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Article ; Online: Stearoyl coenzyme A desaturase-1: multitasker in cancer, metabolism, and ferroptosis.

Sen, Utsav / Coleman, Charles / Sen, Triparna

2023 Volume 9, Issue 6, Page(s) 480–489

Abstract: Cancer progression is a highly balanced process and is maintained by a sequence of finely tuned metabolic pathways. Stearoyl coenzyme A desaturase-1 (SCD1), the fatty enzyme that converts saturated fatty acids into monounsaturated fatty acids, is a ... ...

Abstract	Cancer progression is a highly balanced process and is maintained by a sequence of finely tuned metabolic pathways. Stearoyl coenzyme A desaturase-1 (SCD1), the fatty enzyme that converts saturated fatty acids into monounsaturated fatty acids, is a critical modulator of the fatty acid metabolic pathway. SCD1 expression is associated with poor prognosis in several cancer types. SCD1 triggers an iron-dependent cell death called ferroptosis and elevated levels of SCD1 protect cancer cells against ferroptosis. Pharmacological inhibition of SCD1 as monotherapy and in combination with chemotherapeutic agents shows promising antitumor potential in preclinical models. In this review, we summarize the role of SCD in cancer cell progression, survival, and ferroptosis and discuss potential strategies to exploit SCD1 inhibition in future clinical trials.
MeSH term(s)	Humans ; Ferroptosis ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Fatty Acids/metabolism ; Fatty Acid Desaturases ; Coenzyme A ; Stearoyl-CoA Desaturase/metabolism
Chemical Substances	Fatty Acids ; Fatty Acid Desaturases (EC 1.14.19.-) ; Coenzyme A (SAA04E81UX) ; Stearoyl-CoA Desaturase (EC 1.14.19.1)
Language	English
Publishing date	2023-04-05
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2852626-0
ISSN	2405-8025 ; 2405-8033 ; 2405-8033
ISSN (online)	2405-8025 ; 2405-8033
ISSN	2405-8033
DOI	10.1016/j.trecan.2023.03.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Corrigendum for "Differential sensitivities of triple-negative breast cancer stem cell towards various doses of vitamin C: An insight into the internal antioxidant systems".

Sen, Utsav / Chaudhury, Debajit / Shenoy P, Sudheer / Bose, Bipasha

Journal of cellular biochemistry

2022 Volume 123, Issue 3, Page(s) 697

Language	English
Publishing date	2022-03-13
Publishing country	United States
Document type	Published Erratum
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.30228
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Article ; Online: Arachidonic acid modulates the cellular energetics of human pluripotent stem cells and protects the embryoid bodies from embryotoxicity effects in vitro.

Nihad, Muhammad / Sen, Utsav / Chaudhury, Debajit / Das, Undurti N / Shenoy P, Sudheer / Bose, Bipasha

Reproductive toxicology (Elmsford, N.Y.)

2023 Volume 120, Page(s) 108438

Abstract: Arachidonic acid (AA), an ω-6 polyunsaturated fatty acid involved in signalling pathways that drive cell fate decisions, has an enhancing role in the immunomodulatory effect on mesenchymal stem cells and the vasculogenesis of embryonic stem cells. 3D ... ...

Abstract	Arachidonic acid (AA), an ω-6 polyunsaturated fatty acid involved in signalling pathways that drive cell fate decisions, has an enhancing role in the immunomodulatory effect on mesenchymal stem cells and the vasculogenesis of embryonic stem cells. 3D embryoid bodies (EBs) from pluripotent stem cells (PSCs) have been used as in vitro models for embryotoxicity for various compounds/drugs. Valproic acid (VA), a common anti-epileptic drug, is known to be embryotoxic and cause malformations in embryos. As early embryogenesis depends on AA, we investigated the embryo protective effects of AA against the embryotoxic drug VA in this study. The effects of AA on the proliferation and cell cycle parameters of PSCs were studied. In particular, the potential of AA to abrogate VA-induced embryotoxicity in vitro was evaluated using ROS detection and antioxidant assays. In response to AA, we observed modulation in cell proliferation of induced pluripotent stem cells (iPSCs) and pluripotent NTERA-2 embryonal carcinoma (EC) cells. The present study substantiates the cytoprotective effects of AA against VA. These results imply that AA plays a critical role in the proliferation and differentiation of iPSCs and EC cells and protects the EBs from cytotoxic damage, thereby ensuring normal embryogenesis. Thus, the bioactive lipid AA may be explored for supplementation to benefit pregnant women treated with long-term anti-epileptic drugs to prevent in-utero fetal growth malformations.
MeSH term(s)	Humans ; Female ; Pregnancy ; Embryoid Bodies ; Arachidonic Acid/metabolism ; Arachidonic Acid/pharmacology ; Pluripotent Stem Cells ; Embryonic Stem Cells ; Cell Differentiation
Chemical Substances	Arachidonic Acid (27YG812J1I)
Language	English
Publishing date	2023-07-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639342-1
ISSN	1873-1708 ; 0890-6238
ISSN (online)	1873-1708
ISSN	0890-6238
DOI	10.1016/j.reprotox.2023.108438
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Zs.A 2316: Show issues

