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  1. Article ; Online: Non-antigen-specific Immunoadsorption Is a Risk Factor for Severe Postoperative Infections in ABO-Incompatible Kidney Transplant Recipients.

    Matuschik, Laura / Seifert, Gabriel / Lammich, Katrin / Holzner, Philipp / Tanriver, Yakup / Fichtner-Feigl, Stefan / Walz, Gerd / Schneider, Johanna / Jänigen, Bernd

    Transplant international : official journal of the European Society for Organ Transplantation

    2024  Volume 37, Page(s) 12263

    Abstract: ABO-incompatible (ABOi) living kidney transplantation (KTx) is an established procedure to address the demand for kidney transplants with outcomes comparable to ABO-compatible KTx. Desensitization involves the use of immunoadsorption (IA) to eliminate ... ...

    Abstract ABO-incompatible (ABOi) living kidney transplantation (KTx) is an established procedure to address the demand for kidney transplants with outcomes comparable to ABO-compatible KTx. Desensitization involves the use of immunoadsorption (IA) to eliminate preformed antibodies against the allograft. This monocentric retrospective study compares single-use antigen-selective Glycosorb
    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Retrospective Studies ; ABO Blood-Group System ; Blood Group Incompatibility ; Risk Factors ; Graft Rejection ; Graft Survival ; Living Donors
    Chemical Substances ABO Blood-Group System
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2024.12263
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    Zs.A 2358: Show issues Location:
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  2. Book ; Online ; Thesis: <dc:title>Der Einfluss der prä- und postoperativen psychischen Befindlichkeit gemessen anhand des mehrdimensionalen Befindlichkeitsfragebogens auf das Ergebnis nach elektiver kolorektaler Chirurgie</dc:title>

    Manteufel, Ines [Verfasser] / Huber, Roman [Akademischer Betreuer] / Huber, Roman / Seifert, Gabriel

    2023  

    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universität
    Publishing place Freiburg
    Document type Book ; Online ; Thesis
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  3. Article: Standardoperationen in der Adipositaschirurgie

    Marjanovic, Goran / Seifert, Gabriel / Läßle, Claudia / Fink, Jodok

    Allgemein- und Viszeralchirurgie up2date

    2022  Volume 16, Issue 05, Page(s) 405–423

    Keywords bariatrische Operationen ; metabolische Chirurgie ; Indikationen
    Language German
    Publishing date 2022-09-26
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2317051-7
    ISSN 1611-6461 ; 1611-6437
    ISSN (online) 1611-6461
    ISSN 1611-6437
    DOI 10.1055/a-1838-9597
    Database Thieme publisher's database

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  4. Article ; Online: Parental Obesity Predisposition and Age of Onset Associate with Poor Response to Bariatric and Metabolic Surgery.

    Fink, Mira / Herrmann, Stephan / Fink, Jodok / Lässle, Claudia / Marjanovic, Goran / Fagnocchi, Luca / Pospisilik, J Andrew / Fichtner-Feigl, Stefan / Seifert, Gabriel

    Obesity surgery

    2023  Volume 33, Issue 5, Page(s) 1519–1527

    Abstract: Introduction: Parental predisposition and age of onset may be independently associated with 1-year total weight loss (TWL) failure (< 20%) after metabolic-bariatric surgery (MBS).: Methods: This cohort study includes all cases of the German StuDoQ| ... ...

    Abstract Introduction: Parental predisposition and age of onset may be independently associated with 1-year total weight loss (TWL) failure (< 20%) after metabolic-bariatric surgery (MBS).
    Methods: This cohort study includes all cases of the German StuDoQ|MBE register (2015-2019) with data on parental predisposition, obesity onset, and at least 1-year follow up after primary MBS procedures (n = 14,404). We provide descriptive statistics of the cohort in terms of the main outcome and 1-year TWL failure, and provide characteristics of surgery type subgroups. Finally, we provide a multivariate logistic regression model of 1-year TWL failure.
    Results: 58.8% and 45.7% of patients reported maternal and paternal predisposition for obesity, respectively. Average onset of obesity was 15.5 years and duration of disease 28.3 years prior to MBS. SG is the most frequently performed procedure (47.2%) followed by RYGB (39.7%) and OAGB (13.1%). Mean 1-year TWL is 32.7 ± 9.3%, and 7.8% (n = 1,119) of patients show TWL failure (< 20%). Multivariate analysis shows independent association of early onset of obesity (< 18 years), male sex, age at operation, pre-operative BMI, pre-operative weight loss, sleeve gastrectomy (SG), and type 2 diabetes (T2D) with 1-year TWL failure (p < 0.001).
    Conclusion: The proportions of MBS patients that report on paternal and maternal predisposition for obesity are 45.7% and 58.8% respectively, and average age at onset is 15.5 years. 7.8% of patients do not meet current target criteria of successful response to surgery at 1 year. Early onset, male sex, age at operation, pre-operative BMI, pre-operative weight loss, SG, and T2D are independently associated with weight loss failure.
    MeSH term(s) Humans ; Male ; Adolescent ; Obesity, Morbid/surgery ; Cohort Studies ; Diabetes Mellitus, Type 2/surgery ; Age of Onset ; Treatment Outcome ; Retrospective Studies ; Obesity/surgery ; Bariatric Surgery/methods ; Weight Loss/physiology ; Parents ; Gastrectomy/methods ; Gastric Bypass/methods
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-023-06499-1
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    Zs.A 3381: Show issues Location:
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  5. Article ; Online: Banded Versus Non-banded Sleeve Gastrectomy: 5-Year Results of a 3-Year Randomized Controlled Trial.

