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Article ; Online: A Case of ROS1-Fusion Non-Small Cell Lung Cancer with Acquired BRAF Mutation Developing Unusual Skin Metastasis.

Firoz, Wahed A / Sen, Fatma / Kiuru, Maija / Huang, Victor / Riess, Jonathan W

2024

Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Case Reports
ZDB-ID	2145146-1
ISSN	1938-0690 ; 1525-7304
ISSN (online)	1938-0690
ISSN	1525-7304
DOI	10.1016/j.cllc.2024.01.008
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Zs.A 5893: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 440: Show issues

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Article ; Online: Effect of Cytotoxic Therapy on ALU Expression is Modulated by Hormonal Status in Patients with Breast Cancer

Özgür, Emre / Ferhatoğlu, Ferhat / Şen, Fatma / Gezer, Uğur

Balkan medical journal

2022 Volume 39, Issue 6, Page(s) 450–451

MeSH term(s)	Humans ; Female ; Breast Neoplasms/drug therapy ; Biomarkers, Tumor
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2022-10-07
Publishing country	Turkey
Document type	Letter
ZDB-ID	2612982-6
ISSN	2146-3131 ; 2146-3131
ISSN (online)	2146-3131
ISSN	2146-3131
DOI	10.4274/balkanmedj.galenos.2022.2022-5-18
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Article ; Online: A 49-Year-Old Woman With Exertional Dyspnea and Dizziness.

Liu, Nina / Ghasemiesfe, Ahmadreza / Sen, Fatma / Aman, Edris / Amsterdam, Ezra A / Venugopal, Sandhya

Chest

2023 Volume 163, Issue 4, Page(s) e157–e162

Abstract: Case presentation: A 49-year-old woman with a history of right breast cancer status post radiation therapy presented to our ED with increasing chest pain, exertional dyspnea, fatigue, and dizziness for several weeks. She denied syncope or near-syncope, ... ...

Abstract	Case presentation: A 49-year-old woman with a history of right breast cancer status post radiation therapy presented to our ED with increasing chest pain, exertional dyspnea, fatigue, and dizziness for several weeks. She denied syncope or near-syncope, and she had no personal or family history of cardiac disease. Her outpatient medications included tamoxifen and venlafaxine.
MeSH term(s)	Humans ; Female ; Middle Aged ; Dizziness/diagnosis ; Dizziness/etiology ; Syncope ; Chest Pain/diagnosis ; Tamoxifen ; Dyspnea/diagnosis ; Dyspnea/etiology ; Diagnosis, Differential
Chemical Substances	Tamoxifen (094ZI81Y45)
Language	English
Publishing date	2023-03-14
Publishing country	United States
Document type	Case Reports
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2022.10.040
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Ui III Zs.45: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 349: Show issues

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Article ; Online: Separation of Boron and Arsenic from Geothermal Water with Novel Gel-Type Chelating Ion Exchange Resins: Batch and Column Sorption-Elution Studies.

Altıok, Esra / Şen, Fatma / Wolska, Joanna / Cyganowski, Piotr / Bryjak, Marek / Kabay, Nalan / Arda, Müşerref / Yüksel, Mithat

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 23

Abstract: In this research, the removal of boron and arsenic from geothermal water was examined by using ... ...

Abstract	In this research, the removal of boron and arsenic from geothermal water was examined by using novel
Language	English
Publishing date	2023-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28237708
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Zs.MO 81: Show issues

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Article ; Online: Imaging Cancer in Neuroradiology.

Raslan, Osama / Ozturk, Arzu / Oguz, Kader Karli / Sen, Fatma / Aboud, Orwa / Ivanovic, Vladimir / Assadsangabi, Reza / Hacein-Bey, Lotfi

Current problems in cancer

2023 Volume 47, Issue 2, Page(s) 100965

Abstract: Neuroimaging plays a pivotal role in the diagnosis, management, and prognostication of brain tumors. Recently, the World Health Organization published the fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS5), which ... ...

