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Article ; Online: Explore & actuate: the future of personalized medicine in oncology through emerging technologies.

Babu, Erald / Sen, Subhojit

2024 Volume 36, Issue 2, Page(s) 93–101

Abstract: Purpose of review: The future of medicine is aimed to equip the physician with tools to assess the individual health of the patient for the uniqueness of the disease that separates it from the rest. The integration of omics technologies into clinical ... ...

Abstract	Purpose of review: The future of medicine is aimed to equip the physician with tools to assess the individual health of the patient for the uniqueness of the disease that separates it from the rest. The integration of omics technologies into clinical practice, reviewed here, would open new avenues for addressing the spatial and temporal heterogeneity of cancer. The rising cancer burden patiently awaits the advent of such an approach to personalized medicine for routine clinical settings. Recent findings: To weigh the translational potential, multiple technologies were categorized based on the extractable information from the different types of samples used, to the various omic-levels of molecular information that each technology has been able to advance over the last 2 years. This review uses a multifaceted classification that helps to assess translational potential in a meaningful way toward clinical adaptation. Summary: The importance of distinguishing technologies based on the flow of information from exploration to actuation puts forth a framework that allows the clinicians to better adapt a chosen technology or use them in combination to enhance their goals toward personalized medicine.
MeSH term(s)	Humans ; Precision Medicine ; Medical Oncology ; Neoplasms/genetics ; Neoplasms/therapy
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1049384-0
ISSN	1531-703X ; 1040-8746
ISSN (online)	1531-703X
ISSN	1040-8746
DOI	10.1097/CCO.0000000000001016
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Article ; Online: A potential screening method for epigenetic drugs: uncovering stress-induced gene silencing in

Kaginkar, Snehal / Priya, Srishti / Sharma, Upnishad / D'Souza, Jacinta S / Sen, Subhojit

Free radical research

2021 Volume 55, Issue 5, Page(s) 533–546

Abstract: Histone modifications and DNA methylation together govern promoter availability, thereby influencing gene expression. This study queries the unicellular chlorophyte, ...

Abstract	Histone modifications and DNA methylation together govern promoter availability, thereby influencing gene expression. This study queries the unicellular chlorophyte,
MeSH term(s)	Animals ; Chlamydomonas/genetics ; Epigenomics/methods ; Gene Silencing/immunology ; Mass Screening
Language	English
Publishing date	2021-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1194130-3
ISSN	1029-2470 ; 1071-5762
ISSN (online)	1029-2470
ISSN	1071-5762
DOI	10.1080/10715762.2021.1876231
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Article ; Online: A Novel Method to Generate MNase Ladders Reveal Rapid Chromatin Remodeling upon Gametogenesis and Mating in Chlamydomonas.

Potdar, Pooja / Pinto, Patricia / D'Souza, Nicole / Joshi, Prajakta / Malwade, Akshay / Sen, Subhojit

Protist

2018 Volume 169, Issue 5, Page(s) 632–644

Abstract: To circumvent nuclei isolation for nucleosomal mapping of wild-type (cell walled) algal cells, we developed a quick and versatile methodology, by abrasion of whole cells (Chlamydomonas, Scenedesmus and yeast), allowing Micrococcal Nuclease (MNase) direct ...

