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  1. Article ; Online: Surgical Management of the Axilla in Invasive Lobular Carcinoma in the Z1071 Era: A Propensity-Score Matched Analysis of the National Cancer Database.

    Sinner, Heather F / Naffouje, Samer / Selfridge, Julia M / Lee, Marie C / Hoover, Susan J / Laronga, Christine

    Current oncology (Toronto, Ont.)

    2022  Volume 29, Issue 11, Page(s) 8197–8206

    Abstract: In patients with invasive lobular carcinoma (ILC) and clinically positive nodes (cN1) who demonstrate an axillary clinical response to neoadjuvant-chemotherapy (NAC), the outcomes of sentinel lymph node biopsy (SLNB) compared to axillary lymph node ... ...

    Abstract In patients with invasive lobular carcinoma (ILC) and clinically positive nodes (cN1) who demonstrate an axillary clinical response to neoadjuvant-chemotherapy (NAC), the outcomes of sentinel lymph node biopsy (SLNB) compared to axillary lymph node dissection (ALND) are not well studied. We sought to evaluate axillary surgery practice patterns and the resultant impact on overall survival (OS) in cN1 ILC. The National Cancer Database (NCDB) was queried (2012-2017) for women with cN1 ILC who were treated with NAC followed by surgery. Propensity-score matching was performed between SLNB and ALND cohorts. Kaplan-Meier and Cox regression analyses were performed to identify predictors of OS. Of 1390 patients, 1192 were luminal A ILCs (85.8%). 143 patients (10.3%) had a complete axillary clinical response, while 1247 (89.7%) had a partial clinical response in the axilla. Definitive axillary surgery was SLNB in 211 patients (15.2%). Utilization of SLNB for definitive axillary management increased from 8% to 16% during the study period. Among 201 propensity-score matched patients stratified by SLNB vs. ALND, mean OS did not significantly differ (81.6 ± 1.8 vs. 81.4 ± 2.0 months;
    MeSH term(s) Humans ; Female ; Axilla/pathology ; Carcinoma, Lobular/surgery ; Carcinoma, Lobular/drug therapy ; Carcinoma, Lobular/pathology ; Carcinoma, Ductal, Breast/pathology ; Sentinel Lymph Node Biopsy ; Breast Neoplasms/pathology
    Language English
    Publishing date 2022-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol29110647
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Omission of Axillary Dissection in Node Positive Breast Cancer After Neoadjuvant Systemic Therapy.

    Peery, Gray B / Pak, Joyce / Burkbauer, Laura / Agala, Chris B / Selfridge, Julia M / Gallagher, Kristalyn K / Spanheimer, Philip M

    The Journal of surgical research

    2023  Volume 292, Page(s) 247–257

    Abstract: Introduction: Guidelines recommend axillary lymph node dissection (ALND) for ypN + positive patients as patients receiving neoadjuvant systemic therapy (NST) were excluded from trials omitting ALND in pN + patients. We sought to characterize trends in ... ...

    Abstract Introduction: Guidelines recommend axillary lymph node dissection (ALND) for ypN + positive patients as patients receiving neoadjuvant systemic therapy (NST) were excluded from trials omitting ALND in pN + patients. We sought to characterize trends in omission of ALND in patients with ypN + disease.
    Methods: Adult women with invasive breast carcinoma in the National Cancer Database between 2012 and 2019 who received NST (chemotherapy or endocrine) and had ypN + disease were included. Patients were excluded if they did not have definitive surgery within eight months of diagnosis. The primary study outcome was completion of ALND versus omission. Differences in demographics, tumor characteristics, and treatment were identified using bivariate and multivariate logistic regression models.
    Results: In total, 103,121 women were included. Most had cT1 (26%) or cT2 (45%) tumors, cN + disease (71%), and ductal histology (83%). 69% of patients received neoadjuvant chemotherapy and 31% neoadjuvant endocrine without chemotherapy (30% both). ALND was performed in 77% of patients. Omission of ALND became more prevalent each year from 2012 (14%) to 2019 (34%). On multivariate modeling, year of diagnosis, black race, cN status, higher grade, estrogen receptor+/HER2-receptor subtype, and mastectomy were associated with increased prevalence of ALND. Age, Charlson/Deyo comorbidity index score, endocrine versus chemotherapy, and adjuvant radiation were not associated with receipt of ALND.
    Conclusions: Despite guidelines recommending ALND, omission is common in patients with ypN + breast cancer after NST. Omission of ALND increased significantly over time and is associated with clinical and demographic factors. Future study is needed to determine the oncologic safety of this approach.
    Language English
    Publishing date 2023-09-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2023.08.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 178: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Effect of Microporous Polysaccharide Particles in Patients Undergoing Mastectomy.

