract	Due to connectivity and automation trends, the medical device industry is experiencing increased demand for safety and security mechanisms. Anomaly detection has proven to be a valuable approach for ensuring safety and security in other industries, such as automotive or IT. Medical devices must operate across a wide range of values due to variations in patient anthropometric data, making anomaly detection based on a simple threshold for signal deviations impractical. For example, surgical robots directly contacting the patient's tissue require precise sensor data. However, since the deformation of the patient's body during interaction or movement is highly dependent on body mass, it is impossible to define a single threshold for implausible sensor data that applies to all patients. This also involves statistical methods, such as Z-score, that consider standard deviation. Even pure machine learning algorithms cannot be expected to provide the required accuracy simply due to the lack of available training data. This paper proposes using hybrid filters by combining dynamic system models based on expert knowledge and data-based models for anomaly detection in an operating room scenario. This approach can improve detection performance and explainability while reducing the computing resources needed on embedded devices, enabling a distributed approach to anomaly detection.
MeSH term(s)	Machine Learning ; Humans ; Algorithms
Language	English
Publishing date	2024-05-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24092895
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Article ; Online: Enduring education and employment: Examining motivation and mechanisms of psychological resilience.

Seidel, Laura / Cawley, Elizabeth Irene / Blanchard, Céline

Scandinavian journal of psychology

2024

Abstract: Resilience, the ability to bounce back from difficult events, is critical for an individual to negotiate stressors and adversity. Despite being widely studied, little is known about the processes involved in the development of resilience. The goal of the ...

Abstract	Resilience, the ability to bounce back from difficult events, is critical for an individual to negotiate stressors and adversity. Despite being widely studied, little is known about the processes involved in the development of resilience. The goal of the studies are to investigate the relationship between motivation orientation, emotional intelligence, cognitive appraisals, and psychological resilience. Two studies, using self-report questionnaires were conducted with employed young adults also enrolled in post-secondary studies (pre- and during the pandemic) to test the tenability of our proposed models. Study 1 and Study 2 showed that emotional intelligence and challenge appraisals were mediators of autonomous motivation and resilience. Study 2 revealed statistically significant differences in mean scores of autonomous motivation and emotional intelligence between non-pandemic students and pandemic students. Based on the findings, it is suggested that autonomous motivation, emotional intelligence, and challenge appraisals are important aptitudes for the development of resilience. Furthermore, findings suggest that social isolation caused by the pandemic may have affected levels of emotional intelligence. Ultimately, the research expands the literature on both self-determination theory and resilience by offering a unique multiple mediation model for predicting the development of resilience within the employed undergraduate population.
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	219197-0
ISSN	1467-9450 ; 0036-5564
ISSN (online)	1467-9450
ISSN	0036-5564
DOI	10.1111/sjop.13007
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Article: Clinical Features and Survival of Multiple Primary Melanoma: A Belgian Single Center Cohort.

Absil, G / Collins, P / Seidel, L / Damsin, T / Nikkels, A F

Dermatology and therapy

2023 Volume 13, Issue 2, Page(s) 641–649

Abstract: Introduction: It remains unclear whether multiple primary melanoma (MPM) patients have a worse survival prognosis compared with single primary melanoma (SPM) patients.: Objectives: To investigate the demographics, histological features, and survival ... ...

