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Article ; Online: A Comparison of the Clinicopathological Features, Metastasis Sites and Survival Outcomes of Invasive Lobular, Invasive Ductal and Mixed Invasive Ductal and Lobular Breast Carcinoma

Nüvit Duraker / Semih Hot / Arzu Akan / Pınar Özay Nayır

European Journal of Breast Health, Vol 16, Iss 1, Pp 22-

2020 Volume 31

Abstract: Objective:We compared the breast cancer patients with invasive lobular carcinoma (ILC), invasive ductal carcinoma (IDC) and mixed invasive ductal and lobular carcinoma (IDLC) in terms of clinicopathological and treatment features, metastatic patterns and ...

Abstract	Objective:We compared the breast cancer patients with invasive lobular carcinoma (ILC), invasive ductal carcinoma (IDC) and mixed invasive ductal and lobular carcinoma (IDLC) in terms of clinicopathological and treatment features, metastatic patterns and long-term survival.Materials and Methods: In a 10 years patient cohort, 3412 patients with unilateral breast carcinoma were enrolled in the study. Tumors were classified histologically according to criteria described by World Health Organization classification.Results:The highest rate of T3 tumors were found in IDLC patients, the lowest in IDC patients, and the difference between groups was significant only in comparison of IDC vs IDLC. Axillary positivity rate was highest in IDLC, lowest in ILC; differences were significant in comparisons of IDLC vs ILC and IDLC vs IDC. There was no significant difference between the patient groups in terms of surgical treatment, mastectomy and breast conserving surgery. Rate of bone metastasis was highest in IDLC, lowest in IDC, with significant difference between IDLC and IDC. Locoregional recurrence-free survival (LRFS) rate was 90.9% in ILC patients, 92.5% in IDC patients, 92.9% in IDLC patients, with no significant difference between the groups; in multivariate Cox analysis, histological type had no prognostic significance (p=0.599). Distant metastasis-free survival (DMFS) rate was 66.2% in ILC patients, 66.7% in IDC patients, 57.1% in IDLC patients; in multivariate Cox analysis, histological type had no prognostic significance (p=0.392).Conclusion: Although these results suggest that IDLC may have a worse prognosis than IDC and ILC, in multivariate analysis LRFS and DMFS were not significantly different among the histological type groups.
Keywords	breast cancer ; invasive lobular carcinoma ; invasive ductal carcinoma ; mixed invasive ductal and lobular carcinoma ; survival ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Medicine ; R
Subject code	616 ; 610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Galenos Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The value of adenosine deaminase level in assessing activation of inflammatory bowel disease

Züleyha Akkan Çetinkaya / Yasemin Gökden / Semih Kalyon / Semih Hot / Can Gönen

Journal of Surgery and Medicine, Vol 4, Iss 8, Pp 654-

2020 Volume 659

Abstract: Aim: There is still a need for an ideal laboratory test that can determine the type of disease, the degree of its activity, predict its course, and monitor treatment response in patients with inflammatory bowel disease (IBD). This study aims to ... ...

Abstract	Aim: There is still a need for an ideal laboratory test that can determine the type of disease, the degree of its activity, predict its course, and monitor treatment response in patients with inflammatory bowel disease (IBD). This study aims to investigate the relationship between disease types and activity with Adenosine deaminase (ADA) levels in patients with IBD. Methods: A total of 92 patients with IBD [43 with Crohn’s disease (CD) and 49 with ulcerative colitis (UC)] and 31 healthy control (HC) volunteers were included in this case-control study. Patients’ age, gender, body mass index, location and severity of the disease, medication, endoscopic examination, hemogram, C-reactive Protein (CRP), and ADA results were evaluated. Results: The mean ADA level was 24.87 (9.6 - 74.9) IU/L in the IBD group and 20.8 (13.7 - 38.9) IU/L in the HC group. The difference between the IBD and HC groups was statistically significant (P
Keywords	ulcerative colitis ; crohn’s disease ; adenosine deaminase ; crohn hastalığı ; ülseratif kolit ; adenozin deaminaz ; Medicine ; R ; Medicine (General) ; R5-920 ; Surgery ; RD1-811
Subject code	610
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Journal of Surgery and Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Is language disability a risk factor for complicated appendicitis? A retrospective cohort study

Dursun Özgür Karakaş / Semih Hot / Seracettin Eğin / Berk Gökçek / Metin Yeşiltaş

Journal of Surgery and Medicine, Vol 4, Iss 8, Pp 631-

2020 Volume 635

Abstract: Aim: Acute appendicitis is the most common emergent surgical disease and complicated appendicitis is an indicator of disrupted access to healthcare. Language disability has become more important in the healthcare sector with increasing migration in the ... ...

