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Article: A Rare Cause of Hypoglycemia in Elderly Patients: Insulinoma.

Dirim, Ahmet Baris / Seker, Ahmet

2024 Volume 16, Issue 2, Page(s) e54002

Abstract: Insulinoma is the most common pancreatic neuroendocrine tumor and is often solitary and benign. To make a diagnosis, high insulin levels must be demonstrated, and proinsulin and C-peptide measurements must be done. The presence of hypoglycemic ... ...

Abstract	Insulinoma is the most common pancreatic neuroendocrine tumor and is often solitary and benign. To make a diagnosis, high insulin levels must be demonstrated, and proinsulin and C-peptide measurements must be done. The presence of hypoglycemic measurements and symptoms in the 72-hour fasting test is diagnostic. We present a case of a 91-year-old patient with no known diagnosis of diabetes mellitus who was admitted to the emergency department due to confusion. As a result of the clinical evaluation and differential diagnosis, it was determined that her complaint was due to hypoglycemia, and she was admitted to the internal medicine service for further examination, diagnosis, and treatment.
Language	English
Publishing date	2024-02-11
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.54002
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Article ; Online: Treatment Options and the Management of Complications in Hydatid Cysts of the Liver in Endemic Regions.

Daduk, Yildiray / Seker, Ahmet / Sozutek, Alper / Olmez, Tolga / Kaplan, Kuntay / Dur, Huseyin / Ozdemir, Gorkem

Annali italiani di chirurgia

2024 Volume 95, Issue 2, Page(s) 213–219

Abstract: Background: Hydatid cyst of the liver induced by Echinococcus granulosus is a pervasive zoonotic disease in our region. Its incidence varies across age groups, contingent on community lifespans and hygiene standards. Therapeutic modalities include ... ...

Abstract	Background: Hydatid cyst of the liver induced by Echinococcus granulosus is a pervasive zoonotic disease in our region. Its incidence varies across age groups, contingent on community lifespans and hygiene standards. Therapeutic modalities include Puncture, Aspiration, Injection, Re-aspiration (PAIR), and surgery. Due the limited feasability of PAIR, we suggest that surgery represents the optimal treatment in all stages, especially in endemic regions, depending on patient-specific variables. Method: Patients with hydatid cyst of the liver treated with PAIR and surgery in our center between January 2016 and January 2022 were analyzed retrospectively. PAIR or cystectomy were applied in treatment. These were then compared in terms of efficacy, feasibility, and complications. Results: A single hydatid cyst of the liver was detected in 184 of the 225 cases, two cysts in 33, and three or more cysts in eight. The largest cyst diameter was 233 × 124 mm in the surgery group and 100 × 90 mm in the PAIR group. One hundred thirty-three of the 225 patients underwent open surgery, and no recurrence was encountered in these. However, recurrence was observed 19 patients treated with PAIR. Allergic reaction developed in one case during surgery, postoperative abscess in two cases, biliary fistula in five, and pneumonia in one. Conclusion: Surgical treatment should represent the standard procedure since it is safe and effective, ensures complete elimination of the parasite, involves no intraoperative shedding, preserves healthy tissues, and minimizes the risk of long-term recurrence and cavity-related complications.
MeSH term(s)	Humans ; Echinococcosis, Hepatic/surgery ; Echinococcosis, Hepatic/complications ; Retrospective Studies ; Male ; Female ; Adult ; Middle Aged ; Endemic Diseases ; Aged ; Postoperative Complications/epidemiology ; Young Adult ; Adolescent ; Recurrence ; Suction ; Treatment Outcome
Language	English
Publishing date	2024-04-29
Publishing country	Italy
Document type	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
DOI	10.62713/aic.3379
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Article ; Online: The Role of Ca 19-9, Ca 72-4, Cea and Cholesterol Levels in Predicting Malignancy in Gallbladder Polyps.

Ozer, Nazmi / Sozutek, Alper / Sahin, Abdullah / Seker, Ahmet / Genc, Ismail Caner / Yugruk, Ahmet

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2021 Volume 31, Issue 12, Page(s) 1422–1427

Abstract: Objective: To determine the association of malignancy potential of gallbladder polyps with tumor markers and cholesterol levels, and at which value the presence of malignancy should be suspected.: Study design: Observational study.: Place and ... ...

