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  1. Article ; Online: Single versus bilateral internal thoracic artery grafting in patients with impaired renal function.

    Farkash, Ariel / Gordon, Amit / Mohr, Rephael / Sela, Orr / Pevni, Dmitri / Ziv-Baran, Tomer / Grupper, Ayelet / Kfir, Jonathan E / Ben-Gal, Yanai

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0297194

    Abstract: Objective: The optimal strategy for surgical revascularization in patients with impaired renal function is inconclusive. We compared early and late outcomes between bilateral internal thoracic artery (BITA) and single ITA (SITA) grafting in patients ... ...

    Abstract Objective: The optimal strategy for surgical revascularization in patients with impaired renal function is inconclusive. We compared early and late outcomes between bilateral internal thoracic artery (BITA) and single ITA (SITA) grafting in patients with renal dysfunction.
    Methods: This is a retrospective analysis of all the patients with multivessel disease and impaired renal function (estimated glomerular filtration rate <60mL/min/1.73m2) who underwent isolated coronary artery bypass graft (CABG) in our center during 1996-2011, utilizing either BITA or SITA revascularization.
    Results: Of the 5301 patients with multivessel disease who underwent surgical revascularization during the study period, 391 were with impaired renal function: 212 (54.2%) underwent BITA, 179 (45.8%) underwent SITA. Patients who underwent BITA were less likely to have comorbidities. Statistically significant differences were not observed between the BITA and SITA groups in 30-day mortality (5.6% vs. 9.0%, p = 0.2) and in rates of early stroke, myocardial infarction, and sternal infection (4.5% vs. 6.1%, p = 0.467; 1.7% vs. 2.8%, p = 0.517; and 2.2% vs. 5.7%, p = 0.088, respectively). Long-term survival of the BITA group was better: median 8.36 vs. 4.14 years, p<0.001. In multivariable analysis, BITA revascularization was associated with decreased late mortality (HR = 0.704, 95% CI: 0.556-0.89, p = 0.003). In analysis of a matched cohort (134 pairs), early outcomes did not differ between the groups; however, in multivariable analysis, BITA revascularization was associated with decreased late mortality ‎‎(HR = 0.35 (95%CI 0.18-0.68), p = 0.002)‎.
    Conclusions: BITA revascularization did not impact early outcome in patients with CRF, but demonstrated a significant protective effect on long-term survival ‎in the unmatched and matched cohorts.
    MeSH term(s) Humans ; Retrospective Studies ; Mammary Arteries/transplantation ; Treatment Outcome ; Coronary Artery Bypass/adverse effects ; Kidney/surgery ; Coronary Artery Disease/complications ; Coronary Artery Disease/surgery ; Risk Factors
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297194
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  2. Article ; Online: Between Symmetry and Duality in Supersymmetric Quantum Field Theories.

    Razamat, Shlomo S / Sela, Orr / Zafrir, Gabi

    Physical review letters

    2018  Volume 120, Issue 7, Page(s) 71604

    Abstract: We study two cases of interrelations between the enhancement of symmetries in the infrared (IR) and duality properties of supersymmetric quantum field theories in four dimensions. First, we discuss an SU(2) N=1 model with four flavors, singlet fields, ... ...

    Abstract We study two cases of interrelations between the enhancement of symmetries in the infrared (IR) and duality properties of supersymmetric quantum field theories in four dimensions. First, we discuss an SU(2) N=1 model with four flavors, singlet fields, and a superpotential. We show that this model flows to a conformal field theory with E_{6}×U(1) global symmetry. The enhancement of the flavor symmetry follows from Seiberg duality. The second example is concerned with an SU(4) gauge theory with matter in the fundamental and antisymmetric representations. We argue that this model has enhanced SO(12) symmetry in the IR, and, guided by this enhancement, we deduce a new IR duality.
    Language English
    Publishing date 2018-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.120.071604
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  3. Article ; Online: Saphenous Vein vs Arterial Graft to the Right System in Left-Sided Arterial Revascularization.

    Ben-Gal, Yanai / Gordon, Amit / Teich, Nadav / Sela, Orr / Kramer, Amir / Ziv-Baran, Tomer / Mohr, Rephael / Pevni, Dmitry

    The Annals of thoracic surgery

    2021  Volume 114, Issue 6, Page(s) 2280–2287

    Abstract: Background: To investigate clinical outcomes of various arterial grafts (AGs) vs saphenous vein grafts (VGs) to the right coronary system in patients who received left-sided bilateral internal thoracic artery revascularization.: Methods: We compared ... ...

