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  1. Article ; Online: Superior vena cava coil left alone in the innominate vein: successful removal by a combined approach via jugular and femoral veins.

    Kuroki, Kenji / Sekiguchi, Yukio / Aonuma, Kazutaka / Sato, Akira

    European heart journal. Case reports

    2024  Volume 8, Issue 2, Page(s) ytae077

    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytae077
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  2. Article ; Online: Zinc-Mediated Hydroxyallylation of Aldehydes with Cyclopropanols: Direct Access to Vicinal

    Sekiguchi, Yoshiya / Yoshikai, Naohiko

    Organic letters

    2022  Volume 24, Issue 3, Page(s) 960–965

    Abstract: Direct and diastereoselective synthesis of ... ...

    Abstract Direct and diastereoselective synthesis of vicinal
    Language English
    Publishing date 2022-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.1c04331
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  3. Article ; Online: Can the mini-sling become the golden standard for treating stress urinary incontinence? Comment: The TFS retropubic tensioned minisling for SUI-a 14 year experience with high long-term RCT cure.

    Inoue, H / Sekiguchi, Y / Nakamura, R

    International urogynecology journal

    2021  Volume 32, Issue 10, Page(s) 2877–2878

    MeSH term(s) Humans ; Suburethral Slings ; Urinary Incontinence, Stress/surgery
    Language English
    Publishing date 2021-07-21
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1050631-7
    ISSN 1433-3023 ; 0937-3462
    ISSN (online) 1433-3023
    ISSN 0937-3462
    DOI 10.1007/s00192-021-04922-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3070: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article: Zinc-Mediated Hydroxyallylation of Aldehydes with Cyclopropanols: Direct Access to Vicinal anti-sec,tert-Diols via Enolized Homoenolates

    Sekiguchi, Yoshiya / Yoshikai, Naohiko

    Organic letters. 2022 Jan. 14, v. 24, no. 3

    2022  

    Abstract: Direct and diastereoselective synthesis of vicinal anti-sec,tert-diols has been achieved by zinc-mediated α-hydroxyallylation of aldehydes with cyclopropanols. The reaction features the action of the zinc-enolized homoenolate as a γ-oxyallyl nucleophile ... ...

    Abstract Direct and diastereoselective synthesis of vicinal anti-sec,tert-diols has been achieved by zinc-mediated α-hydroxyallylation of aldehydes with cyclopropanols. The reaction features the action of the zinc-enolized homoenolate as a γ-oxyallyl nucleophile toward the carbonyl electrophile. The diastereoselectivity of the present reaction is ascribed to the strong preference for a chelated (Z)-configuration of the enolized homoenolate as well as the bicyclic chairlike transition state it forms with the aldehyde, where the aldehyde substituent prefers to occupy the pseudoaxial position.
    Keywords Lewis acids ; Lewis bases ; aldehydes ; diastereoselective synthesis ; diastereoselectivity
    Language English
    Dates of publication 2022-0114
    Size p. 960-965.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.1c04331
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Engineering Critical Residues of SOX9 Discovers a Variant With Potent Capacity to Induce Chondrocytes.

    Sekiguchi, Yuya / Fukuda, Aya / Nishimura, Ken / Hisatake, Koji

    Stem cells (Dayton, Ohio)

    2023  Volume 41, Issue 12, Page(s) 1157–1170

    Abstract: Articular cartilage plays vital roles as a friction minimizer and shock absorber during joint movement but has a poor capacity to self-repair when damaged through trauma or disease. Cartilage tissue engineering is an innovative technique for cartilage ... ...