Abstract	Objective: To determine the association of malignancy potential of gallbladder polyps with tumor markers and cholesterol levels, and at which value the presence of malignancy should be suspected. Study design: Observational study. Place and duration of study: University of Health Sciences, Adana City training and research Hospital from December 2017 to November 2020. Methodology: Ninety patients diagnosed with gallbladder polyp by abdominal ultrasonography, were included in the study. Patients were divided into subgroups of true pseudopolyp, cholesterol-non-cholesterolpolyp, malignant-non-malignant polyp. The groups were compared in terms of age, gender, polyp size, number of polyps, preoperative total cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), triglyceride, Ca 19-9 (carbohydrate antigen 19-9), Ca 72-4 (carbohydrate antigen 72-4), Cea (carcinoembryonic antigen) levels. Results: In the true polyp group, polyp size, Ca 19-9, Ca 72-4 and Cea median values were significantly higher (p=0.001, p=0.029, p=0.003, and p=0.007, respectively); whereas, triglyceride levels were significantly lower compared to the pseudopolyp group (p=0.002). Polyp size was significantly lower in cholesterol polyp group compared to non-cholesterol polyp group (p= 0.032), and LDL and triglyceride medians were significantly higher (p=0.031, and p<0.001) in cholesterol group. Among the true polyps, polyp size, Ca 19-9, Ca 72-4 and Cea levels were significantly higher in adenocarcinoma group than non-malignant polyp groups (p<0.05). Cut-off values were determined as >11 mm AUC: 0.906 for size, >24.1 U/mL. AUC: 1.00 for Ca 19-9, >9.6 U/mL AUC: 1.00 for Ca 72-4, and >40 ng/mL AUC: 0.984 for CEA, respectively. Conclusion: Polyps larger than 11mm with high levels of CEA, Ca 72-4, Ca 19-9, evaluated together, may act as a guide for the clinician in predicting malignancy. The availability of economical and accessible parameters may allow a new algorithm to be developed in the treatment and follow-up approach of gallbladder polyps. Key Words: Gallbladder polpys, Ca 19-9 antigen, Ca 72-4 antigen, Tumor marker, Gallbladder cancer.
MeSH term(s)	CA-19-9 Antigen ; Carcinoembryonic Antigen ; Cholesterol ; Gallbladder Neoplasms/diagnosis ; Humans ; Polyps
Chemical Substances	CA-19-9 Antigen ; Carcinoembryonic Antigen ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2021-11-18
Publishing country	Pakistan
Document type	Journal Article ; Observational Study
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2021.12.1422
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Article ; Online: Evaluating the feasibility of performing elective gastrointestinal cancer surgery during the COVID-19 pandemic: An observational study with 60 days follow-up results of a tertiary referral pandemic hospital.

Sozutek, Alper / Seker, Ahmet / Kuvvetli, Adnan / Ozer, Nazmi / Genc, Ismail Caner

Journal of surgical oncology

2021 Volume 123, Issue 4, Page(s) 834–841

Abstract: Background: The coronavirus disease 2019 (COVID-19) pandemic has interfered with the treatment algorithm for patients with gastrointestinal (GIS) cancer, resulting in deferral of surgery. We presented the outcomes of our patients to evaluate whether ... ...

Abstract	Background: The coronavirus disease 2019 (COVID-19) pandemic has interfered with the treatment algorithm for patients with gastrointestinal (GIS) cancer, resulting in deferral of surgery. We presented the outcomes of our patients to evaluate whether surgery could be safely performed and followed-up without delaying any stage of GIS cancer during the pandemic. Methods: This was an observational study of 177 consecutive patients who underwent elective GIS cancer surgery between March 11 and November 1, 2020. They were assessed regarding their perioperative and 60 days follow-up results for either surgical or COVID-19 status. Morbidity was determined according to the Clavien-Dindo classification (CDC). Continuous and categorical data were presented as median ± SD and number with percentage (%), respectively. Results: The study included 44 gastric, 33 pancreatic, 40 colon, and 59 rectal cancer patients. All patients underwent surgery and received neo/adjuvant treatments without delay. The overall morbidity (CDC grade II-IV) and mortality rates were 10.1% and 3.9%, respectively. None of the patients or medical staff were infected with COVID-19 during the study period. Conclusion: GIS cancer surgery can be safely performed even within a pandemic hospital if proper isolation measures can be achieved for both patients and health workers. Regardless of the tumor stage, surgery should not be deferred, depending on unstandardized algorithms.
MeSH term(s)	Adult ; Aged ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Elective Surgical Procedures ; Feasibility Studies ; Female ; Follow-Up Studies ; Gastrointestinal Neoplasms/mortality ; Gastrointestinal Neoplasms/pathology ; Gastrointestinal Neoplasms/surgery ; Humans ; Infection Control/organization & administration ; Length of Stay ; Male ; Middle Aged ; Operative Time ; Patient Selection ; Postoperative Complications/epidemiology ; Tertiary Care Centers ; Turkey
Language	English
Publishing date	2021-02-09
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	82063-5
ISSN	1096-9098 ; 0022-4790
ISSN (online)	1096-9098
ISSN	0022-4790
DOI	10.1002/jso.26396
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Article ; Online: Gastric cancer diagnosis and staging in coronavirus disease 2019 (Covid-19) pandemic.

