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  1. Article ; Online: Contextual drive of neuronal responses in mouse V1 in the absence of feedforward input.

    Kirchberger, Lisa / Mukherjee, Sreedeep / Self, Matthew W / Roelfsema, Pieter R

    Science advances

    2023  Volume 9, Issue 3, Page(s) eadd2498

    Abstract: Neurons in the primary visual cortex (V1) respond to stimuli in their receptive field (RF), which is defined by the feedforward input from the retina. However, V1 neurons are also sensitive to contextual information outside their RF, even if the RF ... ...

    Abstract Neurons in the primary visual cortex (V1) respond to stimuli in their receptive field (RF), which is defined by the feedforward input from the retina. However, V1 neurons are also sensitive to contextual information outside their RF, even if the RF itself is unstimulated. Here, we examined the cortical circuits for V1 contextual responses to gray disks superimposed on different backgrounds. Contextual responses began late and were strongest in the feedback-recipient layers of V1. They differed between the three main classes of inhibitory neurons, with particularly strong contextual drive of VIP neurons, indicating a contribution of disinhibitory circuits to contextual drive. Contextual drive was strongest when the gray disk was perceived as figure, occluding its background, rather than a hole. Our results link contextual drive in V1 to perceptual organization and provide previously unknown insight into how recurrent processing shapes the response of sensory neurons to facilitate figure perception.
    MeSH term(s) Mice ; Animals ; Visual Cortex/physiology ; Neurons/physiology ; Retina ; Neurons, Afferent ; Orientation/physiology ; Visual Perception/physiology ; Photic Stimulation/methods
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.add2498
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  2. Article ; Online: Neuroscience: Figured Out by Feedback to the Thalamus.

    Self, Matthew W / Roelfsema, Pieter R

    Current biology : CB

    2019  Volume 29, Issue 12, Page(s) R574–R577

    Abstract: The lateral geniculate nucleus of the thalamus (LGN) is a relay nucleus between the retina and the visual cortex. A new brain imaging study shows that LGN activity is modulated by figure-ground organization, even when the figure and ground are presented ... ...

    Abstract The lateral geniculate nucleus of the thalamus (LGN) is a relay nucleus between the retina and the visual cortex. A new brain imaging study shows that LGN activity is modulated by figure-ground organization, even when the figure and ground are presented to different eyes: a hallmark of a cortical feedback effect.
    MeSH term(s) Attention ; Geniculate Bodies ; Humans ; Retina ; Thalamus ; Visual Cortex
    Language English
    Publishing date 2019-06-18
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2019.05.022
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Neuroscience: Out of Sight but Not Out of Mind.

    Self, Matthew W / Roelfsema, Pieter R

    Current biology : CB

    2017  Volume 27, Issue 7, Page(s) R269–R271

    Abstract: How does the brain hold information about multiple stimuli online after they have disappeared? A new study shows that neurons in the human medial temporal remain active while images are memorized, demonstrating that spiking activity keeps multiple ... ...

    Abstract How does the brain hold information about multiple stimuli online after they have disappeared? A new study shows that neurons in the human medial temporal remain active while images are memorized, demonstrating that spiking activity keeps multiple memories online.
    MeSH term(s) Brain ; Humans ; Memory, Short-Term ; Neurons ; Neurosciences ; Temporal Lobe
    Language English
    Publishing date 2017-04-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2017.02.050
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  4. Article ; Online: Paying Attention to the Cortical Layers.

    Self, Matthew W / Roelfsema, Pieter R

    Neuron

    2017  Volume 93, Issue 1, Page(s) 9–11

    Abstract: In this issue of Neuron, Nandy et al. (2017) reveal a number of important new insights into the neural mechanisms that are responsible for attentional selection. ...

    Abstract In this issue of Neuron, Nandy et al. (2017) reveal a number of important new insights into the neural mechanisms that are responsible for attentional selection.
    MeSH term(s) Attention ; Humans ; Neurons
    Language English
    Publishing date 2017-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2016.12.032
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    Zs.A 2496: Show issues Location:
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    Zs.MG 92: Show issues

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  5. Article ; Online: The representation of occluded image regions in area V1 of monkeys and humans.

    Papale, Paolo / Wang, Feng / Morgan, A Tyler / Chen, Xing / Gilhuis, Amparo / Petro, Lucy S / Muckli, Lars / Roelfsema, Pieter R / Self, Matthew W

    Current biology : CB

    2023  Volume 33, Issue 18, Page(s) 3865–3871.e3

    Abstract: Neuronal activity in the primary visual cortex (V1) is driven by feedforward input from within the neurons' receptive fields (RFs) and modulated by contextual information in regions surrounding the RF. The effect of contextual information on spiking ... ...