    Fink, Jodok M / Reutebuch, Marina / Seifert, Gabriel / Laessle, Claudia / Fichtner-Feigl, Stefan / Marjanovic, Goran / Fink, Mira

    Obesity surgery

    2023  Volume 34, Issue 2, Page(s) 310–317

    Abstract: Purpose: Banded sleeve gastrectomy (BSG) has been shown to enable better weight loss than non-banded sleeve gastrectomy (SG) in retrospective analyses. These findings were supported by two randomized controlled trials (RCT). However, to date, mid-term ... ...

    Abstract Purpose: Banded sleeve gastrectomy (BSG) has been shown to enable better weight loss than non-banded sleeve gastrectomy (SG) in retrospective analyses. These findings were supported by two randomized controlled trials (RCT). However, to date, mid-term prospective data is not available.
    Materials and methods: We invited all 94 patients of an RCT comparing banded to non-banded sleeve gastrectomy at 3 years (DRKS00007729) for a 5-year follow-up visit. Eighty-two patients (BSG n = 42; SG n = 40) came for evaluation. Outcome measures were identical with the RCT to allow longitudinal comparison. Data analysis was descriptive and focused on biometric data, development of comorbidities, mid-term complications, quality of life, and type of body contouring surgery (BCS).
    Results: The per-protocol analysis revealed a treatment difference of 9% (CI - 1.5 to 19.6) excess weight loss (EWL). Total weight loss (TWL) was 27.4% (CI 23.5-31.3) after SG and 31.6% (CI 27.3-35.5) after BSG. Twenty percent of patients after SG and 11.9% following BSG had been converted to a gastric bypass. Type 2 diabetes went into remission in most patients (SG 66.7% vs. BSG 63.6%). Antihypertensive medication was stopped or reduced in 81.3% after SG and 80% after BSG. Reflux symptoms were similar in both groups (symptoms [Formula: see text] 1/ week: SG 28.2% vs. BSG 26.8%). Frequency of postprandial regurgitation was higher after BSG (SG 23% vs. BSG 59%). Forty percent of patients had undergone BCS at time of follow-up.
    Conclusion: Five-year weight loss after BSG was 9% EWL and 4.2% TWL higher compared to SG. The main added morbidity following BSG was postprandial regurgitation.
    MeSH term(s) Humans ; Obesity, Morbid/surgery ; Gastric Bypass/methods ; Gastroplasty/methods ; Retrospective Studies ; Gastrectomy/methods ; Weight Loss ; Treatment Outcome ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-023-06982-9
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  6. Conference proceedings: Searching for the molecular benchmark of physiological intestinal anastomotic healing in rats: an experimental study

    Seifert, Gabriel

    2013  , Page(s) 13dgch169

    Event/congress 130. Kongress der Deutschen Gesellschaft für Chirurgie; München; Deutsche Gesellschaft für Chirurgie; 2013
    Keywords Medizin, Gesundheit
    Publishing date 2013-04-26
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/13dgch169
    Database German Medical Science

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  7. Article ; Online: Reply to the letter to the editor: to band or not to band: is that the question… or the answer for sleeve gastrectomy?

    Fink, Jodok M / Seifert, Gabriel / Marjanovic, Goran

    Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

    2019  Volume 15, Issue 9, Page(s) 1644–1645

    MeSH term(s) Gastrectomy ; Humans ; Matched-Pair Analysis ; Obesity, Morbid/surgery
    Language English
    Publishing date 2019-07-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2274243-8
    ISSN 1878-7533 ; 1550-7289
    ISSN (online) 1878-7533
    ISSN 1550-7289
    DOI 10.1016/j.soard.2019.07.011
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    Zs.A 6572: Show issues Location:
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  8. Article ; Online: Obesity Surgery.

    Fink, Jodok / Seifert, Gabriel / Blüher, Matthias / Fichtner-Feigl, Stefan / Marjanovic, Goran

    Deutsches Arzteblatt international

    2021  Volume 119, Issue 5, Page(s) 70–80

    Abstract: Background: In 2017, the prevalence of obesity (BMI ≥= 30 kg/m2) in Germany was approximately 16%. Obesity increases an individual's risk of developing type 2 diabetes (T2DM) and arterial hypertension; it also increases overall mortality. Consequently, ... ...

