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  1. Article ; Online: MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections.

    Roehrig, Christian / Huemer, Markus / Lorgé, Dominique / Arn, Fabienne / Heinrich, Nadine / Selvakumar, Lavanja / Gasser, Lynn / Hauswirth, Patrick / Chang, Chun-Chi / Schweizer, Tiziano A / Eichenseher, Fritz / Lehmann, Steffi / Zinkernagel, Annelies S / Schmelcher, Mathias

    mBio

    2024  Volume 15, Issue 2, Page(s) e0254023

    Abstract: Bacterial infections are a growing global healthcare concern, as an estimated annual 4.95 million deaths are associated with antimicrobial resistance (AMR). Methicillin- ... ...

    Abstract Bacterial infections are a growing global healthcare concern, as an estimated annual 4.95 million deaths are associated with antimicrobial resistance (AMR). Methicillin-resistant
    MeSH term(s) Humans ; Animals ; Mice ; Staphylococcus aureus ; Methicillin-Resistant Staphylococcus aureus ; Peptidoglycan ; Zebrafish ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Staphylococcus ; N-Acetylmuramoyl-L-alanine Amidase/genetics ; N-Acetylmuramoyl-L-alanine Amidase/therapeutic use ; Sepsis/drug therapy
    Chemical Substances Peptidoglycan ; Anti-Bacterial Agents ; N-Acetylmuramoyl-L-alanine Amidase (EC 3.5.1.28)
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02540-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Glycotyping and Specific Separation of Listeria monocytogenes with a Novel Bacteriophage Protein Tool Kit.

    Sumrall, Eric T / Röhrig, Christian / Hupfeld, Mario / Selvakumar, Lavanja / Du, Jiemin / Dunne, Matthew / Schmelcher, Mathias / Shen, Yang / Loessner, Martin J

    Applied and environmental microbiology

    2020  Volume 86, Issue 13

    Abstract: The Gram-positive ... ...

    Abstract The Gram-positive pathogen
    MeSH term(s) Bacteriophages/chemistry ; Listeria monocytogenes/classification ; Recombinant Proteins/analysis ; Serogroup ; Serotyping/methods ; Viral Proteins/analysis
    Chemical Substances Recombinant Proteins ; Viral Proteins
    Language English
    Publishing date 2020-06-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/AEM.00612-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 201: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Linker-Improved Chimeric Endolysin Selectively Kills Staphylococcus aureus

    Eichenseher, Fritz / Herpers, Bjorn L / Badoux, Paul / Leyva-Castillo, Juan M / Geha, Raif S / van der Zwart, Mathijs / McKellar, James / Janssen, Ferd / de Rooij, Bob / Selvakumar, Lavanja / Röhrig, Christian / Frieling, Johan / Offerhaus, Mark / Loessner, Martin J / Schmelcher, Mathias

    Antimicrobial agents and chemotherapy

    2022  Volume 66, Issue 5, Page(s) e0227321

    Abstract: Staphylococcus aureus causes a broad spectrum of diseases in humans and animals. It is frequently associated with inflammatory skin disorders such as atopic dermatitis, where it aggravates symptoms. Treatment of S. aureus-associated skin infections with ... ...

    Abstract Staphylococcus aureus causes a broad spectrum of diseases in humans and animals. It is frequently associated with inflammatory skin disorders such as atopic dermatitis, where it aggravates symptoms. Treatment of S. aureus-associated skin infections with antibiotics is discouraged due to their broad-range deleterious effect on healthy skin microbiota and their ability to promote the development of resistance. Thus, novel S. aureus-specific antibacterial agents are desirable. We constructed two chimeric cell wall-lytic enzymes, Staphefekt SA.100 and XZ.700, which are composed of functional domains from the bacteriophage endolysin Ply2638 and the bacteriocin lysostaphin. Both enzymes specifically killed S. aureus and were inactive against commensal skin bacteria such as Staphylococcus epidermidis, with XZ.700 proving more active than SA.100 in multiple
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cellulitis ; Disease Models, Animal ; Endopeptidases ; Epidermis ; Humans ; Mice ; Skin/microbiology ; Skin Diseases, Infectious ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus
    Chemical Substances Anti-Bacterial Agents ; Endopeptidases (EC 3.4.-) ; endolysin (EC 3.4.99.-)
    Language English
    Publishing date 2022-04-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.02273-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Einzelsignatur: Show issues

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