    Abstract Neuronal activity in the primary visual cortex (V1) is driven by feedforward input from within the neurons' receptive fields (RFs) and modulated by contextual information in regions surrounding the RF. The effect of contextual information on spiking activity occurs rapidly and is therefore challenging to dissociate from feedforward input. To address this challenge, we recorded the spiking activity of V1 neurons in monkeys viewing either natural scenes or scenes where the information in the RF was occluded, effectively removing the feedforward input. We found that V1 neurons responded rapidly and selectively to occluded scenes. V1 responses elicited by occluded stimuli could be used to decode individual scenes and could be predicted from those elicited by non-occluded images, indicating that there is an overlap between visually driven and contextual responses. We used representational similarity analysis to show that the structure of V1 representations of occluded scenes measured with electrophysiology in monkeys correlates strongly with the representations of the same scenes in humans measured with functional magnetic resonance imaging (fMRI). Our results reveal that contextual influences rapidly alter V1 spiking activity in monkeys over distances of several degrees in the visual field, carry information about individual scenes, and resemble those in human V1. VIDEO ABSTRACT.
    MeSH term(s) Animals ; Humans ; Visual Perception/physiology ; Haplorhini ; Primary Visual Cortex ; Visual Cortex/physiology ; Visual Fields ; Photic Stimulation/methods
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Video-Audio Media ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.08.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Involvement of superior colliculus in complex figure detection of mice.

    Cazemier, J Leonie / Haak, Robin / Tran, T K Loan / Hsu, Ann T Y / Husic, Medina / Peri, Brandon D / Kirchberger, Lisa / Self, Matthew W / Roelfsema, Pieter / Heimel, J Alexander

    eLife

    2024  Volume 13

    Abstract: Object detection is an essential function of the visual system. Although the visual cortex plays an important role in object detection, the superior colliculus can support detection when the visual cortex is ablated or silenced. Moreover, it has been ... ...

    Abstract Object detection is an essential function of the visual system. Although the visual cortex plays an important role in object detection, the superior colliculus can support detection when the visual cortex is ablated or silenced. Moreover, it has been shown that superficial layers of mouse SC (sSC) encode visual features of complex objects, and that this code is not inherited from the primary visual cortex. This suggests that mouse sSC may provide a significant contribution to complex object vision. Here, we use optogenetics to show that mouse sSC is involved in figure detection based on differences in figure contrast, orientation, and phase. Additionally, our neural recordings show that in mouse sSC, image elements that belong to a figure elicit stronger activity than those same elements when they are part of the background. The discriminability of this neural code is higher for correct trials than for incorrect trials. Our results provide new insight into the behavioral relevance of the visual processing that takes place in sSC.
    MeSH term(s) Animals ; Mice ; Superior Colliculi ; Optogenetics ; Visual Cortex ; Visual Perception
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.83708
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  7. Article ; Online: A Quantitative Comparison of Inhibitory Interneuron Size and Distribution between Mouse and Macaque V1, Using Calcium-Binding Proteins.

    Kooijmans, Roxana N / Sierhuis, Wesley / Self, Matthew W / Roelfsema, Pieter R

    Cerebral cortex communications

    2020  Volume 1, Issue 1, Page(s) tgaa068

    Abstract: The mouse is a useful and popular model for studying of visual cortical function. To facilitate the translation of results from mice to primates, it is important to establish the extent of cortical organization equivalence between species and to identify ...

    Abstract The mouse is a useful and popular model for studying of visual cortical function. To facilitate the translation of results from mice to primates, it is important to establish the extent of cortical organization equivalence between species and to identify possible differences. We focused on the different types of interneurons as defined by calcium-binding protein (CBP) expression in the layers of primary visual cortex (V1) in mouse and rhesus macaque. CBPs parvalbumin (PV), calbindin (CB), and calretinin (CR) provide a standard, largely nonoverlapping, labeling scheme in macaque, with preserved corresponding morphologies in mouse, despite a slightly higher overlap. Other protein markers, which are relevant in mouse, are not preserved in macaque. We fluorescently tagged CBPs in V1 of both species, using antibodies raised against preserved aminoacid sequences. Our data demonstrate important similarities between the expression patterns of interneuron classes in the different layers between rodents and primates. However, in macaque, expression of PV and CB is more abundant, CR expression is lower, and the laminar distribution of interneuron populations is more differentiated. Our results reveal an integrated view of interneuron types that provides a basis for translating results from rodents to primates, and suggest a reconciliation of previous results.
    Language English
    Publishing date 2020-09-24
    Publishing country United States
    Document type Journal Article
    ISSN 2632-7376
    ISSN (online) 2632-7376
    DOI 10.1093/texcom/tgaa068
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  8. Article ; Online: A neuronal basis of iconic memory in macaque primary visual cortex.

