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  1. Article: Current Medical and Surgical Treatment of Hidradenitis Suppurativa-A Comprehensive Review.

    Ocker, Lennart / Abu Rached, Nessr / Seifert, Caroline / Scheel, Christina / Bechara, Falk G

    Journal of clinical medicine

    2022  Volume 11, Issue 23

    Abstract: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with recurrent inflammatory lesions in intertriginous body regions. HS has a pronounced impact on patients' quality of life and is associated with a variety of comorbidities. ...

    Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with recurrent inflammatory lesions in intertriginous body regions. HS has a pronounced impact on patients' quality of life and is associated with a variety of comorbidities. Treatment of HS is often complex, requiring an individual approach with medical and surgical treatments available. However, especially in moderate-to-severe HS, there is an urgent need for new treatment approaches. In recent years, increased research has led to the identification of new potential therapeutic targets. This review aims to give a comprehensive and practical overview of current treatment options for HS. Furthermore, the clinically most advanced novel treatment approaches will be discussed.
    Language English
    Publishing date 2022-12-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11237240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Care Concept of Community Health Nursing Interventions for Adults With Chronic Health Conditions in an Urban Area: Protocol for a Randomized Controlled Field Trial (CoSta Study).

    Nock, Annike Morgane / Iversen, Linda / Waidhas, Lukas / Zapf, Antonia / Seifert, Caroline / Petersen-Ewert, Corinna

    JMIR research protocols

    2022  Volume 11, Issue 9, Page(s) e37965

    Abstract: Background: Implementing community health nursing programs is a new field of application in the primary health sector of Germany. Hence, there is limited evidence of effective community-based and nurse-led interventions with regard to the German health ... ...

    Abstract Background: Implementing community health nursing programs is a new field of application in the primary health sector of Germany. Hence, there is limited evidence of effective community-based and nurse-led interventions with regard to the German health care system. International research findings are mostly not transferable. The Community Health Nursing in der Stadt (CoSta; ie, "Community Health Nursing in the City") project is the first study that examines a community health nurse-led intervention for adults with chronic health conditions.
    Objective: This study protocol describes the design and methods of a randomized controlled field trial that will investigate if a community health nurse-based intervention has an impact on health-related quality of life in adults with chronic conditions.
    Methods: The study was designed as a randomized controlled trial that will be conducted under real-life conditions in the field. In a 4-month period, patients with at least 1 chronic International Classification of Diseases, Tenth Revision, diagnosis will be enrolled. Participants will be randomly allocated to an intervention group or a control group. The sample size was assumed based on an effect size of 0.50 with a significance level of .05, using a 2-sided (2-tailed), 2-sample unequal variance t test. The control group will be treated as usual. The intervention group will receive-in addition to the usual treatment-preventive home visits; consultations; and educative training, which will be offered by 2 community health nurses for up to 12 months. Both groups will be followed up at baseline, after 6 months, and after 12 months. The primary outcome measure is the mental component summary score from the 36-Item Short Form Health Survey after 12-months. Secondary patient outcomes will be included. The study received ethics approval from the Competence Health Center's institutional review board at the University of Applied Sciences Hamburg (procedure number: 2020-14).
    Results: The CoSta project was funded by the Federal Ministry of Education and Research Germany (contract number: 13FH019SX8). In total, 187 participants were recruited at the beginning of August 2021. Further, 92 were excluded and 94 were randomized. Data collection will be conducted until the end of 2022.
    Conclusions: Our study will provide data with regard to the effectiveness of community nurse-led interventions that focus on the treatment of vulnerable adults with chronic health conditions in a community health center. In secondary analyses, the associations among influencing social factors (education, income, and employment) will be examined. We expect results that will help reduce the research-to-practice gap.
    Trial registration: German Clinical Trials Register DRKS00026164; https://tinyurl.com/yckxc5ut.
    International registered report identifier (irrid): DERR1-10.2196/37965.
    Language English
    Publishing date 2022-09-28
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2719222-2
    ISSN 1929-0748
    ISSN 1929-0748
    DOI 10.2196/37965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Fallbericht: Elektiver Mutismus

    Seifert, Caroline

    PiD - Psychotherapie im Dialog

    (Sexuelle Traumatisierung)

    2014  Volume 15, Issue 01, Page(s) 106–109

    Abstract: Eine 19-jährige Studentin hat ihr mündliches Abitur in Biologie mit 12 Punkten bestanden – ohne ein Wort zu sagen. Jetzt benötigt sie ihre Stimme, um soziale Kontakte aufzubauen und ihr Studium erfolgreich zu beenden. ...