Seker, Ahmet / Ozdemir, Gorkem / Sozutek, Alper / Olmez, Tolga / Ozer, Nazmi / Sahin, Abdullah / Dirim, Ahmet Baris / Genc, Ismail Caner / Kuvvetli, Adnan / Parlakgumus, Alper

Annali italiani di chirurgia

2023 Volume 94, Page(s) 203–208

Abstract: Aim: The aim of the study was to analyze whether COVID-19 cause a delay in the diagnosis of gastric cancer patients particularly in the TNM staging of the tumor, or not.: Material and methods: This retrospective single-center study included the ... ...

Abstract	Aim: The aim of the study was to analyze whether COVID-19 cause a delay in the diagnosis of gastric cancer patients particularly in the TNM staging of the tumor, or not. Material and methods: This retrospective single-center study included the patients diagnosed with gastric cancer from March, 2019 to December 2020. The patients were divided into two groups: baseline and the pandemic groups. The following parameters were compared between the groups; demographic data, numbers of newly diagnosed patients, type of the surgery, location of the tumor, frequency of neoadjuvant treatment, ASA score, length of hospital stay, clinical staging and pathologic TNM staging. Results: The mean monthly number of newly diagnosed gastric cancer patients showed a significant decline from 7.5 to 5.6 (p< .001). There were no statistically significant differences between the groups with regard to the demographic factors, except CA 19-9 levels. Patients in the pandemic group had higher both clinical and pathological T-stages (p < 0.05). Conclusions: Our study showed a decline in the number of the newly diagnosed patients with gastric cancer during the pandemic and also more patients presented with advanced stage during the pandemic period. This study showed that the pandemic causes a potential delay in the diagnosis of gastric cancer patients. Key words: Cancer surgery, COVID-19, Gastric cancer, Gastric surgery SARS-COV-2, Pandemic.
MeSH term(s)	Humans ; COVID-19/diagnosis ; COVID-19/epidemiology ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/drug therapy ; Retrospective Studies ; SARS-CoV-2 ; Pandemics ; Neoplasm Staging ; COVID-19 Testing
Language	English
Publishing date	2023-01-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
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Article: Evaluation of current therapeutic approach to obstructive and perforated colorectal cancers.

Kaya, Selçuk / Seker, Ahmet / Altın, Önder / Altuntaş, Yunus Emre / Kaptanoğlu, Levent / Kement, Metin / Bildik, Nejdet / Küçük, Hasan

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

2019 Volume 25, Issue 6, Page(s) 589–596

Abstract: Background: Late diagnosis continues to be a significant problem in the treatment of colorectal cancer (CRC). Most cases require emergency surgical intervention due to acute intestinal obstruction or perforation. This retrospective study was formed from ...

Title translation	Obstrükte ve perforasyonlu kolorektal kanser hastalarına güncel tedavi yaklaşımının değerlendirilmesi.
Abstract	Background: Late diagnosis continues to be a significant problem in the treatment of colorectal cancer (CRC). Most cases require emergency surgical intervention due to acute intestinal obstruction or perforation. This retrospective study was formed from an assessment of the clinical presentation, treatment, early results, and survival of patients with CRC undergoing emergency surgery for acute obstruction or perforation. Methods: Between 2012 and 2017, 612 patients underwent surgery for CRC. In all, 179 patients who required emergency treatment were retrospectively evaluated according to age, gender, significant comorbidities, physiological status, surgical indications, tumor location, tumor stage, perioperative blood transfusion rate, type of surgery, and the length of the operation and hospitalization. Results: In total, 152 (85%) patients had a complete obstruction and 27 (15%) patients had a perforation. A major postoperative complication was identified nearly in half of the patients. The overall mortality rate was 12% (22 patients). Mortality was seen in 12% (18 patients) cases received surgery due to obstruction and in 15% (four patients) cases received surgery due to perforation. Perioperative blood transfusion and a high Acute Physiology and Chronic Health Evaluation II score were independent factors that predicted a major complication. Advanced age and perioperative blood transfusion were statistically independent prognostic factors for mortality. Conclusion: Consisted with the findings of studies in the literature, the results of this study also revealed a high perioperative morbidity and mortality rate in patients with CRC who required urgent surgery. Our findings suggest that early detection and treatment of CRC with screening programs can be life-saving.
MeSH term(s)	Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Delayed Diagnosis ; Emergency Treatment/adverse effects ; Emergency Treatment/statistics & numerical data ; Humans ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Intestinal Perforation/etiology ; Intestinal Perforation/surgery ; Postoperative Complications ; Retrospective Studies
Language	English
Publishing date	2019-11-07
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2253739-9
ISSN	1306-696X
ISSN	1306-696X
DOI	10.14744/tjtes.2019.03828
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Article ; Online: Are the single-step resection and primary anastomosis suitable for obstructıve colorectal patients in older cases?