Abstract	To circumvent nuclei isolation for nucleosomal mapping of wild-type (cell walled) algal cells, we developed a quick and versatile methodology, by abrasion of whole cells (Chlamydomonas, Scenedesmus and yeast), allowing Micrococcal Nuclease (MNase) direct access to nuclear chromatin, in situ. Varying parameters such as bead abrasion, vortex and incubation conditions, we optimized capture of an 'early digest' which may probe chromatin differentially, based on nucleosome accessibility. A comparison of such ladders across vegetative cells, gametes and zygotes revealed an increase in the average nucleosomal repeat length (+17-34nt) upon gametogenesis, indicating a trend of chromatin compaction. Using PCR, we compared promoter enrichment in increasing orders of fractionated nucleosomal repeats (mono-, di-, up to penta-), each differing in cleavability based on chromatin accessibility. Concordant with higher gene expression (mating locus), promoters revealed an enrichment in mono-nucleosomal fractions. Interestingly, the zygote specific gene, MT0828 displayed rapid remodelling from penta-nucleosomal enrichment when completely repressed (vegetative), to intermediate states during gametogenesis (24hrs), which finally shifted to being largely mono-nucleosomal, when induced (1h zygotes). Summarizing three candidate genes from the mating locus, we conclude that the MNase based 'Chromatin Accessibility Assay' can track a range of large-scale rapid chromatin remodelling transitions within the binaries of gene expression.
MeSH term(s)	Biocatalysis ; Chlamydomonas/chemistry ; Chlamydomonas/cytology ; Chlamydomonas/genetics ; Chlamydomonas/physiology ; Chromatin/chemistry ; Chromatin/genetics ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; Gametogenesis ; Micrococcal Nuclease/chemistry ; Nucleosomes/chemistry ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Reproduction ; Restriction Mapping/methods
Chemical Substances	Chromatin ; Nucleosomes ; Micrococcal Nuclease (EC 3.1.31.1)
Language	English
Publishing date	2018-07-17
Publishing country	Germany
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2036014-9
ISSN	1618-0941 ; 1434-4610
ISSN (online)	1618-0941
ISSN	1434-4610
DOI	10.1016/j.protis.2018.06.006
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Article ; Online: Genome-wide positioning of bivalent mononucleosomes.

Sen, Subhojit / Block, Kirsten F / Pasini, Alice / Baylin, Stephen B / Easwaran, Hariharan

BMC medical genomics

2016 Volume 9, Issue 1, Page(s) 60

Abstract: Background: Bivalent chromatin refers to overlapping regions containing activating histone H3 Lys4 trimethylation (H3K4me3) and inactivating H3K27me3 marks. Existence of such bivalent marks on the same nucleosome has only recently been suggested. ... ...

Abstract	Background: Bivalent chromatin refers to overlapping regions containing activating histone H3 Lys4 trimethylation (H3K4me3) and inactivating H3K27me3 marks. Existence of such bivalent marks on the same nucleosome has only recently been suggested. Previous genome-wide efforts to characterize bivalent chromatin have focused primarily on individual marks to define overlapping zones of bivalency rather than mapping positions of truly bivalent mononucleosomes. Results: Here, we developed an efficacious sequential ChIP technique for examining global positioning of individual bivalent nucleosomes. Using next generation sequencing approaches we show that although individual H3K4me3 and H3K27me3 marks overlap in broad zones, bivalent nucleosomes are focally enriched in the vicinity of the transcription start site (TSS). These seem to occupy the H2A.Z nucleosome positions previously described as salt-labile nucleosomes, and are correlated with low gene expression. Although the enrichment profiles of bivalent nucleosomes show a clear dependency on CpG island content, they demonstrate a stark anti-correlation with methylation status. Conclusions: We show that regional overlap of H3K4me3 and H3K27me3 chromatin tend to be upstream to the TSS, while bivalent nucleosomes with both marks are mainly promoter proximal near the TSS of CpG island-containing genes with poised/low expression. We discuss the implications of the focal enrichment of bivalent nucleosomes around the TSS on the poised chromatin state of promoters in stem cells.
MeSH term(s)	Cell Line, Tumor ; CpG Islands/genetics ; Epigenesis, Genetic ; Genomics ; Histones/chemistry ; Histones/metabolism ; Humans ; Lysine/metabolism ; Methylation ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Promoter Regions, Genetic/genetics ; Transcription Initiation Site
Chemical Substances	Histones ; Nucleosomes ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2016-09-15
Publishing country	England
Document type	Journal Article
ISSN	1755-8794
ISSN (online)	1755-8794
DOI	10.1186/s12920-016-0221-6
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Article ; Online: DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk.