    Selfridge, Julia M / Sinner, Heather F / Whiting, Junmin / Sun, Weihong / Mallory, Melissa A / Hoover, Susan J / Kiluk, John V / Khakpour, Nazanin / Czerniecki, Brian J / Laronga, Christine / Mo, Qianxing / Lee, Marie C

    Clinical breast cancer

    2022  Volume 22, Issue 8, Page(s) e922–e927

    Abstract: Background: Microporous polysaccharide particles (MPP, proprietary name "Arista AH"), derived from purified plant starch, are used to augment hemostasis at surgery. The effect of MPP regarding short-term complications after mastectomy remains an area of ...

    Abstract Background: Microporous polysaccharide particles (MPP, proprietary name "Arista AH"), derived from purified plant starch, are used to augment hemostasis at surgery. The effect of MPP regarding short-term complications after mastectomy remains an area of ongoing investigation.
    Patients and methods: A single-institution, retrospective chart review of patients undergoing unilateral mastectomy without reconstruction from January 2019 to 2021 was performed. Primary endpoints included antibiotic prescription, seroma or abscess drainage, readmission, wound dehiscence, and time to drain removal within 30 days of initial surgery. Wilcoxon rank sum test or Student t test was used for group comparisons for continuous variables; Chi-square test or Fisher exact test was used to evaluate the associations among categorical variables.
    Results: One hundred ninety patients were included; 119 received MPP and 71 did not. There was no difference in antibiotic prescription, infection drainage, hematoma, readmission, dehiscence, or time to drain removal with regards to MPP use. MPP treated patients were older (65.8 years vs. 59.1, P < .001) and had lower albumin levels (4.1 g/dL vs. 4.3, P = .025). Patients who underwent abscess drainage had higher body mass index ( mean 36.1 vs. 30.1 P = .036). Patients requiring seroma drainage were more likely to be diabetic (12.8% vs. 4%, P = .035) and to have been treated with lymphovenous anastomosis (LVA, 15.6% vs. 3.8%, P = .009). Patients who had LVA were significantly less likely to receive MPP when compared to other groups (3.1% vs. 74.7% P < .001).
    Conclusion: Consider utilizing MPP in patients at higher risk of seroma, such as those undergoing axillary surgery including LVA.
    MeSH term(s) Humans ; Female ; Mastectomy/adverse effects ; Seroma/epidemiology ; Seroma/etiology ; Retrospective Studies ; Abscess/complications ; Breast Neoplasms/complications ; Drainage ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Polysaccharides ; Anti-Bacterial Agents
    Chemical Substances Polysaccharides ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2106734-X
    ISSN 1938-0666 ; 1526-8209
    ISSN (online) 1938-0666
    ISSN 1526-8209
    DOI 10.1016/j.clbc.2022.07.015
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5800: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 498: Show issues

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  4. Article: Opening the Debate: How to Fulfill the Need for Physicians' Training in Circadian-Related Topics in a Full Medical School Curriculum.

    Selfridge, Julia M / Moyer, Kurtis / Capelluto, Daniel G S / Finkielstein, Carla V

    Journal of circadian rhythms

    2015  Volume 13, Page(s) 7

    Abstract: Background: Circadian rhythms are daily changes in our physiology and behavior that are manifested as patterns of brain wave activity, periodic hormone production, recurring cell regeneration, and other oscillatory biological activities. Their ... ...