Abstract	Aim: Acute appendicitis is the most common emergent surgical disease and complicated appendicitis is an indicator of disrupted access to healthcare. Language disability has become more important in the healthcare sector with increasing migration in the last decade. We aimed to evaluate language disability as a risk factor for complicated appendicitis. Methods: From January 2014 to December 2018, patients who were operated for acute appendicitis were evaluated retrospectively. Patients’ age, gender, language disability (LD) (no (C) or yes (F)), whether surgical drainage was required, pathological findings (appendix diameter, severity as uncomplicated (UCA) or complicated (CA), and presence of local peritonitis), levels of C-Reactive Protein (CRP), White Blood Cells (Wbc), Neutrophil% (Neu%), and ultrasonography (USG) and computed tomography (CT) results were noted and compared. Results: Six hundered twenty-eight patients were included in the study, among which 15.1% (n=95) were considered F, and 12% (n=74) were CA. Age and gender did not significantly differ in terms of LD and severity (P=0.15, P=0.24 and P=0.2, P=0.21, respectively). Drainage requirement, local peritonitis, levels of CRP, Wbc, and Neu% were significantly higher in the CA group (P
Keywords	apandisit ; şiddet ; dil engeli ; appendicitis ; severity ; language disability ; Medicine ; R ; Medicine (General) ; R5-920 ; Surgery ; RD1-811
Subject code	610
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Journal of Surgery and Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Periappendicular Inflammatory Masses

Dursun Özgür Karakaş / Metin Yeşiltaş / Berk Gökçek / Seracettin Eğin / Semih Hot

Turkish Journal of Colorectal Disease, Vol 30, Iss 3, Pp 191-

2020 Volume 197

Abstract: Aim:Periappendicular inflammatory mass (PIM) defined as a mass located at the right lower quadrant of the abdomen due to inflammation, and can not clearly distinguish from borders of appendix. The aim of this study is evaluating the PIM.Method:The ... ...

Abstract	Aim:Periappendicular inflammatory mass (PIM) defined as a mass located at the right lower quadrant of the abdomen due to inflammation, and can not clearly distinguish from borders of appendix. The aim of this study is evaluating the PIM.Method:The patients who hospitalized for PIM evaluated retrospectively. Patient’s age, gender, length of hospital stay (LOS), performing colonoscopy, comorbidity, etiology, and treatment evaluated. Also, etiology elaborated with age, gender, LOS, treatment, levels of C-reactive protein (CRP), white blood cells, neutrophil % (Neu%), and performing colonoscopy.Results:One hundred fourty four patients were included to study. The mean age was 41.35±17.9 years, and 54.2% of the patients were male. The mean LOS was 4.2±2.6 days. Colonoscopy performed only 28.5% of the patients. The most common etiology was plastron appendicitis (PA) (75%), and 32.4% of the PA was with abscess. 67.3% of the patients were treated conservatively (medical treatment or percutaneous drainage), and the rest treated surgically. The most common surgical approach was diagnostic laparoscopy and drainage. Malignancy reported at two right at age, LOS, treatment, CRP, Neu%, and colonoscopy between etiologies were statistically hemicolectomy patients. The most common comorbidities were hypertension and diabetes (12.5%, and 8.3%, respectively). 44.4% of PIM had negative ultrasonography, 71.5% had positive CT imaging. The differences significant (p<0.05).Conclusion:Not only plastron appendicitis but also Crohn’s disease, diverticulitis, mucocele, and malignancy should keep in mind when evaluating the inflammatory mass of the right lower quadrant. Age, LOS, treatment, inflammatory markers, and performing colonoscopy significantly vary due to etiology.
Keywords	periappendicular ; mass ; plastron appendicitis ; inflammatory ; right lower quadrant ; Medicine ; R ; Internal medicine ; RC31-1245 ; Diseases of the digestive system. Gastroenterology ; RC799-869
Subject code	610
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Prognostic Value of Lymph Node Ratio in Patients with Node-Positive Colorectal Cancer

Nüvit Duraker / Zeynep Civelek Çaynak / Semih Hot

Turkish Journal of Colorectal Disease, Vol 27, Iss 3, Pp 76-

2017 Volume 83

Abstract: Aim: Lymph node metastasis is one of the most important prognostic factors in colorectal cancer. We investigated the prognostic value of lymph node ratio (LNR); (the ratio of the number of metastatic lymph nodes to the number of removed lymph nodes) in ... ...