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Article: Mitochondria-targeted half-sandwich iridium(iii)-Cp*-arylimidazophenanthroline complexes as antiproliferative and bioimaging agents against triple negative breast cancer cells MDA-MB-468

Mondal, Ashaparna / Shanavas, Shanooja / Sen, Utsav / Das, Utpal / Roy, Nilmadhab / Bose, Bipasha / Paira, Priyankar

RSC advances. 2022 Apr. 19, v. 12, no. 19

2022

Abstract: To reduce the side effects of marketed cancer drugs against triple negative breast cancer cells we have reported mitochondria targeting half-sandwich iridium(iii)-Cp*-arylimidazophenanthroline complexes for MDA-MB-468 cell therapy and diagnosis. Out of ... ...

Abstract	To reduce the side effects of marketed cancer drugs against triple negative breast cancer cells we have reported mitochondria targeting half-sandwich iridium(iii)-Cp-arylimidazophenanthroline complexes for MDA-MB-468 cell therapy and diagnosis. Out of five Ir(iii) complexes (IrL1–IrL5), [iridium(iii)-Cp-2-(naphthalen-1-yl)-1H-imidazo[4,5-f][1,10]phenanthroline]PF₆ (IrL1) has exhibited the best cytoselectivity against MDA-MB-468 cells compared to normal HaCaT cells along with excellent binding efficacy with DNA as well as serum albumin. The subcellular localization study of the complex revealed the localization of the compound in cytoplasm thereby pointing to a possible mitochondrial localization and consequent mitochondrial dysfunction via MMP alteration and ROS generation. Moreover, the IrL1 complex facilitated a substantial G₁ phase cell-cycle arrest of MDA-MB-468 cells at the highest tested concentration of 5 μM. The study verdicts support the prospective therapeutic potential of the IrL1 complex in the treatment and eradication of triple negative breast cancer cells. These results validate that these types of scaffolds will be fairly able to exert great potential for tumor diagnosis as well as therapy in the near future.
Keywords	DNA ; bioimaging ; breast neoplasms ; cell cycle checkpoints ; iridium ; mitochondria ; serum albumin ; therapeutics
Language	English
Dates of publication	2022-0419
Size	p. 11953-11966.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/d2ra01036d
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mitochondria-targeted half-sandwich iridium(iii)-Cp*-arylimidazophenanthroline complexes as antiproliferative and bioimaging agents against triple negative breast cancer cells MDA-MB-468.

Mondal, Ashaparna / Shanavas, Shanooja / Sen, Utsav / Das, Utpal / Roy, Nilmadhab / Bose, Bipasha / Paira, Priyankar

RSC advances

2022 Volume 12, Issue 19, Page(s) 11953–11966

Abstract	To reduce the side effects of marketed cancer drugs against triple negative breast cancer cells we have reported mitochondria targeting half-sandwich iridium(iii)-Cp-arylimidazophenanthroline complexes for MDA-MB-468 cell therapy and diagnosis. Out of five Ir(iii) complexes (IrL1-IrL5), [iridium(iii)-Cp-2-(naphthalen-1-yl)-1
Language	English
Publishing date	2022-04-19
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra01036d
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Article ; Online: Assessment of Threshold Dose of Thoron Inhalation and Its Biological Effects by Mimicking the Radiation Doses in Monazite Placer Deposits Corresponding to the Normal, Medium and Very High Natural Background Radiation Areas.