Abstract	Neuroimaging plays a pivotal role in the diagnosis, management, and prognostication of brain tumors. Recently, the World Health Organization published the fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS5), which places greater emphasis on tumor genetics and molecular markers to complement the existing histological and immunohistochemical approaches. Recent advances in computational power allowed modern neuro-oncological imaging to move from a strictly morphology-based discipline to advanced neuroimaging techniques with quantifiable tissue characteristics such as tumor cellularity, microstructural organization, hemodynamic, functional, and metabolic features, providing more precise tumor diagnosis and management. The aim of this review is to highlight the key imaging features of the recently published CNS5, outlining the current imaging standards and summarizing the latest advances in neuro-oncological imaging techniques and their role in complementing traditional brain tumor imaging and management.
MeSH term(s)	Humans ; Magnetic Resonance Imaging/methods ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/therapy ; Neuroimaging/methods ; Brain
Language	English
Publishing date	2023-06-04
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	441816-5
ISSN	1535-6345 ; 0147-0272
ISSN (online)	1535-6345
ISSN	0147-0272
DOI	10.1016/j.currproblcancer.2023.100965
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Se 549: Show issues

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Article ; Online: Identification of Cutinolytic Esterase from Microplastic-Associated Microbiota Using Functional Metagenomics and Its Plastic Degrading Potential.

Adıgüzel, Ali Osman / Şen, Fatma / Könen-Adıgüzel, Serpil / Kıdeyş, Ahmet Erkan / Karahan, Arzu / Doruk, Tuğrul / Tunçer, Münir

Molecular biotechnology

2023

Abstract: Plastic pollution has threatened biodiversity and human health by shrinking habitats, reducing food quality, and limiting the activities of organisms. Therefore, global interest in discovering novel enzymes capable of degrading plastics has increased ... ...

Abstract	Plastic pollution has threatened biodiversity and human health by shrinking habitats, reducing food quality, and limiting the activities of organisms. Therefore, global interest in discovering novel enzymes capable of degrading plastics has increased considerably. Within this context, the functional metagenomic approach, which allows for unlocking the functional potential of uncultivable microbial biodiversity, was used to discover a plastic-degrading enzyme. First, metagenomic libraries derived from microplastic-associated microbiota were screened for esterases capable of degrading both tributyrin and polycaprolactone. Clone KAD01 produced esterase highly active against p-nitrophenyl esters (C2-C16). The gene corresponding to the enzyme activity showed moderate identity (≤ 55.94%) to any known esterases/cutinases. The gene was extracellularly expressed with a 6× histidine tag in E. coli BL21(DE3), extracellularly. Titer of the enzyme (CEstKAD01) was raised from 21.32 to 35.17 U/mL by the statistical optimization of expression conditions and media components. CEstKAD01 was most active at pH 7.0 and 30 °C. It was noteworthy stable over a wide pH (6.0-10.0) and temperature (20-50 °C). The enzyme was active and stable in elevated NaCl concentrations up to 12% (w/v). Pre-incubation of CEstKAD01 with Mg
Language	English
Publishing date	2023-10-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1193057-3
ISSN	1559-0305 ; 1073-6085
ISSN (online)	1559-0305
ISSN	1073-6085
DOI	10.1007/s12033-023-00916-7
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Zs.A 4031: Show issues

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Article ; Online: Dose Reduction in Pediatric Oncology Patients with Delayed Total-Body [

Mingels, Clemens / Spencer, Benjamin A / Nalbant, Hande / Omidvari, Negar / Rokni, Mehrad / Rominger, Axel / Sen, Fatma / Cherry, Simon R / Badawi, Ramsey D / Abdelhafez, Yasser G / Nardo, Lorenzo

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2024

Abstract: Our aim was to define a lower limit of reduced injected activity in delayed [ ...