Kaya, Selcuk / Altin, Onder / Altuntas, Yunus Emre / Kement, Metin / Kaptanoglu, Levent / Seker, Ahmet / Bildik, Nejdet / Kucuk, Hasan Fehmi

Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina

2018 Volume 16, Issue 1, Page(s) 83–87

Abstract: Aim To investigate the efficacy and safety of the single-step surgery in elderly patients with obstructive colorectal cancer. Methods All patients who underwent single-step surgery and primary anastomosis for obstructive colorectal cancer in the period ... ...

Abstract	Aim To investigate the efficacy and safety of the single-step surgery in elderly patients with obstructive colorectal cancer. Methods All patients who underwent single-step surgery and primary anastomosis for obstructive colorectal cancer in the period between January 2021 December 2017 were evaluated in this study. The patients were divided into two groups: younger than 65 (Group Young) and older than 65 (Group Old). Demographic data, American Society of Anesthesiologists scores (ASA) scores, comorbidities, preoperative albumin levels, type of surgery, postoperative morbidity and mortality, pathological stages, and overall survival rates were investigated. Results A total of 89 patients were included: 49 (54%) were older than 65 (Group Old). In Group Old, the mean age was 75 (65-97), of which 28 (58.3%) were males. There were 41 patients younger than 65 (Group Young) with the mean age of 52.6 (41-64 years of age), of which 21 (51.2%) were males. There was no difference between groups according to albumin level. There was no statistical difference between two groups according to tumour localization, pathological stage and type of surgery, as well as according to surgical complications. The median overall survival rate was 11 months in both groups (0-66) (p=0.320). Conclusion Meticulous preparation of older patients (correction of anaemia, electrolyte levels and pH ) paves the road for successful surgeries, including single-step resection and primary anastomosis.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Anastomosis, Surgical ; Colectomy ; Colorectal Neoplasms/complications ; Colorectal Neoplasms/surgery ; Digestive System Surgical Procedures ; Female ; Humans ; Intestinal Obstruction/etiology ; Intestine, Large/surgery ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Retrospective Studies
Language	English
Publishing date	2018-09-26
Publishing country	Bosnia and Herzegovina
Document type	Journal Article
ZDB-ID	2378942-6
ISSN	1840-2445 ; 1840-0132
ISSN (online)	1840-2445
ISSN	1840-0132
DOI	10.17392/971-19
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Article ; Online: Laparoscopic Retroperitoneal Removal of Schwannoma.

Akin, Yigit / Demir, Mehmet / Seker, Ahmet / Altay, Nuray / Gulum, Mehmet / Yeni, Ercan

Archives of Iranian medicine

2015 Volume 18, Issue 5, Page(s) 332

MeSH term(s)	Humans ; Male ; Neurilemmoma/diagnosis ; Retroperitoneal Neoplasms/diagnosis
Language	English
Publishing date	2015-05
Publishing country	Iran
Document type	Comment ; Letter
ZDB-ID	2204979-4
ISSN	1735-3947 ; 1029-2977
ISSN (online)	1735-3947
ISSN	1029-2977
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Article ; Online: May mean platelet volume levels be a predictor in the diagnosis of pelvic inflammatory disease?

Incebiyik, Adnan / Seker, Ahmet / Vural, Mehmet / Gul Hilali, Nese / Camuzcuoglu, Aysun / Camuzcuoglu, Hakan

Wiener klinische Wochenschrift

2014 Volume 126, Issue 13-14, Page(s) 422–426

Abstract: Background: Our aim in this study was to investigate whether mean platelet volume (MPV) value could be used as an early marker to predict pelvic inflammatory disease (PID).: Methods: Overall, 44 patients with PID and 44 healthy women were included in ...

