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  1. Article ; Online: Editorial for "Beta-Catenin-Mutated Hepatocellular Adenomas at Hepatobiliary Phase MRI: A Systematic Review and Meta-Analysis".

    Schmidt, Sabine / Sempoux, Christine

    Journal of magnetic resonance imaging : JMRI

    2024  

    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.29331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3648: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 236: Show issues

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  2. Article ; Online: Pathological features in non-neoplastic congenital and adult hyperinsulinism: from nesidioblastosis to current terminology and understanding.

    Sempoux, Christine / Klöppel, Günter

    Endocrine-related cancer

    2023  Volume 30, Issue 9

    Abstract: Nesidioblastoma and nesidioblastosis were terms given to neoplastic and non-neoplastic lesions of the pancreas associated with pancreatogenous hyperinsulinaemic hypoglycaemia. While nesidioblastoma was rapidly replaced by islet cell tumour, ... ...

    Abstract Nesidioblastoma and nesidioblastosis were terms given to neoplastic and non-neoplastic lesions of the pancreas associated with pancreatogenous hyperinsulinaemic hypoglycaemia. While nesidioblastoma was rapidly replaced by islet cell tumour, nesidioblastosis, defined as the proliferation of islet cells budding off from pancreatic ducts, was the diagnostic term associated with congenital hyperinsulinism of infancy (CHI) and adult non-neoplastic hyperinsulinaemic hypoglycaemia (ANHH). When it was shown that nesidioblastosis was not specific for CHI or ANHH, it was no longer applied to CHI but kept for the morphological diagnosis of ANHH. In severe CHI cases, a diffuse form with hypertrophic ß-cells in all islets can be distinguished from a focal form with hyperactive ß-cells changes in a limited adenomatoid hyperplastic area. Genetically, mutations were identified in several ß-cell genes involved in insulin secretion. Most common are mutations in the ABCC8 or KCNJ11 genes, solely affected in the diffuse form and associated with a focal maternal allelic loss on 11p15.5 in the focal form. Focal CHI can be localized by 18F-DOPA-PET and is thus curable by targeted resection. Diffuse CHI that fails medical treatment requires subtotal pancreatectomy. In ANHH, an idiopathic form can be distinguished from a form associated with gastric bypass, in whom GLP1-induced stimulation of the ß-cells is discussed. While the ß-cells in idiopathic ANHH are diffusely affected and are either hypertrophic or show only little changes, it is controversial whether there is a ß-cell increase or ß-cell hyperactivity in patients with gastric bypass. Recognizing morphological signs of ß-cell hyperactivity needs a good knowledge of the non-neoplastic endocrine pancreas across all ages.
    MeSH term(s) Humans ; Adult ; Congenital Hyperinsulinism/genetics ; Congenital Hyperinsulinism/pathology ; Nesidioblastosis/diagnosis ; Nesidioblastosis/pathology ; Nesidioblastosis/surgery ; Hyperinsulinism/genetics ; Pancreas/pathology ; Pancreatic Neoplasms ; Adenoma, Islet Cell
    Language English
    Publishing date 2023-07-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1218450-0
    ISSN 1479-6821 ; 1351-0088
    ISSN (online) 1479-6821
    ISSN 1351-0088
    DOI 10.1530/ERC-23-0034
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    Zs.A 4192: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The enigma of glutamine synthetase and b-catenin expression in hepatocellular adenoma in familial adenomatous polyposis coli.

    Gouw, Annette S H / Sempoux, Christine / Bioulac-Sage, Paulette

    Virchows Archiv : an international journal of pathology

    2024  Volume 484, Issue 4, Page(s) 553–554

    MeSH term(s) Humans ; Adenomatous Polyposis Coli/pathology ; beta Catenin/metabolism ; Glutamate-Ammonia Ligase/metabolism ; Liver Neoplasms/pathology ; Liver Neoplasms/metabolism ; Adenoma, Liver Cell/pathology ; Adenoma, Liver Cell/metabolism ; Biomarkers, Tumor/metabolism ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics
    Chemical Substances beta Catenin ; Glutamate-Ammonia Ligase (EC 6.3.1.2) ; CTNNB1 protein, human ; Biomarkers, Tumor
    Language English
    Publishing date 2024-03-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-024-03772-1
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    Ud III Zs.10: Show issues Location:
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  4. Article ; Online: Response to a letter to the editor: a better understanding of Immune Checkpoint Inhibitor-induced cholangitis for better management.

    Coukos, Alexander / Vionnet, Julien / Sempoux, Christine / Fraga, Montserrat

    Journal for immunotherapy of cancer

    2023  Volume 11, Issue 2

    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Cholangitis/chemically induced
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2023-006877
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  5. Article ; Online: Closing the scissor-shaped curve: Strategies to promote gender equality in academia.

    Joyce, Johanna A / Masina, Slavica / Michalik, Liliane / Pot, Caroline / Sempoux, Christine / Amati, Francesca

    Cell

    2024  Volume 187, Issue 6, Page(s) 1335–1342

    Abstract: Gender inequality in STEM fields remains pervasive and undermines the ability for talented individuals to excel. Despite advances, women still encounter obstacles in pursuing academic careers and reaching leadership positions. This commentary discusses ... ...

