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  1. Book ; Thesis: Die extrazerebrale Toxoplasmose im Autopsiegut bei Verstorbenen mit AIDS

    Sell, Manfred

    1991  

    Author's details vorgelegt von Manfred Sell
    Size 1 Mikrofiche : 24x
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 1991
    Note Mikroreprod. eines Ms. 92 Bl.: Ill., graph. Darst.
    HBZ-ID HT004316281
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1992 MB 1722 order for loan Magazin

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  2. Article ; Online: Obesity induced by Borna disease virus in rats: key roles of hypothalamic fast-acting neurotransmitters and inflammatory infiltrates.

    Gosztonyi, Georg / Ludwig, Hanns / Bode, Liv / Kao, Moujahed / Sell, Manfred / Petrusz, Peter / Halász, Béla

    Brain structure & function

    2020  Volume 225, Issue 5, Page(s) 1459–1482

    Abstract: Human obesity epidemic is increasing worldwide with major adverse consequences on health. Among other possible causes, the hypothesis of an infectious contribution is worth it to be considered. Here, we report on an animal model of virus-induced obesity ... ...

    Abstract Human obesity epidemic is increasing worldwide with major adverse consequences on health. Among other possible causes, the hypothesis of an infectious contribution is worth it to be considered. Here, we report on an animal model of virus-induced obesity which might help to better understand underlying processes in human obesity. Eighty Wistar rats, between 30 and 60 days of age, were intracerebrally inoculated with Borna disease virus (BDV-1), a neurotropic negative-strand RNA virus infecting an unusually broad host spectrum including humans. Half of the rats developed fatal encephalitis, while the other half, after 3-4 months, continuously gained weight. At tripled weights, rats were sacrificed by trans-cardial fixative perfusion. Neuropathology revealed prevailing inflammatory infiltrates in the median eminence (ME), progressive degeneration of neurons of the paraventricular nucleus, the entorhinal cortex and the amygdala, and a strikingly high-grade involution of the hippocampus with hydrocephalus. Immune histology revealed that major BDV-1 antigens were preferentially present at glutamatergic receptor sites, while GABAergic areas remained free from BDV-1. Virus-induced suppression of the glutamatergic system caused GABAergic predominance. In the hypothalamus, this shifted the energy balance to the anabolic appetite-stimulating side governed by GABA, allowing for excessive fat accumulation in obese rats. Furthermore, inflammatory infiltrates in the ME and ventro-medial arcuate nucleus hindered free access of appetite-suppressing hormones leptin and insulin. The hormone transport system in hypothalamic areas outside the ME became blocked by excessively produced leptin, leading to leptin resistance. The resulting hyperleptinemic milieu combined with suppressed glutamatergic mechanisms was a characteristic feature of the found metabolic pathology. In conclusion, the study provided clear evidence that BDV-1 induced obesity in the rat model is the result of interdependent structural and functional metabolic changes. They can be explained by an immunologically induced hypothalamic microcirculation-defect, combined with a disturbance of neurotransmitter regulatory systems. The proposed mechanism may also have implications for human health. BDV-1 infection has been frequently found in depressive patients. Independently, comorbidity between depression and obesity has been reported, either. Future studies should address the exciting question of whether BDV-1 infection could be a link, whatsoever, between these two conditions.
    MeSH term(s) Animals ; Borna Disease/complications ; Borna Disease/metabolism ; Borna Disease/pathology ; Borna disease virus/physiology ; Brain/metabolism ; Brain/pathology ; Brain/virology ; Encephalitis, Viral/pathology ; Hypothalamus/metabolism ; Hypothalamus/pathology ; Hypothalamus/virology ; Neurons/metabolism ; Neurons/pathology ; Neurons/virology ; Neuropeptides/metabolism ; Obesity/metabolism ; Obesity/pathology ; Obesity/virology ; Rats, Wistar
    Chemical Substances Neuropeptides
    Language English
    Publishing date 2020-05-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2273162-3
    ISSN 1863-2661 ; 1863-2653
    ISSN (online) 1863-2661
    ISSN 1863-2653
    DOI 10.1007/s00429-020-02063-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.90: Show issues Location:
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  3. Article: Ventriculitis and hydrocephalus as the primary manifestation of cerebral toxoplasmosis associated with AIDS.

    Sell, Manfred / Sander, Bernhard / Klingebiel, Randolf

    Journal of neurology

    2005  Volume 252, Issue 2, Page(s) 234–236

    MeSH term(s) Acquired Immunodeficiency Syndrome/complications ; Acquired Immunodeficiency Syndrome/pathology ; Acquired Immunodeficiency Syndrome/virology ; Homosexuality ; Humans ; Hydrocephalus/etiology ; Immunohistochemistry/methods ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Staining and Labeling/methods ; Toxoplasmosis, Cerebral/complications ; Toxoplasmosis, Cerebral/pathology ; Toxoplasmosis, Cerebral/virology ; Vasculitis, Central Nervous System/etiology
    Language English
    Publishing date 2005-02
    Publishing country Germany
    Document type Letter
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-005-0620-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.40: Show issues Location:
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  4. Book ; Thesis: Die extrazerebrale Toxoplasmose im Autopsiegut bei Verstorbenen mit AIDS