    Abstract Background: Circadian rhythms are daily changes in our physiology and behavior that are manifested as patterns of brain wave activity, periodic hormone production, recurring cell regeneration, and other oscillatory biological activities. Their importance to human health is becoming apparent; they are deranged by shift work and jet-lag and in disparate conditions such as insomnia, sleep syndromes, coronary heart attacks, and depression, and are endogenous factors that contribute to cancer development and progression.
    Discussion: As evidence of the circadian connection to human health has grown, so has the number of Americans experiencing disruption of circadian rhythms due to the demands of an industrialized society. Today, there is a growing work force that experiences night shift work and time-zone shifts shaping the demands on physicians to best meet the needs of patients exposed to chronic circadian disruptions. The diverse range of illness associated with altered rhythms suggests that physicians in various fields will see its impact in their patients. However, medical education, with an already full curriculum, struggles to address this issue.
    Summary: Here, we emphasize the need for incorporating the topic of circadian rhythms in the medical curriculum and propose strategies to accomplish this goal.
    Language English
    Publishing date 2015-11-05
    Publishing country England
    Document type Journal Article
    ISSN 1740-3391
    ISSN 1740-3391
    DOI 10.5334/jcr.ah
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  5. Article ; Online: Chronotherapy: Intuitive, Sound, Founded…But Not Broadly Applied.

    Selfridge, Julia M / Gotoh, Tetsuya / Schiffhauer, Samuel / Liu, JingJing / Stauffer, Philip E / Li, Andrew / Capelluto, Daniel G S / Finkielstein, Carla V

    Drugs

    2016  Volume 76, Issue 16, Page(s) 1507–1521

    Abstract: Circadian rhythms are a collection of endogenously driven biochemical, physiological, and behavioral processes that oscillate in a 24-h cycle and can be entrained by external cues. Circadian clock molecules are responsible for the expression of ... ...

    Abstract Circadian rhythms are a collection of endogenously driven biochemical, physiological, and behavioral processes that oscillate in a 24-h cycle and can be entrained by external cues. Circadian clock molecules are responsible for the expression of regulatory components that modulate, among others, the cell's metabolism and energy consumption. In clinical practice, the regulation of clock mechanisms is relevant to biotransformation of therapeutics. Accordingly, xenobiotic metabolism and detoxification, the two processes that directly influence drug effectiveness and toxicity, are direct manifestations of the daily oscillations of the cellular and biochemical processes taking place within the gastrointestinal, hepatic/biliary, and renal/urologic systems. Consequently, the impact of circadian timing should be factored in when developing therapeutic regimens aimed at achieving maximum efficacy, minimum toxicity, and decreased adverse effects in a patient. However, and despite a strong mechanistic foundation, only 0.16 % of ongoing clinical trials worldwide exploit the concept of 'time-of-day' administration to develop safer and more effective therapies. In this article, we (1) emphasize points of control at which circadian biology intersects critical processes governing treatment interventions; (2) explore the extent to which chronotherapeutics are incorporated into clinical trials; (3) recognize roadblocks; and (4) recommend approaches to precipitate the integration of chronobiological concepts into clinical practice.
    MeSH term(s) Chronotherapy ; Circadian Rhythm/physiology ; Humans ; Inactivation, Metabolic/physiology
    Language English
    Publishing date 2016-10
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.1007/s40265-016-0646-4
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    Zs.A 762: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas.

    Chou, Arthur P / Chowdhury, Reshmi / Li, Sichen / Chen, Weidong / Kim, Andrew J / Piccioni, David E / Selfridge, Julia M / Mody, Reema R / Chang, Stephen / Lalezari, Shadi / Lin, Jeffrey / Sanchez, Desiree E / Wilson, Ryan W / Garrett, Matthew C / Harry, Bret / Mottahedeh, Jack / Nghiemphu, Phioanh L / Kornblum, Harley I / Mischel, Paul S /
    Prins, Robert M / Yong, William H / Cloughesy, Timothy / Nelson, Stanley F / Liau, Linda M / Lai, Albert

    Journal of the National Cancer Institute

    2012  Volume 104, Issue 19, Page(s) 1458–1469

    Abstract: Background: Mutations in isocitrate dehydrogenase 1 (IDH1) and associated CpG island hypermethylation represent early events in the development of low-grade gliomas and secondary glioblastomas. To identify candidate tumor suppressor genes whose promoter ...