    Abstract Gender inequality in STEM fields remains pervasive and undermines the ability for talented individuals to excel. Despite advances, women still encounter obstacles in pursuing academic careers and reaching leadership positions. This commentary discusses the "scissor-shaped curve" and examines effective strategies to fix it, including data-driven initiatives that we have implemented at our university.
    MeSH term(s) Humans ; Female ; Gender Equity ; Academia ; Leadership ; Universities
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.01.050
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    Zs.A 1167: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 58: Show issues

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  6. Article ; Online: Retraction Note: Hypermethylation of the 5' CpG island of the p14

    Nyiraneza, Christine / Sempoux, Christine / Detry, Roger / Kartheuser, Alex / Dahan, Karin

    Clinical epigenetics

    2023  Volume 15, Issue 1, Page(s) 88

    Language English
    Publishing date 2023-05-17
    Publishing country Germany
    Document type Retraction of Publication
    ZDB-ID 2553921-8
    ISSN 1868-7083 ; 1868-7075
    ISSN (online) 1868-7083
    ISSN 1868-7075
    DOI 10.1186/s13148-023-01504-x
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  7. Article ; Online: Porto-sinusoidal vascular disorder.

    De Gottardi, Andrea / Sempoux, Christine / Berzigotti, Annalisa

    Journal of hepatology

    2022  Volume 77, Issue 4, Page(s) 1124–1135

    Abstract: It is well established that portal hypertension can occur in the absence of cirrhosis, as reported in patients with immune disorders, infections and thrombophilia. However, similar histological abnormalities primarily affecting the hepatic sinusoidal and ...

    Abstract It is well established that portal hypertension can occur in the absence of cirrhosis, as reported in patients with immune disorders, infections and thrombophilia. However, similar histological abnormalities primarily affecting the hepatic sinusoidal and (peri)portal vasculature have also been observed in patients without portal hypertension. Thus, the term porto-sinusoidal vascular disorder (PSVD) has recently been introduced to describe a group of vascular diseases of the liver featuring lesions encompassing the portal venules and sinusoids, irrespective of the presence/absence of portal hypertension. Liver biopsy is fundamental for PSVD diagnosis. Specific histology findings include nodular regenerative hyperplasia, obliterative portal venopathy/portal vein stenosis and incomplete septal fibrosis/cirrhosis. Since other conditions including alcohol-related and non-alcoholic fatty liver disease, or viral hepatitis, or the presence of portal vein thrombosis may occur in patients with PSVD, their relative contribution to liver damage should be carefully assessed. In addition to histology and clinical diagnostic criteria, imaging and non-invasive tests such as liver and spleen stiffness measurements could aid in the diagnostic workup. The introduction of PSVD as a novel clinical entity will facilitate collaborative studies and investigations into the underlying molecular pathomechanisms encompassed by this term.
    MeSH term(s) Fibrosis ; Humans ; Hypertension, Portal/complications ; Hypertension, Portal/diagnosis ; Liver/pathology ; Liver Cirrhosis/diagnosis ; Portal Vein/pathology ; Vascular Diseases/diagnosis ; Vascular Diseases/etiology ; Vascular Diseases/pathology
    Language English
    Publishing date 2022-06-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2022.05.033
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    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Immunohistochemistry for hepatitis E virus capsid protein cross-reacts with cytomegalovirus-infected cells: a potential diagnostic pitfall.

    Lenggenhager, Daniela / Grossmann, Jonas / Gouttenoire, Jérôme / Sempoux, Christine / Weber, Achim

    Histopathology

    2022  Volume 82, Issue 2, Page(s) 354–358

    Abstract: Immunohistochemistry for hepatitis E virus (HEV) ORF2 (capsid) protein is a powerful tool for tissue-based diagnosis of hepatitis E, particularly useful in evaluating abnormal liver values in immunocompromised patients. We report here a previously ... ...

