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  1. AU="Seon-Hwa Kim"
  2. AU="de Souza, Sibele Pinheiro"
  3. AU="Agnès Sartor"
  4. AU="Donda, Alena"
  5. AU="Park, B H"
  6. AU="Leishman, Stuart"
  7. AU="Somma McGivney, Melissa A"
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  14. AU="Alonso-Sánchez, Jesús"
  15. AU="Zhuo, J C"
  16. AU="Pazurek, Angelica" AU="Pazurek, Angelica"
  17. AU=Sundararaman T
  18. AU="Singla, Amit Kumar"
  19. AU="Shu, Ran"
  20. AU="Kim, Jiha"
  21. AU="MacDonald, Suzanne E."
  22. AU="Heather Limburg"
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  24. AU="Perkins, George H"
  25. AU="Jormanainen, J"
  26. AU="Pichardo-González, Priamo A"
  27. AU="Cannegieter, Suzanne"
  28. AU="Trocino, Giuseppe"
  29. AU="Emiliano, Thais Moura"
  30. AU=Sinelli Mariateresa
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  32. AU="Benoit-Pilven, Clara"
  33. AU="Lanza, Stefania"
  34. AU="Chilingarian, A"
  35. AU="Baldovini, Nicolas"
  36. AU="López Rodríguez, David"
  37. AU="Alexander König"
  38. AU="Jakobsen, Henrik L"
  39. AU="Yong-Zhao Dai"
  40. AU="Tara L. Pukala"
  41. AU="Addo‐Danso, Shalom D."
  42. AU=Ficheux Q.
  43. AU="Tomoyo Sawada"
  44. AU="Mohammad Kawsar Sharif Siam"
  45. AU=Kushnareva Yulia
  46. AU="Canova, Christopher T"
  47. AU="Hasnaoui, Naoual"
  48. AU="Maradana, Jhansi"
  49. AU="Raggini, Elisa"
  50. AU="Baxter, A."
  51. AU="Jackson, Shirnae"
  52. AU="Schenzle, Lisa"
  53. AU="Veronica Phillips"
  54. AU="Braun, Jörg"
  55. AU="Cassandra E. Holbert"
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  1. Artikel ; Online: ATP-Binding Cassette (ABC) Transporters in Fusarium Specific Mycoparasite Sphaerodes mycoparasitica during Biotrophic Mycoparasitism

    Seon Hwa Kim / Vladimir Vujanovic

    Applied Sciences, Vol 12, Iss 15, p

    2022  Band 7641

    Abstract: Recent transcriptomic profiling has revealed importance membrane transporters such as ATP-binding cassette (ABC) transporters in fungal necrotrophic mycoparasites. In this study, RNA-Seq allowed rapid detection of ABC transcripts involved in biotrophic ... ...

