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Article ; Online: Vitamin E at a high dose as an anti-ferroptosis drug and not just a supplement for COVID-19 treatment.

Tavakol, Shima / Seifalian, Alexander M

2021 Volume 69, Issue 3, Page(s) 1058–1060

MeSH term(s)	COVID-19/drug therapy ; Dietary Supplements ; Humans ; Iron ; Vitamin E/therapeutic use
Chemical Substances	Vitamin E (1406-18-4) ; Iron (E1UOL152H7)
Language	English
Publishing date	2021-05-21
Publishing country	United States
Document type	Editorial
ZDB-ID	883433-7
ISSN	1470-8744 ; 0885-4513
ISSN (online)	1470-8744
ISSN	0885-4513
DOI	10.1002/bab.2176
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Article ; Online: COVID-19 Vaccines in Clinical Trials and their Mode of Action for Immunity against the Virus.

Tavakol, Shima / Alavijeh, Mo S / Seifalian, Alexander M

Current pharmaceutical design

2020 Volume 27, Issue 13, Page(s) 1553–1563

Abstract: For nearly two decades, coronaviruses have caused many health and economic problems, while no effective commercial vaccine has yet been developed. It is worth mentioning that despite some mutations and recombination in SARS-CoV-2, its genotype is very ... ...

Abstract	For nearly two decades, coronaviruses have caused many health and economic problems, while no effective commercial vaccine has yet been developed. It is worth mentioning that despite some mutations and recombination in SARS-CoV-2, its genotype is very close to the original strain from Wuhan, China. Therefore, the development of an effective vaccine would be promising. It might be hypothesized that BCG vaccination is performed in high-risk populations before the commercialization of an effective SARS-CoV-2 vaccine. However, the development of an effective vaccine without considering the adverse immune reactions derived from antibody-dependent or cell-based immune enhancement may threaten vaccinated people's lives and long-term side effects must be considered. To this end, targeting of the receptor-binding domain (RBD) in spike and not whole spike, glycolization of FC receptors, PD-1 blockers, CPPs, etc., are promising. Therefore, the subunit vaccines or RNA vaccines that encode the RBP segment of the spike are of interest. To enhance the vaccine efficacy, its co-delivery with an adjuvant has been recommended. Nanoparticles modulate immune response with higher efficiency than the soluble form of antigens and can be functionalized with the positively charged moieties and ligands of targeted cells, such as dendritic cells, to increase cellular uptake of the antigens and their presentation on the surface of immune cells. This research aimed to discuss the COVID-19 vaccines entering the clinical trial and their mode of action effective immunity against the virus and discusses their advantages compared to each other.
MeSH term(s)	COVID-19 ; COVID-19 Vaccines ; China ; Humans ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Viral Vaccines
Chemical Substances	COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; Viral Vaccines
Keywords	covid19
Language	English
Publishing date	2020-10-24
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612826666201023143956
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Article: Preparation of internally-crosslinked alginate microspheres: Optimization of process parameters and study of pH-responsive behaviors

Sadeghi, Davoud / Solouk, Atefeh / Samadikuchaksaraei, Ali / Seifalian, Alexander M.

Carbohydrate polymers. 2021 Mar. 01, v. 255

2021

Abstract: In this study, the effects of various parameters of the water-in-oil emulsification/internal gelation method on the properties of calcium-alginate microparticles were evaluated and optimized. Results showed that the spherical-shaped microparticles with ... ...

Abstract	In this study, the effects of various parameters of the water-in-oil emulsification/internal gelation method on the properties of calcium-alginate microparticles were evaluated and optimized. Results showed that the spherical-shaped microparticles with the highest circularity and high production yield can be produced by alginate solution with a concentration of 2 wt.%, calcium carbonate/alginate ratio of 10/1 (w/w), water/oil volume ratio of 1/20, emulsifier concentration of 5 % (v/v), and emulsification speed of 1000 rpm. Two model drugs including simvastatin lactone and simvastatin β-hydroxyacid were loaded into the microspheres with promising encapsulation efficiencies of 73 % and 69 %, respectively. The microspheres showed a pH-responsive swelling behavior with a percentage of 10.60 %, 352.65 %, 690.03 %, and 1211.46 % at the pH values of 2.0, 4.5, 7.4, and 8.5, respectively. The microspheres showed an increasing trend of release rate in direct proportion to pH. These findings would be useful for therapeutic applications which need pH-responsive drug carriers.
Keywords	calcium carbonate ; emulsifiers ; emulsifying ; encapsulation ; gelation ; microparticles ; oils ; pH ; simvastatin
Language	English
Dates of publication	2021-0301
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2020.117336
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Human Adipose-Derived Stem Cells with Great Therapeutic Potential.

