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  1. Book: Oxford textbook of endocrinology and diabetes / Volume 1

    Wass, John A. H. / Arlt, Wiebke / Semple, Robert K.

    2022  

    Author's details edited by John A.H. Wass, Wiebke Arlt, Robert K. Semple
    Collection Oxford textbook of endocrinology and diabetes
    Language English
    Size xxxi, 1096 Seiten, 17 Blatt, Illustrationen, Diagramme
    Publishing country Great Britain
    Document type Book
    Note Zugang zu Online-Ausgabe über Code
    HBZ-ID HT030045208
    ISBN 978-0-19-880232-7 ; 0-19-880232-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2023 A 641 available for loan (reading room) Lesesaal EG
    Zugang zu Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Book: Oxford textbook of endocrinology and diabetes / Volume 2

    Wass, John A. H. / Arlt, Wiebke / Semple, Robert K.

    2022  

    Author's details edited by John A.H. Wass, Wiebke Arlt, Robert K. Semple
    Collection Oxford textbook of endocrinology and diabetes
    Language English
    Size xxxi Seiten, Seite 1099-2213, 17 Blatt, Illustrationen, Diagramme
    Publishing country Great Britain
    Document type Book
    Note Index ungezählt
    HBZ-ID HT030045216
    ISBN 978-0-19-887018-0 ; 0-19-887018-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2023 A 642 available for loan (reading room) Lesesaal EG

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  3. Book ; Collection: Oxford textbook of endocrinology and diabetes

    Wass, John A. H. / Arlt, Wiebke / Semple, Robert K.

    2022  

    Title variant Endocrinology and diabetes
    Author's details edited by John A.H. Wass, Wiebke Arlt, Robert K. Semple
    Keywords Endokrinologie ; Diabetes
    Subject Harnruhr
    Language English
    Size 2 Bände
    Edition Third edition
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Collection (display volumes)
    HBZ-ID HT030010387
    ISBN 978-0-19-887019-7 ; 9780192523273 ; 0-19-887019-1 ; 0192523279
    DOI 10.1093/med/9780198802327.001.0001
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Insulin Resistance and Adrenal Androgen Synthesis Viewed Through a Monogenic Lens.

    Semple, Robert K

    The Journal of clinical endocrinology and metabolism

    2022  Volume 107, Issue 11, Page(s) e4326–e4327

    MeSH term(s) Female ; Humans ; Insulin Resistance ; Androgens ; Receptor, Insulin ; Hyperandrogenism ; Polycystic Ovary Syndrome
    Chemical Substances Androgens ; Receptor, Insulin (EC 2.7.10.1)
    Language English
    Publishing date 2022-08-11
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases?

    Semple, Robert K. / Morton, Nicholas M. / Fromentin, Gilles / Virtue, Sam / Even, Patrick C.

    2018  

    Abstract: Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as ... ...

    Abstract Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases
    Keywords Medicine (General) ; Nutrition. Foods and food supply ; Diseases of the endocrine glands. Clinical endocrinology
    Size 1 electronic resource (161 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020099617
    ISBN 9782889454259 ; 2889454258
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: Achievements, prospects and challenges in precision care for monogenic insulin-deficient and insulin-resistant diabetes.

    Bonnefond, Amélie / Semple, Robert K

    Diabetologia

    2022  Volume 65, Issue 11, Page(s) 1782–1795

    Abstract: Integration of genomic and other data has begun to stratify type 2 diabetes in prognostically meaningful ways, but this has yet to impact on mainstream diabetes practice. The subgroup of diabetes caused by single gene defects thus provides the best ... ...

    Abstract Integration of genomic and other data has begun to stratify type 2 diabetes in prognostically meaningful ways, but this has yet to impact on mainstream diabetes practice. The subgroup of diabetes caused by single gene defects thus provides the best example to date of the vision of 'precision diabetes'. Monogenic diabetes may be divided into primary pancreatic beta cell failure, and primary insulin resistance. In both groups, clear examples of genotype-selective responses to therapy have been advanced. The benign trajectory of diabetes due to pathogenic GCK mutations, and the sulfonylurea-hyperresponsiveness conferred by activating KCNJ11 or ABCC8 mutations, or loss-of-function HNF1A or HNF4A mutations, often decisively guide clinical management. In monogenic insulin-resistant diabetes, subcutaneous leptin therapy is beneficial in some severe lipodystrophy. Increasing evidence also supports use of 'obesity therapies' in lipodystrophic people even without obesity. In beta cell diabetes the main challenge is now implementation of the precision diabetes vision at scale. In monogenic insulin-resistant diabetes genotype-specific benefits are proven in far fewer patients to date, although further genotype-targeted therapies are being evaluated. The conceptual paradigm established by the insulin-resistant subgroup with 'adipose failure' may have a wider influence on precision therapy for common type 2 diabetes, however. For all forms of monogenic diabetes, population-wide genome sequencing is currently forcing reappraisal of the importance assigned to pathogenic mutations when gene sequencing is uncoupled from prior suspicion of monogenic diabetes.
    MeSH term(s) Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/genetics ; Humans ; Insulin/therapeutic use ; Insulin Resistance/genetics ; Leptin/therapeutic use ; Mutation/genetics ; Obesity
    Chemical Substances Insulin ; Leptin
    Language English
    Publishing date 2022-05-27
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-022-05720-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 279: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: PIK3CA-related overgrowth: silver bullets from the cancer arsenal?

