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  1. Article ; Online: Unveiling the cancer risk nexus of the steatotic liver.

    Kim, Jieun / Seki, Ekihiro

    Trends in endocrinology and metabolism: TEM

    2024  

    Abstract: Steatotic liver, characterized by the accumulation of fat in the liver, poses significant health risks including metabolic dysfunction-associated steatotic liver disease (MASLD) and an elevated risk of primary liver cancer. Emerging evidence indicates a ... ...

    Abstract Steatotic liver, characterized by the accumulation of fat in the liver, poses significant health risks including metabolic dysfunction-associated steatotic liver disease (MASLD) and an elevated risk of primary liver cancer. Emerging evidence indicates a robust association between steatotic liver and increased susceptibility to extrahepatic primary cancers and their metastases. The deposition of fat induces dynamic changes in hepatic microenvironments, thereby fostering inflammation and immune responses that enhance liver metastasis from extrahepatic primary cancers. This review explores the impact of steatotic liver on hepatic carcinogenesis and metastasis from extrahepatic cancers, with a specific focus on hepatocyte-derived factors and the immune microenvironment. By emphasizing novel conclusions, this article underscores the timely relevance of understanding these intricate connections.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2024.02.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2999: Show issues Location:
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  2. Article ; Online: FAP: Not Just a Biomarker but Druggable Target in Liver Fibrosis.

    Kim, Jieun / Seki, Ekihiro

    Cellular and molecular gastroenterology and hepatology

    2023  Volume 15, Issue 4, Page(s) 1018–1019

    MeSH term(s) Humans ; Liver Cirrhosis/drug therapy ; Serine Endopeptidases ; Biomarkers
    Chemical Substances Serine Endopeptidases (EC 3.4.21.-) ; Biomarkers
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2022.12.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hyaluronan in liver fibrosis: basic mechanisms, clinical implications, and therapeutic targets.

    Kim, Jieun / Seki, Ekihiro

    Hepatology communications

    2023  Volume 7, Issue 4

    Abstract: Hyaluronan (HA), also known as hyaluronic acid, is a glycosaminoglycan that is a critical component of the extracellular matrix (ECM). Production and deposition of ECM is a wound-healing response that occurs during chronic liver disease, such as ... ...

    Abstract Hyaluronan (HA), also known as hyaluronic acid, is a glycosaminoglycan that is a critical component of the extracellular matrix (ECM). Production and deposition of ECM is a wound-healing response that occurs during chronic liver disease, such as cirrhosis. ECM production is a sign of the disease progression of fibrosis. Indeed, the accumulation of HA in the liver and elevated serum HA levels are used as biomarkers of cirrhosis. However, recent studies also suggest that the ECM, and HA in particular, as a functional signaling molecule, facilitates disease progression and regulation. The systemic and local levels of HA are regulated by de novo synthesis, cleavage, endocytosis, and degradation of HA, and the molecular mass of HA influences its pathophysiological effects. However, the regulatory mechanisms of HA synthesis and catabolism and the functional role of HA are still poorly understood in liver fibrosis. This review summarizes the role of HA in liver fibrosis at molecular levels as well as its clinical implications and discusses the potential therapeutic uses of targeting HA in liver fibrosis.
    MeSH term(s) Humans ; Hyaluronic Acid/therapeutic use ; Hyaluronic Acid/metabolism ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/metabolism ; Fibrosis ; Extracellular Matrix ; Disease Progression
    Chemical Substances Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1097/HC9.0000000000000083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: In Vivo and In Vitro Models to Study Liver Fibrosis: Mechanisms and Limitations.

    Lee, Young-Sun / Seki, Ekihiro

    Cellular and molecular gastroenterology and hepatology

    2023  Volume 16, Issue 3, Page(s) 355–367

    Abstract: Liver fibrosis is a common result of liver injury owing to various kinds of chronic liver diseases. A deeper understanding of the pathophysiology of liver fibrosis and identifying potential therapeutic targets of liver fibrosis is important because liver ...

    Abstract Liver fibrosis is a common result of liver injury owing to various kinds of chronic liver diseases. A deeper understanding of the pathophysiology of liver fibrosis and identifying potential therapeutic targets of liver fibrosis is important because liver fibrosis may progress to advanced liver diseases, such as cirrhosis and hepatocellular carcinoma. Despite numerous studies, the underlying mechanisms of liver fibrosis remain unclear. Mechanisms of the development and progression of liver fibrosis differ according to etiologies. Therefore, appropriate liver fibrosis models should be selected according to the purpose of the study and the type of underlying disease. Many in vivo animal and in vitro models have been developed to study liver fibrosis. However, there are no perfect preclinical models for liver fibrosis. In this review, we summarize the current in vivo and in vitro models for studying liver fibrosis and highlight emerging in vitro models, including organoids and liver-on-a-chip models. In addition, we discuss the mechanisms and limitations of each model.
    MeSH term(s) Animals ; Liver Cirrhosis/pathology ; Fibrosis ; Carcinoma, Hepatocellular ; Liver Neoplasms/pathology
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2023.05.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Experimental Workflow for Preclinical Studies of Human Antifibrotic Therapies.