Xie, Wenbing / Kagiampakis, Ioannis / Pan, Lixia / Zhang, Yang W / Murphy, Lauren / Tao, Yong / Kong, Xiangqian / Kang, Byunghak / Xia, Limin / Carvalho, Filipe L F / Sen, Subhojit / Chiu Yen, Ray-Whay / Zahnow, Cynthia A / Ahuja, Nita / Baylin, Stephen B / Easwaran, Hariharan

Cancer cell

2018 Volume 33, Issue 2, Page(s) 309–321.e5

Abstract: Overall shared DNA methylation patterns between senescence (Sen) and cancers have led to the model that tumor-promoting epigenetic patterns arise through senescence. We show that transformation-associated methylation changes arise stochastically and ... ...

Abstract	Overall shared DNA methylation patterns between senescence (Sen) and cancers have led to the model that tumor-promoting epigenetic patterns arise through senescence. We show that transformation-associated methylation changes arise stochastically and independently of programmatic changes during senescence. Promoter hypermethylation events in transformation involve primarily pro-survival and developmental genes, similarly modified in primary tumors. Senescence-associated hypermethylation mainly involves metabolic regulators and appears early in proliferating "near-senescent" cells, which can be immortalized but are refractory to transformation. Importantly, a subset of transformation-associated hypermethylated developmental genes exhibits highest methylation gains at all age-associated cancer risk states across tissue types. These epigenetic changes favoring cell self-renewal and survival, arising during tissue aging, are fundamentally important for stratifying cancer risk and concepts for cancer prevention.
MeSH term(s)	Animals ; Cell Transformation, Neoplastic/genetics ; Cellular Senescence/genetics ; CpG Islands/genetics ; DNA Methylation/genetics ; Epigenesis, Genetic/genetics ; Humans ; Mice ; Mice, SCID ; Neoplasms/genetics ; Promoter Regions, Genetic/genetics ; Risk
Language	English
Publishing date	2018-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2078448-X
ISSN	1878-3686 ; 1535-6108
ISSN (online)	1878-3686
ISSN	1535-6108
DOI	10.1016/j.ccell.2018.01.008
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Zs.A 5650: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: RecA-promoted sliding of base pairs within DNA repeats: quantitative analysis by a slippage assay.

Navadgi, Vasundhara M / Sen, Subhojit / Rao, Basuthkar J

Biochemical and biophysical research communications

2002 Volume 296, Issue 4, Page(s) 983–987

Abstract: RecA that catalyses efficient homology search and exchange of DNA bases has to effect major transitions in the structure as well as the dynamics of bases within RecA-DNA filament. RecA induces slippage of paired strands in poly(dA)-poly(dT) duplex using ... ...

