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Article: Advances in Poultry Vaccines: Leveraging Biotechnology for Improving Vaccine Development, Stability, and Delivery.

Abdelaziz, Khaled / Helmy, Yosra A / Yitbarek, Alexander / Hodgins, Douglas C / Sharafeldin, Tamer A / Selim, Mohamed S H

Vaccines

2024 Volume 12, Issue 2

Abstract: With the rapidly increasing demand for poultry products and the current challenges facing the poultry industry, the application of biotechnology to enhance poultry production has gained growing significance. Biotechnology encompasses all forms of ... ...

Abstract	With the rapidly increasing demand for poultry products and the current challenges facing the poultry industry, the application of biotechnology to enhance poultry production has gained growing significance. Biotechnology encompasses all forms of technology that can be harnessed to improve poultry health and production efficiency. Notably, biotechnology-based approaches have fueled rapid advances in biological research, including (a) genetic manipulation in poultry breeding to improve the growth and egg production traits and disease resistance, (b) rapid identification of infectious agents using DNA-based approaches, (c) inclusion of natural and synthetic feed additives to poultry diets to enhance their nutritional value and maximize feed utilization by birds, and (d) production of biological products such as vaccines and various types of immunostimulants to increase the defensive activity of the immune system against pathogenic infection. Indeed, managing both existing and newly emerging infectious diseases presents a challenge for poultry production. However, recent strides in vaccine technology are demonstrating significant promise for disease prevention and control. This review focuses on the evolving applications of biotechnology aimed at enhancing vaccine immunogenicity, efficacy, stability, and delivery.
Language	English
Publishing date	2024-01-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines12020134
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Durable graphene-based alkyd nanocomposites for surface coating applications.

Selim, Mohamed S / El-Hoshoudy, Abdelaziz N / Zaki, ElSayed G / El-Saeed, Ashraf M / Farag, Ahmed A

Environmental science and pollution research international

2024

Abstract: Recently, the scientific community's main goal is the long-term sustainability. Vegetable oils are easily accessible, non-depletable, and cost-effective materials. Vegetable oils are used to prepare polymeric alkyd surfaces. Novel and exciting designs of ...

Abstract	Recently, the scientific community's main goal is the long-term sustainability. Vegetable oils are easily accessible, non-depletable, and cost-effective materials. Vegetable oils are used to prepare polymeric alkyd surfaces. Novel and exciting designs of alkyd/graphene nanocomposites have provided eco-friendly thermal stability and protective coating surfaces. This review has briefly described important graphene-based alkyd nanocomposites along with their applications as protective coatings. These alkyd composites have high hydrophobicity, corrosion resistance, and durability. Graphene-based alkyd nanocoatings have many industrial and research interests because of their exceptional thermal and chemical properties. This work introduces an advanced horizon for developing protective nanocomposite coatings. The anti-corrosion properties and coatings' longevity may be improved by combining the synergistic effects of hybrid nanofillers introduced in this work.
Language	English
Publishing date	2024-05-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-33339-1
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Article: A comparative study between two novel silicone/graphene-based nanostructured surfaces for maritime antifouling

Selim, Mohamed S. / Fatthallah, Nesreen A. / Higazy, Shimaa A. / Hao, Zhifeng / Jing Mo, Ping

Journal of colloid and interface science. 2022 Jan. 15, v. 606

2022

Abstract: Two novel superhydrophobic nanocomposite series of polydimethylsiloxane (PDMS) enriched with reduced graphene oxide (RGO) and graphene oxide/boehmite nanorods (GO-γ-AlOOH) nanofillers were synthesized as maritime fouling-release (FR) surfaces. ... ...