Abstract	Background: Our aim in this study was to investigate whether mean platelet volume (MPV) value could be used as an early marker to predict pelvic inflammatory disease (PID). Methods: Overall, 44 patients with PID and 44 healthy women were included in the study. The control group consisted of 44 women who applied to the clinic for a routine gynaecological check-up, without chronic disease or a history of medication use. Owing to the fact that it would affect thrombocyte function, women who have the following conditions were excluded from the study: women who were taking anticoagulant therapy, oral contraceptives, nonsteroid anti-inflammatory medications and who had chronic diseases. The leukocyte count, platelet count, neutrophil ratio and MPV values were collected from PID and the control group. C reactive protein values of patients with PID were also noted. Results: MPV values in patients with PID were lower than those in the control group. This reduction in MPV is statistically significant when the PID patient group is compared with the control group (p < 0.001). A negative correlation was discovered between platelet count and MPV values (p = 0.019, r = - 0.425). Receiver-operating curve analysis pointed out that MPV has greater area under curve value than neutrophil rate, leukocyte and platelet count (0.73, 0.64, 0.72 and 0.49 respectively). Conclusion: Since the MPV value was significantly decreased in patients with PID, it may serve as an additional and even more valuable marker than leukocyte count in the diagnosis of PID.
MeSH term(s)	Adult ; Biomarkers ; Blood Sedimentation ; C-Reactive Protein/metabolism ; Case-Control Studies ; Early Diagnosis ; Female ; Humans ; Mean Platelet Volume ; Pelvic Inflammatory Disease/blood ; Pelvic Inflammatory Disease/diagnosis ; Platelet Count ; Predictive Value of Tests
Chemical Substances	Biomarkers ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2014-06-24
Publishing country	Austria
Document type	Journal Article
ZDB-ID	200462-8
ISSN	1613-7671 ; 0043-5325 ; 0300-5178
ISSN (online)	1613-7671
ISSN	0043-5325 ; 0300-5178
DOI	10.1007/s00508-014-0560-2
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Article ; Online: Surgical treatment of hepatic hydatid cysts A retrospective analysis of 425 patients.

Yucel, Yusuf / Seker, Ahmet / Eser, Irfan / Ozgonul, Abdullah / Terzi, Alpaslan / Gozeneli, Orhan / Aydogan, Timucin / Uzunkoy, Ali

Annali italiani di chirurgia

2015 Volume 86, Page(s) 437–443

Abstract: Background: We aimed to retrospectively analyze patients who underwent surgical treatment in our clinic for hydatid cysts in terms of the surgical methods implemented and their results.: Methods: Archival records of the patients who underwent surgery ...

Abstract	Background: We aimed to retrospectively analyze patients who underwent surgical treatment in our clinic for hydatid cysts in terms of the surgical methods implemented and their results. Methods: Archival records of the patients who underwent surgery for the treatment of hydatid cysts between 2007 and 2014 were analyzed retrospectively. Results: The records of 425 patients who underwent surgery with varying ages of 16 to 88 years (mean: 44.5) were obtained. Among the patients, 33.9% (n=144) were male and 66.1% (n=281) were female. The most frequent symptoms were abdominal pain (46.4%) and dyspepsia (30.9%). About 79.5% of the patients had hydatid cysts in their livers, and 66.8% of these cysts were on the right lobe of the liver. Surgical intervention was performed on 513 cysts. The average diameter of these cysts was 8.3 cm. About 85.5% (n= 438) of the interventions implemented were partial cystectomy. Laparotomy was performed through the right subcostal incision on 81% (n=345) of the patients who underwent conventional surgery. The most frequently encountered complication was biliary fistula. The mortality rate was 0%. Conclusions: The results showed that most of the cases were uncomplicated isolated hepatic hydatid cysts frequently found on the right lobe of the liver. The most frequently implemented surgical procedure was partial cystectomy. This procedure was simple, fast and applicable for uncomplicated hepatic hydatid cysts. Key words: Hepatic hydatid cyst, Mortality, Partial cystectomy.
MeSH term(s)	Abdominal Pain/etiology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biliary Fistula/etiology ; Echinococcosis, Hepatic/complications ; Echinococcosis, Hepatic/epidemiology ; Echinococcosis, Hepatic/surgery ; Female ; Hepatectomy/methods ; Hepatectomy/statistics & numerical data ; Humans ; Male ; Middle Aged ; Postoperative Complications/etiology ; Recurrence ; Retrospective Studies ; Rupture, Spontaneous ; Turkey/epidemiology ; Young Adult
Language	English
Publishing date	2015
Publishing country	Italy
Document type	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
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