    Reolizo, Lien / Matsuda, Michitaka / Seki, Ekihiro

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2669, Page(s) 285–306

    Abstract: Chronic liver diseases accompanied by liver fibrosis have caused significant morbidity and mortality in the world with increasing prevalence. Nonetheless, there are no approved antifibrotic therapies. Although numerous preclinical studies showed ... ...

    Abstract Chronic liver diseases accompanied by liver fibrosis have caused significant morbidity and mortality in the world with increasing prevalence. Nonetheless, there are no approved antifibrotic therapies. Although numerous preclinical studies showed satisfactory results in targeting fibrotic pathways, these animal studies have not led to success in humans. In this chapter, we summarize the experimental approaches currently available, including in vitro cell culture models, in vivo animal models, and new experimental tools relevant to humans, and discuss how we translate laboratory results to clinical trials. We will also address the obstacles in transitioning promising therapies from preclinical studies to human antifibrotic treatments.
    MeSH term(s) Animals ; Humans ; Workflow ; Liver Cirrhosis/metabolism ; Fibrosis ; Liver Diseases ; Research
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3207-9_18
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  6. Article ; Online: Crossing the Rubicon: Adipose Tissue Autophagy Breaks Out NAFLD.

    Kim, Jieun / Seki, Ekihiro

    Cellular and molecular gastroenterology and hepatology

    2021  Volume 12, Issue 5, Page(s) 1877–1878

    MeSH term(s) Adipose Tissue ; Autophagy ; Humans ; Intracellular Signaling Peptides and Proteins ; Non-alcoholic Fatty Liver Disease
    Chemical Substances Intracellular Signaling Peptides and Proteins
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2021.08.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An Intestine-Derived HDL as a Novel Regulator of the Activity of Gut-Derived LPS: Ushering in a New Era of Research on the Gut-Liver Axis.

    Kim, Jieun / Seki, Ekihiro

    Gastroenterology

    2021  Volume 162, Issue 2, Page(s) 651–652

    Language English
    Publishing date 2021-09-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.09.045
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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.44: Show issues Location:
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    Zs.MO 572: Show issues

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  8. Article ; Online: Global Spread of a Local Fire: Transmission of Endoplasmic Reticulum Stress via Connexin 43.

    Yang, Yoon Mee / Seki, Ekihiro

    Cell metabolism

    2021  Volume 33, Issue 2, Page(s) 229–230

    Abstract: Endoplasmic reticulum (ER) stress is essential in the development of obesity, insulin resistance, and hepatosteatosis. In the latest issue of Cell Metabolism, Tirosh et al. (2020) demonstrate that intracellular ER stress can be transmitted to neighboring ...

    Abstract Endoplasmic reticulum (ER) stress is essential in the development of obesity, insulin resistance, and hepatosteatosis. In the latest issue of Cell Metabolism, Tirosh et al. (2020) demonstrate that intracellular ER stress can be transmitted to neighboring hepatocytes via connexin 43, thus propagating ER stress and promoting hepatosteatosis and insulin resistance.
    MeSH term(s) Connexin 43 ; Endoplasmic Reticulum Stress ; Humans ; Insulin Resistance ; Liver ; Obesity
    Chemical Substances Connexin 43
    Language English
    Publishing date 2021-01-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2021.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6169: Show issues Location:
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  9. Article: Acrolein, a New Villain in the Development of Alcoholic Liver Disease.

    Seki, Ekihiro

    Cellular and molecular gastroenterology and hepatology

    2016  Volume 2, Issue 5, Page(s) 544–545

    Language English
    Publishing date 2016-07-26
    Publishing country United States
    Document type Editorial
    ISSN 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2016.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: HEDGEHOG Signal in hepatocytes mediates macrophage recruitment: A new mechanism and potential therapeutic target for fatty liver disease.

    Seki, Ekihiro

    Hepatology (Baltimore, Md.)

    2016  Volume 63, Issue 4, Page(s) 1071–1073

    MeSH term(s) Anilides/pharmacology ; Animals ; Diet, High-Fat ; Hedgehog Proteins/metabolism ; Inflammation/drug therapy ; Non-alcoholic Fatty Liver Disease/pathology ; Pyridines/pharmacology ; Signal Transduction/physiology
    Chemical Substances Anilides ; Hedgehog Proteins ; Pyridines
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.28381
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