Abstract	Two novel superhydrophobic nanocomposite series of polydimethylsiloxane (PDMS) enriched with reduced graphene oxide (RGO) and graphene oxide/boehmite nanorods (GO-γ-AlOOH) nanofillers were synthesized as maritime fouling-release (FR) surfaces. Controlling the nanofillers' structures and distribution in the silicone matrix influenced the self-cleaning and antifouling properties. γ-AlOOH nanorods had a single crystallinity with an average diameter of 10–20 nm and < 200 nm length. A hydrothermal method was used to prepare RGO, while the chemical deposition method was used to synthesis GO-γ-AlOOH nanocomposites for use as fouling-release coating materials. For studying the synergetic effects of graphene-based materials on the surface, mechanical, and FR features, these nanofillers were dispersed in the silicone matrix using the solution casting method. The hydrophobicity and antifouling properties of the surface were studied using water contact angle (WCA), scanning electron, and atomic force microscopes (SEM and AFM). Coatings' roughness, superhydrophobicity, and surface mechanical properties all improved for the homogeneity of the dispersion of the nanocomposite. Laboratory assessments were carried out for 30 days using selected microorganisms to determine the antifouling effects of the coating systems. PDMS/GO-γ-AlOOH nanorod composite had better antibacterial activity than PDMS/RGO nanocomposite against different bacterial strains. This is caused by the high surface area and stabilizing effects of the GO-γ-AlOOH hybrid nanofillers. The PDMS/GO-γ-AlOOH nanorod composite (3 wt%) had the lowest biodegradability percentage (1.6%) and the microbial endurability percentages for gram-positive, gram-negative, and fungi were 86.42%, 97.94%, and 85.97%, respectively. A field trial in natural seawater was conducted to confirm the coatings' FR performance based on the screening process and image analysis for 45 days in a tropical area. The most profound superhydrophobic antifouling nanostructured coating was the homogeneity of the GO-γ-AlOOH (3 wt%) dispersion, which had a WCA of 151° and a rough surface.
Keywords	antibacterial properties ; biodegradability ; boehmite ; comparative study ; contact angle ; crystal structure ; field experimentation ; graphene ; graphene oxide ; hot water treatment ; hydrophobicity ; image analysis ; nanocomposites ; nanorods ; polydimethylsiloxane ; roughness ; seawater ; surface area
Language	English
Dates of publication	2022-0115
Size	p. 367-383.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2021.08.026
Database	NAL-Catalogue (AGRICOLA)

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Article: Immobilized arginine/tryptophan-rich cyclic dodecapeptide on reduced graphene oxide anchored with manganese dioxide for microbial biofilm eradication

Samak, Nadia A. / Selim, Mohamed S. / Hao, Zhifeng / Xing, Jianmin

Journal of hazardous materials. 2022 Mar. 15, v. 426

2022

Abstract: To avoid the accumulation of bacterial biofilms in water pipelines, it is critical to develop potent antimicrobial agents with good ability to reduce extracellular polymeric substances (EPS). In this study, cyclic dodecapeptides were synthesized, and ... ...

Abstract	To avoid the accumulation of bacterial biofilms in water pipelines, it is critical to develop potent antimicrobial agents with good ability to reduce extracellular polymeric substances (EPS). In this study, cyclic dodecapeptides were synthesized, and different mutations for increasing the ratio of arginine (Arg) and tryptophan (Trp) were introduced. Separately, the synthesized dodecapeptides were immobilized on a reduced graphene oxide nanocomposite anchored with a hierarchical β-MnO₂ (RGO/β-MnO₂) hybrid. With a minimum inhibitory concentration of 0.97 g/mL, the immobilized Arg–Trp rich antimicrobial peptides (AMP) on RGO/MnO₂ nanocomposite, Cdp-4/RGO/MnO₂, showed superior efficacy against multidrug-resistant Pseudomonas aeruginosa ATCC 15692 (P. aeruginosa) planktonic cells. The immobilized Cdp-4/RGO/β-MnO₂ also eradicated the mature biofilm by 99% with a minimum inhibitory concentration value of 62.5 µg/mL with significant reduction of EPS. These characteristics allow the use of the immobilized Arg–Trp rich AMP as a promising antimicrobial agent against microbial biofilms, present in water distribution systems.
Keywords	Pseudomonas aeruginosa ; anti-infective agents ; antimicrobial peptides ; arginine ; biofilm ; graphene oxide ; manganese dioxide ; minimum inhibitory concentration ; multiple drug resistance ; nanocomposites ; plankton ; polymers ; tryptophan ; water distribution
Language	English
Dates of publication	2022-0315
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.128035
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Article ; Online: Immobilized arginine/tryptophan-rich cyclic dodecapeptide on reduced graphene oxide anchored with manganese dioxide for microbial biofilm eradication.

