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  1. Article ; Online: Musculoskeletal Metastasis From Soft-tissue Sarcomas: A Review of the Literature.

    Pretell-Mazzini, Juan / Seldon, Crystal S / D'Amato, Gina / Subhawong, Ty K

    The Journal of the American Academy of Orthopaedic Surgeons

    2022  Volume 30, Issue 11, Page(s) 493–503

    Abstract: Soft-tissue sarcomas are a rare and extremely heterogeneous group of cancers, representing <1% of all human malignancies. The lungs are the most common site of distant metastasis, followed by the bone, lymph nodes, liver, brain, and subcutaneous tissue. ... ...

    Abstract Soft-tissue sarcomas are a rare and extremely heterogeneous group of cancers, representing <1% of all human malignancies. The lungs are the most common site of distant metastasis, followed by the bone, lymph nodes, liver, brain, and subcutaneous tissue. Clinical experience suggests that skeletal metastasis is part of the natural history affecting the prognosis and quality of life in these patients. Approximately 2.2% of patients have skeletal metastasis at diagnosis. However, up to 10% will develop skeletal metastasis after a mean interval of 21.3 months. Although systemic therapy with conventional chemotherapy remains the primary treatment modality for those with metastatic sarcoma, increased survival has been achieved in selected patients who receive multimodality therapy, including surgery, for their metastatic disease. The 5-year overall survival of patients with isolated bone metastases was 41.2% (26.9% to 54.9%), which decreased to 32.9% (21.2% to 45.1%) in the setting of combined bone and lung metastases. Moreover, the resection of the primary soft-tissue sarcoma is a predictor of survival, resulting in a 58% decrease in mortality after surgery (hazard ratio, 0.42, P = 0.013). Understanding the effect of these metastases on patient survival may influence imaging, surveillance, and treatment decisions.
    MeSH term(s) Bone Neoplasms/therapy ; Humans ; Prognosis ; Quality of Life ; Retrospective Studies ; Sarcoma/diagnosis ; Sarcoma/therapy ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/therapy
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1200524-1
    ISSN 1940-5480 ; 1067-151X
    ISSN (online) 1940-5480
    ISSN 1067-151X
    DOI 10.5435/JAAOS-D-21-00944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 274: Show issues

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  2. Article ; Online: Genomic alterations predictive of poor clinical outcomes in pan-cancer.

    Seldon, Crystal S / Meiyappan, Karthik / Hoffman, Hannah / Guo, Jimmy A / Goel, Neha / Hwang, William L / Nguyen, Paul L / Mahal, Brandon A / Alshalalfa, Mohammed

    Oncotarget

    2022  Volume 13, Page(s) 1069–1077

    Abstract: Background: Genomic alterations are highly frequent across cancers, but their prognostic impact is not well characterized in pan-cancer cohorts. Here, we use pan-cancer cohorts from TCGA and MSK-IMPACT to evaluate the associations of common genomic ... ...

    Abstract Background: Genomic alterations are highly frequent across cancers, but their prognostic impact is not well characterized in pan-cancer cohorts. Here, we use pan-cancer cohorts from TCGA and MSK-IMPACT to evaluate the associations of common genomic alterations with poor clinical outcome.
    Materials and methods: Genomic alterations in commonly altered genes were extracted from Pan-Cancer TCGA and MSK-IMPACT cohorts. Multivariable Cox regression analyses stratified by cancer type defined adjusted hazard ratios (AHRs) for disease-specific survival (DSS), progression-free survival (PFS) and overall survival (OS).
    Results: Using TCGA we identified 32 mutated genes, and 15 copy number (CN) genes with frequency >= 4% in 9,104 patients across 28 cancers. On UVA, having a TP53-mutations or any mutation in the 31 genes (mut31) were associated with worse PFS (HR: 1.22,
    Conclusions: TP53-mutations, CDKN2A-deletion, PTEN-deletion, and MYC-amplification are independent pan-cancer prognostic genomic alterations.
    MeSH term(s) DNA Copy Number Variations ; Genomics ; Humans ; Mutation ; Neoplasms/genetics ; Prognosis
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.28276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bone Marrow Suppression during Postoperative Radiation for Bladder Cancer and Comparative Benefit of Proton Therapy-Phase 2 Trial Secondary Analysis.

