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Egypt J Bronchol
| Keywords | covid19 |
|---|---|
| Publisher | PMC |
| Document type | Article ; Online |
| DOI | 10.1186/s43168-020-00045-8 |
| Database | COVID19 |
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2017 Volume 118, Issue 5, Page(s) 557–563
Abstract: Background: Despite the use of alfacalcidol in the management of corticosteroid-induced osteoporosis, it has never been considered an adjunct treatment for asthma management. It can target vitamin D deficiency, a possible risk factor for asthma, and, ... ...
| Abstract | Background: Despite the use of alfacalcidol in the management of corticosteroid-induced osteoporosis, it has never been considered an adjunct treatment for asthma management. It can target vitamin D deficiency, a possible risk factor for asthma, and, hence, improve pulmonary function of patients with asthma. Objective: To explore the effect of alfacalcidol administration on pulmonary function and study the pattern of vitamin D deficiency in adults with asthma in Egypt. Methods: Serum 25-hydroxyvitamin D was measured in 115 adults: 33 healthy subjects and 82 patients with asthma. Then, patients with asthma were randomized to receive standard asthma treatment only (n = 39) or receive it in addition to 1 μg of alfacalcidol daily for 4 months (n = 43). Randomization was stratified by the stage of asthma severity. Spirometry and measurement of 25-hydroxyvitamin were performed at baseline and end of follow-up. Results: Vitamin D deficiency was more common in patients with asthma (57.3%) than in healthy subjects (21.2%; P < .001). In patients with asthma, alfacalcidol significantly improved forced expiratory volume in the first second and forced vital capacity (P < .001 for the 2 tests). Moreover, more patients in the intervention arm showed improvement in asthma severity stage (P = .04). A nonsignificant difference was observed in improvement of forced expiratory volume in the first second between patients with vitamin D deficiency and those without deficiency in the intervention group (P > .05). Conclusion: Alfacalcidol supplementation improved the pulmonary function and severity stage of adult patients with asthma regardless of deficiency. Trial registration: ClinicalTrials.gov Identifier: NCT02747381. |
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| MeSH term(s) | Adrenal Cortex Hormones/adverse effects ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Anti-Asthmatic Agents/adverse effects ; Anti-Asthmatic Agents/therapeutic use ; Asthma/complications ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/physiopathology ; Bone Density Conservation Agents/therapeutic use ; Case-Control Studies ; Egypt ; Female ; Forced Expiratory Volume/drug effects ; Humans ; Hydroxycholecalciferols/therapeutic use ; Male ; Middle Aged ; Severity of Illness Index ; Spirometry ; Treatment Outcome ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/drug therapy ; Young Adult |
| Chemical Substances | Adrenal Cortex Hormones ; Anti-Asthmatic Agents ; Bone Density Conservation Agents ; Hydroxycholecalciferols ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H) ; alfacalcidol (URQ2517572) |
| Language | English |
| Publishing date | 2017 |
| Publishing country | United States |
| Document type | Clinical Trial ; Journal Article ; Randomized Controlled Trial |
| ZDB-ID | 1228189-x |
| ISSN | 1534-4436 ; 0003-4738 ; 1081-1206 |
| ISSN (online) | 1534-4436 |
| ISSN | 0003-4738 ; 1081-1206 |
| DOI | 10.1016/j.anai.2017.02.014 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Uh III Zs.136: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Reading through the Modern Arab City
2011
Abstract: The third volume in the groundbreaking new series "Theory in the World", Neighborhood and Boulevard combines memoir, history, anthropology, and theory to offer an innovative reflection on the materiality of culture. Through its style and content, the ... ...
| Abstract | The third volume in the groundbreaking new series "Theory in the World", Neighborhood and Boulevard combines memoir, history, anthropology, and theory to offer an innovative reflection on the materiality of culture. Through its style and content, the text challenges the Orientalist bifurcation between tradition and modernity in the Arab world, revealing instead tradition's own dynamism and its coexistence alongside modernity |
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| Language | English |
| Size | Online-Ressource (191 p.) |
| Publisher | Palgrave Macmillan |
| Publishing place | Basingstoke |
| Document type | Book ; Online |
| Note | Description based upon print version of record |
| ISBN | 9780230103610 ; 0230103618 |
| Database | Library catalogue of the German National Library of Science and Technology (TIB), Hannover |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.