Samak, Nadia A / Selim, Mohamed S / Hao, Zhifeng / Xing, Jianmin

Journal of hazardous materials

2021 Volume 426, Page(s) 128035

Abstract	To avoid the accumulation of bacterial biofilms in water pipelines, it is critical to develop potent antimicrobial agents with good ability to reduce extracellular polymeric substances (EPS). In this study, cyclic dodecapeptides were synthesized, and different mutations for increasing the ratio of arginine (Arg) and tryptophan (Trp) were introduced. Separately, the synthesized dodecapeptides were immobilized on a reduced graphene oxide nanocomposite anchored with a hierarchical β-MnO
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Antimicrobial Peptides ; Arginine ; Biofilms ; Graphite ; Manganese Compounds ; Microbial Sensitivity Tests ; Oxides ; Pseudomonas aeruginosa ; Tryptophan
Chemical Substances	Anti-Bacterial Agents ; Antimicrobial Peptides ; Manganese Compounds ; Oxides ; graphene oxide ; Graphite (7782-42-5) ; Tryptophan (8DUH1N11BX) ; Arginine (94ZLA3W45F) ; manganese dioxide (TF219GU161)
Language	English
Publishing date	2021-12-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.128035
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Article: Ru(II) Complex Grafted Ti

Liu, Xiaofang / Xie, Hongchi / Zhuo, Shi / Zhou, Yuanhong / Selim, Mohamed S / Chen, Xiang / Hao, Zhifeng

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 6

Abstract: For a long time, the emergence of microbial drug resistance due to the abuse of antibiotics has greatly reduced the therapeutic effect of many existing antibiotics. This makes the development of new antimicrobial materials urgent. Light-assisted ... ...

Abstract	For a long time, the emergence of microbial drug resistance due to the abuse of antibiotics has greatly reduced the therapeutic effect of many existing antibiotics. This makes the development of new antimicrobial materials urgent. Light-assisted antimicrobial therapy is an alternative to antibiotic therapy due to its high antimicrobial efficiency and non-resistance. Here, we develop a nanocomposite material (Ru@MXene) which is based on Ru(bpy)(dcb)
Language	English
Publishing date	2023-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13060958
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Article: Serum Transforming Growth Factor β1 and Its Genetic Variants Are Associated with Increased Macrophage Inflammatory Protein 1β and Susceptibility to Idiopathic Carpal Tunnel Syndrome.

Fattah, Shaimaa A / Selim, Mohamed S / Abdel Fattah, Maha A / Abo-Elmatty, Dina M / Mesbah, Noha M / Abdel-Hamed, Asmaa R

Journal of personalized medicine

2023 Volume 13, Issue 5

Abstract: Carpal tunnel syndrome (CTS) is a common entrapment neuropathy in which one of the body's peripheral nerves becomes pinched or crushed. Transforming growth factor beta 1 (TGF-β1) plays an important role in the pathogenesis of CTS. An association between ... ...