    Abstract Background: In 2017, the prevalence of obesity (BMI ≥= 30 kg/m2) in Germany was approximately 16%. Obesity increases an individual's risk of developing type 2 diabetes (T2DM) and arterial hypertension; it also increases overall mortality. Consequently, effective treatment is a necessity. Approximately 20 000 bariatric operations are performed in Germany each year.
    Methods: This review is based on pertinent publications retrieved by a selective search in the PubMed and Cochrane databases and on current German clinical practice guidelines.
    Results: The types of obesity surgery most commonly performed in Germany, Roux-en-Y gastric bypass and sleeve gastrectomy, lead to an excess weight loss of 27-69% ≥= 10 years after the procedure. In obese patients with T2DM, the diabetes remission rate ≥= 10 years after these procedures ranges from 25% to 62%. Adjusted regression analyses of data from large registries have shown that the incidence of malignancies is 33% lower in persons who have undergone obesity surgery compared to control subjects with obesity (unadjusted incidence 5.6 versus 9.0 cases per 1000 person-years). The operation can cause vitamin deficiency, surgical complications, gastroesophageal reflux, and dumping syndrome. Therefore, lifelong follow-up is necessary.
    Conclusion: In view of an increasing number of patients undergoing bariatric surgery, it will probably not be feasible in the future for lifelong follow-up to be provided exclusively in specialized centers.
    MeSH term(s) Bariatric Surgery/methods ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Gastric Bypass/methods ; Humans ; Laparoscopy ; Obesity/complications ; Obesity/epidemiology ; Obesity/surgery ; Obesity, Morbid/complications ; Obesity, Morbid/epidemiology ; Obesity, Morbid/surgery ; Treatment Outcome
    Language English
    Publishing date 2021-11-25
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2021.0359
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  9. Article ; Online: Long-Term Diabetes Improvement After Duodenal Exclusion in Zucker Diabetic Fatty Rats Is Associated with Prevention of Strain-Specific Pancreatic Remodeling and Increased Beta Cell Proliferation.

    Seifert, Gabriel / Malyi, Ambrus / Bronsert, Peter / Plohmann, Sven / Kesselring, Rebeccca / Fichtner-Feigl, Stefan / Marjanovic, Goran / Fink, Jodok Matthias / Laessle, Claudia

    Obesity surgery

    2022  Volume 32, Issue 6, Page(s) 1980–1989

    Abstract: Background: Response to metabolic surgery is heterogeneous and the metabolic states that underpin weight loss and metabolic improvement are still unclear. In this study, we investigate parameters of post-bariatric fasting glucoregulation and leverage ... ...

    Abstract Background: Response to metabolic surgery is heterogeneous and the metabolic states that underpin weight loss and metabolic improvement are still unclear. In this study, we investigate parameters of post-bariatric fasting glucoregulation and leverage artificial intelligence-assisted whole-slide image analyses to characterize associated immunohistologic features of the pancreas.
    Materials and methods: We performed either loop duodeno-jejunostomy (DJOS) with exclusion of 1/3 of total intestinal length, loop duodeno-ileostomy with exclusion of 2/3 of total intestinal length (DiOS), or a sham operation on 8-week-old male obese ZDF rats. Six months post-operative, we measured blood metabolites and hormones. Subsequently, pancreatic and intestinal tissue was removed, formalin fixed, and paraffin embedded. Immunohistologic (IHC) analyses included proliferating cell nuclear antigen (PCNA) to visualize the proliferation fraction and pancreatic and duodenal homeobox 1 (PDX 1) as a measure of pancreatic cell differentiation. For IHC quantification, all slides were digitalized and analyzed using QuPath. All analyzed slides were reviewed by two independent pathologists for correctness.
    Results: DJOS and DiOS were associated with preserved fasting insulin production compared to sham. Histopathologic evaluation showed significantly higher numbers of beta cells and specifically of clustered cell organization in DJOS and DiOS compared to sham. Cell proliferation (PCNA) was significantly elevated in DJOS and DiOS compared to sham.
    Conclusion: In this interventional model of bariatric surgery in severe genetic diabetes, we demonstrate post-operative histologic and immunohistologic features of the pancreas associated with improved fasting glucose homeostasis.
    MeSH term(s) Animals ; Artificial Intelligence ; Blood Glucose/metabolism ; Cell Proliferation ; Diabetes Mellitus, Type 2/complications ; Humans ; Insulin ; Jejunum/surgery ; Male ; Obesity, Morbid/surgery ; Pancreas/metabolism ; Pancreas/surgery ; Proliferating Cell Nuclear Antigen/metabolism ; Rats ; Rats, Zucker
    Chemical Substances Blood Glucose ; Insulin ; Proliferating Cell Nuclear Antigen
    Language English
    Publishing date 2022-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-022-06040-w
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  10. Book ; Online ; Thesis: <dc:title>Behandlungsergebnisse nach einer hohen Tibiakopfosteotomie im 10-Jahres-Follow-Up: Analyse der Faktoren und Rate der Konversion zur endoprothetischen Versorgung</dc:title>

    Brenner, Anna-Sophie [Verfasser] / Bode, Lisa [Akademischer Betreuer] / Bode, Gerrit [Sonstige] / Seifert, Gabriel [Sonstige]

    2022  

    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universität
    Publishing place Freiburg
    Document type Book ; Online ; Thesis
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