    Abstract Articular cartilage plays vital roles as a friction minimizer and shock absorber during joint movement but has a poor capacity to self-repair when damaged through trauma or disease. Cartilage tissue engineering is an innovative technique for cartilage regeneration, yet its therapeutic application requires chondrocytes in large numbers. Direct reprogramming of somatic cells to chondrocytes by expressing SOX9, KLF4, and c-MYC offers a promising option to generate chondrocytes in sufficient numbers; however, the low efficiency of the reprogramming system warrants further improvement. Here we referred to structural and functional features of SOX9 and performed alanine-scanning mutagenesis of functionally critical residues in the HMG box and at putative posttranslational modification (PTM) sites. We discovered that a SOX9 variant H131A/K398A, doubly mutated in the HMG box (H131) and at a PTM site (K398), significantly upregulated expression of chondrogenic genes and potently induced chondrocytes from mouse embryonic fibroblasts. The H131A/K398A variant remained unsumoylated in cells and exhibited a stronger DNA-binding activity than wild-type SOX9, especially when complexed with other proteins. Our results show that the novel SOX9 variant may be useful for efficient induction of chondrocytes and illuminate the strategic feasibility of mutating a transcription factor at functionally critical residues to expedite discovery of an optimized reprogramming factor.
    MeSH term(s) Animals ; Mice ; Chondrocytes/metabolism ; Fibroblasts/metabolism ; Transcription Factors/metabolism ; Cartilage, Articular ; Gene Expression Regulation ; SOX9 Transcription Factor/genetics ; SOX9 Transcription Factor/metabolism ; Cells, Cultured
    Chemical Substances Transcription Factors ; SOX9 Transcription Factor
    Language English
    Publishing date 2023-08-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1143556-2
    ISSN 1549-4918 ; 1066-5099
    ISSN (online) 1549-4918
    ISSN 1066-5099
    DOI 10.1093/stmcls/sxad066
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    Zs.A 1894: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Chemical emasculation in cowpea (Vigna unguiculata (L.) Walp.) and dicotyledonous model species using trifluoromethanesulfonamide (TFMSA).

    Sekiguchi, Yuka / Ubi, Benjamin Ewa / Ishii, Takayoshi

    Plant reproduction

    2023  Volume 36, Issue 3, Page(s) 273–284

    Abstract: Hybridization plays an indispensable role in creating the diversity associated with plant evolution and genetic improvement of crops. Production of hybrids requires control of pollination and avoidance of self-pollination for species that are ... ...

    Abstract Hybridization plays an indispensable role in creating the diversity associated with plant evolution and genetic improvement of crops. Production of hybrids requires control of pollination and avoidance of self-pollination for species that are predominantly autogamous. Hand emasculation, male sterility genes or male gametocides have been used in several plant species to induce pollen sterility. However, in cowpea (Vigna unguiculata (L.) Walp), a self-pollinated cleistogamous dryland crop, only hand emasculation is used, but it is tedious and time-consuming. In this study, male sterility was effectively induced in cowpea and two dicotyledonous model species (Arabidopsis thaliana (L.) Heynh. and Nicotiana benthamiana Domin) using trifluoromethanesulfonamide (TFMSA). Pollen viability assays using Alexander staining showed that 30 ml of 1000 mg/l TFMSA with two-time treatments of one-week interval at the early stage of the reproductive phase under field or greenhouse conditions induced 99% pollen sterility in cowpea. TFMSA treatment induced non-functional pollen in diploid A. thaliana at two-time treatment of 10 ml of 125-250 mg/l per plant and N. benthamiana at two-time treatment of 10 ml of 250-1000 mg/l per plant. TFMSA-treated cowpea plants produced hybrid seeds when used as the female parent in crosses with non-treated plants used as male parents, suggesting that TFMSA had no effect on female functionality in cowpea. The ease of TFMSA treatment and its effectiveness to induce pollen sterility in a wide range of cowpea genotypes, and in the two model plant species tested in this study, may expand the scope of techniques for rapid pollination control in self-pollinated species, with potential applications in plant breeding and plant reproduction science.
    MeSH term(s) Male ; Humans ; Vigna/genetics ; Plant Breeding ; Magnoliopsida/genetics ; Genes, Plant ; Infertility, Male/genetics
    Language English
    Publishing date 2023-05-25
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2700598-7
    ISSN 2194-7961 ; 2194-7953
    ISSN (online) 2194-7961
    ISSN 2194-7953
    DOI 10.1007/s00497-023-00469-4
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  7. Article ; Online: Overexertion and heat stress in the fire service: a new conceptual framework.

    Wohlgemuth, Kealey / Sekiguchi, Yasuki / Mota, Jacob

    American journal of industrial medicine

    2023  Volume 66, Issue 8, Page(s) 705–709

    Abstract: From the year 2000, the United States Fire Administration (USFA) has been recording all line-of-duty deaths in the fire service. Stress or overexertion caused 1096 out of 2598 total line-of-duty deaths in the United States from 2000 to 2021. Those deaths ...