    Abstract Background: Mutations in isocitrate dehydrogenase 1 (IDH1) and associated CpG island hypermethylation represent early events in the development of low-grade gliomas and secondary glioblastomas. To identify candidate tumor suppressor genes whose promoter methylation may contribute to gliomagenesis, we compared methylation profiles of IDH1 mutant (MUT) and IDH1 wild-type (WT) tumors using massively parallel reduced representation bisulfite sequencing.
    Methods: Reduced representation bisulfite sequencing was performed on ten pathologically matched WT and MUT glioma samples and compared with data from a methylation-sensitive restriction enzyme technique and data from The Cancer Genome Atlas (TCGA). Methylation in the gene retinol-binding protein 1 (RBP1) was identified in IDH1 mutant tumors and further analyzed with primer-based bisulfite sequencing. Correlation between IDH1/IDH2 mutation status and RBP1 methylation was evaluated with Spearman correlation. Survival data were collected retrospectively and analyzed with Kaplan-Meier and Cox proportional hazards analysis. All statistical tests were two-sided.
    Results: Methylome analysis identified coordinated CpG island hypermethylation in IDH1 MUT gliomas, consistent with previous reports. RBP1, important in retinoic acid metabolism, was found to be hypermethylated in 76 of 79 IDH1 MUT, 3 of 3 IDH2 MUT, and 0 of 116 IDH1/IDH2 WT tumors. IDH1/IDH2 mutation was highly correlated with RBP1 hypermethylation (n = 198; Spearman R = 0.94, 95% confidence interval = 0.92 to 0.95, P < .001). The Cancer Genome Atlas showed IDH1 MUT tumors (n = 23) to be RBP1-hypermethylated with decreased RBP1 expression compared with WT tumors (n = 124). Among patients with primary glioblastoma, patients with RBP1-unmethylated tumors (n = 102) had decreased median overall survival compared with patients with RBP1-methylated tumors (n = 22) (20.3 months vs 36.8 months, respectively; hazard ratio of death = 2.48, 95% confidence interval = 1.30 to 4.75, P = .006).
    Conclusion: RBP1 promoter hypermethylation is found in nearly all IDH1 and IDH2 mutant gliomas and is associated with improved patient survival. Because RBP1 is involved in retinoic acid synthesis, our results suggest that dysregulation of retinoic acid metabolism may contribute to glioma formation along the IDH1/IDH2-mutant pathway.
    MeSH term(s) Adult ; Aged ; Biomarkers, Tumor/genetics ; Blotting, Western ; Brain Neoplasms/chemistry ; Brain Neoplasms/genetics ; CpG Islands/genetics ; DNA Methylation ; DNA Mutational Analysis/methods ; Female ; Gene Expression Profiling ; Glioma/chemistry ; Glioma/genetics ; Humans ; Isocitrate Dehydrogenase/genetics ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Mutation ; Promoter Regions, Genetic/genetics ; Proportional Hazards Models ; Real-Time Polymerase Chain Reaction ; Restriction Mapping ; Retinol-Binding Proteins, Cellular/analysis ; Retinol-Binding Proteins, Cellular/genetics ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; Sulfites/metabolism ; Tretinoin/metabolism
    Chemical Substances Biomarkers, Tumor ; RBP1 protein, human ; Retinol-Binding Proteins, Cellular ; Sulfites ; Tretinoin (5688UTC01R) ; IDH2 protein, human (EC 1.1.1.41) ; Isocitrate Dehydrogenase (EC 1.1.1.41) ; IDH1 protein, human (EC 1.1.1.42.) ; hydrogen sulfite (OJ9787WBLU)
    Language English
    Publishing date 2012-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djs357
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    Uh III Zs.131: Show issues Location:
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