Sheykhhasan, Mohsen / Wong, Joanna K L / Seifalian, Alexander M

Current stem cell research & therapy

2019 Volume 14, Issue 7, Page(s) 532–548

Abstract: The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs offers a paradigm shift in regenerative medicine. The use of either embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) in ... ...

Abstract	The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs offers a paradigm shift in regenerative medicine. The use of either embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) in clinical situations is limited because of regulations and ethical considerations even though these cells are theoretically highly beneficial. While clinically, adipose-derived stem cells (ADSCs) are one of the most widely used types of stem cells used more than five years in clinically setting. It has many advantages including; yields a high number of ADSCs per volume of tissue, high rate of proliferation, anti-fibrotic, anti-apoptotic, anti-inflammation, immunomodulation, and paracrine mechanisms have been demonstrated in various preclinical studies. It is much easier to harvest compared with bone marrow stem cells. Results of clinical studies have demonstrated the potentials of ADSCs for stem cells therapy for a number of clinical disorders. The aim of this paper was to provide an update on the most recent developments of ADSCs, by highlighting the properties and features of ADSCs, critically discussing its clinical benefit and its clinical trials in treatment and regeneration. This is a multi-billion dollars industry with huge interest to clinician, academia and industries.
MeSH term(s)	Adipose Tissue/cytology ; Animals ; Cell Differentiation ; Humans ; Regenerative Medicine ; Stem Cell Transplantation/methods ; Stem Cells/cytology ; Tissue Engineering/methods
Language	English
Publishing date	2019-04-10
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2251937-3
ISSN	2212-3946 ; 1574-888X
ISSN (online)	2212-3946
ISSN	1574-888X
DOI	10.2174/1574888X14666190411121528
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Article ; Online: Editorial: Manufacturing living organs using tissue engineering strategy.

Seifalian, Alexander M

Biotechnology and applied biochemistry

2011 Volume 58, Issue 5, Page(s) 285–287

MeSH term(s)	Adult ; Animals ; Bioartificial Organs ; Bioreactors ; Humans ; Intercellular Signaling Peptides and Proteins/administration & dosage ; Male ; Swine ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry
Chemical Substances	Intercellular Signaling Peptides and Proteins
Language	English
Publishing date	2011-09
Publishing country	United States
Document type	Editorial ; Introductory Journal Article
ZDB-ID	883433-7
ISSN	1470-8744 ; 0885-4513
ISSN (online)	1470-8744
ISSN	0885-4513
DOI	10.1002/bab.54
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1865: Show issues

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Article ; Online: Preparation of internally-crosslinked alginate microspheres: Optimization of process parameters and study of pH-responsive behaviors.

Sadeghi, Davoud / Solouk, Atefeh / Samadikuchaksaraei, Ali / Seifalian, Alexander M

Carbohydrate polymers

2020 Volume 255, Page(s) 117336

Abstract	In this study, the effects of various parameters of the water-in-oil emulsification/internal gelation method on the properties of calcium-alginate microparticles were evaluated and optimized. Results showed that the spherical-shaped microparticles with the highest circularity and high production yield can be produced by alginate solution with a concentration of 2 wt.%, calcium carbonate/alginate ratio of 10/1 (w/w), water/oil volume ratio of 1/20, emulsifier concentration of 5 % (v/v), and emulsification speed of 1000 rpm. Two model drugs including simvastatin lactone and simvastatin β-hydroxyacid were loaded into the microspheres with promising encapsulation efficiencies of 73 % and 69 %, respectively. The microspheres showed a pH-responsive swelling behavior with a percentage of 10.60 %, 352.65 %, 690.03 %, and 1211.46 % at the pH values of 2.0, 4.5, 7.4, and 8.5, respectively. The microspheres showed an increasing trend of release rate in direct proportion to pH. These findings would be useful for therapeutic applications which need pH-responsive drug carriers.
Language	English
Publishing date	2020-11-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2020.117336
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Article: Graphene Oxide: Opportunities and Challenges in Biomedicine.