Abstract	Our aim was to define a lower limit of reduced injected activity in delayed [
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.124.267521
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 328: Show issues

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Article ; Online: Germline mutational variants of Turkish ovarian cancer patients suspected of Hereditary Breast and Ovarian Cancer (HBOC) by next-generation sequencing.

Tuncer, Seref Bugra / Celik, Betul / Erciyas, Seda Kilic / Erdogan, Ozge Sukruoglu / Gültaslar, Busra Kurt / Odemis, Demet Akdeniz / Avsar, Mukaddes / Sen, Fatma / Saip, Pınar Mualla / Yazici, Hulya

Pathology, research and practice

2024 Volume 254, Page(s) 155075

Abstract: Hereditary Breast and Ovarian Cancer (HBOC) syndrome is characterized by an increased risk of developing breast cancer (BC) and ovarian cancer (OC) due to inherited genetic mutations. Understanding the genetic variants associated with HBOC is crucial for ...

Abstract	Hereditary Breast and Ovarian Cancer (HBOC) syndrome is characterized by an increased risk of developing breast cancer (BC) and ovarian cancer (OC) due to inherited genetic mutations. Understanding the genetic variants associated with HBOC is crucial for identifying individuals at high risk and implementing appropriate preventive measures. The study included 630 Turkish OC patients with confirmed diagnostic criteria of The National Comprehensive Cancer Network (NCCN) concerning HBOC. Genomic DNA was extracted from peripheral blood samples, and targeted Next-generation sequencing (NGS) was performed. Bioinformatics analysis and variant interpretation were conducted to identify pathogenic variants (PVs). Our analysis revealed a spectrum of germline pathogenic variants associated with HBOC in Turkish OC patients. Notably, several pathogenic variants in BRCA1, BRCA2, and other DNA repair genes were identified. Specifically, we observed germline PVs in 130 individuals, accounting for 20.63% of the total cohort. 76 distinct PVs in genes, BRCA1 (40 PVs), BRCA2 (29 PVs), ATM (1 PV), CHEK2 (2 PVs), ERCC2 (1 PV), MUTYH (1 PV), RAD51C (1 PV), and TP53 (1PV) and also, two different PVs (i.e., c.135-2 A>G p.? in BRCA1 and c.6466_6469delTCTC in BRCA2) were detected in a 34-year-old OC patient. In conclusion, our study contributes to a better understanding of the genetic variants underlying HBOC in Turkish OC patients. These findings provide valuable insights into the genetic architecture of HBOC in the Turkish population and shed light on the potential contribution of specific germline PVs to the increased risk of OC.
MeSH term(s)	Humans ; Female ; Adult ; Genetic Predisposition to Disease ; Breast Neoplasms/genetics ; Breast Neoplasms/diagnosis ; Hereditary Breast and Ovarian Cancer Syndrome/genetics ; BRCA1 Protein/genetics ; Ovarian Neoplasms/genetics ; Germ-Line Mutation ; High-Throughput Nucleotide Sequencing ; Germ Cells ; Xeroderma Pigmentosum Group D Protein/genetics
Chemical Substances	BRCA1 Protein ; ERCC2 protein, human (EC 5.99.-) ; Xeroderma Pigmentosum Group D Protein (EC 3.6.4.12)
Language	English
Publishing date	2024-01-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2023.155075
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Ud III Zs.20: Show issues

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Article ; Online: Henna Application in the Prevention of Capecitabine-Induced Hand-Foot Syndrome in Breast and Colorectal Cancer Patients.

Kayikci, Emel Emine / Can, Gulbeyaz / Sen, Fatma / Saip, Pınar

Florence Nightingale journal of nursing

2020 Volume 28, Issue 3, Page(s) 299–311

Abstract: Aim: This study investigates the prophylactic effect of henna on the occurrence of hand-foot syndrome (HFS) in patients receiving capecitabine for breast and colorectal cancer.: Method: This experimental study was carried out between May 2014 and May ...