    Series title Sexuelle Traumatisierung
    Abstract Eine 19-jährige Studentin hat ihr mündliches Abitur in Biologie mit 12 Punkten bestanden – ohne ein Wort zu sagen. Jetzt benötigt sie ihre Stimme, um soziale Kontakte aufzubauen und ihr Studium erfolgreich zu beenden.
    Language German
    Publishing date 2014-03-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2015119-6
    ISSN 1439-913X ; 1438-7026
    ISSN (online) 1439-913X
    ISSN 1438-7026
    DOI 10.1055/s-0034-1370827
    Database Thieme publisher's database

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  4. Article ; Online: The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review.

    Abu Rached, Nessr / Gambichler, Thilo / Dietrich, Johannes W / Ocker, Lennart / Seifert, Caroline / Stockfleth, Eggert / Bechara, Falk G

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: Hidradenitis suppurativa (HS) is a chronic inflammatory disease manifesting in inverse body regions. In a systematic review, the role of hormones in HS will be presented to better understand the pathomechanisms of HS. The review is based on the PRISMA ... ...

    Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory disease manifesting in inverse body regions. In a systematic review, the role of hormones in HS will be presented to better understand the pathomechanisms of HS. The review is based on the PRISMA criteria. Systematic research was carried out using keywords. Subsequently, the data were analyzed based on the clinical response and other relevant information. The main focus of our systematic review was on HS manifestation, exacerbation, sex hormones, antiandrogen therapy, thyroid function, polycystic ovary syndrome, insulin resistance, and adipokines. In HS, there appears to be a dysregulated adipokine release that is shifted towards pro-inflammatory adipokines. Insulin resistance is significantly more common in HS than in healthy patients regardless of BMI, age, and gender. Insulin resistance in HS patients leads to further cardiovascular disease. The mechanism of insulin resistance and role of adipokines should be investigated in future studies to better provide the pathomechanisms of HS. The role of androgens seems to be important in a certain subgroup of female patients. Anti-androgenic therapy can be useful and helpful in some patients. However, further studies are needed to better understand the hormonal relationship in HS.
    Language English
    Publishing date 2022-12-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232315250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Screening for Diabetes Mellitus in Patients with Hidradenitis Suppurativa-A Monocentric Study in Germany.

    Abu Rached, Nessr / Gambichler, Thilo / Ocker, Lennart / Dietrich, Johannes W / Quast, Daniel R / Sieger, Christina / Seifert, Caroline / Scheel, Christina / Bechara, Falk G

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: Hidradenitis suppurativa (HS) is a chronic skin disease that is often associated with metabolic disorders. Diabetes mellitus (DM) is a frequent comorbidity in HS. There is currently no established screening for DM in HS patients. The aim of our study was ...

    Abstract Hidradenitis suppurativa (HS) is a chronic skin disease that is often associated with metabolic disorders. Diabetes mellitus (DM) is a frequent comorbidity in HS. There is currently no established screening for DM in HS patients. The aim of our study was to identify high-risk groups of HS patients that develop DM and to assess the frequency of different types of DM present in HS patients. To do so, we conducted a monocentric study in 99 patients with HS. All patients underwent detailed clinical and laboratory assessments, including the determination of glycated hemoglobin. Among the 20.2% of patients that presented with DM, type 2 was by far the most prevalent (19 out of 20 patients). Moreover, male gender, age, BMI, Hurley stage, modified Hidradenitis Suppurativa Score (mHSS), DLQI and hypertension all correlated with the glycated hemoglobin levels in the HS patients. In the multivariable analysis, Hurley stage III, older age, and higher BMI were significantly associated with DM. Specifically, patients at Hurley stage III were at a 5.3-fold increased risk of having DM type II compared to patients at earlier Hurley stages. Since many of the HS patients had not been diagnosed, our study reveals shortcomings in the screening for DM and suggest that this should be routinely performed in HS patients at high risk to avoid secondary complications.
    MeSH term(s) Humans ; Male ; Hidradenitis Suppurativa/complications ; Hidradenitis Suppurativa/diagnosis ; Hidradenitis Suppurativa/epidemiology ; Glycated Hemoglobin ; Severity of Illness Index ; Comorbidity ; Germany/epidemiology ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology
    Chemical Substances Glycated Hemoglobin
    Language English
    Publishing date 2023-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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