Zare, Pariya / Aleemardani, Mina / Seifalian, Amelia / Bagher, Zohreh / Seifalian, Alexander M

Nanomaterials (Basel, Switzerland)

2021 Volume 11, Issue 5

Abstract: Desirable carbon allotropes such as graphene oxide (GO) have entered the field with several biomedical applications, owing to their exceptional physicochemical and biological features, including extreme strength, found to be 200 times stronger than steel; ...

Abstract	Desirable carbon allotropes such as graphene oxide (GO) have entered the field with several biomedical applications, owing to their exceptional physicochemical and biological features, including extreme strength, found to be 200 times stronger than steel; remarkable light weight; large surface-to-volume ratio; chemical stability; unparalleled thermal and electrical conductivity; and enhanced cell adhesion, proliferation, and differentiation properties. The presence of functional groups on graphene oxide (GO) enhances further interactions with other molecules. Therefore, recent studies have focused on GO-based materials (GOBMs) rather than graphene. The aim of this research was to highlight the physicochemical and biological properties of GOBMs, especially their significance to biomedical applications. The latest studies of GOBMs in biomedical applications are critically reviewed, and in vitro and preclinical studies are assessed. Furthermore, the challenges likely to be faced and prospective future potential are addressed. GOBMs, a high potential emerging material, will dominate the materials of choice in the repair and development of human organs and medical devices. There is already great interest among academics as well as in pharmaceutical and biomedical industries.
Language	English
Publishing date	2021-04-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano11051083
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The risk of pancreatic adenocarcinoma following SARS-CoV family infection.

Ebrahimi Sadrabadi, Amin / Bereimipour, Ahmad / Jalili, Arsalan / Gholipurmalekabadi, Mazaher / Farhadihosseinabadi, Behrouz / Seifalian, Alexander M

Scientific reports

2021 Volume 11, Issue 1, Page(s) 12948

Abstract: COVID 19 disease has become a global catastrophe over the past year that has claimed the lives of over two million people around the world. Despite the introduction of vaccines against the disease, there is still a long way to completely eradicate it. ... ...

Abstract	COVID 19 disease has become a global catastrophe over the past year that has claimed the lives of over two million people around the world. Despite the introduction of vaccines against the disease, there is still a long way to completely eradicate it. There are concerns about the complications following infection with SARS-CoV-2. This research aimed to evaluate the possible correlation between infection with SARS-CoV viruses and cancer in an in-silico study model. To do this, the relevent dataset was selected from GEO database. Identification of differentially expressed genes among defined groups including SARS-CoV, SARS-dORF6, SARS-BatSRBD, and H1N1 were screened where the \|Log FC\| ≥ 1and p < 0.05 were considered statistically significant. Later, the pathway enrichment analysis and gene ontology (GO) were used by Enrichr and Shiny GO databases. Evaluation with STRING online was applied to predict the functional interactions of proteins, followed by Cytoscape analysis to identify the master genes. Finally, analysis with GEPIA2 server was carried out to reveal the possible correlation between candidate genes and cancer development. The results showed that the main molecular function of up- and down-regulated genes was "double-stranded RNA binding" and actin-binding, respectively. STRING and Cytoscape analysis presented four genes, PTEN, CREB1, CASP3, and SMAD3 as the key genes involved in cancer development. According to TCGA database results, these four genes were up-regulated notably in pancreatic adenocarcinoma. Our findings suggest that pancreatic adenocarcinoma is the most probably malignancy happening after infection with SARS-CoV family.
MeSH term(s)	Adenocarcinoma/etiology ; COVID-19/complications ; COVID-19/genetics ; COVID-19/metabolism ; COVID-19/virology ; Carcinogenesis/genetics ; Caspase 3/genetics ; Cyclic AMP Response Element-Binding Protein/genetics ; Gene Expression Regulation ; Gene Ontology ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human/complications ; Influenza, Human/genetics ; Influenza, Human/metabolism ; Influenza, Human/virology ; PTEN Phosphohydrolase/genetics ; Pancreatic Neoplasms/etiology ; Protein Interaction Maps ; Risk ; Severe acute respiratory syndrome-related coronavirus ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/complications ; Severe Acute Respiratory Syndrome/genetics ; Severe Acute Respiratory Syndrome/metabolism ; Severe Acute Respiratory Syndrome/virology ; Signal Transduction/genetics ; Smad3 Protein/genetics ; Up-Regulation/genetics
Chemical Substances	CREB1 protein, human ; Cyclic AMP Response Element-Binding Protein ; SMAD3 protein, human ; Smad3 Protein ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67) ; CASP3 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2021-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-92068-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury.

