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  1. Book ; Thesis: Chronische myeloische Leukämie

    Schwarz, Annemarie / Seifert, Michael / Suttorp, Meinolf

    Datenanalyse der molekularen Veränderungen bei unbehandelter Krankheitsprogression

    2022  

    Institution Institut für Medizinische Informatik und Biometrie
    Author's details von Annemarie Schwarz geboren in Schrobenhausen ; Institut für Medizinische Informatik und Biometrie [Dresden]
    Language German
    Size 82 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2023
    HBZ-ID HT030643874
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 338 order for loan Magazin

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  2. Article: Biomarkers of alloimmune events in pediatric kidney transplantation.

    Deville, Kyle A / Seifert, Michael E

    Frontiers in pediatrics

    2023  Volume 10, Page(s) 1087841

    Abstract: Alloimmune events such as the development ... ...

    Abstract Alloimmune events such as the development of
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.1087841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Pflege von Diabetespatienten

    Seifert, Michael

    (Pflege kompakt)

    2002  

    Author's details Michael Seifert
    Series title Pflege kompakt
    Keywords Diabetes mellitus ; Krankenpflege
    Subject Krankenpflegekonzept ; Diabetes verus ; Zuckerharnruhr ; Zuckerkrankheit
    Language German
    Size 134 S. : Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher Kohlhammer
    Publishing place Stuttgart u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT013273850
    ISBN 3-17-016330-2 ; 978-3-17-016330-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 830 order for loan Magazin

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  4. Book: Aromatasehemmer in der endokrinen Therapie des Mammakarzinoms

    Kubista, Ernst / Seifert, Michael / Singer, Christian

    (UNI-MED Science)

    2008  

    Author's details [Ernst Kubista ; Michael Seifert ; Christian Singer]
    Series title UNI-MED Science
    Keywords Brustkrebs ; Aromatasehemmer
    Subject Aromatase-Hemmer ; Aromataseinhibitor ; Brustdrüsenkrebs ; Carcinoma mammae ; Mammacarcinom ; Mammakarzinom
    Language German
    Size 53 S. : Ill., graph. Darst.
    Publisher UNI-MED Verl
    Publishing place Bremen
    Publishing country Germany
    Document type Book
    HBZ-ID HT015601998
    ISBN 978-3-89599-280-3 ; 3-89599-280-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2008 A 3737 order for loan Magazin

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  5. Book ; Thesis: Der Einfluss von Nahrungsaufnahme sowie der Einfluss von Leberzirrhose auf die Pharmakokinetik von oral verabreichtem Zidovudin

    Seifert, Michael Stefan

    2002  

    Author's details vorgelegt von Michael Seifert
    Language German
    Size 136 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 2002
    HBZ-ID HT013491899
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2002 MB 4384 order for loan Magazin

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  6. Book ; Thesis: Rehabilitationsaussichten beinamputierter Alterspatienten im Hinblick auf die prothetische Versorgung

    Seifert, Michael

    1997  

    Author's details vorgelegt von: Michael Seifert
    Keywords Alter ; Beinamputierter ; Rehabilitation ; Beinprothese
    Subject Rehabilitierung ; Alter Mensch ; Betagter ; Senioren ; Senior
    Language German
    Size 75 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Muenster (Westfalen), Univ., Diss., 1997
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x
    HBZ-ID HT007717130
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 MB 1484 order for loan Magazin

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  7. Article ; Online: Meta-analysis of expression and the targeting of cell adhesion associated genes in nine cancer types - a one research lab re-evaluation

    Borodins, Olegs / Broghammer, Felix / Seifert, Michael / Cordes, Nils

    Computational and Structural Biotechnology Journal. 2023 Apr. 19,

    2023  

    Abstract: Cancer presents as a highly heterogeneous disease with partly overlapping and partly distinct (epi)genetic characteristics. These characteristics determine inherent and acquired resistance, which need to be overcome for improving patient survival. In ... ...

    Abstract Cancer presents as a highly heterogeneous disease with partly overlapping and partly distinct (epi)genetic characteristics. These characteristics determine inherent and acquired resistance, which need to be overcome for improving patient survival. In line with the global efforts in identifying druggable resistance factors, extensive preclinical research of the Cordes lab and others designated the cancer adhesome as a critical and general therapy resistance mechanism with multiple druggable cancer targets. In our study, we addressed pancancer cell adhesion mechanisms by connecting the preclinical datasets generated in the Cordes lab with publicly available transcriptomic and patient survival data. We identified similarly changed differentially expressed genes (scDEGs) in nine cancers and their corresponding cell models relative to normal tissues. Those scDEGs interconnected with 212 molecular targets from Cordes lab datasets generated during two decades of research on adhesome and radiobiology. Intriguingly, integrative analysis of adhesion associated scDEGs, TCGA patient survival and protein-protein network reconstruction revealed a set of overexpressed genes adversely affecting overall cancer patient survival and specifically the survival in radiotherapy-treated cohorts. This pancancer gene set includes key integrins (e.g. ITGA6, ITGB1, ITGB4) and their interconnectors (e.g. SPP1, TGFBI), affirming their critical role in the cancer adhesion resistome. In summary, this meta-analysis demonstrates the importance of the adhesome in general, and integrins together with their interconnectors in particular, as potentially conserved determinants and therapeutic targets in cancer.
    Keywords adhesion ; antibiotic resistance genes ; biotechnology ; cell adhesion ; data collection ; gene expression regulation ; integrins ; meta-analysis ; patients ; therapeutics ; transcriptomics ; aaGOIs ; aaGOIs-All/RT ; "All" ; CSC ; COAD ; DEG ; ECM ; EMT ; EVs ; FDR ; GBM ; GO ; GOI ; GSEA ; HNSCC ; KEGG ; LGG ; LUAD ; LUSC ; "No RT" ; MSigDB ; OS ; PAAD ; PCA ; PRAD ; READ ; "RT" ; scDEGs ; TARGET ; TCGA ; TFs ; gene expression ; network analysis ; pancancer
    Language English
    Dates of publication 2023-0419
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2023.04.017
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Meta-analysis of expression and the targeting of cell adhesion associated genes in nine cancer types - A one research lab re-evaluation.