Abstract	RecA that catalyses efficient homology search and exchange of DNA bases has to effect major transitions in the structure as well as the dynamics of bases within RecA-DNA filament. RecA induces slippage of paired strands in poly(dA)-poly(dT) duplex using the energy of ATP hydrolysis. Here, we have adopted the targeted ligation assay and quantified the strand slippage within a short central cassette of (dA)(4)-(dT)(4) duplex. The design offers a stringent test case for scoring a cross-talk between A residues with those of T that are diagonally placed on the opposite strand at either -3, -2, -1, +1, +2, or +3 pairing frames. As expected, the cross-talk levels in RecA mediated as well as thermally annealed duplexes were maximal in non-diagonal pairing frame (i.e., 0-frame), the levels of which fell off gradually as the frames became more diagonal, i.e., -3<-2<-1 or +3<+2<+1. Interestingly, the level of cross-talk in naked duplexes was intrinsically less efficient in minus frames than their plus frame counterparts. The asymmetry created in naked duplexes by such a disparity between minus versus plus frames was partially obviated by RecA. Moreover, RecA promoted a significantly higher level of cross-talk selectively in -2 and -1 frames, as compared to that in naked DNA, which suggests a model that the elevated cross-talk in RecA filament may be limited to base pairs housed within the same rather than adjacent RecA monomers.
MeSH term(s)	Adenosine Triphosphate/metabolism ; DNA/chemistry ; DNA/metabolism ; Escherichia coli/enzymology ; Hydrolysis ; Oligonucleotides/pharmacology ; Protein Binding ; Rec A Recombinases/metabolism ; Time Factors
Chemical Substances	Oligonucleotides ; Adenosine Triphosphate (8L70Q75FXE) ; DNA (9007-49-2) ; Rec A Recombinases (EC 2.7.7.-)
Language	English
Publishing date	2002-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/s0006-291x(02)02027-2
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Article: Local repeat sequence organization of an intergenic spacer in the chloroplast genome ofChlamydomonas reinhardtii leads to DNA expansion and sequence scrambling: A complex mode of “copychoice replication”?

Wagle, Mahendra D / Sen, Subhojit / Rao, Basuthkar J

Journal of biosciences. 2001 Dec., v. 26, no. 5

2001

Abstract: Parent-specific, randomly amplified polymorphic DNA (RAPD) markers were obtained from total genomic DNA ofChlamydomonas reinhardtii. Such parent-specific RAPD bands (genomic fingerprints) segregated uniparentally (through mt+) in a cross between a pair ... ...

Abstract	Parent-specific, randomly amplified polymorphic DNA (RAPD) markers were obtained from total genomic DNA ofChlamydomonas reinhardtii. Such parent-specific RAPD bands (genomic fingerprints) segregated uniparentally (through mt+) in a cross between a pair of polymorphic interfertile strains ofChlamydomonas (C. reinhardtii andC. minnesotti), suggesting that they originated from the chloroplast genome. Southern analysis mapped the RAPD-markers to the chloroplast genome. One of the RAPD-markers, “P2” (1.6 kb) was cloned, sequenced and was fine mapped to the 3 kb region encompassing 3′ end of 23S, full 5S and intergenic region between 5S and psbA. This region seems divergent enough between the two parents, such that a specific PCR designed for a parental specific chloroplast sequence within this region, amplified a marker in that parent only and not in the other, indicating the utility of RAPD-scan for locating the genomic regions of sequence divergence. Remarkably, the RAPD-product, “P2” seems to have originated from a PCR-amplification of a much smaller (about 600 bp), but highly repeat-rich (direct and inverted) domain of the 3 kb region in a manner that yielded no linear sequence alignment with its own template sequence. The amplification yielded the same uniquely “sequence-scrambled” product, whether the template used for PCR was total cellular DNA, chloroplast DNA or a plasmid clone DNA corresponding to that region. The PCR product, a "unique" new sequence, had lost the repetitive organization of the template genome where it had originated from and perhaps represented a “complex path” of copy-choice replication.
Keywords	chloroplast DNA ; chloroplast genome ; chloroplasts ; genomics ; intergenic DNA ; molecular cloning ; parents ; plasmids ; random amplified polymorphic DNA technique ; sequence alignment
Language	English
Dates of publication	2001-12
Size	p. 583-594.
Publishing place	Springer India
Document type	Article
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
DOI	10.1007/BF02704757
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Article: DNA dynamics in RecA-DNA filaments: ATP hydrolysis-related flexibility in DNA.

Ramreddy, T / Sen, Subhojit / Rao, Basuthkar J / Krishnamoorthy, G

Biochemistry

2003 Volume 42, Issue 41, Page(s) 12085–12094

Abstract: RecA-catalyzed DNA recombination is initiated by a mandatory, high-energy form of DNA in RecA-nucleoprotein filaments, where bases are highly unstacked and the backbone is highly unwound. Interestingly, only the energetics consequent to adenosine ... ...