Abstract	Introduction: It remains unclear whether multiple primary melanoma (MPM) patients have a worse survival prognosis compared with single primary melanoma (SPM) patients. Objectives: To investigate the demographics, histological features, and survival of MPM versus SPM patients. Methods: Cox regression analyses compared survival between SPM and MPM patients. Furthermore, demographics and histological features of the MPM cohort were compared with the SPM patients retrieved from dermatopathology files between 2000 and 2019. Results: Out of 3853 melanoma patients, 95 MPM patients were retrieved: 81 with two primary melanomas (85.2%) and 14.8% with three or more. Mean Breslow of the first melanoma was 0.84 mm [minimum (min): 0 mm, maximum (max): 16 mm, standard deviation (SD) 1.77] versus 0.37 mm (second MPM) (min: 0 mm, max: 2.5 mm, SD 0.50) and 0.33 mm (third MPM) (min: 0 mm, max: 0.6 mm, SD 0.22). The mean Breslow for the second MPM was significantly higher for men than women (0.59 mm versus 0.27 mm). First and second melanoma in MPM patients developed on preexisting melanocytic nevi in 13% and 12%, respectively. In contrast with the mean age of primary melanoma in Belgium for women (58.2 years) and men (63.3 years), MPM patients developed their first melanoma earlier, at 44.8 years and 54.6 years, respectively. The mean distribution of anatomical localization of primary and secondary melanoma was highly similar in women, whereas in men a shift towards lower extremities was observed (19% versus 28%). The thicker the primary melanoma was, the sooner the second appeared. Follow-up (2-4/year) versus (1/year) yielded a mean Breslow of 0.29 mm and 0.55 mm, respectively. Cox regression analysis with time-varying covariate revealed a tendency for a worse prognosis in 5-year survival rates, but this was not statistically significant (p = 0.09). Patient phenotypes were not available on the histological reports. Conclusion: A closer follow-up regimen of MPM versus SPM patients is probably justified.
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2680284-3
ISSN	2190-9172 ; 2193-8210
ISSN (online)	2190-9172
ISSN	2193-8210
DOI	10.1007/s13555-022-00884-x
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Article ; Online: Clinical usefulness of quantitative thermal sensory testing in the diagnosis and surgical treatment of women with pudendal neuropathy.

Beco, Jacques / Seidel, Laurence / Albert, Adelin

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2023 Volume 44, Issue 7, Page(s) 2517–2526

Abstract: Background: The aim of this study, conducted on women with pudendal neuropathy, was to evaluate the usefulness of quantitative thermal sensory testing (QTST) in the diagnosis, surgical management, and prognosis of the disease.: Methods: The study was ...

Abstract	Background: The aim of this study, conducted on women with pudendal neuropathy, was to evaluate the usefulness of quantitative thermal sensory testing (QTST) in the diagnosis, surgical management, and prognosis of the disease. Methods: The study was conducted on 90 women with pudendal neuropathy. QTST in pudendal nerve sensory innervation territory was realized before and more than 24 months after operative pudendoscopy on most patients. Cold and warm thresholds were evaluated together with a search for qualitative anomalies. The diagnostic value of QTST was assessed by comparing baseline data with normative values previously derived from 41 presumably healthy women. The effect of operative pudendoscopy on thermal sensitivity was tested by comparing preoperative and postoperative measurements. Assessment of the long-term prognostic value of QTST was based on "surgical success" defined as a VAS pain level less than 4 at least 2 years after surgery. Results: The existence of qualitative anomalies, like anesthesia, allodynia, dysesthesia, radiation, and dyslocalization, was clearly indicative of pudendal neuropathy. The presence of after sensation and "out of limit" values of skin temperature and cold detection threshold were also helpful for diagnosing the disease. Surgery reduced qualitative anomalies but had no positive effect on QTST thresholds. QTST measurements had no real prognostic value but other factors like constipation and abnormal perineal descent were predictive of surgical success. Conclusion: For women with pudendal neuropathy, QTST can be considered a useful, non-invasive tool in the diagnosis, and management of the disease, but it cannot predict satisfactorily long-term outcome of operative pudendoscopy.
MeSH term(s)	Humans ; Female ; Pudendal Neuralgia ; Pudendal Nerve/surgery ; Constipation
Language	English
Publishing date	2023-02-14
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-023-06663-6
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Article: Impact d’un second stade de travail prolongé sur la morbidité périnatale : quelle est notre expérience?

Jenchenne, N / Seidel, L / Gangolf, M / Vanlinthout, C / Capelle, X / Emonts, P / Grandfils, S

Revue medicale de Liege

2022 Volume 77, Issue 10, Page(s) 571–577

Abstract: Objective: the management of the second stage of labor and its optimal duration are controversial, particularly for nulliparous women. Our aim is to analyze the impact of a prolonged second stage on perinatal morbidity in our institution.: Material ... ...