    Press, Robert H / Shelton, Joseph W / Zhang, Chao / Dang, Quang / Tian, Sibo / Shu, Timothy / Seldon, Crystal S / Hasan, Shaakir / Jani, Ashesh B / Zhou, Jun / McDonald, Mark W

    International journal of particle therapy

    2021  Volume 8, Issue 3, Page(s) 1–10

    Abstract: Purpose: For patients with high-risk bladder cancer (pT3: Materials and methods: All enrolled patients were retrospectively analyzed after pelvic radiation per protocol with 50.4 to 55.8 Gy in 28 to 31 fractions. Comparative PBT plans were generated ... ...

    Abstract Purpose: For patients with high-risk bladder cancer (pT3
    Materials and methods: All enrolled patients were retrospectively analyzed after pelvic radiation per protocol with 50.4 to 55.8 Gy in 28 to 31 fractions. Comparative PBT plans were generated using pencil-beam scanning and a 3-beam multifield optimization technique. Changes in hematologic nadirs were assessed using paired
    Results: Eighteen patients with a median age of 70 were analyzed. Mean cell count values after radiation therapy decreased compared with preradiation therapy values for white blood cells (WBCs), absolute neutrophil count (ANC), absolute lymphocyte count (all
    Conclusion: Increased PBM mean dose and V20 to V40 were associated with lower hematologic nadirs. PBT plans reduced PBM dose and may be a valuable strategy to reduce the risk of hematologic toxicity in these patients.
    Language English
    Publishing date 2021-07-06
    Publishing country United States
    Document type Journal Article
    ISSN 2331-5180
    ISSN (online) 2331-5180
    DOI 10.14338/IJPT-21-00003.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Prophylactic Radiotherapy for Prevention of Heterotopic Ossification After Periacetabular Fractures: A Review of Efficacy and Associated Conditions.

    Geller, Joseph S / Allegra, Paul R / Seldon, Crystal S / Spieler, Benjamin O / Cohen, Lara L / Barnhill, Spencer W / Huntley, Samuel R / Samuels, Stuart / Wang, Lora / Isrow, Derek / Zerda, Alberto De La / Wolfson, Aaron H / Hernandez, Giselle / Vilella, Fernando E / Yechieli, Raphael L

    Journal of surgical orthopaedic advances

    2022  Volume 31, Issue 2, Page(s) 113–118

    Abstract: Prophylactic radiotherapy (XRT) is a commonly used treatment to decrease heterotopic ossification (HO) in patients with traumatic hip injuries. We conducted a retrospective review of patients at risk for HO who underwent XRT. Of the patients reviewed, 27. ...

    Abstract Prophylactic radiotherapy (XRT) is a commonly used treatment to decrease heterotopic ossification (HO) in patients with traumatic hip injuries. We conducted a retrospective review of patients at risk for HO who underwent XRT. Of the patients reviewed, 27.3% developed radiographic HO, 11.2% developed symptoms, and 2.0% required resection surgery. Patients were divided into primary (n = 71) and secondary prophylaxis (n = 27) cohorts. In the primary group, 25.0% developed radiographic HO, 5.6% developed symptoms, and 0 required surgery. In the secondary cohort, 33.3% of patients developed new radiographic HO, and 25.9% were symptomatic: four had a Brooker score of 3, and three had a score of 4 (p = 0.03), and 7.4% required surgical resection. (Journal of Surgical Orthopaedic Advances 31(2):113-118, 2022).
    MeSH term(s) Fractures, Bone/complications ; Fractures, Bone/surgery ; Humans ; Ossification, Heterotopic/etiology ; Ossification, Heterotopic/prevention & control ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2022-07-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2189157-6
    ISSN 2158-3811 ; 1548-825X ; 1059-1052
    ISSN (online) 2158-3811
    ISSN 1548-825X ; 1059-1052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4751: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Primary Versus Secondary Radiotherapy for Heterotopic Ossification Prevention About the Elbow.

