Article: Infection with HIV type 1 group M non-B subtypes in individuals living in New York City.
Journal of acquired immune deficiency syndromes (1999)
2004 Volume 36, Issue 3, Page(s) 835–844
Abstract: Objective: To document infection with HIV type 1 (HIV-1) group M non-B subtypes in individuals living in New York City.: Design: From October 1999 through April 2003, HIV-1-seropositive individuals were selected from 3 clinics in New York City based ... ...
| Abstract | Objective: To document infection with HIV type 1 (HIV-1) group M non-B subtypes in individuals living in New York City. Design: From October 1999 through April 2003, HIV-1-seropositive individuals were selected from 3 clinics in New York City based on having risk factors for infection with HIV-1 non-B subtypes. Methods: HIV-1 RNA was extracted from plasma samples, and partial gag, pol, or env genes were amplified by PCR analysis. The infecting HIV-1 group M subtype was determined based on results of either heteroduplex mobility assay or sequencing and phylogenetic analysis. Results: Ninety-seven subjects were enrolled in the study. Of the 97 subjects, 91 (94%) were selected based on having emigrated from a non-European country, while 6 (6%) were native United States citizens. Subtypes were successfully determined in 53 (55%) of the 97 plasma samples tested. The subtypes in 2 plasma samples were unclassifiable. HIV-1 infections were classified as those due to the following group M subtypes: A (n = 4; 7%), B (n = 12; 22%), C (n = 8; 15%), F (n = 2; 4%), CRF01_AE-like (n = 7; 13%), CRF02_AG-like (n = 19; 34%), an intersubtype recombinant form G/A (n = 1; 2%), and unclassifiable viruses (n = 2; 4%). Conclusion: This study reveals infection with a broad variety of HIV-1 group M subtypes mostly in the immigrant population of New York City as well as how several non-B subtypes are being introduced into the United States. |
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| MeSH term(s) | Adult ; Base Sequence ; Emigration and Immigration ; Female ; Genes, env ; Genes, gag ; Genes, pol ; Genotype ; HIV Infections/epidemiology ; HIV Infections/virology ; HIV-1/classification ; HIV-1/genetics ; HIV-1/isolation & purification ; Humans ; Male ; Middle Aged ; Molecular Epidemiology ; New York City/epidemiology ; Phylogeny ; RNA, Viral/blood ; RNA, Viral/genetics ; Risk Factors ; Travel | |||||
| Chemical Substances | RNA, Viral | |||||
| Language | English | |||||
| Publishing date | 2004-06-28 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. | |||||
| ZDB-ID | 645053-2 | |||||
| ISSN | 1944-7884 ; 1077-9450 ; 1525-4135 ; 0897-5965 ; 0894-9255 | |||||
| ISSN (online) | 1944-7884 ; 1077-9450 | |||||
| ISSN | 1525-4135 ; 0897-5965 ; 0894-9255 | |||||
| DOI | 10.1097/00126334-200407010-00011 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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