Abstract	Aim: Lymph node metastasis is one of the most important prognostic factors in colorectal cancer. We investigated the prognostic value of lymph node ratio (LNR); (the ratio of the number of metastatic lymph nodes to the number of removed lymph nodes) in node-positive colorectal cancer patients. Method: We assessed 321 node-positive colorectal cancer patients. To determine the LNR threshold value that will separate patients in two prognostic groups with significantly different cancer-specific survival (CSS) rates, survival analyses were conducted with LNR threshold values between 0.05 and 0.95, at increments of 0.05. Results: In the whole series, the most significant LNR threshold value separating patients in low-risk (213 patients) and high-risk (108 patients) groups in terms of CSS was 0.40 (p<0.001) and LNR grouping had independent prognostic significance in multivariate Cox analysis (p<0.001). CSS of patients with tumor-node-metastasis (TNM) N1 and N2 disease was significantly different (p<0.001) and TNM nodal classification had independent prognostic significance in Cox analysis (p<0.001). When LNR and TNM nodal groupings were included together in the Cox analysis, LNR grouping maintained its independent prognostic significance (p<0.001), while TNM nodal grouping lost its prognostic significance (p=0.095). Conclusion: LNR is a stronger prognostic parameter than TNM nodal grouping in separating node-positive colorectal cancer patients into prognostic groups.
Keywords	Colorectal carcinoma ; prognosis ; lymph node metastasis ; lymph node ratio ; tumor-node-metastasis classification ; Medicine ; R ; Internal medicine ; RC31-1245 ; Diseases of the digestive system. Gastroenterology ; RC799-869
Subject code	610 ; 616
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Value of D-Dimer in Diagnosis of Acute Mesenteric Ischemia and Differential Diagnosis from Acute Pancreatitis and Acute Cholecystitis

Semih Hot / Nüvit Duraker / Ayhan Sarı / Kenan Çetin

Dicle Medical Journal, Vol 43, Iss 1, Pp 88-

2016 Volume 92

Abstract: Objective: Because of its poor prognosis and high mortality rate, early diagnosis of acute mesenteric ischemia (AMI) is a challenge. The value of serum markers in the diagnosis of AMI is limited and the studies related with the D-dimer test carried out ... ...

Abstract	Objective: Because of its poor prognosis and high mortality rate, early diagnosis of acute mesenteric ischemia (AMI) is a challenge. The value of serum markers in the diagnosis of AMI is limited and the studies related with the D-dimer test carried out in recent years. In this prospective study we investigated the value of the level of plasma D-dimer in the diagnosis of AMI and the differential diagnosis from acute pancreatitis and acute cholecystitis. Methods: We included 89 patients who admitted to our emergency department with abdominal pain. The number and the diagnosis of the patients were 17 AMI, 42 acute pancreatitis and 30 acute cholecystitis, respectively. We measured the levels of plasma D-dimer of all patients by using a latex agglutination ‘immunoassay’ method. Eventually we calculated the sensitivity and specificity of D-dimer test in the diagnosis of AMI. Results: We determined the specificity of the D-dimer test in the differential diagnosis of AMI as 50% from acute pancreatitis, 70% from acute cholecystitis, 58.3% from all the control group and the sensitivity was 100%. Conclusion: The measurement of plasma D-dimer concentration may be useful in the differential diagnosis of AMI from acute pancreatitis and acute cholecystitis. However, to reveal the diagnostic value of D-dimer test more clearly, further studies with larger series are needed, where cut-off value is highly defined, and other patients with acute abdominal pain are added into the control group.
Keywords	Acute mesenteric ischemia ; diagnosis ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2016-03-01T00:00:00Z
Publisher	Dicle University Medical School
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Four Determinative Factors in Fournier’s Gangrene Mortality

Seracettin Eğin / Sedat Kamalı / Berk Gökçek / Metin Yeşiltaş / Semih Hot / Dursun Özgür Karakaş

Turkish Journal of Colorectal Disease, Vol 29, Iss 1, Pp 12-

2019 Volume 18

Abstract: Aim: We aimed to more accurately predict mortality in Fournier’s gangrene (FG) by investigating factors affecting mortality such as age, extent of infection, presence of accompanying comorbidities, the intensive care unit (ICU) length of stay (LOS). ... ...