Abstract	RecA-catalyzed DNA recombination is initiated by a mandatory, high-energy form of DNA in RecA-nucleoprotein filaments, where bases are highly unstacked and the backbone is highly unwound. Interestingly, only the energetics consequent to adenosine triphosphate (ATP) binding, rather than its hydrolysis, seems sufficient to mediate such a high-energy structural hallmark of a recombination filament. The structural consequence of ATP hydrolysis on the DNA part of the filament thus remains largely unknown. We report time-resolved fluorescence dynamics of bases in RecA-DNA complexes and demonstrate that DNA bases in the same exhibit novel, motional dynamics with a rotational correlation time of 7-10 ns, specifically in the presence of ATP hydrolysis. When the ongoing ATP hydrolysis of RecA-DNA filament is "poisoned" by a nonhydrolyzable form of ATP (ATPgammaS), the motional dynamics cease and reveal a global motion with a rotational correlation time of >20 ns. Such ATP hydrolysis-induced flexibility ensues in single-stranded as well as double-stranded bases of RecA-DNA filaments. These results suggest that the role of ATP hydrolysis is to induce a high level of backbone flexibility in RecA-DNA filament, a dynamic property that is likely to be important for efficient strand exchanges in ATP hydrolysis specific RecA reactions. It is the absence of these motions that may cause high rigidity in RecA-DNA filaments in ATPgammaS. Dynamic light scattering measurement comparisons of RecA-ss-DNA filaments formed in ATPgammaS vs that of ATP confirmed such an interpretation, where the former showed a complex of larger (30 nm) hydrodynamic radius than that of latter (12-15 nm). Taken together, these results reveal a more dynamic state of DNA in RecA-DNA filament that is hydrolyzing ATP, which encourage us to model the role of ATP hydrolysis in RecA-mediated DNA transactions.
MeSH term(s)	Adenosine Triphosphate/chemistry ; Base Pairing ; DNA, Bacterial/chemistry ; DNA, Single-Stranded/chemistry ; DNA-Binding Proteins/chemistry ; Escherichia coli Proteins/chemistry ; Fluorescence Polarization ; Hydrolysis ; Light ; Nucleoproteins/chemistry ; Oligonucleotides/chemistry ; Rec A Recombinases/chemistry ; Recombination, Genetic ; Scattering, Radiation ; Spectrometry, Fluorescence ; Thermodynamics
Chemical Substances	DNA, Bacterial ; DNA, Single-Stranded ; DNA-Binding Proteins ; Escherichia coli Proteins ; Nucleoproteins ; Oligonucleotides ; Adenosine Triphosphate (8L70Q75FXE) ; Rec A Recombinases (EC 2.7.7.-)
Language	English
Publishing date	2003-10-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/bi034667k
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Article ; Online: ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex.

Mizuguchi, Gaku / Shen, Xuetong / Landry, Joe / Wu, Wei-Hua / Sen, Subhojit / Wu, Carl

Science (New York, N.Y.)

2004 Volume 303, Issue 5656, Page(s) 343–348

Abstract: The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. How histone variants such as H2AZ are incorporated into nucleosomes has been obscure. ...