    Abstract Recent transcriptomic profiling has revealed importance membrane transporters such as ATP-binding cassette (ABC) transporters in fungal necrotrophic mycoparasites. In this study, RNA-Seq allowed rapid detection of ABC transcripts involved in biotrophic mycoparasitism of Sphaerodes mycoparasitica against the phytopathogenic and mycotoxigenic Fusarium graminearum host, the causal agent of Fusarium head blight (FHB). Transcriptomic analyses of highly expressed S. mycoparasitica genes, and their phylogenetic relationships with other eukaryotic fungi, portrayed the ABC transporters’ evolutionary paths towards biotrophic mycoparasitism. Prior to the in silico phylogenetic analyses, transmission electron microscopy (TEM) was used to confirm the formation of appressorium/haustorium infection structures in S. mycoparasitica during early (1.5 d and 3.5 d) stages of mycoparasitism. Transcripts encoding biotrophy-associated secreted proteins did uncover the enrolment of ABC transporter genes in this specific biocontrol mode of action, while tandem ABC and BUB2 (non-ABC) transcripts seemed to be proper for appressorium development. The next-generation HiSeq transcriptomic profiling of the mycoparasitic hypha samples, revealed 81 transcripts annotated to ABC transporters consisting of a variety of ABC-B (14%), ABC-C (22%), and ABC-G (23%), and to ABC-A, ABC-F, aliphatic sulfonates importer (TC 3.A.1.17.2), BtuF, ribose importer (TC 3.A.1.2.1), and unknown families. The most abundant transcripts belonged to the multidrug resistance exporter (TC 3.A.1.201) subfamily of the ABC-B family, the conjugate transporter (TC 3.A.1.208) subfamily of the ABC-C family, and the pleiotropic drug resistance (PDR) (TC 3.A.1.205) subfamily of the ABC-G family. These findings highlight the significance of ABC transporter genes that control cellular detoxification against toxic substances (e.g., chemical pesticides and mycotoxins) in sustaining a virulence of S. mycoparasitica for effective biotrophic mycoparasitism on the F. graminearum host. ...
    Schlagwörter RNA-Seq ; Sphaerodes ; ABC transporters ; specific biocontrol ; Fusarium head blight ; Fusarium graminearum ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Specific Mycoparasite- Fusarium Graminearum Molecular Signatures in Germinating Seeds Disabled Fusarium Head Blight Pathogen’s Infection

    Seon Hwa Kim / Rachid Lahlali / Chithra Karunakaran / Vladimir Vujanovic

    International Journal of Molecular Sciences, Vol 22, Iss 5, p

    2021  Band 2461

    Abstract: Advances in Infrared (IR) spectroscopies have entered a new era of research with applications in phytobiome, plant microbiome and health. Fusarium graminearum 3-ADON is the most aggressive mycotoxigenic chemotype causing Fusarium head blight (FHB) in ... ...

    Abstract Advances in Infrared (IR) spectroscopies have entered a new era of research with applications in phytobiome, plant microbiome and health. Fusarium graminearum 3-ADON is the most aggressive mycotoxigenic chemotype causing Fusarium head blight (FHB) in cereals; while Sphaerodes mycoparasitica is the specific Fusarium mycoparasite with biotrophic lifestyle discovered in cereal seeds and roots. Fourier transform infrared (FTIR) spectroscopy analyses depicted shifts in the spectral peaks related to mycoparasitism mainly within the region of proteins, lipids, also indicating a link between carbohydrates and protein regions, involving potential phenolic compounds. Especially, S. mycoparasitica contributes to significant changes in lipid region 3050–2800 cm −1 , while in the protein region, an increasing trend was observed for the peaks 1655–1638 cm −1 (amide I) and 1549–1548 cm −1 (amide II) with changes in indicative protein secondary structures. Besides, the peak extending on the region 1520–1500 cm −1 insinuates a presence of aromatic compounds in presence of mycoparasite on the F. graminearum root sample. Monitoring shift in improved seed germination, fungus-fungus interface through scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM), and FTIR molecular signatures combined with principal component analysis (PCA) proved useful tools to detect an early mycoparasitism as a vital asset of the preventive biocontrol strategy against plant pathogens.
    Schlagwörter seeds ; fourier transform infrared (FTIR) ; interactome ; mycoparasitism ; Fusarium graminearum ; fusarium head blight (FHB) ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Natural Fungicolous Regulators of Biscogniauxia destructiva sp. nov. That Causes Beech Bark Tarcrust in Southern European ( Fagus sylvatica ) Forests

    Vladimir Vujanovic / Seon Hwa Kim / Jelena Latinovic / Nedeljko Latinovic

    Microorganisms, Vol 8, Iss 1999, p

    2020  Band 1999

    Abstract: Mycoparasites are a collection of fungicolous eukaryotic organisms that occur on and are antagonistic to a wide range of plant pathogenic fungi. To date, this fungal group has largely been neglected by biodiversity studies. However, this fungal group is ... ...