Abstract	Aim: This study investigates the prophylactic effect of henna on the occurrence of hand-foot syndrome (HFS) in patients receiving capecitabine for breast and colorectal cancer. Method: This experimental study was carried out between May 2014 and May 2015. In this self-control experimental study, 52 patients with breast and colorectal cancer were included on the first day of capecitabine treatment and had a minimum follow-up of 3 cycles. One hand/foot of each patient constituted the study hand/foot, whereas the others constituted the control. Henna was administered to the study hand/foot on the first day of treatment and application renewed weekly. Development of grade 1-3 toxicity was set as the termination criterion for study. Results: Painful skin changes such as rawness, intumescence and bulla formation, blocking the daily activities or self-care were observed in 26.9% of the patients in the 3rd or 4th cycles of treatment. Development time and severity of skin changes over time did not differ significantly between the study and the control hand/foot. Conclusion: Further studies with a larger sample size are needed to conclude on the prophylactic effect of henna in the management of the HFS.
Language	English
Publishing date	2020-10-26
Publishing country	Turkey
Document type	Journal Article
ISSN	2687-6442
ISSN (online)	2687-6442
DOI	10.5152/FNJN.2020.19097
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Article ; Online: Circulating lncRNA H19 may be a useful marker of response to neoadjuvant chemotherapy in breast cancer.

Özgür, Emre / Ferhatoğlu, Ferhat / Şen, Fatma / Saip, Pinar / Gezer, Ugur

Cancer biomarkers : section A of Disease markers

2019 Volume 27, Issue 1, Page(s) 11–17

Abstract: Background: Novel biomarkers are needed to predict the effectiveness of the treatment of presurgical neoadjuvant chemotherapy (NAC) in breast cancer (BC).: Objective: This is an exploratory study to assess the impact of 3 cancer-related long non- ... ...

Abstract	Background: Novel biomarkers are needed to predict the effectiveness of the treatment of presurgical neoadjuvant chemotherapy (NAC) in breast cancer (BC). Objective: This is an exploratory study to assess the impact of 3 cancer-related long non-coding RNAs (lncRNAs) (H19, MALAT1 and GA5) in blood plasma of patients with BC in predicting the response to NAC. Methods: The plasma levels of RNAs were relatively measured by quantitative PCR at baseline, and at the end of the fourth cycle of NAC in patients with locally advanced BC. Results: Only H19 was associated with patients' characteristics, and with the response to NAC. Higher plasma expression of H19 was associated with younger age at diagnosis, triple negative tumors, and Ki-67 index. Patients with a pathological complete response (20%) had lower pre-therapeutic levels of H19 compared with the non-complete responders (relative levels 0.1 vs 0.2, respectively, P: 0.04). In addition, the patients with higher degree of downstaging of initial tumors had lower baseline levels of H19 among non-complete responders. Conclusion: Our study reveals that H19, but not MALAT1 and GAS5, may be a useful marker of response to NAC in BC.
MeSH term(s)	Adult ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Breast/drug effects ; Breast/pathology ; Breast Neoplasms/blood ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cyclophosphamide/administration & dosage ; Doxorubicin/administration & dosage ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Ki-67 Antigen/blood ; Liquid Biopsy ; Middle Aged ; Neoadjuvant Therapy ; Paclitaxel/administration & dosage ; RNA, Long Noncoding/blood ; RNA, Long Noncoding/genetics
Chemical Substances	Biomarkers, Tumor ; H19 long non-coding RNA ; Ki-67 Antigen ; MALAT1 long non-coding RNA, human ; RNA, Long Noncoding ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2019-10-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2203517-5
ISSN	1875-8592 ; 1574-0153 ; 1875-8592
ISSN (online)	1875-8592 ; 1574-0153
ISSN	1875-8592
DOI	10.3233/CBM-190085
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