Abstract	Aim: We aimed to more accurately predict mortality in Fournier’s gangrene (FG) by investigating factors affecting mortality such as age, extent of infection, presence of accompanying comorbidities, the intensive care unit (ICU) length of stay (LOS). Method: Routinely recorded data of 37 FG patients treated between February 2012-May 2018 were retrospectively evaluated. The patients were divided in two groups as the deceased group (DG) (n=10) and surviving group (SG) (n=27) and compared in terms of sex, age score (AS), dissemination score (DS), Uludağ Fournier’s gangrene severity index (UFGSI) score, Fournier gangrene severity index (FGSI) score, serum urea levels, presence of diabetes and obesity, presence of comorbidities other than diabetes and obesity (COTDO), presence of diversion colostomy, number of days of vacuum-assisted closure treatment, hospital LOS, ICU LOS, and species of isolated bacteria. Associations between mortality and factors such as age, DS, COTDO, and ICU LOS were investigated in all cases. Results: There was a significant difference between the two groups in terms of AS. DS was significantly higher in the DG than in SG. All of the patients in the DG had COTDO, while only 13 of the patients in the SG had these comorbidities, and the difference between the two groups was statistically significant. ICU LOS was significantly higher in the MG. In reciever operator characteristics curve analysis, UFGSI and FGSI had 93% specificity and 90% and 70% sensitivity, respectively. In logistic regression analysis, age, DS, COTDO, and ICU LOS were independent predictive factors associated with mortality. Conclusion: Age, DS, COTDO, and ICU LOS showed significant differences between deceased and surviving patients, and emerged as independent predictive factors associated with mortality. As a result, these factors have been shown to be determinative factors in FG mortality.
Keywords	Fournier’s gangrene ; mortality ; vacuum-assisted closure ; Medicine ; R ; Internal medicine ; RC31-1245 ; Diseases of the digestive system. Gastroenterology ; RC799-869
Subject code	616
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: TOTAL EXCISION ACCOMPANIED BY ROLL IN NON-PALPABLE BREAST LESION

Ayhan Sarı / Semih Hot / Ömer Bender / Aslı Ertürk / Enis Yüney / Semra Günay / Ali Alemdar

European Journal of Breast Health, Vol 9, Iss 3, Pp 151-

2013 Volume 155

Abstract: Objective: The development and extensive use of methods of breast imaging has increased the diagnosis of non-palpable breast lesions (NPBL). Although several methods have been applied in the localization of NPBL throughout the world, the technique of ... ...

Abstract	Objective: The development and extensive use of methods of breast imaging has increased the diagnosis of non-palpable breast lesions (NPBL). Although several methods have been applied in the localization of NPBL throughout the world, the technique of wire-guided localization is used as a standard. The aim of this study is to present the results of ROLL (Radioguided occult lesion localization), which is a new technique in our clinic for localization of NPBL.Materials and Methods: We included 44 patients who had NPBL in the study. The lesions were localized preoperatively with TC-99m labelled human serum albumin. A gamma probe was used to determine the place of lesion and to guide the excisional biopsy. We assessed the duration of the localization, the excisional biopsy and hospital stay, the volume of the excised piece, the surgical margin in the malign facts, complication, cost calculation, and the comfort of the procedure from the points of view of the surgeon, radiologist and patient for every case.Results: We successfully localized and excised all lesions with ROLL. As a result of the pathologic evaluation, 54.4% of the lesions were reported as benign, 45.6% as malign. An adequate surgical margin was obtained in 71.4% of the malignant lesions.Conclusion: ROLL is an alternative method to wire-guided localization for NPBL.
Keywords	radioguided occult lesion local-ization ; non-palpable breast lesions ; breast cancer ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Medicine ; R
Subject code	616
Language	English
Publishing date	2013-07-01T00:00:00Z
Publisher	Galenos Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Protective effects of pentoxifylline in small intestine after ischemia–reperfusion

Seracettin Eğin / Mehmet İlhan / Süleyman Bademler / Berk Gökçek / Semih Hot / Hakan Ekmekçi / Özlem Balcı Ekmekçi / Gamze Tanrıverdi / Fatma Kaya Dağıstanlı / Gülçin Kamalı / Sedat Kamalı / Recep Güloğlu

Journal of International Medical Research, Vol

2018 Volume 46

Abstract: Objective This study was performed to determine the healing effects of pentoxifylline on molecular responses and protection against severe ischemic damage in the small intestine. Methods Thirty-six Wistar albino rats were divided into six groups. The ... ...

Abstract	Objective This study was performed to determine the healing effects of pentoxifylline on molecular responses and protection against severe ischemic damage in the small intestine. Methods Thirty-six Wistar albino rats were divided into six groups. The superior mesenteric artery was clamped for 120 minutes, and reperfusion was performed for 60 minutes. Saline (0.4 mL), pentoxifylline (1 mg/kg), and pentoxifylline (10 mg/kg) were intraperitoneally administered to the rats in the C 1 , P 1 , and P 3 groups, respectively, 60 minutes before ischemia and to the rats in the C 2 , P 2 , and P 4 groups, respectively, during reperfusion onset. Malondialdehyde, myeloperoxidase, tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in serum and tissue were measured by enzyme-linked immunosorbent assay. Intestinal ischemic injury was histopathologically evaluated by the Chiu score and immunohistochemical staining. Results All serum and tissue molecular responses were significantly blunted in the pentoxifylline-treated groups compared with the controls. Significant improvement in ischemic damage was demonstrated in the pentoxifylline-treated groups by histological grading and immunohistochemical scoring. Conclusions The protective effects of pentoxifylline were confirmed by molecular responses and histopathological examination.
Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2018-10-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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