    Sell, Manfred

    1991  

    Author's details vorgelegt von Manfred Sell
    Language Undetermined
    Size 1 Mikrofiche, 24x
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @Berlin, Freie Univ., Diss. : 1991 (Nur als Mikrofiche für den Austausch)
    Note Mikroreprod. eines Ms. 92 Bl. : Ill., graph. Darst.
    Database Former special subject collection: coastal and deep sea fishing

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  5. Book ; Thesis: Musikantenleben

    Sell, Manfred

    zur Volkskunde und Sozialgeschichte ländlich lebender Musikanten im ausgehenden 19. Jahrhundert

    (Schriften des Freilichtmuseums am Kiekeberg ; 2)

    1988  

    Institution Freilichtmuseum am Kiekeberg
    Author's details Manfred Sell
    Series title Schriften des Freilichtmuseums am Kiekeberg ; 2
    Language German
    Size 80 S, Ill., graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zugl.: Hamburg, Univ., Magisterarbeit, 1988 u.d.T.: Sell: Heidjers Tanzmusik
    Database Former special subject collection: coastal and deep sea fishing

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  6. Article: Congenital glioblastoma multiforme with abnormal vascularity presenting as intracranial hemorrhage in prenatal ultrasound.

    Sell, Manfred / Huber-Schumacher, Sabine / van Landeghem, Frank K H

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2006  Volume 22, Issue 7, Page(s) 729–733

    Abstract: Background: A rare case of a congenital brain neoplasm with intratumoral massive hemorrhage suggested by prenatal ultrasound examination in a 32-week gestational age male fetus is reported. The child died shortly after birth due to cardiorespiratory ... ...

    Abstract Background: A rare case of a congenital brain neoplasm with intratumoral massive hemorrhage suggested by prenatal ultrasound examination in a 32-week gestational age male fetus is reported. The child died shortly after birth due to cardiorespiratory insufficiency.
    Methods: Autopsy disclosed a large well-delimited tumor with a sponge-like appearance due to high vascularization, which involved nearly the whole left cerebral hemisphere and led to marked hydrocephalus by secondary aqueductal stenosis. Histological and immunohistochemical examination confirmed the diagnosis of a malignant glioma with features of a glioblastoma multiforme (GBM) matching well with previous findings in primary pediatric GBMs.
    Findings: The present case demonstrates that malignant congenital neoplasms should be considered in the differential diagnosis of fetal intracranial hemorrhage.
    MeSH term(s) Adult ; Brain Neoplasms/complications ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/pathology ; Female ; Fetal Diseases/diagnostic imaging ; Fetal Diseases/pathology ; Fetus ; Glioblastoma/complications ; Glioblastoma/diagnostic imaging ; Glioblastoma/pathology ; Humans ; Intracranial Hemorrhages/diagnostic imaging ; Intracranial Hemorrhages/etiology ; Intracranial Hemorrhages/pathology ; Male ; Pregnancy ; Ultrasonography, Prenatal/methods
    Language English
    Publishing date 2006-05-04
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0256-7040 ; 0302-2803
    ISSN (online) 1433-0350
    ISSN 0256-7040 ; 0302-2803
    DOI 10.1007/s00381-006-0049-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2036: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Thesis: Heidjers Tanzmusik

    Sell, Manfred

    zur Volkskunde und Sozialgeschichte ländlich lebender Musikanten im ausgehenden 19. Jahrhundert

    1987  

    Author's details vorgelegt von Manfred Sell
    Language German
    Size 109 S, Ill
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Mag.-Schr. (Nicht f. d. Austausch)--Hamburg, 1988
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book ; Conference proceedings: Waschen - eine saubere Sache

    Sell, Manfred / Fahl, Andreas

    (Schriften des Freilichtmuseums am Kiekeberg ; 7)

    1991  

    Institution Freilichtmuseum am Kiekeberg
    Event/congress Sonderausstellung Waschen - eine saubere Sache (1, 1991, Ehestorf)
    Author's details Manfred Sell. Mit Beitr. von Andreas Fahl
    Series title Schriften des Freilichtmuseums am Kiekeberg ; 7
    Language German
    Size 80 S, Ill., graph. Darst
    Publisher Selbstverl
    Publishing place Ehestorf
    Document type Book ; Conference proceedings
    ISBN 3927521094 ; 9783927521094
    Database Former special subject collection: coastal and deep sea fishing

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Book ; Conference proceedings: Waschen - eine saubere Sache

    Sell, Manfred / Fahl, Andreas

    (Schriften des Freilichtmuseums am Kiekeberg ; 7)

    1991  

    Institution Freilichtmuseum am Kiekeberg
    Event/congress Sonderausstellung Waschen - eine saubere Sache (1, 1991, Ehestorf)
    Author's details Manfred Sell. Mit Beitr. von Andreas Fahl
    Series title Schriften des Freilichtmuseums am Kiekeberg ; 7
    Language German
    Size 80 S, Ill., graph. Darst
    Publisher Selbstverl
    Publishing place Ehestorf
    Document type Book ; Conference proceedings
    ISBN 3927521094 ; 9783927521094
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Book: Die neutralen Alpen

    Sell, Manfred

    1965  

    Author's details Manfred Sell
    Language German
    Size 241 S, Kt
    Publisher Seewald
    Publishing place Stuttgart
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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