    Abstract Mycoparasites are a collection of fungicolous eukaryotic organisms that occur on and are antagonistic to a wide range of plant pathogenic fungi. To date, this fungal group has largely been neglected by biodiversity studies. However, this fungal group is of interest, as it may contain potential biocontrol agents of pathogenic fungi that cause beech Tarcrust disease (BTC), which has contributed to the devastation of European beech ( Fagus sylvatica ) forests. Biscogniauxia nummularia has been demonstrated to cause BTC. However, a trophic association between mycoparasites and pathogenic Biscogniauxia spp., has not been established. This study aimed to taxonomically identify and characterize Biscogniauxia , a fungus causing destructive BTC disease in European beech at Lovćen national park, Montenegro and to uncover the diversity of mycopathogens that are natural regulators of xylariaceous Biscogniauxia stroma formation, associated with beech decline. This finding is supported by distinctive phylogenetic and evolutionary characteristics, as well as unique morphological-microscopic fungal features indicating that Biscogniauxia from Montenegro, which is a major cause of BTC occurring in ancient beech forests at the edge of southern Fagus sylvatica distribution, may be described as a novel fungus specific to Fagus. Its evolutionary nuSSU–complete ITS–partial nuLSU rDNA phylogeny indicates its likely emergence by asexual fusion or introgressive hybridization between diverged B. nummularia and B. anceps species. The name Biscogniauxia destructiva is proposed for the novel fungus, as it is aggressive and highly destructive BTC disease.
    Schlagwörter Tarcrust disease ; beech forest ; Biscogniauxia ; fungicolous fungi ; mycoparasites ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2020-12-01T00:00:00Z
    Verlag MDPI AG
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Characterization of Marine Organism Extracellular Matrix-Anchored Extracellular Vesicles and Their Biological Effect on the Alleviation of Pro-Inflammatory Cytokines

    Sung-Han Jo / Seon-Hwa Kim / Changsu Kim / Sang-Hyug Park

    Marine Drugs, Vol 19, Iss 592, p

    2021  Band 592

    Abstract: Representative marine materials such as biopolymers and bioceramics contain bioactive properties and are applied in regenerative medicine and tissue engineering. The marine organism-derived extracellular matrix (ECM), which consists of structural and ... ...

    Abstract Representative marine materials such as biopolymers and bioceramics contain bioactive properties and are applied in regenerative medicine and tissue engineering. The marine organism-derived extracellular matrix (ECM), which consists of structural and functional molecules, has been studied as a biomaterial. It has been used to reconstruct tissues and improve biological functions. However, research on marine-derived extracellular vesicles (EVs) among marine functional materials is limited. Recent studies on marine-derived EVs were limited to eco-system studies using bacteria-released EVs. We aimed to expand the range of representative marine organisms such as fish, crustaceans, and echinoderms; establish the extraction process; and study the bioactivity capability of marine EVs. Results confirmed that marine organism ECM-anchored EVs (mEVs) have a similar morphology and cargos to those of EVs in land animals. To investigate physiological effects, lipopolysaccharide (LPS)-infected macrophages were treated with EVs derived from sea cucumber, fish, and shrimp. A comparison of the expression levels of inflammatory cytokine genes revealed that all types of mEVs alleviated pro-inflammatory cytokines, although to different degrees. Among them, the sea cucumber-derived EVs showed the strongest suppression ability. This study showed that research on EVs derived from various types of marine animals can lead to the development of high value-added therapeutics from discarded marine wastes.
    Schlagwörter marine organism ; extracellular matrix ; extracellular vesicle ; sea cucumber ; anti-inflammation ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2021-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Collagen Peptide in a Combinatorial Treatment with Lactobacillus rhamnosus Inhibits the Cariogenic Properties of Streptococcus mutans

    Hee-Young Jung / Jian-Na Cai / Sung Chul Yoo / Seon-Hwa Kim / Jae-Gyu Jeon / Dongyeop Kim

    International Journal of Molecular Sciences, Vol 23, Iss 1860, p

    An In Vitro Study

    2022  Band 1860

    Abstract: Dental caries is caused by the formation of cariogenic biofilm, leading to localized areas of enamel demineralization. Streptococcus mutans , a cariogenic pathogen, has long been considered as a microbial etiology of dental caries. We hypothesized that ... ...