    Abstract From the year 2000, the United States Fire Administration (USFA) has been recording all line-of-duty deaths in the fire service. Stress or overexertion caused 1096 out of 2598 total line-of-duty deaths in the United States from 2000 to 2021. Those deaths due to stress or overexertion were further classified as myocardial infarction (90%), cerebrovascular accident (6.8%), other (2.6%), and heat exhaustion (0.6%). Environmental heat exposure is a concern in firefighting, as firefighters work in extreme conditions, such as high ambient temperatures, while wearing protective clothing. Heat stress is not only hazardous to the cardiovascular system, but may accentuate muscle fatigue and overexertion. In addition, overexertion itself is related to increased incidence of musculoskeletal injuries, usually to the lower extremities. Further, there is a strong physiological mechanistic link to suggest that the increased occupational heat exposure and thermoregulatory strain firefighters experience may be a stressor that increases the risk of injuries. This commentary hopes to show the need for further research on the effects of occupational exposures and physiological strain in the fire service.
    MeSH term(s) Humans ; United States/epidemiology ; Occupational Exposure/adverse effects ; Occupational Exposure/analysis ; Myocardial Infarction ; Hot Temperature ; Heat Stress Disorders/epidemiology ; Heat Stress Disorders/etiology ; Firefighters ; Heat-Shock Response
    Language English
    Publishing date 2023-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604538-8
    ISSN 1097-0274 ; 0271-3586
    ISSN (online) 1097-0274
    ISSN 0271-3586
    DOI 10.1002/ajim.23482
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    Zs.A 1605: Show issues Location:
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  8. Article ; Online: Enantioselective Conjugate Addition of Catalytically Generated Zinc Homoenolate.

    Sekiguchi, Yoshiya / Yoshikai, Naohiko

    Journal of the American Chemical Society

    2021  Volume 143, Issue 12, Page(s) 4775–4781

    Abstract: We report herein an enantioselective conjugate addition reaction of a zinc homoenolate, catalytically generated via ring opening of a cyclopropanol, to an α,β-unsaturated ketone. The reaction is promoted by a zinc aminoalkoxide catalyst generated from ... ...

    Abstract We report herein an enantioselective conjugate addition reaction of a zinc homoenolate, catalytically generated via ring opening of a cyclopropanol, to an α,β-unsaturated ketone. The reaction is promoted by a zinc aminoalkoxide catalyst generated from Et
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c00869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Zinc-Catalyzed β-Functionalization of Cyclopropanols via Enolized Homoenolate.

    Sekiguchi, Yoshiya / Yoshikai, Naohiko

    Journal of the American Chemical Society

    2021  Volume 143, Issue 44, Page(s) 18400–18405

    Abstract: We report herein a zinc-catalyzed β-allylation of cyclopropanols with Morita-Baylis-Hillman (MBH) carbonates with retention of the cyclopropane ring. The reaction is promoted by a zinc aminoalkoxide catalyst, affording cyclopropyl-fused α-alkylidene-δ- ... ...

    Abstract We report herein a zinc-catalyzed β-allylation of cyclopropanols with Morita-Baylis-Hillman (MBH) carbonates with retention of the cyclopropane ring. The reaction is promoted by a zinc aminoalkoxide catalyst, affording cyclopropyl-fused α-alkylidene-δ-valerolactone derivatives in moderate to good yields. Mechanistic experiments suggest that the present reaction does not proceed via direct β-C-H cleavage of the cyclopropanol, but involves zinc homoenolate and its enolization to generate a key bis-nucleophilic species. α-Allylation of this "enolized homoenolate" with MBH carbonate would be followed by regeneration of the cyclopropane ring and irreversible lactonization. The enolized homoenolate mechanism has also been proven to allow for β-functionalization with alkylidenemalononitrile as the reaction partner. A sequence of the present reaction and known cyclopropanol transformation provides an opportunity to transform a simple cyclopropanol into α,β- or β,β-difunctionalized ketones.
    Language English
    Publishing date 2021-10-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c10109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Effect of Bond-Line Thickness on Fatigue Crack Growth of Structural Acrylic Adhesive Joints.

    Sekiguchi, Yu / Sato, Chiaki

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 7

    Abstract: With an increasing demand for adhesives, the durability of joints has become highly important. The fatigue resistance of adhesives has been investigated mainly for epoxies, but in recent years many other resins have been adopted for structural adhesives. ...

    Abstract With an increasing demand for adhesives, the durability of joints has become highly important. The fatigue resistance of adhesives has been investigated mainly for epoxies, but in recent years many other resins have been adopted for structural adhesives. Therefore, understanding the fatigue characteristics of these resins is also important. In this study, the cyclic fatigue behavior of a two-part acrylic-based adhesive used for structural bonding was investigated using a fracture-mechanics approach. Fatigue tests for mode I loading were conducted under displacement control using double cantilever beam specimens with varying bond-line thicknesses. When the fatigue crack growth rate per cycle,
    Language English
    Publishing date 2021-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14071723
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