Chaudhury, Debajit / Sen, Utsav / Biswas, Siddhartha / Shenoy P, Sudheer / Bose, Bipasha

Biological trace element research

2022 Volume 201, Issue 6, Page(s) 2927–2941

Abstract: The dose contributed from thoron ( ...

Abstract	The dose contributed from thoron (
MeSH term(s)	Animals ; Mice ; Air Pollutants, Radioactive/analysis ; Background Radiation ; Air Pollution, Indoor/analysis ; Radon Daughters/analysis ; Radiation Monitoring/methods ; Radon/analysis ; Radiation Dosage
Chemical Substances	monazite (1306-41-8) ; Air Pollutants, Radioactive ; Radon Daughters ; Radon (Q74S4N8N1G)
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-022-03398-x
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Article ; Online: Inhibition of PfMYST Histone Acetyltransferase Activity Blocks Plasmodium falciparum Growth and Survival.

Sen, Utsav / Nayak, Akshaykumar / Khurana, Juhi / Sharma, Deepu / Gupta, Ashish

Antimicrobial agents and chemotherapy

2020 Volume 65, Issue 1

Abstract: One of the major barriers in the prevention and control of malaria programs worldwide is the growing emergence of multidrug resistance ... ...

Abstract	One of the major barriers in the prevention and control of malaria programs worldwide is the growing emergence of multidrug resistance in
MeSH term(s)	Acetylation ; Animals ; Antimalarials/pharmacology ; Erythrocytes/metabolism ; Histone Acetyltransferases/genetics ; Histone Acetyltransferases/metabolism ; Malaria, Falciparum ; Plasmodium falciparum/genetics ; Plasmodium falciparum/metabolism ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Schizonts/metabolism
Chemical Substances	Antimalarials ; Protozoan Proteins ; Histone Acetyltransferases (EC 2.3.1.48)
Language	English
Publishing date	2020-12-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.00953-20
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Differential sensitivities of triple-negative breast cancer stem cell towards various doses of vitamin C: An insight into the internal antioxidant systems.

Sen, Utsav / Chaudhury, Debajit / Shenoy P, Sudheer / Bose, Bipasha

Journal of cellular biochemistry

2020 Volume 122, Issue 3-4, Page(s) 349–366

Abstract: Cancer stem cells (CSCs) are quiescent and self-renewing, having low levels of reactive oxygen species (ROS), and are responsible for cancer recurrence after chemotherapy and radiotherapy. However, the interplay between the ROS production and scavenging ... ...

Abstract	Cancer stem cells (CSCs) are quiescent and self-renewing, having low levels of reactive oxygen species (ROS), and are responsible for cancer recurrence after chemotherapy and radiotherapy. However, the interplay between the ROS production and scavenging from the oxidative stress has never been studied in breast CSCs. In this present study, we have investigated the cellular energetics of two triple-negative breast cancer stem cells (MDA-MB-231 and MDA-MB-468) treated with two pharmacological doses of vitamin C (10 and 20 mM) that generated ROS. Our results indicate a differential behavior of ROS scavenging by both the CSCs. MDA-MB-468 CSCs exhibited higher resistance to ROS induced damage owing to the higher antioxidant activity, lower mitochondrial damage, and less decrease in membrane potential (ΔΨ
MeSH term(s)	Antioxidants/metabolism ; Apoptosis/drug effects ; Ascorbic Acid/pharmacology ; Cell Line, Tumor ; Female ; Flow Cytometry ; Humans ; Immunohistochemistry ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Superoxide Dismutase/metabolism ; Triple Negative Breast Neoplasms/metabolism
Chemical Substances	Antioxidants ; Reactive Oxygen Species ; Superoxide Dismutase (EC 1.15.1.1) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2020-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.29863
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Article ; Online: Significance of Oct-4 transcription factor as a pivotal therapeutic target for CD44

Sen, Utsav / Shanavas, Shanooja / Nagendra, Apoorva H / Nihad, Muhammad / Chaudhury, Debajit / Rachamalla, Hari K / Banerjee, Rajkumar / Shenoy P, Sudheer / Bose, Bipasha

Cell biology international

2022 Volume 47, Issue 4, Page(s) 742–753

Abstract: Breast cancer (BC) remains one of the deadliest and frequently diagnosed metastatic cancers worldwide. Cancer stem cells (CSCs) are the cell population within the tumor niche, having an epithelial to mesenchymal (EMT) transition phenotype, high self- ... ...