Title translation	Impact of prolonged second stage of labor on perinatal morbidity : what is our experience ?
Abstract	Objective: the management of the second stage of labor and its optimal duration are controversial, particularly for nulliparous women. Our aim is to analyze the impact of a prolonged second stage on perinatal morbidity in our institution. Material and methods: this is a retrospective study conducted in the University Hospital of Liège (Belgium) from January to July 2019. The 160 patients included were divided into two groups according to the duration of the second stage and compared in terms of mode of delivery, maternal and neonatal morbidity. Results: group 1 (85 %) had a second stage of labor inferior to 3 hours and group 2 (15 %) ? 3 hours. The cesarean deliveries for non-engagement of the fetus were significantly higher in group 2. No significant difference was observed in terms of maternal morbidity. The median Apgar score at 5 minutes was higher in group 1. The proportion of babies transferred to neonatal intensive care and to the neonatology department was higher in group 2. Conclusion: we mainly noted an increase in neonatal morbidity when the second stage exceeded 3 hours, which is consistent with literature where an increase in maternal morbidity is also described. Prolonging the second stage therefore seems inappropriate to us in the current state of knowledge.
MeSH term(s)	Cesarean Section ; Female ; Humans ; Infant, Newborn ; Labor Stage, Second ; Morbidity ; Obstetric Labor Complications ; Pregnancy ; Retrospective Studies
Language	French
Publishing date	2022-10-13
Publishing country	Belgium
Document type	Observational Study
ZDB-ID	414001-1
ISSN	0370-629X ; 0035-3663
ISSN	0370-629X ; 0035-3663
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Article: Impact clinique de la vidéocapsule endoscopique du grêle dans les saignements digestifs inexpliqués. Etude rétrospective monocentrique.

Moreau, A C / Seidel, L / Vieujean, S / Reenaers, C / Louis, E

Revue medicale de Liege

2022 Volume 77, Issue 1, Page(s) 25–31

Abstract: Introduction: The small-bowel capsule endoscopy (VCE) has been validated in the investigation of obscure gastrointestinal bleeding (OGIB). The aim of this study was to evaluate the clinical impact of VCE for OGIB in routine practice, in terms of ... ...

Title translation	Clinical impact of small bowell capsule endoscopy in obscure gastrointestinal bleeding : retrospective single-center study.
Abstract	Introduction: The small-bowel capsule endoscopy (VCE) has been validated in the investigation of obscure gastrointestinal bleeding (OGIB). The aim of this study was to evaluate the clinical impact of VCE for OGIB in routine practice, in terms of subsequent management and the risk of rebleeding. Methods: Our retrospective study analyzed the VCE at the CHU of Liège from March 2016 to December 2019 (cohort of 110 patients with OGIB). Results: We found a diagnostic yield of 58 %, a change in therapeutic attitude in 39 % of patients and a recurrence rate of 22.5 % (out of 102 patients followed at 2 years). The rate of rebleeding was particularly low in patients with normal VCE and in those for whom a therapeutic modification was made. Finally, about 45 % of patients did not have any change in therapeutic attitude nor recurrence. Conclusion: VCE leads to a therapeutic modification in about 40 % of patients with a low risk of relapse. However, VCE could be avoided in some patients as evidenced by a subgroup representing 45 % of patients for whom there was no therapeutic modification nor recurrence.
MeSH term(s)	Capsule Endoscopy ; Endoscopy, Gastrointestinal ; Gastrointestinal Hemorrhage/diagnosis ; Humans ; Intestine, Small/diagnostic imaging ; Recurrence ; Retrospective Studies
Language	French
Publishing date	2022-01-14
Publishing country	Belgium
Document type	Observational Study
ZDB-ID	414001-1
ISSN	0370-629X ; 0035-3663
ISSN	0370-629X ; 0035-3663
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Article: Baltic Sea coastal sediment-bound eukaryotes have increased year-round activities under predicted climate change related warming.

Li, Songjun / Nilsson, Emelie / Seidel, Laura / Ketzer, Marcelo / Forsman, Anders / Dopson, Mark / Hylander, Samuel

Frontiers in microbiology

2024 Volume 15, Page(s) 1369102

Abstract: Climate change related warming is a serious environmental problem attributed to anthropogenic activities, causing ocean water temperatures to rise in the coastal marine ecosystem since the last century. This particularly affects benthic microbial ... ...