Abstract	The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. How histone variants such as H2AZ are incorporated into nucleosomes has been obscure. We have found that Swr1, a Swi2/Snf2-related adenosine triphosphatase, is the catalytic core of a multisubunit, histone-variant exchanger that efficiently replaces conventional histone H2A with histone H2AZ in nucleosome arrays. Swr1 is required for the deposition of histone H2AZ at specific chromosome locations in vivo, and Swr1 and H2AZ commonly regulate a subset of yeast genes. These findings define a previously unknown role for the adenosine triphosphate-dependent chromatin remodeling machinery.
MeSH term(s)	Adenosine Triphosphatases/chemistry ; Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/isolation & purification ; Adenosine Triphosphatases/metabolism ; Adenosine Triphosphate/metabolism ; Catalysis ; Catalytic Domain ; Chromatin/metabolism ; Chromosomes, Fungal/genetics ; DNA, Fungal/genetics ; DNA, Fungal/metabolism ; Dimerization ; Gene Expression Profiling ; Gene Expression Regulation, Fungal ; Gene Silencing ; Genes, Fungal ; Histones/genetics ; Histones/metabolism ; Mutation ; Oligonucleotide Array Sequence Analysis ; Protein Binding ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/isolation & purification ; Saccharomyces cerevisiae Proteins/metabolism ; Telomere/genetics ; Transcription, Genetic
Chemical Substances	Chromatin ; DNA, Fungal ; Histones ; Saccharomyces cerevisiae Proteins ; Adenosine Triphosphate (8L70Q75FXE) ; Adenosine Triphosphatases (EC 3.6.1.-) ; Swr1 protein, S cerevisiae (EC 3.6.1.3)
Language	English
Publishing date	2004-01-16
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.1090701
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Article ; Online: Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus.

Easwaran, Hariharan P / Van Neste, Leander / Cope, Leslie / Sen, Subhojit / Mohammad, Helai P / Pageau, Gayle J / Lawrence, Jeanne B / Herman, James G / Schuebel, Kornel E / Baylin, Stephen B

Cancer research

2010 Volume 70, Issue 20, Page(s) 8015–8024

Abstract: Aberrant promoter DNA-hypermethylation and repressive chromatin constitutes a frequent mechanism of gene inactivation in cancer. There is great interest in dissecting the mechanisms underlying this abnormal silencing. Studies have shown changes in the ... ...

Abstract	Aberrant promoter DNA-hypermethylation and repressive chromatin constitutes a frequent mechanism of gene inactivation in cancer. There is great interest in dissecting the mechanisms underlying this abnormal silencing. Studies have shown changes in the nuclear organization of chromatin in tumor cells as well as the association of aberrant methylation with long-range silencing of neighboring genes. Furthermore, certain tumors show a high incidence of promoter methylation termed as the CpG island methylator phenotype. Here, we have analyzed the role of nuclear chromatin architecture for genes in hypermethylated inactive versus nonmethylated active states and its relation with long-range silencing and CpG island methylator phenotype. Using combined immunostaining for active/repressive chromatin marks and fluorescence in situ hybridization in colorectal cancer cell lines, we show that aberrant silencing of these genes occurs without requirement for their being positioned at heterochromatic domains. Importantly, hypermethylation, even when associated with long-range epigenetic silencing of neighboring genes, occurs independent of their euchromatic or heterochromatic location. Together, these results indicate that, in cancer, extensive changes around promoter chromatin of individual genes or gene clusters could potentially occur locally without preference for nuclear position and/or causing repositioning. These findings have important implications for understanding relationships between nuclear organization and gene expression patterns in cancer.
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Cell Line, Tumor ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; CpG Islands/genetics ; DNA Methylation ; Epigenesis, Genetic ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Silencing ; Genome-Wide Association Study ; Humans ; In Situ Hybridization ; In Situ Hybridization, Fluorescence ; Intercellular Adhesion Molecule-1/genetics ; Microsatellite Repeats/genetics ; MutL Protein Homolog 1 ; Neoplasms/genetics ; Nuclear Proteins/genetics ; Proto-Oncogene Proteins/genetics ; Reverse Transcriptase Polymerase Chain Reaction
Chemical Substances	Adaptor Proteins, Signal Transducing ; MLH1 protein, human ; Nuclear Proteins ; Proto-Oncogene Proteins ; SFRP4 protein, human ; Intercellular Adhesion Molecule-1 (126547-89-5) ; MutL Protein Homolog 1 (EC 3.6.1.3)
Language	English
Publishing date	2010-08-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-10-0765
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