Abstract	Carpal tunnel syndrome (CTS) is a common entrapment neuropathy in which one of the body's peripheral nerves becomes pinched or crushed. Transforming growth factor beta 1 (TGF-β1) plays an important role in the pathogenesis of CTS. An association between TGF-β1 polymorphisms and the susceptibility or progression of a number of diseases has been reported. In this study, three TGF-β1 single nucleotide polymorphisms (SNPs), serum TGF-β1, and macrophage inflammatory protein 1 beta (MIP-1β) were investigated as potential diagnostic markers for the progression of CTS in Egyptian patients. One hundred CTS patients and 100 healthy controls were recruited for the study. TGF-β1 SNPs +915G/C, -509C/T and -800G/A were determined by TaqMan genotyping assay. Serum TGF-β1 and MIP-1β levels were measured by ELISA. Serum TGF-β1 and MIP-1β levels increased significantly and were strongly correlated with the occurrence of CTS. The C allele of +915G/C, the T allele of -509C/T, and the G allele of -800G/A occurred more frequently in patients from CTS than in controls. The serum levels of TGF-β1 and MIP-1β in the group of carriers of the genotypes +915G/C GC and CC, the genotype -509C/T TT and the genotype -800G/A GA and AA were significantly higher in CTS patients. TGF-β1 and its +915G/C, -509C/T, and -800G/A SNPs and MIP-1β could be useful prognostic markers for the occurrence of CTS.
Language	English
Publishing date	2023-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13050715
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Article ; Online: Bioinspired Graphene Oxide-Magnetite Nanocomposite Coatings as Protective Superhydrophobic Antifouling Surfaces.

Selim, Mohamed S / Fatthallah, Nesreen A / Shenashen, Mohamed A / Higazy, Shimaa A / Madian, Hekmat R / Selim, Mahmoud M / El-Safty, Sherif A

Langmuir : the ACS journal of surfaces and colloids

2023 Volume 39, Issue 6, Page(s) 2333–2346

Abstract: Antifouling (AF) nanocoatings made of polydimethylsiloxane (PDMS) are more cost-efficient and eco-friendly substitutes for the already outlawed tributyltin-based coatings. Here, a catalytic hydrosilation approach was used to construct a design inspired ... ...

Abstract	Antifouling (AF) nanocoatings made of polydimethylsiloxane (PDMS) are more cost-efficient and eco-friendly substitutes for the already outlawed tributyltin-based coatings. Here, a catalytic hydrosilation approach was used to construct a design inspired by composite mosquito eyes from non-toxic PDMS nanocomposites filled with graphene oxide (GO) nanosheets decorated with magnetite nanospheres (GO-Fe
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.2c03061
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Article ; Online: Polymorphic renal transporters and cisplatin's toxicity in urinary bladder cancer patients: current perspectives and future directions.

Selim, Mohamed S / Kassem, Amira B / El-Bassiouny, Noha A / Salahuddin, Ahmad / Abu El-Ela, Raghda Y / Hamza, Marwa Samir

Medical oncology (Northwood, London, England)

2023 Volume 40, Issue 2, Page(s) 80

Abstract: Urinary bladder cancer (UBC) holds a potentially profound social burden and affects over 573,278 new cases annually. The disease's primary risk factors include occupational tobacco smoke exposure and inherited genetic susceptibility. Over the past 30 ... ...