Abstract	Climate change related warming is a serious environmental problem attributed to anthropogenic activities, causing ocean water temperatures to rise in the coastal marine ecosystem since the last century. This particularly affects benthic microbial communities, which are crucial for biogeochemical cycles. While bacterial communities have received considerable scientific attention, the benthic eukaryotic community response to climate change remains relatively overlooked. In this study, sediments were sampled from a heated (average 5°C increase over the whole year for over 50 years) and a control (contemporary conditions) Baltic Sea bay during four different seasons across a year. RNA transcript counts were then used to investigate eukaryotic community changes under long-term warming. The composition of active species in the heated and control bay sediment eukaryotic communities differed, which was mainly attributed to salinity and temperature. The family level RNA transcript alpha diversity in the heated bay was higher during May but lower in November, compared with the control bay, suggesting altered seasonal activity patterns and dynamics. In addition, structures of the active eukaryotic communities varied between the two bays during the same season. Hence, this study revealed that long-term warming can change seasonality in eukaryotic diversity patterns. Relative abundances and transcript expression comparisons between bays suggested that some taxa that now have lower mRNA transcripts numbers could be favored by future warming. Furthermore, long-term warming can lead to a more active metabolism in these communities throughout the year, such as higher transcript numbers associated with diatom energy production and protein synthesis in the heated bay during winter. In all, these data can help predict how future global warming will affect the ecology and metabolism of eukaryotic community in coastal sediments.
Language	English
Publishing date	2024-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2024.1369102
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Article ; Online: Optical imaging (HandScan) can identify ultrasound remission in rheumatoid arthritis.

Rinkin, Charline / Malaise, Olivier / Chauveheid, Florane / Gerard, Caroline / Seidel, Laurence / Malaise, Michel / Ribbens, Clio

BMC musculoskeletal disorders

2024 Volume 25, Issue 1, Page(s) 361

Abstract: Background: Identifying remission is of high importance in rheumatoid arthritis (RA) because remission is associated with less structural progression. We investigated the efficacy of a new optical imaging device, HandScan, to identify RA remission, as ... ...

Abstract	Background: Identifying remission is of high importance in rheumatoid arthritis (RA) because remission is associated with less structural progression. We investigated the efficacy of a new optical imaging device, HandScan, to identify RA remission, as defined by ultrasound (US). Methods: 61 RA patients were included. Disease activity was evaluated by clinical assessment and US, using gray-scale (GS) and Power Doppler (PD). HandScan determined unitary optical spectral transmission (OST) values for wrists, metacarpophalangeal and proximal interphalangeal joints. At the patient level, three composite HandScan (HS) scores were calculated: total HS score; disease activity score OST (DAS-OST) and DAS-OST without patient global assessment (PtGA). Using ROC curves, we determined HS cut-offs to identify US-defined remission. Results: At the joint level, unitary OST values significantly correlated with GS synovitis [odds ratio (OR) 2.43, p < 0.0001] and PD positivity (OR 3.72, p = 0.0002 ). At the patient level, total HS score and DAS-OST were significantly associated with all gray-scale US (GSUS) and power doppler US (PDUS) parameters evaluated (synovitis number and grade, synovial thickness, PD grade) (p < 0.05). The cut-off to identify US-defined remission at the joint level was of 0.92, giving an 81% sensitivity and a 96% positive predictive value (PPV). At the patient level, ROC-curves failed to identify a robust cut-off for the total HS score, but did identify a cut-off (3.68) for DAS-OST to identify US-defined remission, but with lower sensitivity (75%), specificity (56%) and PPV (67%). Conclusions: HandScan is a non-invasive optical imaging technique providing OST values that correlate with GSUS and PDUS parameters. In addition, HandScan is able to reliably identify US-defined remission in RA at the joint level, with a good sensitivity and high PPV. At the patient level, HandScan DAS-OST can also determine US remission (while total HS score failed to do so), but with lower performance.
MeSH term(s)	Humans ; Arthritis, Rheumatoid/diagnostic imaging ; Male ; Female ; Middle Aged ; Aged ; Ultrasonography, Doppler/methods ; Remission Induction ; Adult ; Optical Imaging/methods ; Severity of Illness Index
Language	English
Publishing date	2024-05-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-024-07472-4
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