    Abstract Dental caries is caused by the formation of cariogenic biofilm, leading to localized areas of enamel demineralization. Streptococcus mutans , a cariogenic pathogen, has long been considered as a microbial etiology of dental caries. We hypothesized that an antagonistic approach using a prebiotic collagen peptide in combination with probiotic Lactobacillus rhamnosus would modulate the virulence of this cariogenic biofilm. In vitro S. mutans biofilms were formed on saliva-coated hydroxyapatite discs, and the inhibitory effect of a combination of L. rhamnosus and collagen peptide on S. mutans biofilms were evaluated using microbiological, biochemical, confocal imaging, and transcriptomic analyses. The combination of L. rhamnosus with collagen peptide altered acid production by S. mutans , significantly increasing culture pH at an early stage of biofilm formation. Moreover, the 3D architecture of the S. mutans biofilm was greatly compromised when it was in the presence of L. rhamnosus with collagen peptide, resulting in a significant reduction in exopolysaccharide with unstructured and mixed bacterial organization. The presence of L. rhamnosus with collagen peptide modulated the virulence potential of S. mutans via down-regulation of eno , ldh , and atpD corresponding to acid production and proton transportation, whereas aguD associated with alkali production was up-regulated. Gly-Pro-Hyp, a common tripeptide unit of collagen, consistently modulated the cariogenic potential of S. mutans by inhibiting acid production, similar to the bioactivity of a collagen peptide. It also enhanced the relative abundance of commensal streptococci ( S. oralis ) in a mixed-species biofilm by inhibiting S. mutans colonization and dome-like microcolony formation. This work demonstrates that food-derived synbiotics may offer a useful means of disrupting cariogenic communities and maintaining microbial homeostasis.
    Schlagwörter synbiotics ; probiotics ; prebiotics ; cariogenic biofilms ; metabolic interference ; acidogenicity ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Spectroscopy and SEM imaging reveal endosymbiont-dependent components changes in germinating kernel through direct and indirect coleorhiza-fungus interactions under stress

    Vladimir Vujanovic / Seon Hwa Kim / Rachid Lahlali / Chithra Karunakaran

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Band 9

    Abstract: Abstract In the present study, FTIR spectroscopy and hyperspectral imaging was introduced as a non-destructive, sensitive-reliable tool for assessing the tripartite kernel-fungal endophyte environment interaction. Composition of coleorhizae of Triticum ... ...

    Abstract Abstract In the present study, FTIR spectroscopy and hyperspectral imaging was introduced as a non-destructive, sensitive-reliable tool for assessing the tripartite kernel-fungal endophyte environment interaction. Composition of coleorhizae of Triticum durum was studied under ambient and drought stress conditions. The OH-stretch IR absorption spectrum suggests that the water-deficit was possibly improved or moderated by kernel’s endophytic partner. The OH-stretch frequency pattern coincides with other (growth and stress) related molecular changes. Analysis of lipid (3100–2800 cm−1) and protein (1700–1550 cm−1) regions seems to demonstrate that drought has a positive impact on lipids. The fungal endosymbiont direct contact with kernel during germination had highest effect on both lipid and protein (Amide I and II) groups, indicating an increased stress resistance in inoculated kernel. Compared to the indirect kernel-fungus interaction and to non-treated kernels (control), direct interaction produced highest effect on lipids. Among treatments, the fingerprint region (1800–800 cm−1) and SEM images indicated an important shift in glucose oligosaccharides, possibly linked to coleorhiza-polymer layer disappearance. Acquired differentiation in coleorhiza composition of T. durum, between ambient and drought conditions, suggests that FTIR spectroscopy could be a promising tool for studying endosymbiont-plant interactions within a changing environment.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2019-02-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Phagocytosis influences the intracellular survival of Mycobacterium smegmatis via the endoplasmic reticulum stress response