    Geller, Joseph S / Allegra, Paul R / Seldon, Crystal S / Spieler, Benjamin O / Cohen, Lara L / Barnhill, Spencer W / Huntley, Samuel R / De La Zerda, Alberto / Samuels, Stuart / Wang, Lora / Isrow, Derek / Wolfson, Aaron H / Yechieli, Raphael L

    Journal of orthopaedic trauma

    2021  Volume 36, Issue 2, Page(s) e56–e61

    Abstract: Objectives: To examine the efficacy and safety of radiotherapy for the prevention of heterotopic ossification (HO) about the elbow.: Design: Retrospective chart review.: Setting: Level 1 trauma center.: Patients/participants: Two hundred and ... ...

    Abstract Objectives: To examine the efficacy and safety of radiotherapy for the prevention of heterotopic ossification (HO) about the elbow.
    Design: Retrospective chart review.
    Setting: Level 1 trauma center.
    Patients/participants: Two hundred and twenty-nine patients who received prophylactic radiotherapy (XRT) over a 15-year period were identified. Patients were included if they received XRT to the elbow joint and had at least 12 weeks of follow-up after XRT. Fifty-four patients were ultimately included.
    Intervention: All patients were treated with a single dose of 7 Gy. Ninety-eight percentage of patients received XRT within 24 hours after surgery, and all patients received XRT within 72 hours after surgery.
    Main outcomes measurements: The primary study measures evaluated were the presence or absence of clinically symptomatic HO and the presence of radiographic HO after XRT to the elbow joint.
    Results: Eighteen patients were treated with XRT after a traumatic injury requiring surgery (primary prophylaxis), and 36 were treated with XRT after excision surgery to remove HO which had already formed (secondary prophylaxis). In the primary cohort, 16.7% developed symptomatic HO after XRT and 11.1% required surgery to resect the heterotopic bone. In the secondary cohort, 11.1% developed symptomatic HO after surgery and XRT and 5.5% required resection surgery. No secondary malignancies were identified.
    Conclusions: Our findings suggest that XRT for elbow HO may be safe and effective for both primary and secondary HO. XRT for HO was not shown to be associated with radiation-induced sarcoma in this series, at least in the short term. Further study in a large patient population with extended follow-up is required to better characterize populations at high risk for development of HO and secondary malignancy.
    Level of evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
    MeSH term(s) Elbow ; Elbow Joint/diagnostic imaging ; Elbow Joint/surgery ; Humans ; Ossification, Heterotopic/etiology ; Ossification, Heterotopic/prevention & control ; Ossification, Heterotopic/radiotherapy ; Postoperative Complications/prevention & control ; Retrospective Studies
    Language English
    Publishing date 2021-05-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639099-7
    ISSN 1531-2291 ; 0890-5339
    ISSN (online) 1531-2291
    ISSN 0890-5339
    DOI 10.1097/BOT.0000000000002188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2234: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas.

    Seldon, Crystal S / Colbert, Lauren E / Hall, William A / Fisher, Sarah B / Yu, David S / Landry, Jerome C

    World journal of gastrointestinal oncology

    2015  Volume 8, Issue 4, Page(s) 358–365

    Abstract: Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information ... ...

    Abstract Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomain-helicase-DNA binding protein 5, chromodomain-helicase-DNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation, and should be validated in future studies.
    Language English
    Publishing date 2015-01-05
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573696-6
    ISSN 1948-5204
    ISSN 1948-5204
    DOI 10.4251/wjgo.v8.i4.358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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