    Teeuwen, Rob R M / Wacongne, Catherine / Schnabel, Ulf H / Self, Matthew W / Roelfsema, Pieter R

    Current biology : CB

    2021  Volume 31, Issue 24, Page(s) 5401–5414.e4

    Abstract: After a briefly presented visual stimulus disappears, observers retain a detailed representation of this stimulus for a short period of time. This sensory storage is called iconic memory. We measured iconic memory in the perception of monkeys and its ... ...

    Abstract After a briefly presented visual stimulus disappears, observers retain a detailed representation of this stimulus for a short period of time. This sensory storage is called iconic memory. We measured iconic memory in the perception of monkeys and its neuronal correlates in the primary visual cortex (area V1). We determined how many milliseconds extra viewing time iconic memory is worth and how it decays by varying the duration of a brief stimulus and the timing of a mask. The V1 activity that persists after the disappearance of a stimulus predicted accuracy, with a time course resembling the worth and decay of iconic memory. Finally, we examined how iconic memory interacts with attention. A cue presented after the stimulus disappears boosts attentional influences pertaining to a relevant part of the stimulus but only if it appears before iconic memory decayed. Our results relate iconic memory to neuronal activity in early visual cortex.
    MeSH term(s) Animals ; Attention/physiology ; Macaca ; Memory, Short-Term/physiology ; Photic Stimulation ; Primary Visual Cortex ; Visual Perception/physiology
    Language English
    Publishing date 2021-10-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2021.09.052
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  9. Article ; Online: Scene perception in early vision: Figure-ground organization in the lateral geniculate nucleus.

    Self, Matthew W / Roelfsema, Pieter R

    Proceedings of the National Academy of Sciences of the United States of America

    2015  Volume 112, Issue 22, Page(s) 6784–6785

    MeSH term(s) Animals ; Discrimination, Psychological/physiology ; Pattern Recognition, Visual/physiology ; Thalamus/physiology ; Visual Perception/physiology
    Language English
    Publishing date 2015-05-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1507097112
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    Zs.A 1148: Show issues Location:
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  10. Article ; Online: Experience shapes chandelier cell function and structure in the visual cortex.

    Seignette, Koen / Jamann, Nora / Papale, Paolo / Terra, Huub / Porneso, Ralph O / de Kraker, Leander / van der Togt, Chris / van der Aa, Maaike / Neering, Paul / Ruimschotel, Emma / Roelfsema, Pieter R / Montijn, Jorrit S / Self, Matthew W / Kole, Maarten H P / Levelt, Christiaan N

    eLife

    2024  Volume 12

    Abstract: Detailed characterization of interneuron types in primary visual cortex (V1) has greatly contributed to understanding visual perception, yet the role of chandelier cells (ChCs) in visual processing remains poorly characterized. Using viral tracing we ... ...

    Abstract Detailed characterization of interneuron types in primary visual cortex (V1) has greatly contributed to understanding visual perception, yet the role of chandelier cells (ChCs) in visual processing remains poorly characterized. Using viral tracing we found that V1 ChCs predominantly receive monosynaptic input from local layer 5 pyramidal cells and higher-order cortical regions. Two-photon calcium imaging and convolutional neural network modeling revealed that ChCs are visually responsive but weakly selective for stimulus content. In mice running in a virtual tunnel, ChCs respond strongly to events known to elicit arousal, including locomotion and visuomotor mismatch. Repeated exposure of the mice to the virtual tunnel was accompanied by reduced visual responses of ChCs and structural plasticity of ChC boutons and axon initial segment length. Finally, ChCs only weakly inhibited pyramidal cells. These findings suggest that ChCs provide an arousal-related signal to layer 2/3 pyramidal cells that may modulate their activity and/or gate plasticity of their axon initial segments during behaviorally relevant events.
    MeSH term(s) Animals ; Mice ; Neurons ; Pyramidal Cells ; Visual Cortex ; Interneurons ; Arousal
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.91153
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