    Seon-Hwa Kim / Soo-Na Cho / Yun-Ji Lim / Ji-Ae Choi / Junghwan Lee / Dam Go / Chang-Hwa Song

    Cell & Bioscience, Vol 8, Iss 1, Pp 1-

    2018  Band 11

    Abstract: Abstract Background Mycobacterium smegmatis, a rapidly growing non-tuberculosis mycobacterium, is a good model for studying the pathogenesis of tuberculosis because of its genetic similarity to Mycobacterium tuberculosis (Mtb). Macrophages remove ... ...

    Abstract Abstract Background Mycobacterium smegmatis, a rapidly growing non-tuberculosis mycobacterium, is a good model for studying the pathogenesis of tuberculosis because of its genetic similarity to Mycobacterium tuberculosis (Mtb). Macrophages remove mycobacteria during an infection. Macrophage apoptosis is a host defense mechanism against intracellular bacteria. We have reported that endoplasmic reticulum (ER) stress is an important host defense mechanism against Mtb infection. Results In this study, we found that M. smegmatis induced strong ER stress. M. smegmatis-induced reactive oxygen species (ROS) play a critical role in the induction of ER stress-mediated apoptosis. Pretreatment with an ROS scavenger suppressed M. smegmatis-induced ER stress. Elimination of ROS decreased the ER stress response and significantly increased the intracellular survival of M. smegmatis. Interestingly, inhibition of phagocytosis significantly decreased ROS synthesis, ER stress response induction, and cytokine production. Conclusions Phagocytosis of M. smegmatis induces ROS production, leading to production of proinflammatory cytokines. Phagocytosis-induced ROS is associated with the M. smegmatis-mediated ER stress response in macrophages. Therefore, phagocytosis plays a critical role in the induction of ER stress-mediated apoptosis during mycobacterial infection.
    Schlagwörter ER stress response ; Apoptosis ; Phagocytosis ; Reactive oxygen species ; Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Sprache Englisch
    Erscheinungsdatum 2018-09-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Post-harvest Decay of ‘Campbell Early’ Grape

    Young-Hee Noh / Yong-Eon Kim / Min-Ji Song / Ji-Hye An / Min-Jung Jeong / Jae-Soon Cha / Seung-Beom Hong / Seon-Hwa Kim / Hyok-In Lee

    Research in Plant Disease, Vol 20, Iss 4, Pp 275-

    2014  Band 282

    Abstract: The occurrence of post-harvest diseases and their pathogens in ‘Campbell Early’ which is the most produced grape in Korea was investigated. The ‘Campbell Early’ grapes produced in 3 main grape-producing areas were stored in a cold room (0-4°C) for 2 ... ...

    Abstract The occurrence of post-harvest diseases and their pathogens in ‘Campbell Early’ which is the most produced grape in Korea was investigated. The ‘Campbell Early’ grapes produced in 3 main grape-producing areas were stored in a cold room (0-4°C) for 2 weeks then at room temperature for 4 weeks prior to investigation. The major post-harvest diseases occurred were gray mold, blue mold, ripe rot, new decay 1, and new decay 2. Pathogens isolated from the symptoms were identified as Botrytis cinerea for gray mold, Penicillium sclerotiorum for blue mold and Collectrichum acutatum for ripe rot. Pathogens for new decay 1 and new decay 2 were not identified yet. Incidences of new decay 1 and new decay 2 were much higher than the other 3 decays in all grapes produced from 3 areas. Gray mold and blue mold occurred at much lower frequencies than these two decays, and ripe rot occurred least.
    Schlagwörter Blue mold ; Gray mold ; Ripe rot ; Agriculture (General) ; S1-972
    Sprache Englisch
    Erscheinungsdatum 2014-12-01T00:00:00Z
    Verlag Hanrimwon Publishing Company
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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