Abstract	Urinary bladder cancer (UBC) holds a potentially profound social burden and affects over 573,278 new cases annually. The disease's primary risk factors include occupational tobacco smoke exposure and inherited genetic susceptibility. Over the past 30 years, a number of treatment modalities have emerged, including cisplatin, a platinum molecule that has demonstrated effectiveness against UBC. Nevertheless, it has severe dose-limiting side effects, such as nephrotoxicity, among others. Since intracellular accumulation of platinum anticancer drugs is necessary for cytotoxicity, decreased uptake or enhanced efflux are the root causes of platinum resistance and response failure. Evidence suggests that genetic variations in any transporter involved in the entry or efflux of platinum drugs alter their kinetics and, to a significant extent, determine patients' responses to them. This review aims to consolidate and describe the major transporters and their polymorphic variants in relation to cisplatin-induced toxicities and resistance in UBC patients. We concluded that the efflux transporters ABCB1, ABCC2, SLC25A21, ATP7A, and the uptake transporter OCT2, as well as the organic anion uptake transporters OAT1 and OAT2, are linked to cisplatin accumulation, toxicity, and resistance in urinary bladder cancer patients. While suppressing the CTR1 gene's expression reduced cisplatin-induced nephrotoxicity and ototoxicity, inhibiting the expression of the MATE1 and MATE2-K genes has been shown to increase cisplatin's nephrotoxicity and resistance. The roles of ABCC5, ABCA8, ABCC10, ABCB10, ABCG1, ATP7B, ABCG2, and mitochondrial SLC25A10 in platinum-receiving urinary bladder cancer patients should be the subject of further investigation.
MeSH term(s)	Humans ; Cisplatin/adverse effects ; Platinum ; Organic Cation Transport Proteins/genetics ; Organic Cation Transport Proteins/metabolism ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/metabolism ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/genetics ; Dicarboxylic Acid Transporters
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Platinum (49DFR088MY) ; Organic Cation Transport Proteins ; Antineoplastic Agents ; Slc25a10 protein, human ; Dicarboxylic Acid Transporters
Language	English
Publishing date	2023-01-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-022-01928-0
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Article: Comparative study between three carbonaceous nanoblades and nanodarts for antimicrobial applications.

Selim, Mohamed S / Azzam, Ahmed M / Shenashen, Mohamed A / Higazy, Shimaa A / Mostafa, Bayaumy B / El-Safty, Sherif A

Journal of environmental sciences (China)

2023 Volume 136, Page(s) 594–605

Abstract: The design of nanostructured materials occupies a privileged position in the development and management of affordable and effective technology in the antibacterial sector. Here, we discuss the antimicrobial properties of three carbonaceous nanoblades and ...

Abstract	The design of nanostructured materials occupies a privileged position in the development and management of affordable and effective technology in the antibacterial sector. Here, we discuss the antimicrobial properties of three carbonaceous nanoblades and nanodarts materials of graphene oxide (GO), reduced graphene oxide (RGO), and single-wall carbon nanotubes (SWCNTs) that have a mechano-bactericidal effect, and the ability to piercing or slicing bacterial membranes. To demonstrate the significance of size, morphology and composition on the antibacterial activity mechanism, the designed nanomaterials have been characterized. The minimum inhibitory concentration (MIC), standard agar well diffusion, and transmission electron microscopy were utilized to evaluate the antibacterial activity of GO, RGO, and SWCNTs. Based on the evidence obtained, the three carbonaceous materials exhibit activity against all microbial strains tested by completely encapsulating bacterial cells and causing morphological disruption by degrading the microbial cell membrane in the order of RGO > GO > SWCNTs. Because of the external cell wall structure and outer membrane proteins, the synthesized carbonaceous nanomaterials exhibited higher antibacterial activity against Gram-positive bacterial strains than Gram-negative and fungal microorganisms. RGO had the lowest MIC values (0.062, 0.125, and 0.25 mg/mL against B. subtilis, S. aureus, and E. coli, respectively), as well as minimum fungal concentrations (0.5 mg/mL for both A. fumigatus and C. albicans). At 12 hr, the cell viability values against tested microbial strains were completely suppressed. Cell lysis and death occurred as a result of severe membrane damage caused by microorganisms perched on RGO nanoblades. Our work gives an insight into the design of effective graphene-based antimicrobial materials for water treatment and remediation.
MeSH term(s)	Staphylococcus aureus ; Nanotubes, Carbon/toxicity ; Escherichia coli ; Graphite/toxicity ; Graphite/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Microbial Sensitivity Tests
Chemical Substances	graphene oxide ; Nanotubes, Carbon ; Graphite (7782-42-5) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-03-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1092300-7
ISSN	1878-7320 ; 1001-0742
ISSN (online)	1878-7320
ISSN	1001-0742
DOI	10.1016/j.jes.2023.02.036
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