    Abstract Background: To investigate clinical outcomes of various arterial grafts (AGs) vs saphenous vein grafts (VGs) to the right coronary system in patients who received left-sided bilateral internal thoracic artery revascularization.
    Methods: We compared short- and long-term outcomes of all the patients operated in our center during 1996-2011, who received left-sided bilateral internal thoracic artery (left anterior descending and left circumflex) grafting and either a VG or an AG to the right coronary system.
    Results: Of 1691 patients, 983 received a VG and 708 received an AG to the right coronary system: 387 gastroepiploic arteries and 321 internal thoracic artery grafts. The median follow-up was 15.7 ± 0.32 years. For the VG and AG groups, early mortality (1.6% for VG and 1.3% for AG, P = .55) and other early adverse outcomes did not differ. Long-term (up to 20 years) survival was similar (34.1% ± 3.4% for VG vs 36.0% ±2% for AG, P = .86). In multivariable analysis, VG to the right coronary artery was not found to be a predictor of inferior survival (hazard ratio: 0.99, 95% confidence interval 0.836-1.194, P = .99). Comparing 2 propensity-matched groups of 349 pairs with a VG or an AG, and accounting for the severity of the right coronary lesion, did not demonstrate differences in early outcome or late survival between the groups.
    Conclusions: Early outcomes and long-term survival were comparable among patients who received left-sided bilateral internal thoracic artery revascularization, between various graft types to the right coronary system.
    MeSH term(s) Humans ; Saphenous Vein/transplantation ; Mammary Arteries/transplantation ; Coronary Vessels/surgery ; Gastroepiploic Artery ; Proportional Hazards Models ; Treatment Outcome ; Vascular Patency
    Language English
    Publishing date 2021-11-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2021.10.034
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 252: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Early and late outcomes of single versus bilateral internal thoracic artery revascularization for patients in critical condition.

    Fertouk, Michal / Gordon, Amit / Pevni, Dmitry / Ziv-Baran, Tomer / Sela, Orr / Mohr, Rephael / Farkash, Ariel / Kramer, Amir / Teich, Nadav / Nesher, Nachum / Ben-Gal, Yanai

    PloS one

    2021  Volume 16, Issue 8, Page(s) e0255740

    Abstract: Objective: The optimal surgical approach for critically ill patients with complex coronary disease remains uncertain. We compared outcomes of bilateral internal thoracic artery (BITA) versus single ITA (SITA) revascularization in critical patients.: ... ...

    Abstract Objective: The optimal surgical approach for critically ill patients with complex coronary disease remains uncertain. We compared outcomes of bilateral internal thoracic artery (BITA) versus single ITA (SITA) revascularization in critical patients.
    Methods: We evaluated 394 consecutive critical patients with multi-vessel disease who underwent CABG during 1996-2001. Outcomes measured were early mortality, strokes, myocardial-infarctions, sternal infections, revisions for bleeding, and late survival. The critical preoperative state was acknowledged concisely by one or more of the following: preoperative ventricular tachycardia/fibrillation, aborted sudden cardiac death, or the need for mechanical ventilation or for preoperative insertion of intra-aortic-balloon counter-pulsation.
    Results: During the study period, 193 of our patients who underwent SITA and 201 who underwent BITA were in critical condition. The SITA group was older (mean 68.0 vs. 63.3 years, p = 0.001) and higher proportions were females (28.5% vs. 18.9% p = 0.025), after recent-MI (69.9% vs. 57.2% p = 0.009) and with left-main disease (38.3% vs. 49.3% p = .029); the median logistic EuroSCORE was higher (0.2898 vs. 0.1597, p<0.001). No statistically significant differences were observed between the SITA and BITA groups in 30-day mortality; and in rates of early CVA, MI and sternal infections (13.0% vs. 8.5%, p = 0.148; 4.1% vs. 6.0%, p = 0.49; 6.7% vs. 4.5%, p = 0.32 and 2.1% vs. 2.5%, p>0.99, respectively). Long-term survival (median follow-up of 15 years, interquartile-range: 13.57-15) was better in the BITA group (median 14.39 vs. 9.31± 0.9 years, p = 0.001). Propensity-score matching (132 matched pairs) also yielded similar early outcomes and improved long-term survival (median follow-up of 15 years, interquartile-range: 13.56-15) for the BITA group (median 12.49±1.71 vs. 7.63±0.99 years, p = 0.002). In multivariable analysis, BITA revascularization was found to be a predictor for improved survival (hazard-ratio of 0.419, 95%CI 0.23-0.76, p = 0.004).
    Conclusions: This study demonstrated long-term survival benefit for BITA revascularization in patients in a critical pre-operative state who presented for surgical revascularization.
    MeSH term(s) Aged ; Coronary Disease/surgery ; Critical Care ; Female ; Humans ; Male ; Middle Aged ; Myocardial Revascularization/adverse effects ; Myocardial Revascularization/methods ; Postoperative Complications/epidemiology ; Survival Analysis ; Thoracic Arteries/surgery
    Language English
    Publishing date 2021-08-05
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0255740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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