    Borodins, Olegs / Broghammer, Felix / Seifert, Michael / Cordes, Nils

    Computational and structural biotechnology journal

    2023  Volume 21, Page(s) 2824–2836

    Abstract: Cancer presents as a highly heterogeneous disease with partly overlapping and partly distinct (epi)genetic characteristics. These characteristics determine inherent and acquired resistance, which need to be overcome for improving patient survival. In ... ...

    Abstract Cancer presents as a highly heterogeneous disease with partly overlapping and partly distinct (epi)genetic characteristics. These characteristics determine inherent and acquired resistance, which need to be overcome for improving patient survival. In line with the global efforts in identifying druggable resistance factors, extensive preclinical research of the Cordes lab and others designated the cancer adhesome as a critical and general therapy resistance mechanism with multiple druggable cancer targets. In our study, we addressed pancancer cell adhesion mechanisms by connecting the preclinical datasets generated in the Cordes lab with publicly available transcriptomic and patient survival data. We identified similarly changed differentially expressed genes (scDEGs) in nine cancers and their corresponding cell models relative to normal tissues. Those scDEGs interconnected with 212 molecular targets from Cordes lab datasets generated during two decades of research on adhesome and radiobiology. Intriguingly, integrative analysis of adhesion associated scDEGs, TCGA patient survival and protein-protein network reconstruction revealed a set of overexpressed genes adversely affecting overall cancer patient survival and specifically the survival in radiotherapy-treated cohorts. This pancancer gene set includes key integrins (e.g. ITGA6, ITGB1, ITGB4) and their interconnectors (e.g. SPP1, TGFBI), affirming their critical role in the cancer adhesion resistome. In summary, this meta-analysis demonstrates the importance of the adhesome in general, and integrins together with their interconnectors in particular, as potentially conserved determinants and therapeutic targets in cancer.
    Language English
    Publishing date 2023-04-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2023.04.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: T-bet+ B Cells in Humans: Protective and Pathologic Functions.

    Nellore, Anoma / Zumaquero, Esther / Seifert, Michael

    Transplantation

    2023  

    Abstract: The humoral immune system comprises B cells and plasma cells, which play important roles in organ transplantation, ranging from the production of both protective and injurious antibodies as well as cytokines that can promote operational tolerance. Recent ...

    Abstract The humoral immune system comprises B cells and plasma cells, which play important roles in organ transplantation, ranging from the production of both protective and injurious antibodies as well as cytokines that can promote operational tolerance. Recent data from conditions outside of transplantation have identified a novel human B-cell subset that expresses the transcription factor T-bet and exerts pleiotropic functions by disease state. Here, we review the generation, activation, and functions of the T-bet+ B-cell subset outside of allotransplantation, and consider the relevance of this subset as mediators of allograft injury.
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 509: Show issues

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  10. Article ; Online: Secondary Sclerosing Cholangitis due to Severe COVID-19: An Emerging Disease Entity?

    Seifert, Michael / Kneiseler, Guntje / Dechene, Alexander

    Digestion

    2023  Volume 104, Issue 4, Page(s) 306–312

    Abstract: Introduction: Coronavirus disease 2019 (COVID-19) can lead to many extrapulmonary manifestations. In this case series, we report on 7 patients developing secondary sclerosing cholangitis (SSC) after severe COVID-19 with intensive care treatment.: ... ...

    Abstract Introduction: Coronavirus disease 2019 (COVID-19) can lead to many extrapulmonary manifestations. In this case series, we report on 7 patients developing secondary sclerosing cholangitis (SSC) after severe COVID-19 with intensive care treatment.
    Methods: Between March 2020 and November 2021, 544 patient cases with cholangitis treated at a German tertiary care centre were screened for SSC. Patients found to be suffering from SSC were assigned to COVID-19 group if SSC presented after a severe course of COVID-19 and to non-COVID-19 group if not. Peak liver parameters as well as intensive care treatment factors and data generated from liver elastography were compared between both groups.
    Results: We identified 7 patients who developed SSC after a severe course of COVID-19. In the same period, 4 patients developed SSC due to other causes. Mean values of gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) were higher in the COVID-19 group than in the non-COVID-19 group (GGT: 2,689 U/L vs. 1,812 U/L and ALP: 1,445 U/L vs. 1,027 U/L), whereas intensive care treatment factors were comparable in both groups. Only the mean duration of mechanical ventilation was shorter in the COVID-19 group than in the non-COVID-19 group (22.1 days vs. 36.7 days). Liver elastography indicated a fast progression to liver cirrhosis with a mean liver stiffness of 17.3 kilopascals (kPa) in less than 12 weeks in the COVID-19 group.
    Conclusions: Our data suggest a more severe course of SSC when caused by SARS-CoV-2. Reasons for this are probably multifactorial, including a direct cytopathogenic effect of the virus.
    MeSH term(s) Humans ; Cholangitis, Sclerosing/complications ; Cholangitis, Sclerosing/diagnostic imaging ; Cholangitis, Sclerosing/therapy ; COVID-19/complications ; SARS-CoV-2 ; Liver Cirrhosis/complications ; Alkaline Phosphatase
    Chemical Substances Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1712-7
    ISSN 1421-9867 ; 0012-2823
    ISSN (online) 1421-9867
    ISSN 0012-2823
    DOI 10.1159/000528689
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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