    Madsen, Ralitsa R / Semple, Robert K

    Trends in molecular medicine

    2022  Volume 28, Issue 4, Page(s) 255–257

    Abstract: Mutations that activate growth factor signaling often drive cancer growth. Many also arise in isolation, causing developmental growth disorders. PIK3CA, that encodes a catalytic subunit of phosphatidylinositol 3-kinase (PI3K), is a cardinal example of ... ...

    Abstract Mutations that activate growth factor signaling often drive cancer growth. Many also arise in isolation, causing developmental growth disorders. PIK3CA, that encodes a catalytic subunit of phosphatidylinositol 3-kinase (PI3K), is a cardinal example of this paradigm. Recent exciting progress towards the key goal of cancer drug repurposing for PIK3CA-driven overgrowth is discussed.
    MeSH term(s) Class I Phosphatidylinositol 3-Kinases/genetics ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Growth Disorders/genetics ; Humans ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism
    Chemical Substances Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; PIK3CA protein, human (EC 2.7.1.137)
    Language English
    Publishing date 2022-03-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2022.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4345: Show issues Location:
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  8. Article ; Online: Author Correction: Genotype-stratified treatment for monogenic insulin resistance: a systematic review.

    Semple, Robert K / Patel, Kashyap A / Auh, Sungyoung / Brown, Rebecca J

    Communications medicine

    2024  Volume 4, Issue 1, Page(s) 57

    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Published Erratum
    ISSN 2730-664X
    ISSN (online) 2730-664X
    DOI 10.1038/s43856-024-00482-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Insulin at 100 years - is rebalancing its action key to fighting obesity-related disease?

    Brierley, Gemma V / Semple, Robert K

    Disease models & mechanisms

    2021  Volume 14, Issue 11

    Abstract: One hundred years ago, insulin was purified and administered to people with diabetes to lower blood glucose, suppress ketogenesis and save lives. A century later, insulin resistance (IR) lies at the heart of the obesity-related disease pandemic. Multiple ...

    Abstract One hundred years ago, insulin was purified and administered to people with diabetes to lower blood glucose, suppress ketogenesis and save lives. A century later, insulin resistance (IR) lies at the heart of the obesity-related disease pandemic. Multiple observations attest that IR syndrome is an amalgamation of gain and loss of insulin action, suggesting that IR is a misnomer. This misapprehension is reinforced by shortcomings in common model systems and is particularly pronounced for the tissue growth disorders associated with IR. It is necessary to move away from conceptualisation of IR as a pure state of impaired insulin action and to appreciate that, in the long term, insulin can harm as well as cure. The mixed state of gain and loss of insulin action, and its relationship to perturbed insulin-like growth factor (IGF) action, should be interrogated more fully in models recapitulating human disease. Only then may the potential of rebalancing insulin action, rather than simply increasing global insulin signalling, finally be appreciated.
    MeSH term(s) Blood Glucose/metabolism ; Humans ; Insulin/metabolism ; Insulin Resistance ; Insulin-Like Growth Factor I ; Metabolic Syndrome ; Obesity/complications ; Obesity/metabolism
    Chemical Substances Blood Glucose ; Insulin ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2021-11-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.049340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Systematic review of genotype-stratified treatment for monogenic insulin resistance.

    Semple, Robert K / Patel, Kashyap A / Auh, Sungyoung / Brown, Rebecca J

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Objective: To assess the effects of pharmacologic and/or surgical interventions in monogenic insulin resistance (IR), stratified by genetic aetiology.: Design: Systematic review.: Data sources: PubMed, MEDLINE and Embase, from 1 January 1987 to 23 ...

    Abstract Objective: To assess the effects of pharmacologic and/or surgical interventions in monogenic insulin resistance (IR), stratified by genetic aetiology.
    Design: Systematic review.
    Data sources: PubMed, MEDLINE and Embase, from 1 January 1987 to 23 June 2021.
    Review methods: Studies reporting individual-level effects of pharmacologic and/or surgical interventions in monogenic IR were eligible. Individual subject data were extracted and duplicate data removed. Outcomes were analyzed for each affected gene and intervention, and in aggregate for partial, generalised and all lipodystrophy.
    Results: 10 non-randomised experimental studies, 8 case series, and 21 single case reports met inclusion criteria, all rated as having moderate or serious risk of bias. Metreleptin was associated with lower triglycerides and hemoglobin A1c in aggregated lipodystrophy (n=111), in partial lipodystrophy (n=71) and generalised lipodystrophy (n=41)), and in
    Conclusions: The evidence guiding genotype-specific treatment of monogenic IR is of low to very low quality. Metreleptin and Thiazolidinediones appear to have beneficial metabolic effects in lipodystrophy, and rhIGF-1 appears to lower hemoglobin A1c in INSR-related IR. For other interventions there is insufficient evidence to assess efficacy and risks either in aggregated lipodystrophy or in genetic subgroups. There is a pressing need to improve the evidence base for management of monogenic IR.
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.17.23288671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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