Abstract	Breast cancer (BC) remains one of the deadliest and frequently diagnosed metastatic cancers worldwide. Cancer stem cells (CSCs) are the cell population within the tumor niche, having an epithelial to mesenchymal (EMT) transition phenotype, high self-renewal, vigorous metastatic capacity, drug resistance, and tumor relapse. Identification of targets for induction of apoptosis is essential to provide novel therapeutic approaches in BC. Our earlier studies showed that Vitamin C induces apoptotic cell death by losing redox balance in TNBC CSCs. In this study, we have attempted to identify previously unrecognized CSC survival factors that can be used as druggable targets for bCSCs apoptosis regulators isolated from the TNBC line, MDA MB 468. After a thorough literature review, Oct-4 was identified as the most promising marker for its unique abundance in cancer and absence in normal cells and the contribution of Oct-4 to the sustenance of cancer cells. We then validated a very high expression of Oct-4 in the MDA MB 468 bCSCs population using flow-cytometry. The loss of Oct-4 was carried out using small interfering RNA (siRNA)-mediated knockdown in the bCSCs, followed by assessing for cellular apoptosis. Our results indicated that Oct-4 knockdown induced cell death, changes in cellular morphology, inhibited mammosphere formation, and positive for Annexin-V expression, thereby indicating the role of Oct-4 in bCSC survival. Moreover, our findings also suggest the direct interaction between Oct-4 and Vitamin C using in silico docking. This data, hence, contributes towards novel information about Oct-4 highlighting this molecule as a novel survival factor in bCSCs.
MeSH term(s)	Humans ; Female ; Triple Negative Breast Neoplasms/metabolism ; Octamer Transcription Factor-3/metabolism ; Epithelial-Mesenchymal Transition ; Vitamins ; Neoplastic Stem Cells/metabolism ; Ascorbic Acid ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation ; Hyaluronan Receptors/metabolism
Chemical Substances	Octamer Transcription Factor-3 ; Vitamins ; Ascorbic Acid (PQ6CK8PD0R) ; CD44 protein, human ; Hyaluronan Receptors
Language	English
Publishing date	2022-12-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1143453-3
ISSN	1095-8355 ; 1065-6995
ISSN (online)	1095-8355
ISSN	1065-6995
DOI	10.1002/cbin.11978
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Article: Assessment of oxidative damage in the primary mouse ocular surface cells/stem cells in response to ultraviolet-c (uv-c) damage

Bose, Bipasha / Kapoor, Saketh / Sen, Utsav / Nihad AS, Muhammad / Chaudhury, Debajit / Shenoy P, Sudheer

Journal of visualized experiments. 2020 Feb. 15, , no. 156

2020

Abstract: The ocular surface is subjected to regular wear and tear due to various environmental factors. Exposure to UV-C radiation constitutes an occupational health hazard. Here, we demonstrate the exposure of primary stem cells from the mouse ocular surface to ... ...

Abstract	The ocular surface is subjected to regular wear and tear due to various environmental factors. Exposure to UV-C radiation constitutes an occupational health hazard. Here, we demonstrate the exposure of primary stem cells from the mouse ocular surface to UV-C radiation. Reactive oxygen species (ROS) formation is the readout of the extent of oxidative stress/damage. In an experimental in vitro setting, it is also essential to assess the percentage of dead cells generated due to oxidative stress. In this article, we will demonstrate the 2',7'-Dichlorofluoresceindiacetate (DCFDA) staining of UV-C exposed mouse primary ocular surface stem cells and their quantification based on the fluorescent images of DCFDA staining. DCFDA staining directly corresponds to ROS generation. We also demonstrate the quantification of dead and live cells by simultaneous staining with propidium iodide (PI) and Hoechst 3332 respectively and the percentage of DCFDA (ROS positive) and PI positive cells.
Keywords	environmental factors ; fluorescence ; health hazards ; mice ; occupational health and safety ; oxidative stress ; propidium ; reactive oxygen species ; staining ; stem cells ; ultraviolet radiation
Language	English
Dates of publication	2020-0215
Size	p. e59924.
Publishing place	Journal of Visualized Experiments
Document type	Article
ZDB-ID	2259946-0
ISSN	1940-087X
ISSN	1940-087X
DOI	10.3791/59924
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