Aleemardani, Mina / Zare, Pariya / Seifalian, Amelia / Bagher, Zohreh / Seifalian, Alexander M

Biomedicines

2021 Volume 10, Issue 1

Abstract: Peripheral nerve injury is a common medical condition that has a great impact on patient quality of life. Currently, surgical management is considered to be a gold standard first-line treatment; however, is often not successful and requires further ... ...

Abstract	Peripheral nerve injury is a common medical condition that has a great impact on patient quality of life. Currently, surgical management is considered to be a gold standard first-line treatment; however, is often not successful and requires further surgical procedures. Commercially available FDA- and CE-approved decellularized nerve conduits offer considerable benefits to patients suffering from a completely transected nerve but they fail to support neural regeneration in gaps > 30 mm. To address this unmet clinical need, current research is focused on biomaterial-based therapies to regenerate dysfunctional neural tissues, specifically damaged peripheral nerve, and spinal cord. Recently, attention has been paid to the capability of graphene-based materials (GBMs) to develop bifunctional scaffolds for promoting nerve regeneration, often via supporting enhanced neural differentiation. The unique features of GBMs have been applied to fabricate an electroactive conductive surface in order to direct stem cells and improve neural proliferation and differentiation. The use of GBMs for nerve tissue engineering (NTE) is considered an emerging technology bringing hope to peripheral nerve injury repair, with some products already in preclinical stages. This review assesses the last six years of research in the field of GBMs application in NTE, focusing on the fabrication and effects of GBMs for neurogenesis in various scaffold forms, including electrospun fibres, films, hydrogels, foams, 3D printing, and bioprinting.
Language	English
Publishing date	2021-12-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10010073
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: COVID-19 Vaccines on Clinical Trials and their Mode of Action for Immunity against the Virus

Tavakol, Shima / Alavijeh, Mo S / Seifalian, Alexander M

Curr. pharm. des

Abstract	For nearly two decades, coronaviruses have caused many health and economic problems, while no effective commercial vaccine has yet been developed. It is worth mentioning that despite some mutations and recombination in SARS-CoV-2, its genotype is very close to the original strain from Wuhan, China. Therefore, the development of an effective vaccine would be promising. It might be hypothesized that BCG vaccination is performed in high-risk populations before the commercialization of an effective SARS-CoV-2 vaccine. However, the development of an effective vaccine without considering the adverse immune reactions derived from antibody-dependent or cell-based immune enhancement is may threaten vaccinated people's lives and long-term side effect must be considered. To this end, targeting of the receptorbinding domain (RBD) in spike and not whole spike, glycolization of FC receptors, PD-1 blockers, CPPs, etc. are promising. Therefore, the subunit vaccines or RNA vaccines that encode the RBP segment of the spike are of interest. To enhance the vaccine efficacy, its co-delivery with an adjuvant has been recommended. Nanoparticles modulate immune response with higher efficiency than the soluble form of antigens and can be functionalized with the positively charged moieties and ligands of targeted cells, such as dendritic cells, to increase cellular uptake of the antigens and their presentation on the surface of immune cells. This research aimed to discuss the COVID-19 vaccines entering the clinical trial and their mode of action effective immunity against the virus and discusses their advantages compared to each other.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #890256
Database	COVID19

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