    Abstract Immunohistochemistry for hepatitis E virus (HEV) ORF2 (capsid) protein is a powerful tool for tissue-based diagnosis of hepatitis E, particularly useful in evaluating abnormal liver values in immunocompromised patients. We report here a previously unobserved reactivity of the HEV ORF2 antibody to human cytomegalovirus (CMV) proteins and contrast the staining patterns encountered in HEV and CMV infection, respectively. As part of a routine diagnostic work-up, the liver biopsy of an immunocompromised patient with elevated liver values was examined histologically for infection with viruses including CMV and HEV. Cytopathic changes were found, suggestive of CMV infection, which was confirmed by immunohistochemistry. Surprisingly, reactivity of a portion of CMV-infected cells with a mouse monoclonal antibody (clone 1E6) against HEV ORF2 protein was also detected. This observation prompted a screening of 22 further specimens (including liver, gastrointestinal, lung, brain and placental biopsies) with confirmed CMV infection/reactivation. Immunoreactivity of CMV-infected cells with HEV ORF2 antibody was observed in 18 of 23 specimens. While the HEV ORF2 antibody showed cytoplasmic, nuclear and canalicular positivity in hepatitis E cases, positivity in CMV-infected cells was limited to the nucleus. In conclusion, the HEV ORF2 antibody (clone 1E6) shows unexpected immunoreactivity against CMV proteins. In contrast to the hepatitis E staining pattern with cytoplasmic, nuclear and occasional canalicular positivity, reactivity in CMV-infected cells is restricted to the nucleus. Awareness of this cross-reactivity and knowledge of the differences in staining patterns will prevent pathologists from misinterpreting positive HEV ORF2 immunohistochemistry in liver specimens.
    MeSH term(s) Pregnancy ; Animals ; Mice ; Humans ; Female ; Hepatitis E virus ; Cytomegalovirus ; Capsid Proteins ; Hepatitis E ; Placenta
    Chemical Substances Capsid Proteins
    Language English
    Publishing date 2022-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.14803
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    Zs.A 1328: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Hepatocellular adenoma: what we know, what we do not know, and why it matters.

    Bioulac-Sage, Paulette / Gouw, Annette S H / Balabaud, Charles / Sempoux, Christine

    Histopathology

    2022  Volume 80, Issue 6, Page(s) 878–897

    Abstract: In the last two decades there has been significant progress in research on and diagnosis of hepatocellular adenoma (HCA), resulting in the establishment of a molecular and immunohistological HCA classification. This review aims to fine-tune the current ... ...

    Abstract In the last two decades there has been significant progress in research on and diagnosis of hepatocellular adenoma (HCA), resulting in the establishment of a molecular and immunohistological HCA classification. This review aims to fine-tune the current expertise in order to enhance the histopathological diagnostic possibilities, by refining issues that are already known, addressing diagnostic difficulties, and identifying still unknown aspects of HCA. We discuss novel methods to identify HCA subtypes, in particular the sonic hedgehog HCAs and the interpretation of glutamine synthetase patterns for the recognition of β-catenin-mutated HCAs. The major complications of HCAs, i.e. bleeding and malignant transformation, are considered, including the dilemmas of atypical and borderline lesions. HCAs in different clinical and geographical settings, e.g. pregnancy, cirrhosis and non-western countries, are also discussed. The natural history of the different HCA subtypes in relation to age, sex and risk factors is a feature that is still insufficiently investigated. This is also true for the risks of clinical bleeding and malignant transformation in association with HCA subtypes. As HCA is a relatively rare tumour, a multicentre and multidisciplinary approach across geographical boundaries will be the appropriate method to establish prospective programmes with which to identify, classify and manage HCAs, focusing on several aspects, e.g. aetiology, underlying liver disease, complications, regression, and growth. Updating what we know and identifying and addressing what we do not know matters for optimal patient management.
    MeSH term(s) Adenoma, Liver Cell/diagnosis ; Adenoma, Liver Cell/pathology ; Carcinoma, Hepatocellular/pathology ; Cell Transformation, Neoplastic ; Hedgehog Proteins ; Hemorrhage ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/pathology ; Prospective Studies
    Chemical Substances Hedgehog Proteins
    Language English
    Publishing date 2022-03-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.14605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1328: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article: Etiology, Pathogenesis, Diagnosis, and Practical Implications of Hepatocellular Neoplasms.

    Hytiroglou, Prodromos / Bioulac-Sage, Paulette / Theise, Neil D / Sempoux, Christine

    Cancers

    2022  Volume 14, Issue 15

    Abstract: Hepatocellular carcinoma (HCC), a major global contributor of cancer death, usually arises in a background of chronic liver disease, as a result of molecular changes that deregulate important signal transduction pathways. Recent studies have shown that ... ...

    Abstract Hepatocellular carcinoma (HCC), a major global contributor of cancer death, usually arises in a background of chronic liver disease, as a result of molecular changes that deregulate important signal transduction pathways. Recent studies have shown that certain molecular changes of hepatocarcinogenesis are associated with clinicopathologic features and prognosis, suggesting that subclassification of HCC is practically useful. On the other hand, subclassification of hepatocellular adenomas (HCAs), a heterogenous group of neoplasms, has been well established on the basis of genotype-phenotype correlations. Histologic examination, aided by immunohistochemistry, is the gold standard for the diagnosis and subclassification of HCA and HCC, while clinicopathologic correlation is essential for best patient management. Advances in clinico-radio-pathologic correlation have introduced a new approach for the diagnostic assessment of lesions arising in advanced chronic liver disease by imaging (LI-RADS). The rapid expansion of knowledge concerning the molecular pathogenesis of HCC is now starting to produce new therapeutic approaches through precision oncology. This review summarizes the etiology and pathogenesis of HCA and HCC, provides practical information for their histologic diagnosis (including an algorithmic approach), and addresses a variety of frequently asked questions regarding the diagnosis and practical implications of these neoplasms.
    Language English
    Publishing date 2022-07-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14153670
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